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The Iberian Roma Population Variant Server(IRPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard Javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de biomedicina de Sevilla(IbiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación biomédica en Red Enfermedades Neurodegenerativas(CIbERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain bioinformática en Enfermedades raras(biER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares Silva Tiago Soares barbosa Maria Leonisa Sanchez-nuñez Aldenise Mont Serrat Rosa da Silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice bernardino Helena Carla Castro Izabel Christina nunes de Palmer Paixão Science and biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

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Microstructure and properties of as-cast Zr-2.5Nb-1X(X=Ru,Mo,Ta and Si) alloys for biomedical application

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Rare Metals 2023年第10期42卷 3497-3509页

作者： Xi-nu Tan Fei-Tao Li Yu-Shun Liu Ri-Sheng Qiu Qing Liu Electron Microscopy Center College of Materials Science and EngineeringChongqing UniversityChongqing400044China International Joint Laboratory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing400044China TU Ilmenau Chair Materials for Electrical Engineering and ElectronicsInstitute of Materials Science and Engineering and Institute of Micro-and Nanotechnologies MacroNanoIlmenau98693Germany Department of Mechanical Engineering University of ManitobaWinnipegMBR3T 5V6Canada Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing210009China

The micro structure and properties of as-cast Zr-2.5Nb-1X(X=Ru,Mo,Ta and Si) alloy are screened to explore novel biomedical zirconium alloys for magnetic resonance *** micro structure and phase transformation were characterized using X-ray diffraction(XRD),scanning electron microscope(SEM)and transmission electron microscope(TEM).Hardness test,magnetic detection and electrochemical corrosion measurements are taken to present *** results show that all alloys consist of α-Zr,β-Zr and ω-Zr.α-Zr and β-Zr mainly exist in the form of parallel and intersecting plates,and nanoscale ω-Zr is dispersed in β-Zr ***,blocky ω-Zr with needle-like α-Zr is only found in plate-free blocks of Zr-2.5Nb-1Mo/Ru *** orientation relationship(OR) between α-Zr and ω-Zr follows [1120]_α//[1101]_ω and(0001)_α//([1011]_ω 011)_ω.Combining this OR with the OR between β-Zr and ω-Zr,the transformation relationship between β-Zr/ω-Zr and α-Zr is also ***-2.5Nb-1Ru alloy with high corrosion potential(-0.500 V),low corrosion rate(0.949 μm·year^(-1)) and low magnetic susceptibility(92×10^(-6)) shows great potential to be a novel biomedical implant with magnetic resonance imaging *** on the experimental results,the possible relationship among alloying elements,micro structure and properties has been established in these Zr-2.5Nb-1X alloys.

关键词： Zirconium alloy Microstructure Phase transformation Electrochemical corrosion Magnetic susceptibility

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Hypertrophic Scar Formation and Wound Healing Modulation Fatty Acids as Modulators of Severe Scars

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Modern Plastic Surgery 2023年第1期13卷 41-51页

作者： bárbara Díaz Valerie nuñ ez Department of General Surgery Burn Unit Care Dr. Ricardo Gutiérrez Children’s Hospital Buenos Aires Argentina

Scar tissue usually generates severe discomfort in the short and long term. Common symptoms include anesthetics sequelae, pruritus, joint malfunction, new wounds on the scar surface, and pain. There are several treatments for scars, like compression, topical or intralesional steroid infiltration, 5-fluorouracil, dermabrasion, and surgeries with new scar tissue. For adult patients, it is easier to choose the treatment. However, compression is commonly applied in children to prevent treatments that have adverse effects. This study reports the outcomes of 15 patients submitted to abdominoplasty, traumatic wounds and post-burn scar treatments, which showed significant changes after the continuous use of an ointment composed of petrolatum, cod liver oil, bHT, Chamomilla recutita (chamomile) oil, Helianthus annuus (sunflower) oil, and Prunus amygdalus dulcis (sweet almond) oil. As components of the stratum corneum, unsaturated fatty acids influence the cutaneous structural and immune status and permeability. They also interfere with the maturation and differentiation of the stratum corneum and inhibit the production of proinflammatory eicosanoids, reactive species (ROS and RNS), and cytokines, thereby influencing the inflammatory response and possibly wound healing. This article aims to share our experience with the regular use of an ointment in adult and pediatric patients for three months. The increase in proinflammatory cytokine production at wound sites, resulting in a noninvasive, therapeutical, and effective cutaneous wound healing and scarring modulation, may provide a physiopathological explanation for the fast improvement of scars.

关键词： Scarring burn Scar Inflammatory Modulation Cytokine Sequelae Fatty Acids Eicosanoids Non-Adverse Effects Aesthetics Hypertrophic

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Designing of anisotropic gradient surfaces for directional liquid transport:Fundamentals,construction,and applications

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The Innovation 2023年第6期4卷 115-131页

作者： Lanlan Hou Xiaofei Liu Xinran Ge Rongjun Hu Zhimin Cui nu WangYong Zhao Key Laboratory of bioinspired Smart Interfacial Science and Technology of Minitry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China School of Printing and Packaging Engineer Beijing Institute of Graphic CommunicationBeiing 102600China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBejjing 100190China Institute of Applied Chemistry Jiangxi Academy of SciencesNanchang 330096China

Many biological surfaces are capable of transporting liquids in a directional manner without energy *** by nature,constructing asymmetric gradient surfaces to achieve desired droplet transport,such as a liquid diode,brings an incredibly valuable and promising area of research with a wide range of *** by advances in nano-technology and manufacturing techniques,biomimetics has emerged as a promising avenue for engineering various types of anisotropic material *** the past few decades,this approach has yielded significant progressin both fundamental understanding and practical *** studies revealed that the heterogeneous composition and topography mainly govern the wetting mechanisms and dynamics behavior of droplets,including the interdisciplinary aspects of materials,chemistry,and *** this review,we provide a concise overview of various biological surfaces that exhibit anisotropic droplet *** discussed the theoretical foundations and mechanisms of droplet motion on designed surfaces and reviewed recent research advances in droplet directional transport on designed plane surfaces and Janus *** liquid-diode materials yield diverse promising applications,involving droplet collection,liquid separation and delivery,functional textiles,and biomedical *** also discuss the recent challenges and ongoing approaches to enhance the functionality and application performance of anisotropic materials.

关键词： anisotropic directional gradient

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Polyphenolic Compounds and Antioxidant Activity of Sea buckthorn(Hippophae rhamnoides L.)

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Phyton-International Journal of Experimental botany 2023年第11期92卷 2965-2979页

作者： Ain Raal Linda Rusalepp Tatiana Chiru Nicolae Ciob.nu Kelly Talvistu Michelle Shusta Oleh Koshovyi Tõnu Püssa Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia Chair of Veterinary biomedicine and Food Hygiene Institute of Veterinary Medicine and Animal SciencesEstonian University of Life SciencesTartu51006Estonia Faculty of Pharmacy Nicolae Testemitanu State Medical and Pharmaceutical UniversityChisinauMD-2001Republic of Moldova Pharmacognosy Department The National University of PharmacyKharkiv61002Ukraine

The fruits of the Sea buckthorn(Hippophae rhamnoides L.)are a popular plant food and a valuable health *** plants produces a lot of leaves with fine branches as an unnecessary residue,which needs *** aim of the study was to estimate(by HPLC-MS/MS)the qualitative and quantitative content of polyphenolic compounds in different parts of ***(HR),and to determine the level of antioxidant activity of leaves and fruits(by DPPH,AbTS methods and ferrozine test).Up to 19 compounds were identified in different parts of *** fruits are rich in flavonoids,including various glycosides of flavonols isorhamnetin,quercetin,and *** isorhamnetin glycosides were not identified in the leaves,while isorhamnetin-3-rhamnosylglactosides and the ellagitannins hippophaenin b,stachyurin and casuarinin were present only in the leaves of the *** bark and roots contained considerably more catechins,but minimal flavonols than the fruits and leaves of *** total phenolics and flavonols were most abundant in water infusions from leaves of HR(especially quercetin-3-O-glucoside-7-O-rhamnoside),compared to methanolic *** significant differences in the quantitative and qualitative content of the fresh and dried leaves were *** highest antioxidant activity by all three methods was detected in the leaves of *** addition to the fruits,the leaves may have a perspective as a source of biologically active substances of HR.

关键词： bark flavonols fruits leaves phenols roots

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Arsenate and phosphate interaction in Saccharomyces cerevisiae

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Journal of Environmental Sciences 2006年第1期18卷 96-100页

作者： GENG Chun-nu ZHU Yong-guan Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Shanghai Academy of Environmental Sciences Shanghai 200233 China

In the present study, arsenate（As（V）） and phosphate（P（V）） interactions were investigated in growth, uptake and RNA content in yeast（Saccharomyces cerevisiae）. Yeast grew slowly with As（V） concentrations increasing in the medium. However, the maximal population density was almost the same among different As（V） treatments. It was in the late log phase that yeast growth was aug- mented by low As（V）, which was maybe due to the fact that methionine metabolism was stressed by vitamin b6 deprivation, so As（V） treatments did not affect maximal population density. However, with P （V） concentrations increasing, the maximal population density increased. Therefore, the maximal population density was determined by P （V） concentrations in the medium but not by As （V） concentrations in the medium. Ycflp（a tonoplast transpor） transports As（GS）3 into the vacuole, but arsenic（As） remaining in the thalli was 1.27% with As（V） exposure for 60 h, from which it can be speculated that the percentage of As transported into vacuole should be lower than 1.27%. However, the percentage of As pumped out of cell was 71.49% with As （V） exposure for 68 h. Although two pathways （extrusion and sequestration） were involved in As detoxification in yeast, the extrusion pathway played a major role in As detoxification. RNA content was the highest in the early-log phase and was reduced by As（V）.

关键词： yeast maximal population density arsenic essentiality arsenic speciation

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Climate change impact assessment on three major crops in the north-central region of bangladesh using DSSAT

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International Journal of Agricultural and biological Engineering 2018年第4期11卷 135-143页

作者： Atikur Rahman Mohammad Abdul Mojid selina b.nu Department of Irrigation and Water Management Bangladesh Agricultural UniversityMymensingh-2202Bangladesh Department of Agricultural and Industrial Engineering Hajee Mohammad Danesh Science and Technology UniversityDinajpur-5200Bangladesh

The potential consequences of climate change emanated from global warming are very alarming;the greatest concern is the potentially disastrous consequences on crop agriculture and food security in many parts of the *** is a country highly susceptible to climate change,but information in this regard is still *** study investigated the effects of climate change on three major crops-wheat,potato and rice-in the north-central region of *** climate change scenarios,A2 and b2,of the Intergovernmental Panel on Climate Change(IPCC)were generated by employing MAGICC/SCENGEN model together with the observed climate data of the *** growth and yield of the crops were simulated using DSSAT CERES-Wheat,SUbSTOR-Potato and CERES-Rice models under the present and projected future changing climatic *** a predicted 5.32℃ increase in temperature in the year 2100,the yield of wheat,rice and potato would decrease by 47.6%,67.8%and 38.6%,*** increased temperature would accelerate physiological maturity of the crops as reflected by their reduced length of growing season(LGS)by 1.20%to 18.5%.The reduced LGS would reduce seasonal evapotranspiration(ET)of the crops by shortening time-span for ET *** to dominant yield reduction over ET reduction,the water use efficiency(WUE)for grain/tuber and biomass yields would decrease with the changing *** reduced crop yields are an indicative of a potential future risk of food security in *** results of this study can therefore guide to adopt coping mechanisms in the light of climate change to ensure future food security of the country.

关键词： climate change DSSAT MAGICC/SCENGEN model CERES model SUbSTOR model growing season length crop-water use

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Delamination Testing of AlSi10Mg Sandwich Structures with Pyramidal Lattice Truss Core made by Laser Powder bed Fusion

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Chinese Journal of Mechanical Engineering 2021年第6期34卷 51-62页

作者： M.nuño J.bühring M.N.Rao K.-U.Schröder Institute of Structural Mechanics and Lightweight Design RWTH Aachen UniversityWüllnerstraβe 752072 AachenGermany

Sandwich structures possess a high bending stiffness compared to monolithic structures with a similar *** makes them very suitable for lightweight applications,where high stiffness to weight ratios are *** common manufacturing methods of sandwich structures involve adhesive bonding of the core material with the ***,adhesive bonding is prone to delamination,a failure mode that is often difficult to *** paper presents the results of delamination testing of fully additive manufactured(AM)AlSi10Mg sandwich structures with pyramidal lattice truss core using Laser Powder bed Fusion(LPbF).The faces and struts are 0.5 mm thick,while the core is 2 mm *** inclination of the struts is 45°.To characterise the bonding strength,climbing drum peel tests and out-of-plane tensile tests are *** formulas are derived to predict the expected failure loads and *** analytics and tests are supported by finite element(FE)*** the analytic approach,design guidelines to avoid delamination in AM sandwich structures are *** study presents a critical face sheet thickness to strut diameter ratio for which the structure can *** ratio is mainly influenced by the inclination of the *** peel tests resulted in face yielding,which can also be inferred from the analytics and *** out-of-plane tensile tests didn’t damage the structure.

关键词： Additive Manufacturing Sandwich Structures Pyramidal Lattice Core

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The black pottery coating of longshan times from Taosi Site

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Science China(Technological Sciences) 2011年第7期54卷 1708-1714页

作者： LU XiaoKe LI WeiDong LUO HongJie HE nu LI XinWei Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China Institute of Archaeology Chinese Academy of Social Sciences Beijing 100710 China

Taosi is an archaeological site in Xiangfen county, Shanxi province. It is considered as a capital city site with the rudiment of an early country in Longshan Times. In this work, the black pottery coating was found on the surface of black and grey pottery of Longshan times and confirmed by scientific studies for the first time. It filled in the blank of pottery coating study in this time period at the Yellow River Valley, as well as supplied a new study method of "black skin pottery" besides the carburization craft. In addition, according to the archaeological materials, we inferred that the wares with this pottery coating might be only used by the nobility at that time.

关键词：考古遗址龙山黑陶涂料省会城市表面科学黄河流域考古资料

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