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SHORT-TERM EFFECT OF LATANOPOST ON INTRAOCULAR PRESSURE AND OCU-LAR CIRCULATION IN OCULAR HYPER-TENSION

国际眼科杂志 2003年第1期3卷 31-31页

作者： Cengiz akarsu Y.K.Bilgili P.Taner B.Unal A.Ergin Department of Ophthalmology Department of OphthalmologyDepartment of OphthalmologyDepartment of Radiology Faculty of Medicine Kirikkale University TurkeyDepartment of Ophthalmology

Purpose: To determine the stort-term effects of latano-prost (Xalatan) on the retrobulbar circulation and intraocular pressure (IOP) in ocular hypertension. Materials and Methods: Forty-six eyes of 23 consecutive ocular hypertension patients older than 20 years. All patients had IOP greater than 22 mmHg. One eye of each patient was randomly selected to

关键词：高眼压拉坦前列素眼内压球后循环短期疗效

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硬膜外阻滞与腰麻-硬腹外联合阻滞用于剖宫产对产妇和新生儿影响的比较

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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 19-19页

作者： Karaman S. Akercan F. akarsu T. 朱亮 Department of Obstetrics and Gynecology Ege UniversityFaculty of Medicine Izmir 35100 Turkey

Background: Combined spinal-epidural block (CSEB) has aroused increasing interest, as it combines the reliability of a spinal block and the flexibility of an epidural block (EB). We have conducted a comparative investigation of the maternal and fetal effects of CSEB and of EB administered for Cesarean section. Methods: Eighty pregnant women at term were randomized into two groups. Women in the CSEB group (N = 40) were each given 1.5- 1.8 mL 0.5% hyperbaric bupivacaine intrathecally, followed by 10 mL 0.25% bupivacaine and 50 μ g fentanyl through the epidural catheter 10 min later. Women in the EB group (N = 40) received 14- 16 mL 0.5% bupivacaine and 100 μ g fentanyl. The quality and side effects of surgical anesthesia and the hemodynamic parameters, Apgar scores, and postoperative duration of pain were compared between the two groups. Results: The time for the block to reach the T- 4 level differed significantly between the two groups (8.02± 3.4 versus 18.34± 4.6; P < 0.01). More women in the CSEB group achieved complete motor blockade (Bromage score 3), and it was reached earlier than in the EB group (P < 0.05). Muscle relaxation and motor block were better in the CSEB group than in the EB group (P < 0.01). Apgar scores were 7 or more in almost all newborns in both groups. There were no significant differences between the groups in the incidences of adverse effects such as hypotension or nausea and vomiting, but the patients in the EB group experienced more shivering (P < 0.001). The time to postoperative pain was significantly shorter in the CSEB group. Conclusion: We decided that CSEB, and more specifically spinal anesthesia with supporting epidural anesthesia, has greater efficacy and fewer side effects than EB when administered for Cesarean section.

关键词：剖宫产手术硬膜外阻滞腹外联合阻滞丁哌卡因硬膜外麻醉足月孕妇硬膜外导管肌肉松弛术后疼痛

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高眼压患者的大脑血流动力学

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 35-35页

作者： akarsu C. Bilgili Y.K. nal B. 王海燕 Cagdas Sokak 37/13 Aydinl ikevler 06130 Ankara Turkey

Purpose: To evaluate the cerebral blood flowvelocity in patients with ocular h ypertension. Material and methods: Twentyfour ocular hypertensive patients and 2 4 age-and sex-matched healthy volunteers were recruited in a prospective compa rative study. All subjects had normal findings on full-threshold visual field t ests and clinically normal optic nerves. All patients with ocular hypertension h ad an intraocular pressure (IOP) of > 21 mmHg on three separate occasions withou t treatment. Systolic and diastolic blood pressure by cuff,heart rate by palpati on,IOP by Goldmann applanation tonometry, central corneal thickness by ultrasoun d pachymetry, blood flow velocities, and pulsatility index of the ipsilateralmid dle cerebral artery by transcranial color Doppler were measured. Results: Systol ic and diastolic blood pressures (P=0.40 and P=0.45, respectively), heart rate ( P=0.30), and central corneal thickness (P=0.23) were similar in each group. Peak and end-diastolic blood flow velocities in the middle cerebral artery did not differ between ocular hypertensives and controls (P=0.37 and P=0.87, respectivel y). In addition, pulsatility index did not significantly differ between ocular h ypertensives and controls (P=0.61). Conclusions: The results of this study sugge st that ocular hypertension is not associated with reduction in blood flow veloc ity and elevation of resistance in the middle cerebral artery.

关键词：高眼压脑血流动力学大脑中动脉搏动指数血流速率压平眼压计中央角膜厚度经颅彩色多普勒超声测厚仪临床观察

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