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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1267-1272页

作者： selim doganay Mehmet Omer Kiristioglu Derya doganay Elif Kacmaz Department of Ophthalmology Bursa Uludag University School of MedicineBursa 16059Turkey Department of Ophthalmology University of Health Sciences Bursa Yuksek Ihtisas Training and Research HospitalBursa 16310Turkey

AIM:To investigate changes in choroidal thickness and vascularity in keratoconus patients treated with corneal ***:This study evaluated 28 eyes of 22 patients with keratoconus who underwent corneal *** choroidal thicknesses were evaluated on enhanced depth imaging optical coherence tomography at the preoperative and postoperative 3d,1,and *** thickness in the four cardinal quadrants and the fovea were *** choroidal vascularity index was also ***:There was no significant difference in central choroidal thickness between the preoperative and postoperative 3d,1mo(P>0.05).There was a significant increase in the 3mo(P=0.034)and a significant decrease in the horizontal choroidal vascularity index on the postoperative 3d(P=0.014),there was no statistically significant change in vertical axes and other visits in horizontal sections(P>0.05).CONCLUSION:This study sheds light on choroidal changes in postoperative corneal crosslinking for *** it suggests the procedure’s relative safety for submacular choroid,more extensive research is necessary to confirm these findings and their clinical significance.

关键词： keratoconus corneal crosslinking choroidal vascularity index enhanced depth imaging optical coherence tomography

Short-term effect of topical brinzolamide-timolol fixed combination on ocular surface of glaucoma patients

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International Journal of Ophthalmology(English edition) 2012年第6期5卷 714-718页

作者： Penpe Gul Firat Emine Samdanci selim doganay Mufide Cavdar Nurdan Sahin Abuzer Gunduz Department of Ophthalmology Turgut Ozal Medical CenterInonu University Department of Pathology Turgut Ozal Medical CenterInonu University Department of Pathology State Hospital

AIM: To evaluate the short-term effect of the fixed combination of brinzolamide-timolol on the ocular surface in glaucoma patients. METHODS: This is a prospective study of 23 eyes of 23 patients with newly diagnosed glaucoma. Schirmer Ⅰ test, tear break-up time (BUT) measurement, conjunctival impression cytology and central corneal thickness (CCT) measurements were performed in one of the eyes of each patients before and 4 weeks after brinzolamide-timolol fixed combination therapy. All patients were asked to answer the OSDI questionnaire form about the ocular surface symptoms at baseline and at 1 week and 4 weeks follow-up visits. RESULTS: After brinzolamide-timolol fixed combination theraphy, Schirmer Ⅰ, BUT and CCT values decreased but the only statistically significant decrease was seen in BUT test (P =0.03). OSDI scores increased during the follow-up but this increase was not statistically significant (P =0.22, P = 0.42 respectively). Impression cytology findings ranged from 0.78±0.42 to 0.95±0.36 according to the Nelson classification. There was no statistically significant difference between baseline and 4 weeks follow up in impression cytology grades (P =0.15). CONCLUSION: The results of our study indicate that short-term use of brinzolamide-timolol fixed combination theraphy does not have a profound effect on ocular surface except BUT values.

关键词： fixed combination antiglaucoma drug ocular surface impression cytology

Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies

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World Journal of Gastroenterology 2018年第30期24卷 3347-3360页

作者： Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler doganay Levent doganay Department of Molecular Biology and Genetics Istanbul Technical University Department of Gastroenterology and Hepatology Umraniye Teaching and Research Hospital

The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to ***-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related *** this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver *** persistence is associated with multiple genes with diverse roles in immune *** strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to *** variants affect both epitope binding specificities and expression levels of HLA *** other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs *** persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic *** the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV *** findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection.

关键词： Genome-wide association studies Hepatitis B infection Hepatocellular carcinoma Cirrhosis Antigen presentation Immune response to hepatitis B virus

Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B

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World Journal of Gastroenterology 2014年第25期20卷 8179-8186页

作者： Levent doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler doganay Department of Gastroenterology Goz-tepe Teaching and Research HospitalMedeniyet University Department of Gastroen-terology Umraniye Teaching and Research Hospital Department of Molecular Biology and Genetics Istanbul Tech-nical University

AIM: To investigate the effect of human leukocyte antigen (HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.

关键词： Chronic active hepatitis Cirrhosis Hepatitis B Human leukocyte antigen DQ Human leukocyte antigen DR

Digital Identification of Ecosystem Structure in the FIrtIna Valley of the Kakar Mountains in the Rize City of Turkey

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Journal of Mountain Science 2014年第2期11卷 421-428页

作者： Cagasan KARACAOGLU selim Sualp CAGLAR Department of Biology Faculty of Science Biology Department Ecology Section EBAL Laboratories Hacettepe University

Identifying the structure of protected mountain ecosystems is an important task for understanding conservation sustainability. The study area, the Firtina Valley, located in the Rize City on the Eastern Blacksea Coast, is one of the biological hotspots and a National Park of Turkey. In order to identify the structure of mountain ecosystems, we generated a GIS database for the main environmental parameters of the study area, including elevation,slope and aspect layers for topographic structure, 10year mean values of Normalized Difference Vegetation Index(NDVI), data for vegetation structure, annual mean temperature and precipitation layers for climatic structure, main soil groups for soil structure and stream flow accumulation, stream flow length and stream order layers for hydrological *** identify the complex relations among environmental factors in the study area a data reduction method is applied with Principal Component Analysis(PCA). PCA is performed using data of 16 layers from Geographical Information Systems(GIS). PCA analysis reduced 16 dimensions into 5 dimensions containing 75% of the variation in all data. It is also revealed that the topographic structure, mainly altitude, dominates the ecosystems of the Firtina Valley, but it should be considered that the interactions of environmental factors in an ecosystem dynamics are very complex. The ecosystem structure is determined by the environmental factors direct or indirect effects on energy regulation of an ecosystem. Therefore the relationship between topographic elements and other abiotic-biotic elements in the Firtina Valley are important for environmental assessment and sustainability of a protected area, and these effects are explained in this study.

关键词： PCA GIS Firtina Valley Ecosystem structure Protected areas

Strength properties of xanthan gum and guar gum treated kaolin at different water contents

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 1160-1172页

作者： Irem Bozyigit Akbar Javadi selim Altun Department of Civil Engineering Ege UniversityBornova-IzmirTurkey College of Engineering Mathematics and Physical SciencesUniversity of ExeterExeterUK

Nowadays,using biopolymer as a ground improvement method has become very ***,since biopolymers are organic and degradable,their long-term effect is not fully *** this study,the effects of biopolymers on the mechanical behavior of kaolin clay were investigated through a comprehensive program of *** types of biopolymer,*** gum and guar gum were chosen to investigate the effect of biopolymer *** this purpose,specimens were prepared using standard Proctor energy at four different water contents(25%,30%35%and 40%)with 0.5%,1%,1.5%and 2%biopolymer *** specimens were cured for 1 d,7 d,28 d and 90 ***,some of the specimens were kept in the curing room for 3 years to observe the long-term effect of the *** the end of the curing periods,the specimens were subjected to unconfined compression test,and scanning electron microscopy(SEM)analysis was performed to observe the mechanism of strength *** results revealed that the unconfined compressive strength(UCS)of the specimens treated with biopolymers increased in all biopolymer inclusion levels and water contents up to a 90-d curing *** specimens containing xanthan gum,the maximum strength increase was observed at 25%water content and 2%xanthan gum with 90-d *** strength increased 5.23 times induced by xanthan gum addition when compared to the pure ***,the increase in strength reached 8.53 times in specimens treated with guar ***,increasing water content caused more ductile behavior,thus increasing the axial deformation.

关键词： Biopolymer Clay Unconfined compressive strength(UCS) Xanthan gum Guar gum Strength properties

Recursive harmonic analysis for computing Hansen coefficients

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Research in Astronomy and Astrophysics 2010年第12期10卷 1298-1306页

作者： Mohamed Adel Sharaf Hadia Hassan selim Astronomy Department Faculty of Science King Abdul Aziz University Astronomy Department National Research Institute of Astronomy and Geophysics

We report on a simple pure numerical method developed for computing Hansen coefficients by using a recursive harmonic analysis technique. The precision criteria of the computations are very satisfactory and provide materials for computing Hansen＇s and Hansen＇s like expansions, and also to check the accuracy of some existing algorithms.

关键词： celestial mechanics -- methods: numerical

An Improved Security Scheme for IEC 61850MMS Messages in Intelligent Substation Communication Networks

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Journal of Modern Power Systems and Clean Energy 2020年第3期8卷 591-595页

作者： Taha selim Ustun S.M.Suhail Hussain Fukushima Renewable Energy Institute AIST(FREA)FukushimaJapan Research Institute of the Energy Frontier TsukubaJapan

Advanced connectivity in substations brings along cybersecurity considerations. Especially, the use of standardized data objects and message structures stipulated by IEC 61850 makes them much more vulnerable to unauthorized access and manipulation. In order to tackle these vulnerabilities, different methods are investigated by researchers all over the world. An important aspect of such efforts is the real-time performance consideration since power systems are bound by the rules of physics and all control/communication tasks need to be completed in a certain time frame. Security schemes for substation communication have been proposed in the recent literature. However, they must be improved to ensure a full security solution. Recently published IEC 62351 standard aims to fill this gap. Node authentication is vital for substation communication networks based on IEC 61850 to mitigate a variety of attacks such as man-in-the-middle(MITM) attack. This short communication presents a node authentication mechanism based on transport layer security(TLS) with certificates to address this knowledge gap. It also investigates the real-time performance by implementing the proposed scheme with Python.

关键词： IEC 62351 standard certificate authority cer-tificate-based authentication cybersecurity smart grid

Influence of Silica Fume on Corrosion Behaviour of Reinforced Steel in Different Media

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Journal of Materials Science & Technology 2002年第1期18卷 83-88页

作者： Z.A.El-Hadi I.Z.selim 等 DepartmentofChemistry UniversityCollegeforGirlsAinShamsUniversityEgypt PhysicalChemistryDepartment NationalResearchCenterCairoEgypt

Electrochemical and corrosion behaviour of reinforced steel embedded in cement pastes incorporating different amounts of silica fume as a partial replacement of cement has been studied in chloride and sulphate solutions by using different electrochemical techniques. The results indicate that, while steel passivity degree is low in the control samples' upon soaking in the corrosive media, it has been high in samples incorporating silica fume and increased with increasing silica fume content. The improvement effect of silica fume may be attributed to the pore solution structure of the cement paste, which limits the mobility of aggressive ions near the surface of the steel. The mechanism of steel corrosion due to chloride and sulphate attack and passivation effect of silica fume are discussed.

关键词： Corrosion Reinforced steel Cement pastes Silica fume Aggressive ions

The physical, chemical, and microscopic properties of masonry mortars from Alhambra Palace （Spain） in reference to their earthquake resistance

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Frontiers of Architectural Research 2016年第1期5卷 101-110页

作者： Hanifi Binici selim Kapur Department of Civil Engineering Kahramanmaras Sutcu lmam University Kahramanmaras 46100 Turkey Departments of Soil Science and Archaeometry Cukurova University Adana 01330 Turkey

Al-Andalus mortar is an ancient binding material （lime mortar） that was used for centuries in numerous historical buildings in Al-Andalus, Granada （Spain）. The physico-chemical and microscopic properties of Al-Andalus mortars in Granada were studied as part of an investigation into the mineral raw materials present in the territory of Spain. Scanning electron microscope and X-ray diffraction analyses of eight main types of mortars were performed to show the presence of calcite, gypsum, quartz, and muscovite minerals with organic fibers. Chemical analyses of the specimens showed that high SiO2＋Al2O3 ＋ Fe2O3 contents yielded high values of hydraulicity and cementation indices. A significant result of this study was that mortars with high hydraulicity and cementation indices have high mechanical strengths. This characteristic may be the main reason for the earthquake resistance of the historical Alhambra Palace.

关键词： Al-Andalus mortars Alhambra Palace Microscopic properties