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The in-vivo assessment of Turkish propolis and its nano form on testicular damage induced by cisplatin

Journal of Integrative Medicine 2021年第5期19卷 451-459页

作者： Pinar Tatli Seven Ismail Seven selcan karakus Seda Iflazoglu Mutlu Seyma Ozer Kaya Gozde Arkali Merve Ilgar Ezgi Tan Yesim Muge Sahin Deniz Ismik Ayben Kilislioglu Department of Animal Nutrition and Nutritional Diseases Faculty of Veterinary MedicineFirat UniversityElazig23119Turkey Department of Plant and Animal Production Vocation School of SivriceFtrat UniversityElazig 23119Turkey Department of Chemistry Faculty of EngineeringIstanbul University-CerrahpasaIstanbul 34320Turkey Department of Reproduction and Artificial Insemination Faculty of Veterinary MedicineFirat UniversityElazig 231J9Turkey Department of Physiology Faculty of Veterinary MedicineFirat UniversityElazig 23119Turkey Istanbul Arel University ArelPOTKAM(Polymer Technologies and Composite Application and Research Center)Istanbul 34537Turkey Department of Biomedical Engineering Faculty of Engineering and ArchitectureIstanbul Arel UniversityIstanbul 34537Turkey Department of Electrical Electronics Engineering Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul 34083Turkey

Objective: Chemotherapeutic drugs, such as cisplatin(CP), which are associated with oxidative stress and apoptosis, may adversely affect the reproductive system. This study tests whether administration of propolis and nano-propolis(NP) can alleviate oxidative stress and apoptosis in rats with testicular damage induced by ***: In this study, polymeric nanoparticles including propolis were synthesized with a green sonication method and characterized using Fourier transform-infrared spectroscopy, Brunauer-EmmettTeller, and wet scanning transmission electron microscopy techniques. In total, 56 rats were divided into the following seven groups: control, CP, propolis, NP-10, CP + propolis, CP + NP-10, and CP + ***(100 mg/kg), NP-10(10 mg/kg), and NP-30(30 mg/kg) treatments were administered by gavage daily for 21 d, and CP(3 mg/kg) was administered intraperitoneally in a single dose. After the experiment,oxidative stress parameters, namely, malondialdehyde(MDA), glutathione(GSH), glutathione peroxidase(GPx), and catalase(CAT), and apoptotic pathways including B cell leukemia/lymphoma-2 protein(Bcl-2)and Bcl-2-associated X protein(Bax) were measured in testicular tissues. Furthermore, sperm quality and weights of the testis, epididymis, right cauda epididymis, seminal vesicles and prostate were ***: Propolis and NP(especially NP-30) were able to preserve oxidative balance(decreased MDA levels and increased GSH, CAT, and GPx activities) and activate apoptotic pathways(decreased Bax and increased Bcl-2) in the testes of CP-treated rats. Sperm motility in the control, CP, and CP + NP-30 groups were 60%, 48.75%, and 78%, respectively(P<0.001). Especially, NP-30 application completely corrected the deterioration in sperm features induced by ***: The results show that propolis and NP treatments mitigated the side effects of CP on spermatogenic activity, antioxidant situation, and apoptosis in rats.

关键词： Cisplatin Nano-propolis Reproductive system Testicular damage

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Conjugate Heat Transfer Characterization in Cooling Channels

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Journal of Thermal Science 2012年第3期21卷 286-294页

作者： Beni Cukurel Tony Arts Claudio selcan von Karman Institute for Fluid Dynamics Turbomachinery Department Chaussée de Waterloo

Cooling technology of gas turbine blades,primarily ensured via internal forced convection,is aimed towards withdrawing thermal energy from the *** promote heat exchange,the walls of internal cooling passages are lined with repeated geometrical flow disturbance elements and surface *** the heat transfer at the expense of increased pressure loss;the goal is to obtain the highest possible cooling effectiveness at the lowest possible pressure drop *** cooling channel heat transfer problem involves convection in the fluid domain and conduction in the *** coupled behavior is known as conjugate heat *** experimental study models the effects of conduction coupling on convective heat transfer by applying iso-heat-flux boundary condition at the external side of a scaled serpentine *** involve local temperature measurements performed by Infrared Thermography over flat and ribbed slab *** number distributions along the wetted surface are obtained by means of heat flux distributions,computed from an energy balance within the metal *** the flat plate experiments,the effect of conjugate boundary condition on heat transfer is estimated to be in the order of 3%.In the ribbed channel case,the normalized Nusselt number distributions are compared with the basic flow *** the findings with other conjugate and convective iso-heat-flux literature,a high degree of overall correlation is evident.

关键词： conjugate heat transfer turbine cooling channel convection infrared thermography

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New parameter in diagnosis of acute appendicitis:Platelet distribution width

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World Journal of Gastroenterology 2015年第6期21卷 1821-1826页

作者： Bulent Dinc Alten Oskay selcan Enver Dinc Bilge Bas Sabri Tekin Department of General Surgery Ataturk State Hospital Department of Emergency Denizli State Hospital Department of Emergency Isparta State Hospital Department of Gastroenterology Ataturk State Hospital Department of Surgery Medical Park Hospitals

AIM:To investigate the diagnostic accuracy of the mean platelet volume and platelet distribution width in acute ***:This retrospective,case-controlled study compared 295 patients with acute appendicitis(Group?Ⅰ),100 patients with other intra-abdominal infections(GroupⅡ),and 100 healthy individuals(GroupⅢ)between January 2012 and January *** age,gender,and white blood cell count,neutrophil percentage,mean platelet volume,and platelet distribution width values from blood samples were compared among the *** analyses were performed using SPSS for Windows 21.0 *** addition,the sensitivity,specificity,positive and negative predictive values and likelihood ratios,and diagnostic accuracy were ***:The mean ages of patients were 29.9±12.0years for Group?Ⅰ,31.5±14.0 years for GroupⅡ,and30.4±13.0 years for GroupⅢ.Demographic features such as age and gender were not significantly different among the *** blood cell count,neutrophil percentage and platelet distribution width were significantly higher in Group?Ⅰ?compared to groupsⅡandⅢ(P<0.05).Diagnostically,the sensitivity,specificity and diagnostic accuracy were 73.1%,94.0%,and 78%for white blood cell count,70.0%,96.0%,and 76.0%for neutrophil percentage,29.5%,49.0%,and 34.0%for mean platelet volume,and 97.1%,93.0%,and 96.0%for platelet distribution width,*** highest diagnostic accuracy detected was for platelet distribution width between Group?Ⅰ?and GroupⅢ(P<0.01).CONCLUSION:Platelet distribution width analysis can be used for diagnosis of acute appendicitis without requiring additional tests,thus reducing the cost and loss of time.

关键词： Appendicitis Diagnosis Platelet function test Plat

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通胀阴影笼罩土耳其总统试图恐吓央行

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商业周刊（中文版） 2018年第2期 31-32页

作者： Marc Champion selcan Hacaoglu 竹西

土耳其总统埃尔多安（Recep Tayyip Erdogan）长期以来一直奉行一种公然违背传统经济思想的理论：高利率会加剧而非打压通胀。正因如此，近来他多次公开警告土耳其的独立央行，不要在利率会议上提高借贷成本。2017年12月14日，埃尔多安... 详细信息

土耳其总统埃尔多安（Recep Tayyip Erdogan）长期以来一直奉行一种公然违背传统经济思想的理论：高利率会加剧而非打压通胀。正因如此，近来他多次公开警告土耳其的独立央行，不要在利率会议上提高借贷成本。2017年12月14日，埃尔多安取得了一个小小的胜利。

关键词：土耳其央行总统通胀阴影传统经济思想埃尔多安高利率

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