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Contribution to the Improvement of Transfusion Safety: Assessment of the Pre-Donation Hemoglobin Level at the Yamoussoukro Blood Transfusion Center in Cote d’Ivoire

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Open Journal of Blood Diseases 2023年第2期13卷 78-82页

作者： Renaude Janine Amon Boukalo Guillaume Zaminan Martial Bama Saydou Kaboré Sidonie Gooré Kouamenan Issaka Tiembré Jean-Jacques Dadié Bosso sekongo Yassongui mamadou National Center for Blood Transfusion Abidjan C&#244te d’Ivoire National Institute of Public Hygiene Abidjan C&#244te d’Ivoire Blood Transfusion Center Yamoussoukro C&#244te d’Ivoire

Introduction: Despite the progress recorded at the level of transfusion safety in Côte d’Ivoire, much remains to be done, particularly at the level of the medical selection of blood donors. The objective of the study was to make an assessment of the pre-donation capillary hemoglobin dosage for the year 2020 of the fixed collection, of the Blood Transfusion Center of Yamoussoukro. Method: This is a retrospective study that took place at the Yamoussoukro Blood Transfusion Center. The data collection related to all old and new blood donors were deemed suitable for the fixed collection of the year 2020. The method chosen for the pre-donation control is that of the portable hemoglobinometer of the HémoCue® type, more precisely 201+. Results: Of the 1160 blood donors in the study, the pre-donation hemoglobin level was not measured in 787 (67.8%) subjects of either sex. Of the subjects who had a pre-donation hemoglobin level performed, 97 (26%) blood donors had a sub-standard hemoglobin level, including 15 females and 82 males. Conclusion: Pre-donation hemoglobin testing of blood donors is effective in Yamoussoukro. However, efforts must still be made to improve the quality of the blood collected and to protect blood donors.

关键词： Blood Donation Medical Selection Pre-Donation Hemoglobin Fixed Collection Yamoussoukro

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Comparative Study of Gut Microbiota in Breast Cancer Patients versus Controls in Abidjan, Côte d’Ivoire

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Advances in Microbiology 2024年第9期14卷 405-415页

作者： M’Bengue Gbonon Valérie Gnahore Djeda Franck Kouadio Kouamé Assohoun Stanislas Coulibaly Safiatou Diplo Flore Bernadette sekongo mamadou Osseni Akandji Afran Sidje Arlette N’Guessan Jean-David Dosso Mireille Molecular Genetics Platform Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Laboratory of Biology and Health UFR Biosciences Flix Houphout Boigny University Abidjan Cte dIvoire Department of Environment and Health Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Bioinformatics & Computational Biology Group National Computing Center of Cte dIvoire Flix Houphout Boigny University Bingerville Cte dIvoire National Blood Transfusion Center Abidjan Cte dIvoire Oncology Department Treichville University Hospital Abidjan Cte dIvoire

Context: The gut microbiota represents a complex ecosystem encompassing all unicellular microorganisms residing in the digestive tract, primarily bacteria, fungi, archaea, and even viruses. The relationship between the host and the microbiota is symbiotic: bacteria benefit from a stable environment, while the host gains numerous capabilities in terms of digestion, metabolism, nutrition, and immunity. However, numerous studies suggest that the gut microbiota plays a crucial role in various non-communicable diseases, including obesity, chronic inflammatory bowel diseases, allergic and immune disorders, behavioral disorders, and even certain cancers. The objective of our study was to characterize the gut microbiota of a group of breast cancer patients by comparing it to that of control subjects in Côte d’Ivoire, using a metagenomic approach. Method: A case-control study was conducted from May 2020 to September 2023. A total of 85 women (39 cases and 46 controls) were recruited, and stool samples were collected from both breast cancer patients and healthy women. Among these, ten (10) samples from patients and ten (10) samples from healthy women were randomly selected for the study of the gut microbiota. The gut microbiota was characterized by sequencing the V4 region of 16S rRNA using metagenomic NGS technology, and bioinformatic analysis was performed using the mothur pipeline. Results: In women with breast cancer, we observed a reduction in the relative abundance of the phyla Firmicutes and Bacteroidetes, as well as an increase in the phyla Actinobacteria and Verrucomicrobia. Additionally, their microbiota exhibited lower Chao1 and Sobs diversities compared to the control women (p < 0.05). Molecular variance analysis (AMOVA) revealed a significant difference between the case and control groups (p < 0.001). This study has highlighted a significant difference in the relative abundance of major phyla within the gut microbiota of cases compared to healthy controls. It wil

关键词： Gut Microbiota 16S Metagenomic Sequencing Breast Cancer Dysbiosis

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