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Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly Influenza Vaccination in an Elderly Population

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World Journal of Vaccines 2022年第2期12卷 11-19页

作者： Satoko Kitamura Naoki Komatsu Masahide Matsushita Hiromi Seo seisho takeuchi Department of General Medicine Kochi Medical School Hospital Nankoku Japan Kochi General Rehabilitation Hospital Kochi Japan

Annual vaccination is necessary to maintain humoral immunity in the elderly population. However, the factors influencing the response to influenza vaccination have not been completely identified. The aim of this study was to explore the factors that influenced antibody responses to repeated vaccination using measures that were both objective and quantitative. A total of 111 volunteers aged > 61 years were vaccinated subcutaneously with one dose of influenza vaccine from the 2005-2006 season through the 2009-2010 season. The factors that influenced antibody responses after vaccination were evaluated. The seroprotection rates (PRs) were significantly higher in responders (subjects with a higher antibody titer in the 2005-2006 season) than in nonresponders only in the 2006-2007 and 2007-2008 seasons. PRs after vaccination were significantly higher in seropositive individuals (subjects with a higher prevaccination antibody titer in the 2006-2007 season) than in seronegative individuals for all three virus strains in almost all of the 5 years. Age, gender, and vaccination in the 2004-2005 season did not influence the response. These results suggest that an immune response at a certain time point would predict immune responses only in the near future. However, prevaccination antibody titer in the following season is the ideal predictor for future responses that last over several influenza seasons.

关键词： Influenza Vaccine Elderly Persons Repeated Vaccination Seroprotection Rate

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HIV encephalopathy presenting as schizophrenia-like delusions during highly active antiretroviral therapy (HAART) case report

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Open Journal of Psychiatry 2011年第3期1卷 132-136页

作者： Mikako Fuji Misaki Iseki seisho takeuchi Kyoko Kakeda Shinji Shimodera Hiromi Seo Shimpei Inoue Department of Neuropsychiatry Kochi Medical School Kochi University Kochi Japan Department of Psychiatry Ichiyou Hospital Kochi Japan Department of Medicine Kochi Medical School Kochi University Kochi Japan

After HAART (highly active antiretroviral therapy), which is a powerful antiviral drug regimen, was introduced into HIV therapy for AIDS patients, AIDS mortality decreased dramatically. The incidence of encephalopathy among AIDS patients was reported to be 10% to 40% in the past, but the introduction of HAART resulted in a decrease in HIV encephalopathy and an increase in mild CNS-related deficits, which affect the quality of life of AIDS patients. We report the case of an AIDS patient who developed schizophrenia-like delusions associated with encephalopathy. Administration of an antipsychotic drug and hypnotics was effective in relieving the symptoms of patients with insomnia, depressed mood, and delusions. Further information on the neuronal mechanism underlying the mental symptoms observed in our patient will be necessary to understand the process of pathogenesis of the encephalopathy and to devise an adequate clinical strategy for treatment.

关键词： HIV Encephalopathy Schizophrenia HAART Antipsychotics

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Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly Influenza Vaccination in an Elderly Population

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World Journal of Vaccines（疫苗） 2022年第2期

作者： satoko kitamura naoki komatsu masahide matsushita hiromi seo seisho takeuchi

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