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Growth process of small pancreatic carcinoma: A case report with imaging observation for 22 months

The 2004 Pre-Olympic Congress

作者： Yoji Sato Kaoru Umebayashi Kazuhiro suda Shizuka Michikami Centre for Sport and Health Sciences Gakushuin University Osaka University of Health and Sport Sciences Tokyo Institute of Technology Shiga University

Introduction In recent years tennis rallies have increased in ***,several recent caseshave been described in which mean blood lactate levels approached the onset of blood lactate accumulation(OBLA).Defining contemporary tennis as an intermittent high intensity exercise,the authors aimed to determine a method of evaluating the physical ability of

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World Journal of Gastroenterology 2008年第12期14卷 1958-1960页

作者： Takeshi Hisa Hiroki Ohkubo Satoshi Shiozawa Hiroki Ishigame Masato Takamatsu Masayuki Furutake Bunsei Nobukawa Koichi suda Department of Internal Medicine Saku Central Hospital Nagano 384-0301 Japan Department of Surgery Saku Central Hospital Nagano 384-0301 Japan Department of Clinical Pathology Saku Central Hospital Nagano 384-0301 Japan Department of Human Pathology Juntendo University School of Medicine Tokyo Japan Department of Pathology Tokyo-West Tokusyukai Hospital Tokyo Japan

This report describes serial observations of the growth process of a small invasive ductal carcinoma (IDC) of the pancreas from imaging studies. Histopathological studies showed IDC with macroscopic retention cysts proximal to an intraductal papillary-mucinous adenoma with mild atypia of the branch duct type in the pancreatic body, with no relation between the two lesions. IDC was demonstrated as an extremely low-echoic mass resembling a cyst with an unclear margin on the initial endoscopic ultrasonography. We misinterpreted the low-echoic mass as a benign intraductal mucinous-papillary neoplasm (IPMN) based on findings of other imaging studies, and the patient was followed-up. The mass increased from 7 mm to 13 mm in diameter over 22 mo, and remained smaller than 10 mm in diameter for about 420 d. The tumor volume doubling time was 252 d. The Ki67 labeling index was 15.9%, similar to that described in previous reports. Hence, IDC may grow slowly while remaining small.

关键词： Invasive ductal carcinoma Pancreas Intraductal papillary-mucinous neoplasm Endoscopicultrasonography Tumor volume doubling time

Septic Arthritis of the Temporomandibular Joint without an Apparent Source of Infection: A Case Report

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Open Journal of Stomatology 2017年第4期7卷 242-249页

作者： Daisuke suda Hiroyuki Takatsuji Naoaki Saito Akinori Funayama Kanae Niimi Tadaharu Kobayashi Division of Reconstructive Surgery for Oral and Maxillofacial Region Graduate School of Medical and Dental Sciences Niigata University Niigata Japan

Septic arthritis of the temporomandibular joint (TMJ) is a rare disease that is characterized by preauricular pain, edema, malocclusion, trismus and abscess formation in the TMJ region. An 85-year-old male visited our hospital with the complaint of left-sided TMJ swelling, pain and trismus. Septic arthritis of the left TMJ was diagnosed on the basis of considerable elevation of CRP (Creactive proteins) and CT imaging findings. The patient was treated with oral Faropenem at 450 mg daily, but CRP increased three days after the initial visit. He was hospitalized and treated with intravenous administration of cefazolin at 2 g and clindamycin at 1.2 g daily for six days. Propionibacterium species and Veillonella species grew in a culture of the joint aspirate, but there was no apparent source of infection. After acute infectious symptoms had passed, the patient was treated with oral amoxicillin at 750 mg daily for eight weeks and was instructed to do jaw opening exercise. The patient was discharged on the 11th hospital day. After three weeks of the hospital discharge, the patient healed completely. To avoid serious complications, clinicians should include septic arthritis of the TMJ in the differential diagnosis of preauricular pain, trismus and swelling.

关键词： Septic Arthritis Temporomandibular Joint No Apparent Source of Infection

Effects of Gender, Age, and Clot Formation on the Measurements of Tryptophan Metabolites in Blood

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Food and Nutrition Sciences 2019年第7期10卷 761-775页

作者： Junichi Masuda Masato Karayama Takafumi suda Masato Maekawa Fumiko Shimizu Akikazu Takada Global Application Development Center Shimadzu Corporation Kanagawa-ken Japan Second Department of Internal Medicine Hamamatsu University School of Medicine Hamamatsu Japan Department of Laboratory Medicine Hamamatsu University School of Medicine Hamamatsu Japan Faculty of Life and Environmental Sciences Showa Women’s University Tokyo Japan International Projects on Food and Health (NPO) Tokyo Japan

Background: Tryptophan metabolism plays important roles in health and diseases. Although simultaneous measurements of tryptophan metabolites are successfully measured, influences of age, gender, and clot formation on the measurements have not been reported. Methods: We took blood from young and old Japanese men and women and compared plasma levels of tryptophan metabolites. We also took plasma and serum from the blood of middle-aged men (n = 10). Metabolites analysis was performed by a liquid chromatograph tandem mass spectrometer, the LCMS-8060 quadrupole mass spectrometer combined with Nexera X2 liquid chromatograph system (Shimadzu Corporation, Kyoto, Japan). Body mass index (BMI) and TRP metabolites have been measured in healthy young men (n = 48), young women (n = 47), old men (n = 44), and old women (n = 39). TRP metabolites were measured by using the ultrahigh speed liquid chromatography-mass spectroscopy (Shimadzu Corporation). Results: Tryptophan and its metabolites such as serotonin, 5-hydroxyindole acetic acid, indole-3-acetic acid, kynurenine, anthranilic acid, were higher in young women and old men than young men and old women. Plasma levels of 3-hydroxykynurenine and xanthurenic acid were lower in young women and old men. Comparison of plasma and serum indicates that most of metabolites were higher in serum than plasma except for 3-hydroxy-kynurenine and quinolinic acid. Conclusion: Metabolites of the upper stream of degradation of tryptophan were higher in young women and old men than young men and old women, which suggests that the degradation of tryptophan was accelerated in young men and old women than young women and old men. Serum preparation may activate tryptophan degradation resulting in higher levels of metabolites in serum than in plasma.

关键词： Plasma Serum Platelet Tryptophan Serotonin 5-Hydroxyindole Acetic Acid Kynurenine 3-Hydroxykynurenine Kynurenic Acid Anthranilic Acid Xanthurenic Acid Indole-3-Acetic Acid

Evaluation of the Tokyo Cognitive Assessment for Predicting Cognitive Impairment in Rehabilitation Users

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Open Journal of Therapy and Rehabilitation 2022年第2期10卷 54-61页

作者： Hiroya Miyabara Seigo Koura Moemi Matsuo Makoto Uchinoura Yuki Kishikawa Yuji Yamaguchi Youhei Komatsu seijiro Nishimura Shinichi Shibata Hajime Shibata Faculty of Rehabilitation Nishikyusyu University Kanzaki City Japan Kurume Rehabilitation Hospital Kurume City Japan

[Purpose] This study aimed to evaluation of the Tokyo cognitive assessment (Toca) for predicting cognitive impairment in rehabilitation users. [Method] The variables of age, BMI, educational background, Toca for 36 rehabilitation users and 22 healthy elder were assessed. We compared cognitive functions in rehabilitation users who need support and healthy elders. [Results] Of the Toca 1 to 11 trials, there was a significant difference other than 9, 10 rials. The Toca scores with 8 points higher were significantly higher in healthy elders than in rehabilitation users. The area under the receiver-operator curve (AUC) for predicting mild cognitive impairment (MCI) by the Toca was 0.874. Using a cut-off point of 19/20, the Toca demonstrated a sensitivity of 83.9% and a sensitivity of 85.0% in diagnosing MCI. [Conclusion] The Toca is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in rehabilitation users.

关键词： Tokyo Cognitive Assessment Mild Cognitive Impairment Rehabilitation Users

Correlations between Motor Ability with Gait Speed and Cognitive Functions in Rehabilitation Users

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Open Journal of Therapy and Rehabilitation 2022年第1期10卷 1-8页

Purpose: To compare and examine motor and cognitive functions in people who require support, and in healthy elders. Method: The variables of age, BMI, educational background, blood pressure, grip strength, knee extension, gait speed, MMSE, and subjective health feeling for 36 rehabilitation users and 22 healthy elders were assessed. We compared and examined motor and cognitive functions in rehabilitation users who need support and healthy elders. Results: The percentage of MMSE scores with 27 points or higher and that of subjective health feeling with 3 points or higher were significantly higher in healthy elders than in rehabilitation users. Systolic and diastolic blood pressure were significantly higher in rehabilitation users than in healthy elders. Gait speed and MMSE scores were significantly higher in healthy elders than rehabilitation users. Conclusion: Gait speed could be used for physical fitness in elders. Gait speed was the best physical fitness measurement for elders. Gait speed of rehabilitation users was strongly related to MMSE scores. Gait speed could be a determinant of MMSE scores.

关键词： Elderly Gait Speed Motor Ability Rehabilitation Users The Long-Term Care Insurance

Effects of Curved Periacetabular Osteotomy on the Stress Fields of the Pubic Rami and Ischium: A Finite Element Model Analysis

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Open Journal of Orthopedics 2013年第4期3卷 199-203页

作者： Norio Imai Yoichiro Dohmae Ken suda Dai Miyasaka Tomoyuki Ito Naoto Endo Department of Orthopedic Surgery Nii- gata University Medical and Dental Hospital Niigata Japan. Department of Orthopedic Surgery Niigata Prefectural Shibata Hospital Niigata Japan Department of Orthopedic Surgery Niigata Prefectural Shibata Hospital Niigata Japan

Background: Postoperative pubic or ischial stress fracture may be a complication after curved periacetabular osteotomy (CPO). The discontinuity of the superior pubic rami is a risk factor for this complication. We investigated the stress field differences in standing and sitting positions after CPO. Methods: We used finite element analysis to assess the effects of inferior pubic rami and ischial fractures with or without discontinuity of superior pubic rami. We used the “union model”, obtained from a bony union at the osteotomy site of the superior pubic rami from 38-year-old woman who had undergone CPO for left hip dysplasia. We deleted the bony union region and created a discontinuity in the superior pubic rami equal to the non-union, creating the “discontinuity model”. We compared the stress field and stress value in the simulated standing and half weight-bearing positions on the operative side, one-legged standing position on the non-operative side, and the sitting position. Findings: In 4 cases, the inferior rami experienced the highest stress. Stress values in the discontinuity model were higher than those in the union model: 1.7 times in the case of one-legged standing on the operative side, 2.4 times in the case of half weight-bearing on the operative side, 3.8 times in the case of one-legged standing on the non-operative side, and 2.0 times in the sitting position, respectively. Interpretation: We recommend patients delay weight bearing on the operative side, avoid the sitting position as long as possible, and sit down slowly to prevent inferior pubic rami and ischial fractures after CPO.

关键词： Curved Periacetabular Osteotomy Ischial Fracture Inferior Pubic Ramifracture Stress Field Finite Element Analysis

Surgical Correction of Bifid Nose Due to Tessier’s No. 0 Cleft

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Modern Plastic Surgery 2014年第1期4卷 1-4页

作者： Hiroki Shibayama Takatoshi Yotsuyanagi Tamotsu Saito Ken Yamashita Makoto Yamauchi Tetsuya suda Department of Plastic and Reconstructive Surgery Fujisawa City Hospital Kanagawa Japan Department of Plastic and Reconstructive Surgery Sapporo Medical University School of Medicine Hokkaido Japan Department of Plastic and Reconstructive Surgery Sunagawa City Medical Center Hokkaido Japan

Bifid nose is a rare congenital abnormality and its surgical correction is difficult. We represent a case of bifid nose with mild nasal deformity without cerebral or lip deformity. We performed rhinoplasty with a kind... 详细信息

关键词： Bifid Nose Rhinoplasty Forked Flap Tessier’s No. 0 Cleft

Pre-sarcopenia and Mac-2 binding protein glycosylation isomer as predictors of recurrence and prognosis of early-stage hepatocellular carcinoma

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World Journal of Hepatology 2022年第7期14卷 1480-1494页

作者： Masato Nakai Kenichi Morikawa Shunichi Hosoda Sonoe Yoshida Akinori Kubo Yoshimasa Tokuchi Takashi Kitagataya Ren Yamada Masatsugu Ohara Takuya Sho Goki suda Koji Ogawa Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Faculty of Medicine and Graduate School of MedicineSapporo 060-8638Japan

BACKGROUND The Mac-2 binding protein glycosylation isomer(M2BPGi),a fibrosis marker in various liver diseases,is reportedly a prognostic marker in patients with hepatocellular carcinoma(HCC)who underwent *** To evaluate whether the M2BPGi value,M2BP,and pre-sarcopenia before radiofrequency ablation(RFA)could be useful recurrence and prognostic markers in patients with early-stage *** In total,160 patients with early-stage primary HCC treated with RFA were separately analyzed as hepatitis C virus(HCV)-positive and *** contributing to recurrence and liver-related death,including M2BP,M2BPGi,and skeletal muscle mass index,were statistically ***-three patients were HCV-positive and 77 were *** In HCV-positive patients,only des-γ-carboxy-prothrombin≥23 mAU/mL was a significant poor prognostic factor affecting survival after *** HCV-negative patients,M2BPGi≥1.86 cutoff index was significantly associated with tumor recurrence,while M2BP was not.M2BPGi≥1.86 cutoff index(hazard ratio,4.89;95%confidence interval:1.97-12.18;P<0.001)and pre-sarcopenia(hazard ratio,3.34,95%confidence interval:1.19-9.37;P=0.022)were independent significant poor prognostic factors in HCV-negative *** In HCV-negative patients with primary HCC treated with RFA,lower M2BPGi contributed to a lower tumor recurrence rate and longer survival ***-sarcopenia contributed to the poor prognosis independently in HCV-negative *** factors might be useful recurrence and prognostic markers for early-stage primary HCC.

关键词： Mac-2 binding protein Mac-2 binding protein glycosylation isomer Pre-sarcopenia Primary hepatocellular carcinoma Radiofrequency ablation