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npj Computational Materials 2021年第1期7卷 312-319页

作者： Yuji ikeda Konstantin Gubaev Jörg Neugebauer Blazej Grabowski Fritz Körmann Institute for Materials Science University of StuttgartStuttgartGermany Max-Planck-Institut für Eisenforschung GmbH DüsseldorfGermany Department of Materials Science and Engineering Delft University of TechnologyDelftThe Netherlands

Recent experiments show that the chemical composition of body-centered cubic(bcc)refractory high entropy alloys(HEAs)can be tuned to enable transformation-induced plasticity(TRIP),which significantly improves the ductility of these *** calls for an accurate and efficient method to map the structural stability as a function of composition.A key challenge for atomistic simulations is to separate the structural transformation between the bcc and theωphases from the intrinsic local lattice distortions in such chemically disordered *** solve this issue,we develop a method that utilizes a symmetry analysis to detect differences in the crystal *** this method in combination with ab initio calculations,we demonstrate that local lattice distortions largely affect the phase stability of Ti–Zr–Hf–Ta and Ti–Zr–Nb–Hf–Ta *** relaxation effects are properly taken into account,the predicted compositions near the bcc–hcp energetic equilibrium are close to the experimental compositions,for which good strength and ductility due to the TRIP effect are observed.

关键词： alloys ductility distortion

First principles calculation of stable structure and adhesive strength of plated Ni/Fe(100) or Cu/Fe(100) interfaces

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中国有色金属学会会刊：英文版 2009年第4期19卷 988-991页

作者： Ryota NAKANISHI Koji SUEOKA seiji SHIBA M akoto HINO Koji MURAKAMI Ken MURAOKA Department of System Engineering Okayama Prefectural University Metallic Materials Group Department of Mechanical EngineeringIndustrial Technology Center of Okayam a Prefecture

A study the with first principles calculation of the interfaces of the Ni layer or Cu layer on the Fe(100) surface formed with metal plating was *** or Cu atoms were shown to adopt the corresponding position to the bcc structure of the Fe(100) *** calculations showed that the interfaces of Ni(5 atomic layers)/Fe(100)(5 layers) or Cu(5 atomic layers)/Fe(100)(5 layers) had square *** orientation relationship of Ni/Fe(100) interface corresponds to fcc-Ni(100)//bcc-Fe(100),Ni[011]//Fe[010],and Ni[011]//Fe[001].Similar results were obtained for Cu/Fe(100) *** structure was supported by TEM analysis of plated Ni layer on Fe(100) *** adhesion strength of the Ni/Fe(100) interface evaluated by first principles calculation was higher than that of the Cu/Fe(100) *** experimental results of Hull cell iron plated with Ni or Cu supported the results of the *** results indicate that the first principles calculation,which deals with the ideal interface at the atomic scale,has the potential to evaluate the adhesion strength of metallic material interfaces.

关键词：第一原理计算接口处理稳定结构粘接强度铜原子镀镍胶粘剂界面结合强度

Diabetic neuropathy research: from mouse models to targets for treatment

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Neural Regeneration Research 2019年第11期14卷 1870-1879页

作者： Vuong M. Pham Shinji Matsumura Tayo Katano Nobuo Funatsu seiji Ito Department of Medical Chemistry Kansai Medical UniversityHirakataOsakaJapan Singapore Institute for Neurotechnology (SINAPSE) National University of SingaporeSingapore Department of Anesthesiology Osaka Medical CollegeTakatsukiOsakaJapan

Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.

关键词： brain derived neurotrophic factor diabetes extrinsic factors nerve growth factor nerve regeneration neurotrophic factors non-obese type 2 diabetes phosphatase and tensin homolog stem cell streptozotocin

Effects of cryogenic temperature on tensile and impact properties in a medium-entropy VCoNi alloy

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Journal of Materials Science & Technology 2021年第31期90卷 159-167页

作者： Dae Cheol Yang Yong Hee Jo Yuji ikeda Fritz Kormann Seok Su Sohn Department of Materials Science and Engineering Korea University02841 SeoulSouth Korea Metallic Materials Division Korea Institute of Materials Science51508 ChangwonSouth Korea Institute for Materials Science University of StuttgartPfaffenwaldring 5570569 StuttgartGermany Max-Planck-Institut für Eisenforschung Max-Planck-Straβe 140237 DüsseldorfGermany Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628 CD DelftThe Netherlands

Multi-principal element alloys usually exhibit outstanding strength and toughness at cryogenic temperatures,especially in CrMnFeCoNi and CrCoNi *** remarkable cryogenic properties are attributed to the occurrence of deformation twins,and it is envisaged that a reduced stacking fault energy(SFE)transforms the deformation mechanisms into advantageous properties at cryogenic temperatures.A recently reported high-strength VCoNi alloy is expected to exhibit further notable cryogenic ***,no attempt has been made to investigate the cryogenic properties in detail as well as the underlying deformation ***,the effects of cryogenic temperature on the tensile and impact properties are investigated,and the underlying mechanisms determining those properties are revealed in terms of the temperature dependence of the yield strength and deformation *** the strength and ductility were enhanced at 77 K compared to 298 K,while the Charpy impact toughness gradually decreased with *** planar dislocation glides remained unchanged at 77 K in contrast to the CrMnFeCoNi and CrCoNi alloys resulting in a relatively constant and slightly increasing SFE as the temperature decreased,which is confirmed via ab initio ***,the deformation localization near the grain boundaries at 298 K changed into a homogeneous distribution throughout the whole grains at 77 K,leading to a highly sustained strain hardening *** reduced impact toughness is directly related to the decreased plastic zone size,which is due to the reduced dislocation width and significant temperature dependence of the yield strength.

关键词： Medium-entropy alloy Cryogenic temperature Tensile property Charpy impact property Stacking fault energy

Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions

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Translational Neurodegeneration 2020年第1期9卷 66-80页

作者： seiji Kaji Takakuni Maki Tomoyuki Ishimoto Hodaka Yamakado Ryosuke Takahashi Department of Neurology Graduate School of MedicineKyoto University54 Shogoin-Kawahara-choSakyo-kuKyotoJapan

Multiple system atrophy(MSA)is a debilitating and fatal neurodegenerative *** disease severity warrants urgent development of disease-modifying therapy,but the disease pathogenesis is still *** in MSA brains is preceded by the emergence of glial cytoplasmic inclusions(GCIs),which are insoluble α-synuclein accumulations within oligodendrocytes(OLGs).Thus,preventive strategies against GCI formation may suppress disease ***,although numerous studies have tried to elucidate the molecular pathogenesis of GCI formation,difficulty remains in understanding the pathological interaction between the two pivotal aspects of GCIs;asynuclein and *** difficulty originates from several enigmas:1)what triggers the initial generation and possible propagation of pathogenic α-synuclein species?2)what contributes to OLG-specific accumulation of α-synuclein,which is abundantly expressed in neurons but not in OLGs?and 3)how are OLGs and other glial cells affected and contribute to neurodegeneration?The primary pathogenesis of GCIs may involve myelin dysfunaion and dyshomeostasis of the oligodendroglial cellular environment such as autophagy and iron *** have previously reported that oligodendrocyte precursor cells are more prone to develop intracellular inclusions in the presence of extracellular fibrillary α-*** finding implies a possibility that the propagation of GCI pathology in MSA brains is mediated through the internalization of pathological α-synuclein into oligodendrocyte precursor *** this review,in order to discuss the pathogenesis of GCIs,we will focus on the composition of neuronal and oligodendroglial inclusions in ***,we will introduce some hypotheses on how α-synuclein pathology spreads among OLGs in MSA brains,in the light of our data from the experiments with primary oligodendrocyte lineage cell *** various reports have focused on the mysterious source of α-

关键词： Multiple system atrophy a-synuclein Glial cytoplasmic inclusion Prion Neurodegeneration Oligodendrocyte Microglia Astrocyte Oligodendrocyte precursor cell

An Unusual Acceleration of Amination Reactivity by the Proximal Ester Groups in Catechol Diesters: An Efficient Way for Peptide Synthesis

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Precision Chemistry 2023年第2期1卷 100-106页

作者： An Wu Hirotaka ikeda Hisashi Yamamoto Peptide Research Center Chubu UniversityKasugaiAichi 487-8501Japan Materials Science Department MOLSIS Inc.Chuo-kuTokyo 104-0032Japan

Peptide bond formation has drawn more and more attention due to its importance in medicinal chemistry and drug *** active esters to construct peptide bonds is an indispensable strategy in this *** herein report a fast and efficient amination reaction to synthesize peptides from catechol *** monoesters are good active esters in peptide synthesis due to the anchimeric assistance *** previously reported work,the amination reaction was inactivated if the 2-hydroxyl group in the catechol esters was ***,we found an unusual acceleration of the amination reactivity when the 2-hydroxyl group was functionalized as an ester *** reaction can be complete in 2−3 min in some *** acceleration was found through experimental studies to not result from the anchimeric assistance *** proposed aπ*−π*interaction pathway between the two proximal ester *** computational studies were made to support this assumption.

关键词： catechol diesters peptide synthesis amination π*−π*interaction proximal ester groups

Added Resistance Acting on Hull of a Non Ballast Water Ship

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Journal of Marine Science and Application 2014年第1期13卷 11-22页

作者： Ngo Van He Yoshiho ikeda Marine System Engineering Osaka Prefecture University Department of Ship Engineering and Fluid Mechanics Hanoi University of Science and Technology

In this paper, added resistances acting on a hull of non ballast water ship(NBS) in high waves is discussed. The non ballast water ships were developed at the laboratory of the authors at Osaka Prefecture University, Japan. In the present paper, the performances of three kinds of bow shapes developed for the NBS were theoretically and experimentally investigated to find the best one in high waves. In previous papers, an optimum bow shape for the NBS was developed in calm water and in moderated waves. For a 2 m model for experiments and computations, the wave height is 0.02 m. This means that the wave height is 15% of the draft of the ship in full load conditions. In this paper, added resistances in high waves up to 0.07 m for a 2 m model or 53% of the full load draft are investigated. In such high waves linear wave theories which have been used in the design stage of a ship for a long time may not work well anymore, and experiments are the only effective tool to predict the added resistance in high waves. With the computations for waves, the ship is in a fully captured condition because shorter waves, λ/Lpp<0.6, are assumed.

关键词： added resistance non ballast water ship hull optimum bow shape

Mold Filling and Prevention of Gas Entrapment in High-pressure Die-casting

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Journal of Materials Science & Technology 2008年第1期24卷 139-140页

作者： Itsuo Ohnaka Akira Sugiyama Takashi ikeda Hideyuki Yasuda Department of Entrepreneur Engineering/ieSolution Osaka Sangyo University Daito-shi 574-8530Japan Trois Corp. Japan Osaka University Japan

This paper presents some results of direct observation of mold filling in a specially designed die-casting by X-ray diffraction, including comparison with numerical simulation. Based on such work the authors discuss h... 详细信息

关键词： Direct observation Mold filling High-pressure die-casting Computer simulation Gas entrapment

Inflammatory fibroid polyp occurring in the transverse colon diagnosed by endoscopic biopsy

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World Journal of Gastroenterology 2007年第27期13卷 3765-3766页

作者： Shoji Hirasaki Minoru Matsubara Fusao ikeda Hideaki Taniguchi Seiyuu Suzuki Second Department of Internal Medicine Sumitomo Besshi Hospital 3-1 Ohji-cho Niihama 792-8543 Japan

A case of an inflammatory fibroid polyp occurring in the transverse colon and diagnosed by endoscopic biopsy is reported. The patient was an 82-year-old man who visited our hospital for further evaluation of occult blood in stool. The Colonoscopy revealed a small, red, and peduncular polyp, about 6 mm in diameter, in the transverse colon. Histological examination of the biopsy specimen obtained from the polyp revealed proliferation of fibroblasts and infiltration of inflammatory cells such as plasma cells and eosinophils. This polyp was diagnosed as an inflammatory fibroid polyp, which can appear in many different locations throughout gastrointestinal tract, though still rare in the transverse colon.

关键词： Inflammatory fibroid polyp Colonoscopy Inflammation Type Ⅱ pit pattern

Phonon broadening in high entropy alloys

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npj Computational Materials 2017年第1期3卷 154-162页

作者： Fritz Kormann Yuji ikeda Blazej Grabowski Marcel H.F.Sluiter Materials Science and Engineering Delft University of Technology2628 CD DelftThe Netherlands Center for Elements Strategy Initiative for Structural Materials Kyoto UniversityKyoto 606-8501Japan Computationals Materials Design Max-Planck-Institut fur Eisenforschung GmbH40237 DusseldorfGermany

Refractory high entropy alloys feature outstanding properties making them a promising materials class for next-generation hightemperature *** high temperatures,materials properties are strongly affected by lattice vibrations(phonons).Phonons critically influence thermal stability,thermodynamic and elastic properties,as well as thermal *** contrast to perfect crystals and ordered alloys,the inherently present mass and force constant fluctuations in multi-component random alloys(high entropy alloys)can induce significant phonon scattering and *** their importance,phonon scattering and broadening have so far only scarcely been investigated for high entropy *** tackle this challenge from a theoretical perspective and employ ab initio calculations to systematically study the impact of force constant and mass fluctuations on the phonon spectral functions of 12 body-centered cubic random alloys,from binaries up to 5-component high entropy alloys,addressing the key question of how chemical complexity impacts *** find that it is crucial to include both mass and force constant *** one or the other is neglected,qualitatively wrong results can be obtained such as artificial phonon band *** analyze how the results obtained for the phonons translate into thermodynamically integrated quantities,specifically the vibrational *** in the vibrational entropy with increasing the number of elements can be as large as changes in the configurational entropy and are thus important for phase stability *** set of studied alloys includes MoTa,MoTaNb,MoTaNbW,MoTaNbWV,VW,VWNb,VWTa,VWNbTa,VTaNbTi,VWNbTaTi,HfZrNb,HfMoTaTiZr.

关键词： alloys entropy high