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Storylines of family medicine Ⅱ:foundational building blocks—context,community and health

Family Medicine and community Health 2024年第S3期12卷 12-22页

作者： William B Ventres Leslie A Stone Rupal Shah Tamala carter Geoffrey M Gusoff Winston Liaw Bich-May Nguyen Joanna V Rachelson Mary Alice Scott Teresa L Schiff-Elfalan seiji ya.a.a.robert c like Kathleen Zoppi A Peter catinella Richard M Frankel Shailendra Prasad Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Bridge Lane Group Practice LondonUK Penn center for community Health Workers University of PennsylvaniaPhiladelphiaPennsylvaniaUSA National clinician Scholars Program UCLA David Geffen School of MedicineLos AngelesCaliforniaUSA Health Systems and Population Health Sciences University of Houston Tilman J Fertitta Family College of MedicineHoustonTexasUSA Southern New Mexico Family Medicine Residency Program Las CrucesNew MexicoUSA New Mexico Primary care Training Program Silver CityNew MexicoUSA Anthropology New Mexico State UniversityLas CrucesNew MexicoUSA Family Medicine and community Health University of Hawai'i at Manoa John A Burns School of MedicineHonoluluHawaiiUSA Family Medicine and community Health Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNew JerseyUSA Family Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine–Transmountain Texas Tech University Health Sciences CenterEl PasoTexasUSA Medicine Indiana University School of MedicineIndianapolisIndianaUSA Family Medicine and community Health University of Minnesota Medical School-Twin Cities CampusMinneapolisMinnesotaUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅱ:foundational building blocks—context,community and health’,authors address the following themes:‘context—grounding family medicine in time,place and being’,‘Recentring community’,‘community-oriented primary care’,‘Embeddedness in practice’,‘The meaning of health’,‘Disease,illness and sickness—core concepts’,‘The biopsychosocial model’,‘The biopsychosocial approach’and‘Family medicine as social medicine.’May readers grasp new implications for medical education and practice in these essays.

关键词： thematic illustration dimensions

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Teukolsky-like equations with various spins in spherically symmetric spacetime

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chinese Physics c 2024年第8期48卷 213-223页

作者： ya Guo Hiroaki Nakajima Wenbin Lin School of Physical Science and Technology Southwest Jiaotong UniversityChengdu 610031China School of Mathematics and Physics University of South ChinaHengyang 421001China

We study wave equations with various spins on the background of a general spherically symmetric *** obtain the unified expression of the Teukolsky-like master equations and the corresponding radial equations with the general *** also discuss the gauge dependence in the gravitational-wave equations,which have appeared in previous studies.

关键词： gravitational wave effective one-body dynamics Teukolsky equation wave equations Klein-Gordon equation Weyl equation Maxwell equation

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Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma Xing-yao Yin Zhao-Yun Zong Yuan-Yuan Tan ya-Ming yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution crack opening displacement

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Advances in memristor based artificial neuron fabrication-materials,models,and applications

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International Journal of Extreme Manufacturing 2024年第1期6卷 27-50页

作者： Jingyao Bian Zhiyong Liu Ye Tao Zhongqiang Wang Xiaoning Zhao ya Lin Haiyang Xu Yichun Liu Key Laboratory for UV Light-Emitting Materials and Technology(Northeast Normal University) Ministry of Education5268 Renmin StreetChangchunPeople’s Republic of China

Spiking neural network(SNN),widely known as the third-generation neural network,has been frequently investigated due to its excellent spatiotemporal information processing capability,high biological plausibility,and low energy consumption *** to the working mechanism of human brain,the SNN system transmits information through the spiking action of ***,artificial neurons are critical building blocks for constructing SNN in *** are drawing growing attention due to low consumption,high speed,and nonlinearity characteristics,which are recently introduced to mimic the functions of biological *** have proposed multifarious memristive materials including organic materials,inorganic materials,or even two-dimensional *** advantage of the unique electrical behavior of these materials,several neuron models are successfully implemented,such as Hodgkin–Huxley model,leaky integrate-and-fire model and integrate-and-fire *** this review,the recent reports of artificial neurons based on memristive devices are *** addition,we highlight the models and applications through combining artificial neuronal devices with sensors or other electronic ***,the future challenges and outlooks of memristor-based artificial neurons are discussed,and the development of hardware implementation of brain-like intelligence system based on SNN is also prospected.

关键词： artificial neuron memristor memristive materials neuron model micro-nano manufacturing spiking neural network

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The concept of gene therapy for glaucoma:the dream that has not come true yet

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Neural Regeneration Research 2024年第1期19卷 92-99页

作者： robert Sulak Xiaonan Liu Adrian Smedowski Department of Physiology Faculty of Medical Sciences in KatowiceMedical University of Silesia in KatowiceKatowicePoland Institute of Biotechnology HiLIFEUniversity of HelsinkiHelsinkiFinland GlaucoTech co. KatowicePoland

Gene therapies,despite of being a relatively new therapeutic approach,have a potential to become an important alternative to current treatment strategies in *** glaucoma is not considered a single gene disease,the identified goals of gene therapy would be rather to provide neuroprotection of retinal ganglion cells,especially,in intraocular-pressure-independent *** most commonly reported type of vector for gene delivery in glaucoma studies is adeno-associated virus serotype 2 that has a high tro pism to retinal ganglion cells,res ulting in long-term expression and low immunogenic *** gene thera py studies recruit inducible and genetic animal models of optic neuropathy,like DBA/2J mice model of high-tension glaucoma and the optic nerve *** gene therapy-based neuroprotection of retinal ganglion cells is targeting specific genes translating to growth factors(i.e.,brain derived neurotrophic factor,and its receptor TrkB),regulation of apoptosis and neurodegeneration(i.e.,Bcl-xl,Xiap,FAS system,nicotinamide mononucleotide adenylyl transferase 2,Digit3 and Sarm1),immunomodulation(i.e.,crry,c3 complement),modulation of neuroinflammation(i.e.,e rythropoietin),reduction of excitotoxicity(i.e.,com KIlα)and transcription regulation(i.e.,Max,Nrf2).On the other hand,some of gene therapy studies focus on lowering intra ocular pressure,by impacting genes involved in both,decreasing aqueous humor production(i.e.,aquaporin 1),and increasing outflow facility(i.e.,cOX2,prostaglandin F2a receptor,RhoA/RhoA kinase signaling pathway,MMP1,Myocilin).The goal of this review is to summarize the current stateof-art and the direction of development of gene therapy strategies for glaucomatous neuropathy.

关键词： adeno-associated virus gene editing gene therapy glaucoma IOP lowering IOP-independent mechanisms neuroprotection optic nerve optic neuropathy retinal ganglion cells

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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRc/ERK/cREB Pathway

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chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： LIU Xiao-rong LI Shuo-fu MEI Wen-ya LIU Xiang-dan ZHOU Ri-bao college of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRc were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(cIA)rat model was *** were randomly divided to sham,cIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in cIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRc,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(cREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Pc and reduced the phosphorylation of SRc,ERK,and cREB(Pc overexpression reversed the inhibitory effect of isorhamnetin on RA-FLS viability,migration and invasion,as well as the negative regulation of MMP2 and MMP9(Pcreased arthritis index scores(Pced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRc,ERK,and cRE

关键词： rheumatoid arthritis isorhamnetin SRc/ERK/cREB matrix metalloproteinase

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Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lower Ordovician in Tazhong area of Tarim Basin

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Petroleum Science 2024年第1期21卷 115-124页

作者： Wen-yang Wang Xiong-Qi Pang ya-Ping Wang Zhang-Xin chen Fu-Jie Jiang Ying chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China college of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship between the ratio of drilling to the dry layer and the *** this study,by establishing the relationships between the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships between the depth and dry layer ratio were obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lower Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model

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An ultra-porous g-c_(3)N_(4) micro-tube coupled with MXene(Ti_(3)c_(2)TX)nanosheets for efficient degradation of organics under natural sunlight

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Journal of Environmental Sciences 2024年第3期137卷 258-270页

作者： Zongyang ya Qiyou Wang Jingjin cai Peng Wang Xinyu Jiang Zhiyin cai Shanglin Xiang Tingwei Wang Dongyu cai college of Materials Science&Engineering Nanjing Tech University30 South PuZhu RoadNanjing 211816China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University30 South PuZhu RoadNanjing 211816China

It remains as a challenge for realizing efficient photo-responsive catalysts towards largescale degradation of organic pollutants under natural *** work reports a new pore engineering strategy for creating ultra-porous g-c_(3)N_(4) micro-tubes with an unprecedentedly high specific surface area of 152.96 m^(2)/*** is mainly associated with releasing internal vapor pressure in the autoclave where the hydrothermal treatment of the urea/melamine mixture is *** by microscopic observation,porosity measurement and spectroscopic characterization,it is found that releasing the pressure at halfway of hydrothermal process is vital for forming exfoliated rod-like precursors and the de-aggregation of these rods presents substantial benefits on the production of mesopores on g-c_(3)N_(4) microtubes during the calcination of *** offers a large number of reactive sites required by photocatalytic *** these micro-tubes with Ti_(3)c_(2)T_(X) nanosheets via electrostatic interaction yields a 1D/2D heterojunction with a close interfacial *** addition of metallically conductive Ti_(3)c_(2)T_(X) nanosheets accelerates the separation between electrons and holes,and also enhances the light *** these merits of structural design lead to forming a group of highly efficient catalysts demonstrating an excellent photocatalytic degradation rate of k=0.0560 min^(-1)for RhB dyes under 100 mW/cm~2 visible light radiation that micks sunlight *** laboratory valuation is further supported by an outdoor test that shows a fast degradation rate of 0.0744 min^(-1)under natural sunlight.

关键词： carbon nitride MXene Heterojunction Photocatalysis

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Enhanced crystallization of Poly(butylene adipate-co-terephthalate)by a Self-assembly Nucleating Agent

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chinese Journal of Polymer Science 2024年第5期42卷 663-674,I0010页

作者： cheng Zhou Kun chen Zi-Heng Zhang Meng-Fan Jing chun-Tai Liu chang-Yu Shen ya-Ming Wang State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou450002China

Poly(butylene adipate-co-terephthalate)(PBAT)is a promising biodegradable flexible polymer but suffers from slow crystallization rate,making it less attractive for some applications like the injection-molded products in comparison with low-density polyethylene(LDPE).This work aimed to accelerate the crystallization of PBAT by adding a self-assembly nucleating agent octamethylenedicarboxylic dibenzoylhydrazide(OMBH).PBAT/OMBH composites with various OMBH contents(0 wt%,0.5 wt%,0.7 wt%,1 wt%,2 wt%,3 wt%and 5 wt%)were prepared through *** effect of OMBH on the crystallization behavior,morphologies and mechanical properties of PBAT was *** highest nucleation efficiency value of 59.6%was achieved for PBAT with 0.7 wt%OMBH,much higher than that of 22.7%for PBAT with 0.7 wt%*** force microscopy results showed that OMBH formed fine fibers and induced the formation of transcrystalline layers of *** transform infrared spectroscopy(FTIR)combined with two-dimensional correlation spectra suggested that the intermolecular dipole-dipole N—H…O=c interactions but not hydrogen bond between OMBH and PBAT promoted the crystallization of PBAT in the initial period of *** presence of OMBH did not change the crystal form of PBAT but had positive contribution in enhancing its crystallinity and mechanical *** work is essential for preparing PBAT with high crystallization rate,enhancing its potential applications in injection-molded products.

关键词： Poly(butylene adipate-co-terephthalate) Biodegradable Self-assembly nucleating agent crystallization

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Evolution exploration and structure prediction of Keggin-type group IVB metal-oxo clusters

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chinese chemical Letters 2024年第5期35卷 487-492页

作者： Run-Han Li Tian-Yi Dang Wei Guan Jiang Liu ya-Qian Lan Zhong-Min Su School of chemistry South China Normal UniversityGuangzhou 510006China Institute of Functional Material chemistry Faculty of ChemistryNortheast Normal UniversityChangchun 130024China Institute of Theoretical chemistry Jilin UniversityChangchun 130023China

The fascinating chemical structure and broad application prospect of Keggin-type polyoxometalates(POMs)have attracted many chemists to explore and discover *** the traditional Keggin,larger metal atomic radius,higher metal coordinated numbers,lower metal valence states and other features allow the group IVB metal-based Keggin(IVB-Keggin)more space and unknown in terms of structure and ***,density functional theory(DFT)calculations were performed to explore the influences including cores,shells,caps,and terminal ligands,et *** IVB-Keggin,and analyze the possibility of novel structure *** the perspective of multi-layer onion-like clusters,molecular energy level,host-guest interaction energy,surface charge and covalent bond polarity can be further adjusted to achieve the oriented design of functional *** insights are expected to provide theoretical support for experimental synthesis,opening a new perspective to understand the growth of Keggin.

关键词： Keggin Metal-oxo clusters Group IVB Onion pattern DFT

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