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Management of gastric fundal varices without gastro-renal shunt in 15 patients

World Journal of Gastroenterology 2008年第3期14卷 448-453页

作者： Natsuhiko Kameda Kazuhide Higuchi Masatsugu shiba Kaori Kadouchi Hirohisa Machida Hirotoshi Okazaki Tetsuya Tanigawa Toshio Watanabe Kazunari Tominaga Yasuhiro Fujiwara Kenji Nakamura Tetsuo Arakawa Department of Gastroenterology Graduate School of Medicine Osaka City University Osaka 569-8686 Japan Second Department of Internal Medicine Osaka Medical College Osaka 569-8686 Japan Department of Radiology Graduate School of Medicine Osaka City University Osaka 569-8686 Japan

AIM:To examine the portal hemodynamics of gastric fundal varices (GV) without gastro-renal shunt (GRS), and to retrospectively investigate the effects of various kinds of treatment on eradication. METHODS: Ninety-four liver cirrhosis patients at high- risk of GV were treated in our hospital and enrolled in this study. We retrospectively examined their characteristics, liver function, and portal hemodynamics of GV. We performed balloon-occluded retrograde transvenous obliteration (BRTO) at first. If it was not technically possible to perform BRTO, endoscopic injection sclerotherapy using α-cyanoacrylate glue (CA) or percutaneous transhepatic obliteration (PTO) was performed. RESULTS: Among the 94 patients, a GRS was present in 79 (84.0%), and absent in the remaining 15 (16.0%). The subphrenic vein was connected to the inferior vena cava as the drainage vein in 13 (86.7%) out of the 15 cases without GRS. We performed BRTO in 6 patients, CA in 4 patients and PTO in 5 patients. The eradication rate was 100% for each procedure, but the rate of early recurrence within 6 mo was 16.7% for BRTO, 50.0% for CA and 40.0% for PTO, respectively. CONCLUSION: We should examine the hemodynamics before treatment of GV irrespective of the existence of GRS. If this hemodynamic examination reveals that the drainage vein connects directly to the inferior vena cava in GV without GRS, BRTO may be an effective treatment for GV with GRS.

关键词： Gastric fundal varices Gastro-renal shunt Balloon-occluded retrograde transvenous obliteration

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Synthesis and reactions of some 6-aryl and 2,6-diaryl-4-(4'-antipyrinyl)-2,3,4,5-tetrahydropyridasin-3-ones and screening for their antibacterial activities

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Chinese Journal of Chemistry 1992年第5期10卷 475-480页

作者： SAYED G. H. shiba S. A. RADWAN A. MOHAMED S. M. KHALIL M. Chemistry Department Faculty of Science Ain Shams University Abbassia Cairo Egypt Al-Azhar University for Girls Abbassia Cairo Egypt

Some new pyridazinone derivatives(3) were synthesized through addition of antipyrin to β- aroylacrylic acids (1) followed by cyclization of the adducts. Reactions of 3 with ethyl bromoacetate, benzenesulfonyl chloride, benzoyl chloride and POCl_3 give N-substituted products and monochlorosub- stituted pyridazines (4), respectively. The reactions of the latter with thiourea give unexpected dithio- derivatives(5), which react with phenylhydrazine to give pyrazolopyridazino pyridazine derivatives (6). Reactions of 2 with NH_2OH in ethanol and pyridine afford oxime and oxazinone derivatives 7 and 8, tespectively. The antibacterial activities of several compounds were screened.

关键词： antipyrinyl tetrahydropyridasin-3-ones and screening for their antibacterial activities Synthesis and reactions of some 6-aryl and 2,6-diaryl-4

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Behaviour of 4-(4-chlorophenyl)-6-(4-tolyl)-4,5-dihydro pyrimidine-2(1H)thione and 2-hydrazino derivative toward carbon electrophiles

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Chinese Journal of Chemistry 1991年第2期9卷 189-192页

作者： EL-HASHASH,M.A EL-KAFRAWY,A.F shiba,S.A.Faculty of Science,Ain Shams University,Abbassia, Cairo.Egypt Faculty of Science Ain Shams University Abbassia Cairo. Egypt

The reaction of thiourea with p-methyl-β-p-chlorophenyl acrylophenone(1)is,in princi- ple,an attractive[3+ 3]-fragment approach to the synthesis of dihydropyrimidine bearing aryl groups.

关键词： Behaviour of 4 chlorophenyl dihydro pyrimidine-2 thione and 2-hydrazino derivative toward carbon electrophiles tolyl

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Agaro-Oligosaccharides Prevent Myostatin Hyperexpression and Myosin Heavy Chain Protein Degradation in C2C12 Myotubes Induced by Tumor Necrosis Factor-<i>α</i>

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CellBio 2018年第2期7卷 23-34页

作者： Ikuya Shirai Takehiko Sakai Katsuhiro shiba Yuji Uzuhashi Koji Karasawa Research & Development Ina Food Industry Co. Ltd. Ina Japan

Myostatin is a major factor involved in the regulation of skeletal muscle protein mass. High myostatin levels have been associated with an increase in myotube shrinkage. Enhanced myostatin expression is caused by pro-catabolic reactions involving compounds such as tumor necrosis factor (TNF)-α. The present study investigated the effects of agaro-oligosaccharides (AOSs) on hypercatabolism of myotubes exposed to TNF-α. C2C12 myotubes exposed to TNF-α in the presence or absence of AOSs. Myotube exposure to TNF-α resulted in a reduction in the amount of myosin heavy chain (MyHC) protein and a decrease in myotube diameter, which was associated with increased myostatin mRNA expression. AOSs prevented TNF-α-induced MyHC protein loss and restored normal myostatin mRNA levels, with agarobiose and agarotetraose effectively suppressing the hyperexpression of the mRNA. In addition, expression levels of the known myostatin inhibitors, latent transforming growth factor beta binding protein 3 (Ltbp3) and growth and differentiation factor-associated serum protein 1 (Gasp1) mRNAs, decreased more in TNF-α-induced myotubes than in the TNF-α-free control, possibly resulting in myostatin upregulation. However, AOSs restored nearly normal expression levels of Ltbp3 and Gasp1 mRNA, potentially suppressing myostatin expression. These findings suggest that AOSs could prevent myotube shrinkage induced by TNF-α.

关键词： Agaro-Oligosaccharides Myotubes Myosin Heavy Chain Myostatin

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Tire-derived carbon for catalytic preparation of biofuels from feedstocks containing free fatty acids

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Carbon Resources Conversion 2018年第2期1卷 165-173页

作者： Zachary D.Hood shiba P.Adhikari Samuel F.Evans Hui Wang Yunchao Li Amit K.Naskar Miaofang Chi Abdou Lachgar M.Parans Paranthaman School of Chemistry and Biochemistry Georgia Institute of TechnologyAtlantaGA 30332USA Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Chemistry Wake Forest UniversityWinston-SalemNC 27109USA Center for Energy Environmentand Sustainability(CEES)Wake Forest UniversityWinston-SalemNC 27109USA Chemical Sciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Bredesen Center for Interdisciplinary Research and Graduate Education The University of TennesseeKnoxvilleTN 37996USA Mechanical Engineering and Conn Center for Renewable Energy Research University of LouisvilleLouisvilleKY 40292USA Materials Science and Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831USA Materials Science and Technology Division(MSTD) Oak Ridge National LaboratoryOak RidgeTN 37831USA

The utilization of waste feedstocks rich in free fatty acids(FFAs)improves biofuel production on the basis of economics and ***,converting these feedstocks to usable biofuel poses inherent problems in terms of the FFA to biofuel conversion yield and the catalyst ***,we report novel ferric sulfate impregnated carbon derived from waste tires as highly active catalysts for FFA to biofuel *** approach takes advantage of facile synthesis methods involving sonication and dehydration processes to create materials that are useful for the efficient catalytic conversion of FFAs to advanced *** of FFAs to fatty acid methyl esters was achieved at 65C and atmospheric pressure with>98%yield even in the presence of *** catalysts maintained similar activity after four successive uses,which indicates that the active catalytic sites are effectively supported by the three-dimensional meso/microporous architecture of the tire-derived carbon.

关键词： Biofuels Solid acidcatalyst Recycled tires Free fattyacids Esterification

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DIY自家酿酒术

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2016年

作者： shiba 施爱儿

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4-[α-(苯甲酰甲基)苄基]-1,3-二苯基-2-吡唑啉-5-酮的合成与反应

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化学学报 1985年第12期43卷 1215-1221页

作者： EL-SHEKEIL,A.G. HASSAN,M.A. BABAQI shiba,S.A. Chemistry Department Faculty of Science Sena's University Yemen Arab Republic Chemistry Department Faculty of Science Sena's University Yemen Arab Republic A.S.Chemistry Department Faculty of Science Sena's University Yemen Arab Republic Chemistry Department Faculty of Science Sena's University Yemen Arab Republic

1,3-二苯基-2-吡唑啉-5-酮（1）对查而酮（苯丙烯酰苯,2）的碱性催化加成,生成相应的Michael加成物,4-[α-（苯甲酰甲基）苄基]-1,3-二苯基-2-吡唑啉-5-酮（3）,3在沸醇中经肼或羟胺处理得腙或肟（4）,4经沸乙酸处理生成1和2的吡唑啉衍... 详细信息

1,3-二苯基-2-吡唑啉-5-酮（1）对查而酮（苯丙烯酰苯,2）的碱性催化加成,生成相应的Michael加成物,4-[α-（苯甲酰甲基）苄基]-1,3-二苯基-2-吡唑啉-5-酮（3）,3在沸醇中经肼或羟胺处理得腙或肟（4）,4经沸乙酸处理生成1和2的吡唑啉衍生物（5）的混合物,3的还原产物为相应的仲醇（6a～c）.Grignard试剂与3反应生成叔醇（6d～1）,新化合物的结构经元素分析,IR,1H和13C NMR证明。

关键词： OCH 吡唑啉甲基链烷基苯甲酰 ppm 二苯基二芳基苄基苯甲基芳基反应

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当代美国全面质量管理管理中的四次实用革命

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2005年

作者： Shoji shiba Alan Graham David Walden 李天和译

本书从描述质量的本质开始，叙述了为创造高质量产品以提高在快速变化世界中用户的满意度的TQM的系统概念及其实践。全书着重论述管理思维中的四次革命，即关注用户，不断改进，全员参与和社会网络化。

ISBN: (纸本)7313041098

关键词：高技术产业企业管理:质量管理经验美国

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1-芳基-3-(5-氯-1,3-苯基-1H-4-吡唑基)-2,3-环氧-1-丙酮的新重排反应

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化学学报 1988年第7期46卷 724-726页

作者： El-Shekeil,A.G. Babaqi,A.S. Hassan,M.A. shiba,S.A. Department of Chemistry Faculty of Science Sana’a UniversitySana’aYemen Chemistry Department Faculty of ScienceAin-Shams UniversityAbbasiaEgypt

本文报道标题化合物在碱作用下重排成为3的反应,提出了反应机理.用IR,^(1)H NMR,^(13)C NMR和微量分析证实了新化合物的结构.

关键词： IR NaOH NMR

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从优秀的小组到鼓舞人心的小组

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中国质量 1994年第1期 31-32页

作者： Shoji shiba,徐承秀日本筑波大学山东淄博市经委教授、美国麻省理工学院客座教授

1.引言质量小组引入日本已有三十多年的历史,恰巧,据说日本一般公司的平均寿命也是三十年。可以说,质量小组已进入了一个转折时期,这就说明了为什么在日本围绕质量小组的变革存在诸多争论,社会发生的根本性的迅速变化也迫使质量小组进... 详细信息

1.引言质量小组引入日本已有三十多年的历史,恰巧,据说日本一般公司的平均寿命也是三十年。可以说,质量小组已进入了一个转折时期,这就说明了为什么在日本围绕质量小组的变革存在诸多争论,社会发生的根本性的迅速变化也迫使质量小组进行变革。

关键词：小组质量小组活动日本

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