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Urinary Oxalate Excretion Decreased in Androgen Receptor-Knockout Mice by Suppressing Oxalate Synthesis in the Liver

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Open Journal of Urology 2015年第8期5卷 123-132页

作者： Sayuri Takahashi Seiji Aruga Yoko Yamamoto Takahiro Matsumoto Department of Urology the University of Tokyo Tokyo Japan Department of Urology Kyosai Hospital Tokyo Japan Department of Surgical Oncology the University of Tokyo Tokyo Japan Institute of Health Biosciences the University of Tokushima Graduate School Tokushima Japan

The incidence of calcium oxalate stone in men is higher than that in women. We evaluated the association between the androgen receptor (AR) and urinary oxalate excretion using Crefloxed male androgen receptor-knockout (ARKO) mice (ARL-/Y) and floxed mice (ARL+/Y) as control. Four-teen-week-old ARL-/Y and ARL+/Y mice were fed distilled water. Drinking water was then swapped for 0.5% ethylene glycol (EG). Urinary oxalate was measured on days 0, 14, and 28. Urinary calcium, inorganic phosphorus, citrate, uric acid, and ion-actibity products of calcium oxalate (APCaOx) in mouse, AP (CaOx)-indexMOUSE, were evaluated on days 0 and 15. On day 28, livers were harvested to measure mRNA expression of enzymes. Urinary oxalate excretion was significantly higher in ARL+/Y than in ARL-/Y mice 14 and 28 days after EG treatment (p L-/Y mice exhibited atrophic testes and low serum testosterone, both ARKO and control mice were orchiectomized and implanted DHT pellets (ARL-/Y-ORX-DHT, and ARL+/Y-ORX-DHT), and the same experiments as above were performed. EG loading for 14 and 28 days resulted in significantly higher excretion in ARL+/Y-ORX-DHT mice than ARL-/Y-ORX-DHT mice (p < 0.005). AP(CaOx)-indexMOUSE was significantly higher in ARL+/Y-ORX-DHT mice than in ARL-1/Y-ORX-DHT mice. mRNA expression levels of glycolate oxidase (GO) in liver were lower in ARKO mice than in control ones. AR modulates the excretion of oxalate in urine after EG treatment, which may be associated with increased oxalate synthesis by activated GO in the liver via the AR pathway.

关键词： Androgen Receptor Urinary Stone Oxalate

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