检索结果-南通市图书馆

Insights into the pathogenesis of multiple system atrophy: focus on glial cytoplasmic inclusions

Translational Neurodegeneration 2020年第1期9卷 66-80页

作者： seiji kaji Takakuni Maki Tomoyuki Ishimoto Hodaka Yamakado Ryosuke Takahashi Department of Neurology Graduate School of MedicineKyoto University54 Shogoin-Kawahara-choSakyo-kuKyotoJapan

Multiple system atrophy(MSA)is a debilitating and fatal neurodegenerative disorder.The disease severity warrants urgent development of disease-modifying therapy,but the disease pathogenesis is still enigmatic.Neurodegeneration in MSA brains is preceded by the emergence of glial cytoplasmic inclusions(GCIs),which are insoluble α-synuclein accumulations within oligodendrocytes(OLGs).Thus,preventive strategies against GCI formation may suppress disease progression.However,although numerous studies have tried to elucidate the molecular pathogenesis of GCI formation,difficulty remains in understanding the pathological interaction between the two pivotal aspects of GCIs;asynuclein and OLGs.The difficulty originates from several enigmas:1)what triggers the initial generation and possible propagation of pathogenic α-synuclein species?2)what contributes to OLG-specific accumulation of α-synuclein,which is abundantly expressed in neurons but not in OLGs?and 3)how are OLGs and other glial cells affected and contribute to neurodegeneration?The primary pathogenesis of GCIs may involve myelin dysfunaion and dyshomeostasis of the oligodendroglial cellular environment such as autophagy and iron metabolism.We have previously reported that oligodendrocyte precursor cells are more prone to develop intracellular inclusions in the presence of extracellular fibrillary α-synuclein.This finding implies a possibility that the propagation of GCI pathology in MSA brains is mediated through the internalization of pathological α-synuclein into oligodendrocyte precursor cells.In this review,in order to discuss the pathogenesis of GCIs,we will focus on the composition of neuronal and oligodendroglial inclusions in synucleinopathies.Furthermore,we will introduce some hypotheses on how α-synuclein pathology spreads among OLGs in MSA brains,in the light of our data from the experiments with primary oligodendrocyte lineage cell culture.While various reports have focused on the mysterious source of α-synuclein in GCIs,insights into the mechanism wh

关键词： Multiple system atrophy a-synuclein Glial cytoplasmic inclusion Prion Neurodegeneration Oligodendrocyte Microglia Astrocyte Oligodendrocyte precursor cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SPERA Hydrogen System^(TM)by LOHC-MCH Method for Massive Hydrogen Storage and Transportation

引用

Journal of Environmental Science and Engineering(A) 2024年第2期13卷 50-60页

作者： Yoshimi Okada kaji Naohiro Osamu Ikeda Kenichi Imagawa Hironori Kawai Masashi Nagai Yasuhiro Inoue Frontier Business Division Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan Hydrogen Business Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan R&D Center Chiyoda Corporation3-13 Moriya-cho Kanagawa-kuYokohama 2208765Japan Technology Development Department Chiyoda Corporation4-6-2 Minatomirai Nishi-kuYokohama 2208765Japan

Expanding the hydrogen energy utilization is essential for decarbonization,and the commercialization of hydrogen energy carrier systems that can“store”and“transport”hydrogen in a large scale is necessary.The organic chemical hydride method incorporates hydrogen atoms into the molecular structure of a LOHC(Liquid Organic Hydrogen Carrier)to store and transport hydrogen in a liquid state under normal temperature and pressure,and is a highly safe method with low business risk.Chiyoda has been developing the technology since 2002,completed a pilot demonstration in 2014 and named it the SPERA Hydrogen^(TM) System,and successfully completed an international supply chain demonstration that transports hydrogen from Brunei to Japan in a large scale in 2020,moving to the commercialization stage.Currently,Chiyoda is conducting feasibility studies with a number of domestic and foreign companies with the aim of commercializing the system as soon as possible.In this paper,outline,features,development status and our efforts in commercialization of SPERA HydrogenTM System are introduced.

关键词： Hydrogen carrier LOHC Methylcyclohexane MCH toluene

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Suspension Splittings and Self-maps of Flag Manifolds

引用

Acta Mathematica Sinica,English Series 2019年第4期35卷 445-462页

作者： Shizuo kaji Stephen THERIAULT Institute of Mathematics for Industry Kyushu University Mathematical Sciences University of Southampton

If G is a compact connected Lie group and T is a maximal torus, we give a wedge decomposition of ΣG/T by identifying families of idempotents in cohomology. This is used to give new information on the self-maps of G/T.

关键词： Flag manifold self-map stable splitting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of different land-use systems (grazing and understory cultivation) on growth and yield of semi-arid oak coppices

引用

Journal of Forestry Research 2020年第6期31卷 2235-2244页

作者： Ali Soltani Hamdollah Sadeghi kaji Saleh Kahyani Department of Forest Science Faculty of Natural Resources and Earth SciencesShahrekord UniversityP.O.Box 115ShahrekordIran

The present study examines the extent of negative eff ects of traditional multiple land-use systems on oak coppices,from a forest management point of view.The study area was located in approximately 10,000 ha of hilly Brant’s oak(Quercus brantii Lindl.)woodlands in the central Zagros Mountains.In the same site-quality class,three land-use systems were compared:simple coppice(Co),coppice in conjunction with small ruminant grazing(CoG),and coppice with understory rain-fed wheat cultivation plus grazing(CoCG).Data on total wood volume of trunk and major branches,and annual ring growth,were collected and analyzed from 74 stands in 15 coppiced woodland patches.The results showed the advantage of Co over CoG and CoCG land-uses by 43 and 60 m 3 of mean accumulated wood volume per hectare,respectively.The diameter growth analysis also revealed an annual increase in wood production of trees in Co land-uses over 43 years,with an exception of the recent decade,when growth coincided with a severe drought.Using a back-extrapolation method,the minimum rotation age of woodlands in Co land-use was found to be 23.6 years,5 and 7 years shorter than those of CoG and CoCG land-uses,respectively.Unlike CoCG,woodlands located in Co and CoG land-use systems demonstrated a high level of agreement with self-thinning rule of−3/2.Values for the stand density index for coppiced oak woodlands were between more than 1000 for the least disturbed(Co)and less than 400 for the most disturbed woodlands(CoCG).The structure and growth rate of the coppiced oak woodlands were irreversibly disrupted by understory tillage plus grazing and in less extent by grazing alone.It was concluded that ending undergrowth cultivation in semi-arid oak coppices should be addressed as a priority by adopting minimum regulations.

关键词： Coppicing Land-use impact assessment Diameter growth Multi-purpose land-use Self-thinning rule Stand density index

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Long-term outcomes of postgastrectomy syndrome after total laparoscopic distal gastrectomy using the augmented rectangle technique

引用

World Journal of Gastrointestinal Surgery 2022年第2期14卷 120-131页

作者： Suguru Yamauchi Hajime Orita Jun Chen Hiroki Egawa Yutaro Yoshimoto Akira Kubota Ryota Matsui Yukinori Yube Sanae kaji Shinichi Oka Malcolm V Brock Tetsu Fukunaga Department of Gastroenterology and Minimally Invasive Surgery Juntendo University HospitalTokyo 113-8431Japan Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21205-2196United States

BACKGROUND For total laparoscopic distal gastrectomies for gastric cancer,the reconstruction method is critical to the clinical outcome of the procedure.However,which reconstruction technique is optimal remains controversial.We originally reported the augmented rectangle technique(ART)as a reconstruction option for total laparoscopic Billroth I reconstructions.Still,little is known about its effect on long-term outcomes,specifically the incidence of postgastrectomy syndrome and its impact on quality of life.AIM To analyze postgastrectomy syndrome and quality of life after ART using the Postgastrectomy Syndrome Assessment Scale-37(PGSAS-37)questionnaire.METHODS At Juntendo University,a total of 94 patients who underwent ART for Billroth I reconstruction with total laparoscopic distal gastrectomies for gastric cancer between July 2016 and March 2020 completed the PGSAS-37 questionnaire.Multidimensional analysis was performed,comparing those 94 ART cases from our institution(ART group)to 909 distal gastrectomy cases with a Billroth I reconstruction from other Japanese institutions who also completed the PGSAS-37 as part of a larger national database(PGSAS group).RESULTS Patients in the ART group had significantly better total symptom scores in all the symptom subscales(i.e.,esophageal reflux,abdominal pain,meal-related distress,indigestion,diarrhea,constipation,and dumping).The loss of body weight was marginally greater for those in the ART group than in the PGSAS group(-9.3%vs-7.9%,P=0.054).The ART group scored significantly lower in their dissatisfaction of ongoing symptoms,during meals,and with daily life.CONCLUSION ART for Billroth I reconstruction provided beneficial long-term results for postgastrectomy syndrome and quality of life in patients undergoing total laparoscopic distal gastrectomies for gastric cancer.

关键词： Laparoscopic distal gastrectomy Postgastrectomy syndrome Augmented rectangle technique Billroth I Postgastrectomy Syndrome Assessment Scale-37

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nafamostat mesylate-induced hyperkalemia in critically ill patients with COVID-19: Four case reports

引用

World Journal of Clinical Cases 2020年第21期8卷 5320-5325页

作者： Masaki Okajima Yoshinori Takahashi Takaaki kaji Naohiko Ogawa Hideyuki Mouri Intensive Care Unit Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Rheumatology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Nephrology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan Department of Respiratory Medicine Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Nafamostat mesylate(NM)may prove to be one of the key drugs effective against coronavirus disease 2019(COVID-19)because of its anti-viral properties and the potential to manage coagulopathy.However,NM tends to increase serum potassium levels.CASE SUMMARY We observed hyperkalemia immediately after NM administration(200 mg/d)in four consecutive patients who were admitted to the Kanazawa University Hospital with severe COVID-19 pneumonia.Urinary potassium excretion decreased after NM administration in three patients who underwent urinalysis.CONCLUSION NM is likely to produce hyperkalemia in patients with COVID-19.Therefore,it is necessary to monitor serum potassium values closely after NM initiation in COVID-19 patients who need respiratory support.

关键词： COVID-19 Nafamostat Hyperkalemia Disseminated intravascular coagulation Respiratory insufficiency Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On large scale CFD-DEM simulation for gas-liquid-solid,three-phase flows

引用

Particuology 2021年第6期19卷 2-15页

作者： Kimiaki Washino Ei L.Chan Tetsushi kaji Yoshiaki Matsuno Toshitsugu Tanaka Department of Mechanical Engineering Osaka UniversitySuitaOsaka 565-0871Japan

Particulate flows in a mixture of gas and liquid,i.***.gas-liquid-solid three-phase flows,are frequently encountered both in nature and industry.In such flows,complex interactions between multiple phases,i.***.particle-particle interactions,fluid-particle interactions and interfacial interactions(such as surface tension and particle wetting),play a crucial role.In literature,simulations of three-phase flows are sometimes performed by incorporating interface capturing methods(e.g.VOF method)into the CFD-DEM coupling model.However,it is practically impossible to perform large(industrial)scale simulation because of the high computational cost.One of the strategies often employed to reduce the computational cost in CFD-DEM is to upscale particle size,which is applied mainly to particle single-phase and fluid-solid two-phase flows.The present work is focused on the scaled-up particle model for gas-liquid-solid three-phase flows.The interaction forces between multiple phases are scaled using the general criteria derived from the continuum assumption of particulate flow.A colour function based interface-capturing method with improved interface smoothness is developed,and the diffusion based coarse graining is employed to ensure sufficient space resolution in CFD even when particle size is increased.It is shown that the model developed is capable of predicting the both particles and fluid behaviour in the original system.

关键词： CFD-DEM Three-phase flow Scaled-up particle Surface tension and wetting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of liraglutide on metabolic syndrome in WBN/Kob diabetic fatty rats supplemented with a high-fat diet

引用

Animal Models and Experimental Medicine 2020年第1期3卷 62-68页

作者： Noriyuki kaji Yoshiichi Takagi Satomi Matsuda Anna Takahashi Sakurako Fujio Fumitoshi Asai Laboratory of Veterinary Pharmacology School of Veterinary MedicineAzabu UniversityKanagawaJapan

Background:Liraglutide,a GLP-1 receptor agonist,has recently been used to treat metabolic syndrome(MS)because of its anti-diabetic and anti-obesity effects.We have previously shown that Wistar Bonn Kobori diabetic and fatty(WBN/Kob-Leprfa,WBKDF)rats fed a high-fat diet(HFD)developed MS including marked obesity,hyperglycemia,and dyslipidemia.To obtain further information on WBKDF-HFD rats as a severe MS model,we performed a pharmacological investigation into the anti-MS effects of liraglutide in this model.Methods:Seven-week-old male WBKDF-HFD rats were allocated to three groups(n=8 in each group):a vehicle group,a low-dose liraglutide group,and a high-dose liraglutide group.They received subcutaneous injections of either saline or liraglutide at doses of 75 or 300μg/kg body weight once daily for 4 weeks.Results:Results showed that liraglutide treatment reduced body weight gain and food intake in a dose-dependent manner.The marked hyperglycemia and the glucose tolerance were also significantly ameliorated in the liraglutide-treated groups.Moreover,liraglutide also reduced the plasma triglyceride concentration and liver fat accumulation.Conclusions:The present study demonstrated that liraglutide could significantly alleviate MS in WBKDF-HFD rats,and the reaction to liraglutide is similar to human patients with MS.WBKDF-HFD rats are therefore considered to be a useful model for research on severe human MS.

关键词： diabetes mellitus liraglutide metabolic syndrome models animal obesity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Manipulation of Charge-Transfer States by Molecular Design:Perspective from“Dynamic Exciton”

引用

Accounts of Materials Research 2021年第7期2卷 501-514页

作者： Hiroshi Imahori Yasuhiro Kobori Hironori kaji Department of Molecular Engineering Graduate School of EngineeringKyoto UniversityNishikyokuKyoto 615-8510Japan Institute for Integrated Cell-Material Sciences(WPI-iCeMS) Kyoto UniversitySakyo-kuKyoto 606-8501Japan Molecular Photoscience Research Center and Department of Chemistry Graduate School of ScienceKobe UniversityNada-kuKobe 657-8501Japan Institute for Chemical Research Kyoto UniversityUjiKyoto 611-0011Japan

CONSPECTUS:“Dynamic exciton”,an umbrella term concept in photochemistry,plays an important role in nature,science,and technology,especially in photoinduced and electrically induced electron transfer(ET)between a donor(D)and an acceptor(A).Typically,an exciton in molecular D−A systems is considered a locally excited(LE)state of a donor(D*)or an acceptor(A*)molecule,but let us extend the terminology of“exciton”to an integrated class of LE,charge-transfer(CT),and charge-separated(CS)states.The degree of CT(0−100%),spin multiplicity,and D−A interaction(i.e.,electronic coupling)are pivotal factors in the“exciton”.Another important aspect of the“exciton”is strongly related to the“dynamic”aspect of the“exciton”by movement of atomic nuclei(i.e.,vibration,rotation,and fluctuation)and their collective motions controlling behaviors of electrons and spins by the passage of time.The concept of“dynamic exciton”should cover a wide variety of the photochemical phenomena that are all essential for the energy conversion devices and processes including various kinds of living systems.In these,a huge amount of the nuclear motional modes may cooperatively be entangled to electronic orbitals.Thus,the idea behind“dynamic exciton”includes usage of the cooperation between nuclear motions and the spin−orbital,as electron−phonon coupling for innovative designs of the energy conversion materials and assemblies.For this,it is particularly important to examine how this wide variety of the motions plays roles on electronic couplings,intermediate geometries and mobilities,exciton energies,CT characters,and so on.We draw researchers’attention to this aspect of the vibronic effect,like the entropy role by collective movement of side chains of the conjugated polymer to modulate the electronic coupling time-dependently at the charge delocalization and dissociation,which is reinforced three-dimensionally at the D/A domain interface of organic photovoltaics(OPVs).In addition,to realize the ultimate high-performance OPVs,the voltage loss must be dimin

关键词： excited vibrational collective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic Transition of Exchange Rate Regime in China

引用

China & World Economy 2014年第3期22卷 36-55页

作者： Naoyuki Yoshino Sahoko kaji Tamon Asonuma Asian Development Bank Institute Department of Economics Keio UniversityJapan International Monetary Fund WashingtonDCUSA

Thepaper considers the optimal transition path for China＇s exchange rate regime. How can China successfully make the shift from the current dollar peg regime to a more desirable regime, whether a basket peg or a floating regime？ To answer this question, we develop a dynamic small open economy general equilibrium model. We construct four transition policies based on a basket peg or a floating regime and compare the welfare gains of these policies relative to maintaining the dollar peg regime. Two main results are derived from the quantitative analysis using Chinese data from 1999Q1 to 2010Q4. First, following a gradual adjustment to a basket peg regime is the most appropriate path for China to take, with minimal welfare losses associated with the shift in the exchange rate regime. Second, a sudden shift to the basket peg is the second best solution, and is superior to a sudden shift to floating because the monetary authority can efficiently determine optimal weights to attach to currencies in the basket to achieve policy goals once they adopt a basket peg regime.

关键词： Chinese renminbi Chinese exchange rate regime dynamic adjustment transition path

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：