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后颅凹脑膜瘤

北京医科大学学报 1998年第1期30卷 64-66页

作者：鲍圣德 v.seifert F.M.van Krieken D.Stolke 北京医科大学第一医院神经外科德国埃森大学医学院神经外科医院

目的：提高对后颅凹脑膜瘤诊断与治疗的认识。方法：对１９８７～１９９３年收治、显微手术切除的４５例后颅凹脑膜瘤病例进行回顾性分析。结果：肿瘤全切２９例（２９／４５）。疗效：优２７例（２７／４５），良８例（８／４５），差... 详细信息

目的：提高对后颅凹脑膜瘤诊断与治疗的认识。方法：对１９８７～１９９３年收治、显微手术切除的４５例后颅凹脑膜瘤病例进行回顾性分析。结果：肿瘤全切２９例（２９／４５）。疗效：优２７例（２７／４５），良８例（８／４５），差５例（５／４５），死亡５例（５／４５）。结论：术前精确的诊断对手术及预后非常重要。手术入路主要取决于肿瘤的位置、延伸和大小。统计学分析表明病人的预后与术前ＡＳＡ（美国麻醉学会评分法）级别和术前神经功能状况有关。

关键词：脑膜瘤诊断外科手术预后后颅凹

经额颞颧下颌联合入路切除中颅凹颞下凹沟通肿瘤

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北京医科大学学报 1998年第2期30卷 174-176页

作者：鲍圣德尤玉才张建国俞光岩王象昌 v.seifert 北京医科大学第一医院神经外科德国莱比锡大学医学院

目的：探讨一种切除中颅凹颞下凹沟通肿瘤的颅面联合入路。方法：采用经额颞颧下颌联合手术入路切除肿瘤。结果：显微镜下全切肿瘤的患者经远期随访无神经系统症状及体征。结论：该入路暴露充分，对脑组织牵拉小，能在颈部控制颈内... 详细信息

目的：探讨一种切除中颅凹颞下凹沟通肿瘤的颅面联合入路。方法：采用经额颞颧下颌联合手术入路切除肿瘤。结果：显微镜下全切肿瘤的患者经远期随访无神经系统症状及体征。结论：该入路暴露充分，对脑组织牵拉小，能在颈部控制颈内、外动脉，尽早辨认并保护面神经，对切除中颅凹颞下凹沟通肿瘤十分有利。

关键词：脑肿瘤外科手术颅-面联合入路

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前路显微外科手术治疗多节段颈椎病

现代神经疾病杂志 2001年第1期1卷 23-25页

作者：鲍圣德葛为勇 v seifert 北京大学第一医院神经外科 100034 德国法兰克福大学神经外科

目的探讨单一或多个椎体广泛切除,显微外科手术减压,颈椎植骨融合,钛钢板颈椎固定手术治疗多节段颈椎病的疗效。方法根据临床表现及神经影像学资料选择24例脊髓型颈椎病患者,采用Caspar颈椎手术器械及新型植骨融合固定技术实施手术,... 详细信息

目的探讨单一或多个椎体广泛切除,显微外科手术减压,颈椎植骨融合,钛钢板颈椎固定手术治疗多节段颈椎病的疗效。方法根据临床表现及神经影像学资料选择24例脊髓型颈椎病患者,采用Caspar颈椎手术器械及新型植骨融合固定技术实施手术,于显微镜下切除病变的颈椎椎间盘、椎体和后纵韧带,高速气动磨钻磨除患椎骨赘,以自体髂骨或骨水泥行植骨融合、钛钢板固定。结果根据Nurick神经功能评价标准,术后92％(22例)的患者神经功能不同程度改善,8％(2例)的患者症状无改变,无一例症状加重。结论应用颈椎前入路显微外科手术治疗来自颈脊髓前方压迫的多节段颈椎病患者(包括症状严重者),减压彻底,固定稳定,安全可行,多数患者疗效满意。

关键词：脊柱融合术脊柱骨赘病显微外科手术

microRNAs在癫痫发生中的作用（英文）

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中华神经外科疾病研究杂志 2016年第3期 224-224页

作者： Cattani AA Allene C seifert v Rosenow F Henshall DC Freiman TM Department of Neurosurgery Goethe University

Patients who have sustained brain injury or had developmental brain lesions present a non-negligible risk for developing delayed epilepsy. Finding therapeutic strategies to prevent development of epilepsy in at-risk patients represents a crucial medical challenge. Noncoding microRNA molecules( miRNAs) are promising candidates in this area. Indeed,deregulation of diverse brainspecific miRNAs has been observed in animal models of epilepsy as well as in patients with epilepsy,mostly in temporal lobe epilepsy( TLE). Herein we review deregulated miRNAs reported in epilepsy with potential roles in key molecular and cellular processes underlying epileptogenesis,namely neuroinflammation,cell proliferation and differentiation,migration,apoptosis,and synaptic remodeling. We provide an up-to-date listing of miRNAs altered in epileptogenesis and assess recent functional studies that have interrogated their role in epilepsy. Last,we discuss potential applications of these findings for the future development of disease-modifying therapeutic strategies for antiepileptogenesis.

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颈内动脉分叉部动脉瘤的手术及血管内治疗（英文）

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中华神经外科疾病研究杂志 2015年第1期14卷 11-11页

作者： Konczalla J Platz J Brawanski N Güresir E Lescher S Senft C du Mesnil de Rochemont R Berkefeld J seifert v

BACKGROUND Aneurysms of the internal carotid artery(ICA)bifurcation are rare,and no studies have compared patient outcomes after endovascular vs surgical *** To report the safety,efficacy,and follow-up outcome of these 2treatment options for patients with ICA bifurcation *** Patient and aneurysm characteristics,treatment results,and follow-up outcomes(at 30 months)were analyzed from patient records and review of imaging *** A total of 58 patients with ICA bifurcation aneurysms were *** interdisciplinary consensus,30 aneurysms were assigned for coiling and 28 for *** who underwent surgical clipping were younger and had larger *** patients were assigned to coiling if their aneurysms originated only from the ICA bifurcation or projected *** the combined angiographic endpoint,complete and nearly complete occlusion(Raymond-Roy I+II),similar rates of 96%(coiling)or 100%(clipping)could be ***-Roy I occlusion occurred more often after clipping(79%vs 41%coiling).Follow-up of the endovascular group showed minor recanalization of the aneurysm neck(Raymond-Roy II)in 42%.One patient(4%)showed a major recanalization(Raymond-Roy III)and needed *** incidental findings,no bleeding complications or new persistent neurological deficits occurred during *** Treatment of ICA bifurcation aneurysms after interdisciplinary assignment to clipping or coiling is effective and *** significantly more minor recanalizations after coiling,the re-treatment rate was very low,and no bleeding was observed during *** analysis revealed that origin only from the ICA bifurcation was an independent predictor of aneurysm recanalization after endovascular treatment.

关键词：摘要编辑部编辑工作读者

Wavelength-multiplexed multi-mode EUv reflection ptychography based on automatic differentiation

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Light(Science & Applications) 2024年第10期13卷 2156-2167页

作者： Yifeng Shao Sven Weerdenburg Jacob seifert H.Paul Urbach Allard P.Mosk Wim Coene Imaging Physics Department Applied Science FacultyDelft University of TechnologyLorentzweg 1Delft 2628 CJThe Netherlands Nanophotonics Debye Institute for Nanomaterials Science and Center for Extreme Matter and Emergent PhenomenaUtrecht UniversityP.0.Box 80000Utrecht 3508 TAThe Netherlands Research Department ASML Netherlands B.VDe Run 6501Veldhoven 5504DRThe Netherlands

Ptychographic extreme ultraviolet(EUv)diffractive imaging has emerged as a promising candidate for the next generationmetrology solutions in the semiconductor industry,as it can image wafer samples in reflection geometry at the *** technique has surged attention recently,owing to the significant progress in high-harmonic generation(HHG)EUv sources and advancements in both hardware and software for *** this study,a novel algorithm is introduced and tested,which enables wavelength-multiplexed reconstruction that enhances the measurement throughput and introduces data diversity,allowing the accurate characterisation of sample *** tackle the inherent instabilities of the HHG source,a modal approach was adopted,which represents the crossdensity function of the illumination by a series of mutually incoherent and independent spatial *** proposed algorithm was implemented on a mainstream machine learning platform,which leverages automatic differentiation to manage the drastic growth in model complexity and expedites the computation using GPU *** optimising over 2oo million parameters,we demonstrate the algorithm's capacity to accommodate experimental uncertainties and achieve a resolution approaching the diffraction limit in reflection *** reconstruction of wafer samples with 20-nm high patterned gold structures on a silicon substrate highlights our ability to handle complex physical interrelations involving a multitude of *** results establish ptychography as an efficient and accurate metrology tool.

关键词： metrology mode approaching

Role of Hox genes in stem cell differentiation

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World Journal of Stem Cells 2015年第3期7卷 583-595页

作者： Anne seifert David F Werheid Silvana M Knapp Edda Tobiasch Department of Applied Sciences Bonn-Rhine-Sieg University of Applied Sciences

Hox genes are an evolutionary highly conserved gene family. They determine the anterior-posterior body axis in bilateral organisms and influence the developmental fate of cells. Embryonic stem cells are usually devoidof any Hox gene expression, but these transcription factors are activated in varying spatial and temporal patterns defining the development of various body regions. In the adult body, Hox genes are among others responsible for driving the differentiation of tissue stem cells towards their respective lineages in order to repair and maintain the correct function of tissues and organs. Due to their involvement in the embryonic and adult body, they have been suggested to be useable for improving stem cell differentiations in vitro and in vivo. In many studies Hox genes have been found as driving factors in stem cell differentiation towards adipogenesis, in lineages involved in bone and joint formation, mainly chondrogenesis and osteogenesis, in cardiovascular lineages including endothelial and smooth muscle cell differentiations, and in neurogenesis. As life expectancy is rising, the demand for tissue reconstruction continues to increase. Stem cells have become an increasingly popular choice for creating therapies in regenerative medicine due to their self-renewal and differentiation potential. Especially mesenchymal stem cells are used more and more frequently due to their easy handling and accessibility, combined with a low tumorgenicity and little ethical concerns. This review therefore intends to summarize to date known correlations between natural Hox gene expression patterns in body tissues and during the differentiation of various stem cells towards their respective lineages with a major focus on mesenchymal stem cell differentiations. This overview shall help to understand the complex interactions of Hox genes and differentiation processes all over the body as well as in vitro for further improvement of stem cell treatments in future regenerative me

关键词： Genes Homeobox Stem cells Asymmetriccell division Mesenchymal stromal cells Growth Development Regeneration Patterning Cell lineage

Update on hepatitis C: Direct-acting antivirals

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World Journal of Hepatology 2015年第28期7卷 2829-2833页

作者： Leon L seifert Ryan B Perumpail Aijaz Ahmed Department of Transplantation Medicine University Hospital Münster Division of Gastroenterology and Hepatology Stanford University School of Medicine

Hepatitis C virus(HCv) was discovered 26 years ago. For decades, interferon-based therapy has been the mainstay of treatment for HCv. Recently, several direct-acting antivirals(DAAs) have been approved for treatment of HCv-infected patients and to help combat the virus. These drugs have revolutionized the management of HCv as all-oral regimens with favorable side effect profiles and superior rates of sustained virological response. Emerging real-world data are demonstrating results comparable to registration trials for DAA agents. Suddenly, the potential for eradicating HCv is on the horizon.

关键词： Hepatitis C virus Direct-acting antivirals Sustained virologic response Management Treatment

Non-compliance in surveillance for patients with previous resection of large (≥ 1 cm) colorectal adenomas

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World Journal of Gastroenterology 2006年第45期12卷 7313-7318页

作者： Wolfgang M Brueckl Berit Fritsche Brigitte seifert FrankBoxberger Heinz Albrecht Roland S Croner Axel Wein Eckhart G Hahn Department of Medicine 1 University Hospital of Erlangen91054 Erlangen Germany Department of Surgery University Hospital ofErlangen 91054 Erlangen Germany

AIM: To assess the extent and reasons of non- compliance in surveillance for patients undergoing polypectomy of large (≥ 1 cm) colorectal adenomas. METHODS: Between 1995 and 2002, colorectal adenomas ≥ 1 cm were diagnosed in 210 patients and subsequently documented at the Erlangen Registry of Colorectal Polyps. One hundred and fi fty-eight patients (75.2%) could be contacted by telephone and agreed to be interviewed. Additionally, records were obtained from the treating physicians. RESULTS: Fifty-four out of 158 patients (34.2%) neglected any surveillance. Reasons for non-compliance included lack of knowledge concerning surveillance intervals (45.8%), no symptoms (29.2%), fear of examination (18.8%) or old age/severe illness (6.3%). In a multivariate analysis, the factors including female gender (P = 0.036) and age > 62 years (P = 0.016) proved to be signif icantly associated with non-compliance in surveillance. CONCLUSION: Efforts to increase compliance in surveillance are of utmost importance. This applies particularly to women’s compliance. Effective strategies for avoiding metachronous colorectal adenoma and cancer should focus on both the improvement in awareness and knowledge of patients and information about physicians for surveillance.

关键词： Colorectal adenoma Colorectal cancer Surveillance colonoscopy, Non-compliance