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Gorlin Goltz综合征与并指(趾)畸形中隐匿性的致命性贲门肿瘤

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世界核心医学期刊文摘（儿科学分册） 2005年第3期1卷 47-47页

作者： Doede Th. seidel j. Riede F.-T. 肖莉 Department of Pediatric Surgery Universit atsklinikum JenaJenaGermany

小儿外科、矫形外科、整形外科和手掌外科的医生都会对并指(趾)畸形进行外科矫正。然而有时忘记了并指(趾)现象仅是Gorlin Goltz综合征中的一种表现。这种综合征的每一种临床表现都能威胁生命。一个7个月大的男童以皮肤的并指(趾)畸形... 详细信息

小儿外科、矫形外科、整形外科和手掌外科的医生都会对并指(趾)畸形进行外科矫正。然而有时忘记了并指(趾)现象仅是Gorlin Goltz综合征中的一种表现。这种综合征的每一种临床表现都能威胁生命。一个7个月大的男童以皮肤的并指(趾)畸形就医。孩子母亲声称除了这个并指(趾)畸形外孩子是健康的。然而,回顾陈述的档案时发现家庭医生曾怀疑是Gorlin Goltz综合征。外科手术前的超声心动图描记显示在患儿左心室壁内有一个3.9 cm大小的肿瘤。心电图证明有室性心动过速。由于这种恶性室性心动过速有生命危险,所以切除了肿瘤。在切除前,因为肿瘤的大小曾考虑过心脏移植术。组织学检查还发现了纤维瘤。当观察到并指(趾)畸形时,人们必须意识到这种症候群的可能性。外科手术治疗前使用心电图检查和超声心动图描记进行筛查是非常重要的。

关键词：并指(趾) 组织学检查超声心动图家庭医生心脏移植术外科手术左心室壁整形外科生命危险隐匿性

A Comprehensive FIB Lift-out Sample Preparation Method for Scanning Probe Microscopy

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Nanomanufacturing and Metrology 2022年第1期5卷 67-79页

作者： F.j. Y.Yao T.Xin j.seidel School of Materials Science and Engineering UNSW SydneySydneyNSW 2052Australia ARC Centre of Excellence in Future Low-Energy Electronics Technologies(FLEET) UNSW SydneySydneyNSW 2052Australia Electron Microscopy Unit(EMU) Mark Wainwright Analytical CentreUNSW SydneySydneyNSW 2052Australia

In this work,we investigate cross-sectional sample preparation for atomic force microscopy and general scanning probe microscopy(SPM)*** light of traditional cross-sectional sample preparation solutions for transmission electron microscopy,mechanical polishing and focused ion beam(FIB)milling have been employed to prepare cross-sectional samples for *** present an optimized solution for thin films and oxide heterostructures that allows for examining the prepared surfaces using various SPM *** particular,post-cleaning after FIB milling is shown to be crucial and precision ion polishing was conducted to remove rough layers on mechanically polished *** also study SPM mechanical milling to remove amorphous layers on FIB-milled ***,a reliable solution for making cross sections suitable for SPM has been achieved providing a useful methodology that can also be employed for other material systems with different hardness,such as polymers and metals.

关键词： Oxide heterostructures Cross-sectional measurements Scanning probe microscopy AFM FIB

Kaede for Detection of Protein Oligomerization

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Molecular Plant 2013年第5期6卷 1453-1462页

作者： Heike Wolf B. George Barisas KarI-j.sef Dietz Thorsten seidel Dynamic Cell Imaging Faculty of Biology Bielefeld University D-33501 Bielefeld Germany Department of Chemistry Colorado State University Fort Collins CO 80523 usa Biochemistry and Physiology of Plants Faculty of Biology Bielefeld University D-33501 Bielefeld Germany

Photoconvertible fluorescent proteins such as Kaede are routinely used for tracking proteins, organelles, and whole cells. Kaede was the first identified photoconvertible fluorescent protein and has since become the most commonly used photoconvertible fluorescent protein in vertebrates. Kaede can be irreversibly converted from a green to a red fluo- rescent form upon UV/blue light irradiation and fluorescence of each form can be isolated separately by appropriate filter sets. Spectral properties of the Kaede forms allow F6rster resonance energy transfer （FRET） from the green form as donor to the red form as acceptor. As a sample containing oligomerized Kaede-containing proteins is exposed to UV or blue light, FRET first increases as green Kaede is converted to red and then decreases as the green donor becomes depleted. Thus, FRET information is potentially obtained from a number of independent measurements taken as photoconversion proceeds. We demonstrate here the application of this approach to detect homo-aggregation and conformational dynamics of plant pro- tein constructs. Structural alterations of 2-cys peroxiredoxin-Kaede were successfully detected depending on the redox state in living plant cells. Photoconversion was performed gradually and donor emission, acceptor emission, and FRET-derived sensitized acceptor emission were measured at each step of conversion. Since photoconvertible proteins have not been rou- tinely used in plants, two plasmids have been designed to facilitate plant applications. The plasmids allow either transient expression of Kaede-containing protein constructs in plant cells or Gateway cloning and stable transformation of plants.

关键词： protein structure fluorescence imaging protein-protein interaction.

Evaluation of RSI-induced stresses in Francis runners

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Evaluation of RSI-induced stresses in Francis runners

The role of diabetes mellitus in localized and metastatic renal cell carcinoma

The 26th IAHR Symposium on Hydraulic Machinery and Systems

作者： U seidel B Hübner j.Lfflad P Faigle Voith Hydro Holding GmbH ＆ Co.KGAlexanderstr.11 89522 HeidenheimGermany

Modern design of hydraulic turbines aims to achieve very high levels of efficiency and structural integrity in the environment of highly variable loading *** combine those requirements,a profound knowledge of static and dynamic loads acting on hydraulic components is *** loadings of Francis runners strongly depend on head range and required operating *** higher head （low specific speed） Francis runners,the main dynamic loading is caused by Rotor-Stator Interaction （RSI）.The knowledge of dynamic loads and stresses in Francis runners is often derived from strain gauge measurements and/or simulation of flow interacting with structural *** simulations of FluidStructure Interaction （FSI） are necessary to predict the dynamic behavior,especially in terms of hydrodynamic mass and damping *** contribution describes the equipment and procedure of strain gauge measurements in Francis prototype runners,including the challenges to overcome during such *** provides an overview of strain gauge test results for Francis runners in different head ranges and describes the characteristic differences depending on specific *** data is compared with state of the art simulations of Francis runner dynamics to predict dynamic stresses caused by *** contribution underlines the fact that a calibrated analysis procedure is the key to optimize the design of Francis runners.

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j.urnal of Diabetes Mellitus 2011年第4期1卷 104-108页

作者： Sandra Steffens Christoph von Klot Hendrik Egggers Christoph seidel Gerd Wegener Mark Schrader Markus A. Kuczyk Andres j. Schrader 不详

Introduction & Obj.ctives: Until recently, the incidence of renal cell carcinoma (RCC) has been increasing worldwide, mainly in western countries, at a rate between 2% and 4% per year. However, the reason for this dramatic increase in number has not been fully understood. Diabetes mellitus (DM) is a known risk factor for RCC, but the impact of DM on the prognosis of RCC is unclear. In the present study, we investigated the potential influence of DM on clinicopathological features of localized and metastatic RCC. Material & Methods: We evaluated 863 patients with primary RCC who had undergone renal surgery between 1991 and 2005 in the University Hospital Hannover;the mean follow-up was 58 months. To test the association of DM with survival end-points, Kaplan-Meier Method and Cox multivariable logistic regression models were applied. Results: In total, we identified 123 diabetic patients who suffered from RCC, 9 patients with diabetes type 1 and 114 with type 2. Patients with DM type 2 presented significantly more often with pT1a tumours at diagnosis (40.0 vs. 31.7%, p = 0.02), had less frequently high grade cancer (G3/4;10.3 vs. 16.2%, p = 0.03), were older (median, 65.3 vs. 61.6 years;p < 0.001), and had a higher BMI at diagnosis (median, 27.6 vs. 25.8, p < 0.001). However, there was no difference between diabetic and non-diabetic patients concerning sex, histological subtype, lymphatic and distant metastasis. In addition, there was no discrepancy in 5-year cancer specific survival between both groups (62.2 vs. 64.9% for patients without and with DM type 2, respectively). Applying multivariable analysis, unlike age, tumour stage, grade and N/M status, diabetes was not identified as a significant independent prognostic factor. Conclusions: To our knowledge this is the first study to show that even though diabetes is a risk factor for RCC it does not seem to influence its prognoses even though it might be diagnosed earlier in diabetic patients.

关键词： Renal Cell Cancer Risk Factor Diabetes Mellitus Survival Prognosis

Performance and calibration of quark/gluon-j.t taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuj. X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j.F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of j.ts originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rej.cting j.ts from gluon over j.ts from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the j.t,and the other combines several j.t substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the j.t *** in tagging efficiency between data and simulation are provided for j.ts with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS j.T QUARK GLUON TAGGING

Selective Adsorption of Molecules on Metal Surfaces

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Selective Adsorption of Molecules on Metal Surfaces

中国化学会第九届全国量子化学学术会议

作者： C．seidel H．Kopf H．Fuchs S．j.Pennycook S．Pantelides Physics Institute uenster University MuensterGermany Physics Institute uenster University MuensterGermany Physics Institute uenster University MuensterGermany Condensed Matter Sciences Division ak Ridge National Laboratory Oak Ridge 37831USA Department of PhysicsVanderbilt UniversityNashvilleTN38845USA Condensed Matter Sciences Division ak Ridge National Laboratory Oak Ridge 37831USA Department of PhysicsVanderbilt UniversityNashvilleTN38845USA

＜正＞Selective adsorption of different molecules on the same surfaces is an effective technique of controllable design of multifunctional molecular devices. To study the mechanism of selective adsorption, two organic molecules with different sizes and different functional groups, 3,4,9,10-perylene-tetracarboxylicacid-dianhydride （PTCDA） and 2, 5-dimethyl-N, N’-dicyano-quinonediimine （DMe-DCNQI）, are evaporated on a designed Ag（775） substrate with two facets

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能量原理在确定岩石节理抗剪强度方面的应用

地质科学译丛 1997年第1期14卷 46-50页

作者： j.P.seidel 杨锋 Monash University Claytoh Australia

为了确定剪胀节理的剪切强度,人们已开始运用能量原理研究岩体结构面(Ladanyi 和 Archambault,1970)。本项工作基于分析规则的粗糙起伏面,并且假定其是不可变形的。自然条件下的复杂岩体结构面中,很难辩认出要测量的有代表性的起伏角。L... 详细信息

为了确定剪胀节理的剪切强度,人们已开始运用能量原理研究岩体结构面(Ladanyi 和 Archambault,1970)。本项工作基于分析规则的粗糙起伏面,并且假定其是不可变形的。自然条件下的复杂岩体结构面中,很难辩认出要测量的有代表性的起伏角。Ladanyi 和 Archambault 通过假定等价结构面的张开度和结构面的有效起伏角将其成果推广到天然节理。显然,这种等量假设不是普遍适用的,而且可能导致结构面的剪切强度偏小。此外,对于弹性岩体中结构面的有效摩擦角,不同倾斜度的粗糙起伏面所组成的结构面的有效摩擦角,发生峰后剪切位移的结构面的有效摩擦角和裂隙岩体中结构面的有效摩擦角都可以用 Ladanyi 和 Archambault 方法加以扩延论证分析。

关键词：能量原理岩石节理抗剪强度

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节理粗糙度研究的新进展

地质科学译丛 1996年第2期13卷 70-78页

作者： j.P.seidel C.M.Haberfield 杨翠珠 Department of Civil Engineering Monash UniversityClaytonAustralia

当前采用的节理模型,如果不凭借经验,是不可能准确预测节理的剪切行为的,这已成为争论的热点。这是因为这些模型不能定量地评价节理粗糙度或尺度的重要性。介绍一种新的方法,它用分形几何来调查节理的粗糙度。这种方法已超出了简单地描... 详细信息

当前采用的节理模型,如果不凭借经验,是不可能准确预测节理的剪切行为的,这已成为争论的热点。这是因为这些模型不能定量地评价节理粗糙度或尺度的重要性。介绍一种新的方法,它用分形几何来调查节理的粗糙度。这种方法已超出了简单地描述粗糙度的“症状”,而是去寻找“原因”。在该法的应用中,引入了分形几何、分维数和自相似的概念,并系统地阐述岩体节理粗糙度的统计依据和实用模型的框架。推导了分维数和起伏角与粗糙高度的标准差这两个更有用统计参数之间的重要关系。这些关系不仅为定量评价节理粗糙度提供了有用的方法,而且为解释巴顿(Barton)的经验模型(j.C-j.S)提供了基础。另外,分形模型可以为节理剪切行为的正应力作用效应和节理尺度效应提供理论模型。

关键词：节理粗糙度系数分维数自相似岩石