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Pembrolizumab-induced psoriatic arthritis treated with disease-modifying anti-rheumatic drugs in a patient with gastric cancer:A case report

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World Journal of Clinical Cases 2023年第1期11卷 218-224页

作者： sehan kim Jong Hee Sun Hongsik kim Hee Kyung kim Yaewon Yang Jun Su Lee In Ah Choi Hye Sook Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Immune checkpoint inhibitor(ICI)-induced rheumatic immune-related adverse events(ir AEs)have been infrequently reported,and the treatment of severe or refractory arthritis as ir AEs has not been established *** SUMMARY The patient was a 67-year-old man with a history of well-controlled foot psoriasis who presented with *** had received pembrolizumab for metastatic gastric adenocarcinoma 2 mo *** examination revealed erythematous swelling in the distal interphalangeal joints,left shoulder,and both *** had plaque psoriasis with psoriatic nail dystrophy and dactylitis in the distal joints of the fingers and *** markers including C-reactive protein and erythrocyte sedimentation rate were elevated but rheumatoid factor and anticyclic citrullinated peptide antibody were *** patient was diagnosed with psoriatic arthritis(PsA)and started on methylprednisolone 1 mg/kg/day after pembrolizumab ***,despite 1 wk of methylprednisolone treatment,PsA worsened;hence,leflunomide and methotrexate were *** 4 wk of steroid treatment,PsA worsened and improved repeatedly with steroid ***,the therapy was intensified to include etanercept,a tumor necrosis factor inhibitor,which ultimately resulted in adequate PsA *** This is the first report of ICI-induced PsA in a gastric cancer *** rheumatic ir AEs with refractory severe arthritis may require disease-modifying anti-rheumatic drugs and long-term management.

关键词： Pembrolizumab Psoriatic arthritis Disease-modifying anti-rheumatic drugs Gastric cancer Case report

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Physical Properties of Ophthalmic Copolymers Containing Vinylaniline and ZnO Nanoparticles

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Journal of Biomaterials and Nanobiotechnology 2013年第4期4卷 309-315页

作者： A-Young Sung Tae-Hun kim Department of Ophthalmic Optics Sehan University Jeonnam South Korea Department of Visual Optics Baekseok University Chonan South Korea.

The mixture of vinylaniline and 2-hydroxyethyl mrthacrylate mixed according to the mixing ratio, was allowed to stir in order to add functionality. ZnO nanoparticles, dispersed for approximately 1 hr in an ultrasonic bench top cleaner, were added to the mixture of monomers. Then the mixture at a mould was thermally polymerized to prepare high-performance hydrogel ophthalmic lens. The produced ophthalmic hydrogel lens was then put in 0.9% NaCl (normal saline solution) for 24 hrs for hydration, and various measurements were carried out. The surface analysis of ZnO nanoparticles dispersed in the macromolecular polymer was conducted using AFM (XE-100, Parks System). The produced hydrogel lens generally exhibited yellowish color, transparent and hydrophilic characteristics. Also, the contact lenses hydrated in standard saline solution generally exhibited the characteristics of flexibility and softness. The physical properties of the ophthalmic hydrogel lens material were measured. The refractive indexes of 1.359-1.423, water content of 37%-43%, and visible transmittance of 74%-82% were obtained.

关键词： ZnO Nanoparticles Vinylaniline Spectral Transmittances Contact Angles

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Application of Contemporary Educational Psychology in University Education

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心理学研究评论（中英文版） 2023年第1期9卷 7-12页

作者： Xiaoman Meng Suksu kim Liaoning Institute of Science and Technology sehan University

At the present stage,in the field of education in China,universities are able to produce more high-quality talents for national *** the discipline of psychology,educators can effectively achieve the set teaching goals by using contemporary educational *** present,influenced by traditional concepts and exam-oriented education,there are still more practical problems to be solved in the stage of psychology education in various higher education institutions in *** paper briefly outlines the current situation of psychological education in colleges and universities,and analyzes the significance and means of applying contemporary educational psychology.

关键词： Educational Psychology College Education Application

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中国沿海省份渔业产业竞争力比较研究

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现代农业科技 2022年第14期 197-201页

作者：赵海婷李倩郭永军李春杰金炯浩天津农学院水产学院天津300384 天津农学院经济管理学院天津300384 韩国世翰大学航空物流系韩国唐津31746

为比较中国沿海省份渔业产业竞争力,通过分析并借鉴产业竞争力理论,查阅《2020中国渔业统计年鉴》获取统计数据,运用AHP方法和德尔菲法建立指标评价体系进行计算。结果表明,山东省是沿海省份中渔业产业竞争力最强的省份,影响渔业产业竞... 详细信息

为比较中国沿海省份渔业产业竞争力,通过分析并借鉴产业竞争力理论,查阅《2020中国渔业统计年鉴》获取统计数据,运用AHP方法和德尔菲法建立指标评价体系进行计算。结果表明,山东省是沿海省份中渔业产业竞争力最强的省份,影响渔业产业竞争力的最重要因素是资源禀赋,其次是长期获利能力;休闲渔业的发展状况在评价渔业产业竞争力中倍受重视,将成为乡村休闲观光旅游新的经济增长点。建议各地区要因地制宜推进渔业一、二、三产融合发展,提高渔业产品附加值和产业竞争力。

关键词：渔业产业竞争力沿海省份比较

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