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Impression of prognosis regarding pathologic stage after preoperative chemoradiotherapy in rectal cancer

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World Journal of Gastroenterology 2015年第2期21卷 563-570页

作者： Kyungyeon Hwang In Ja Park Chang Sik Yu Seok-Byung lim Jong Lyul Lee Yong Sik yoon Chan Wook Kim Jin Cheon Kim Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical CenterSeoul 138-736South Korea

AIM: To ascertain pathologic stage as a prognostic indicator for rectal cancer patients receiving preoperative chemoradiotherapy(PCRT).METHODS: Patients with mid- and low rectal carcinoma(magnetic resonance imaging- based clinical stage Ⅱ or Ⅲ) between 2000 and 2009 and treated with curative radical resection were identified. Patients were divided into two groups: PCRT and No-PCRT. Recurrence-free survival(RFS) was examined according to pathologic stage and addition of adjuvant ***: Overall, 894 patients were identified. Of these, 500 patients received PCRT. Adjuvant chemotherapy was delivered to 81.5% of the No-PCRT and 94.8% of the PCRT patients. Adjuvant radiotherapy was given to 29.4% of the patients in the No PCRT group. The 5-year RFS for the No-PCRT group was 92.6% for StageⅠ, 83.3% for Stage Ⅱ, and 72.9% for Stage Ⅲ. The 5-year RFS for the PCRT group was 95.2% for yp Stage 0, 91.7% for yp StageⅠ, 73.9% for yp Stage Ⅱ, and 50.7% for yp Stage Ⅲ.CONCLUSION: Pathologic stage can predict prognosis in PCRT patients. Five-year RFS is significantly lower among PCRT patients than No-PCRT patients in pathologic stage Ⅱ and Ⅲ. These results should be taken into account when considering adjuvant treatment for patients treated with PCRT.

关键词： Preoperative Chemoradiotherapy Rectal cancer Patho

The effect of Al addition to prevent Ni sintering in steam reforming of bio-ethanol

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The effect of Al addition to prevent Ni sintering in steam r...

第九届全国氢能学术会议

作者： H.Devianto S.P.yoon S.W.Nam T.H.lim H.I.Lee Seoul National University Korea Institute of Science and Technology

＜正＞Reforming of bio-ethanol provides a promising method for hydrogen production from renewable *** most well-known active metal for ethanol steam reforming is Ni. Unfortunately,Ni sintering,however,cannot be avoided at high temperature and high water content,as shown in steam reforming of bio-ethanol for high temperature fuel cell application,

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Ratio of metastatic lymph nodes is more important for rectal cancer patients treated with preoperative chemoradiotherapy

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World Journal of Gastroenterology 2015年第11期21卷 3274-3281页

作者： In Ja Park Chang Sik Yu Seok-Byung lim Yong Sik yoon Chan Wook Kim Tae Won Kim Jong Hoon Kim Jin Cheon Kim Department of colon and rectal Surgery University of Ulsan College of Medicine and Asan Medical Center Department of Medical Oncology University of Ulsan College of Medicine and Asan Medical Center Department of Radiation Oncology University of Ulsan College of Medicine and Asan Medical Center

AIM:To evaluate the predictive value of the lymph node(LN) ratio(LNR,number of metastatic LNs/ examined LNs) for recurrence in patients with rectal cancer and to compare its applicability according to preoperative chemoradiotherapy(PCRT).METHODS:From 2000 to 2009,967 patients with metastatic LNs after curative resection for locally advanced rectal cancer were *** were categorized according to PCRT(PCRT vs No PCRT).The cut-off LNR was determined based on the p N1 vs p N2 when the recommended number of LNs was *** 5-year recurrence-free survival(RFS) rates using the Kaplan-Meier method were compared according to p/yp N stage and the LNR in each ***:Among patients with the same p/yp N stage,the 5-year RFS rate differed according to the *** addition,the 5-year RFS rate was significantly different between p N and LNR groups in patients with No *** PCRT group,however,only LNR was associated with *** multivariate analysis,both p N and LNR were significant independent prognostic factors for 5-year RFS in the No PCRT *** the PCRT group,only LNR category was found to be associated with RFS(HR = 2.36,95%CI:1.31-3.84,and P = 0.001).CONCLUSION:The LNR is an important prognostic predictor of RFS in rectal cancer patients especially treated with *** p N categories could not discriminate between prognostic groups of RFS after PCRT.

关键词： Rectal cancer Preoperative chemoradiotherapy Lymph

Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype

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World Journal of Gastroenterology 2013年第41期19卷 7078-7088页

作者： Jae Yun lim Sun Och yoon So-Young Seol Soon Won Hong Jong Won Kim Seung Ho Choi Ju-Seog Lee Jae Yong Cho Department of Medical Oncology Gangnam Severance Cancer HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Systems Biology Division of Cancer MedicineUniversity of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Pathology Gangnam Severance Cancer HospitalYonsei University College of Medicine 135-720SeoulSouth Korea Department of Surgery Gangnam Severance Cancer HospitalYonsei University College of MedicineSeoul 135-720South Korea

AIM:To identify molecular biologic differences between two gastric adenocarcinoma subgroups presenting different prognoses through the analysis of microRNA and protein ***:Array technologies were used to generate1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric *** the integrative analysis,we used established mRNA expression data published in our previous *** mRNA expression levels were acquired from microarray data for 60 identical gastric cancer *** gastric adenocarcinoma subgroups with distinct mRNA expression profiles presented distinctly different *** and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two different prognostic *** expressed microRNA,associated mRNA,and protein in patients with poor-prognosis gastric cancer were validated by quantitative reverse transcription polymerase chain reaction and immunochemistry in independent ***:We obtained the expression data of 1146microRNAs and 124 cancer-related *** microRNAs were aberrantly expressed in the two prognostic groups and in cancer vs non-cancer tissues(P<0.05).In the poor-prognosis group,miR-196b,miR-135b,and miR-93 were up-regulated and miR-29c*was ***-196b expression positively correlated with Homeobox A10(HOXA10)expression(r=0.726,P<0.001),which was significantly increased in poor-prognosis patients(P<0.001).Comparing gastric cancer with non-cancer tissues,46/124 proteins showed differential expression(P<0.05);COX2(P<0.001)and cyclin B1(P=0.017)were clearly overexpressed in the poor-prognosis ***:Co-activation of miR-196b and HOXA10characterized a poor-prognosis subgroup of patients with gastric *** of the biologic function of miR-196b and HOXA10 is warranted.

关键词： Gastric cancer Gene expression Microarray MicroRNA miR-196b Homeobox A10

Effects of Composted Cattle Manure Application on the Productivity of Forages Under Rye and Whole Crop Rice Double Cropping System in Asan,Korea

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Effects of Composted Cattle Manure Application on the Produc...

The 3rd Korea-China-Japan Joint Symposium on Grassland Agriculture and Livestock Production

作者： Young Chul lim Min Woong Jung Sei Hyung yoon Joung Kyong Lee Nam Chul Jo Ki-Won Lee Wan Bang Yook National Institute of Animal Science RDACheonan-SiChungnam 330-801 Korea College of Animal Bioscience and Technology Konkuk University

The experimental work was conducted to investigate the effects of the application level of composted cattle manure(CCM) on forage productivity using rye-whole crop rice(WCR) double cropping system for 3 *** plot was consisted of application level of CCM such as 150%,200%and control *** total DMY of of rye-WCR in treatment of CCM 150%significantly decreased as compared with that of treatment of CF and CCM 200%.However, NDF,ADF and CP content of rye and WCR were hardly influenced by CCM application.

关键词： Whole crop rice Composted Cattle manure Cropping system

Clinical validation of scoring systems of postoperative pancreatic fistula after pancreatoduodenectomy: applicability to Eastern cohorts?

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 211-218页

作者： Jae Seung Kang Taesung Park Youngmin Han Seungyeon Lee Jae Ri Kim Hongbeom Kim Wooil Kwon Sun-Whe Kim Jin Seok Heo Seong Ho Choi Dong Wook Choi Song Cheol Kim Tae Ho Hong Dong Sup yoon Joon Seong Park Sang Jae Park Sung-Sik Han Sae-Byeol Choi Joo Seop Kim Chang-Sup lim Jin-Young Jang Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Statistics and Interdisciplinary Program in Biostatistics Seoul National UniversitySeoulRepublic of Korea Department of Mathematics and Statistics Sejung UniversitySeoulRepublic of Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryUlsan University College of Medicine and Asan Medical CenterSeoulRepublic of Korea Department of Surgery Seoul St.Mary’s HospitalThe Catholic University of KoreaCollege of MedicineSeoulRepublic of Korea Pancreatobiliary Cancer Clinic Department of SurgeryGangnam Severance HospitalYonsei University College of MedicineSeoulRepublic of Korea Center for Liver Cancer National Cancer CenterGyeonggidoRepublic of Korea Department of Surgery Korea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Department of Surgery Kangdong Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Surgery Seoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoul National University College of MedicineSeoulRepublic of Korea

Background:Although several prediction models for the occurrence of postoperative pancreatic fistula(POPF)after pancreatoduodenectomy(PD)exist,all were established using Western ***-scale external validation studies in Eastern cohorts that consider demographic variables including lower body mass index(BMI)are *** purpose of this study was to externally validate POPF prediction models using nationwide large-scale Korean ***:Nine tertiary university hospitals in the Republic of Korea ***'preoperative characteristics,intraoperative factors,and pathologic findings were *** grades were determined according to the 2016 International Study Group on Pancreatic Surgery *** POPF risk models(Callery,Roberts,and Mungroop)were selected for external ***:A total of 1,898 PD patients were enrolled.A non-pancreatic disease diagnosis[hazard ratio(HR),1.856;95%confidence interval(CI),1.223–2.817;P=0.004),higher preoperative BMI(HR,1.069;95%CI,1.019–1.121;P=0.006),and soft pancreatic texture(HR,1.859;95%CI,1.264–2.735;P=0.002)were independent risk factors for clinically relevant POPF(CR-POPF).The area under the receiver operating characteristic curve(AUC)values were 0.61,0.64,and 0.63 on the Callery,Roberts,and Mungroop models,respectively;all were lower than those published in each external validation ***:Western POPF prediction models performed less well when applied to Korean ***,a large-scale Eastern-specific and externally validated POPF prediction model is needed.

关键词： Pancreatic fistula pancreatoduodenectomy(PD) predictive score

Integrity Assessment of Pipe System in a Full-Scale Membrane Water Treatment Plant

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Journal of Water Resource and Protection 2014年第4期6卷 363-374页

作者： H. K. Oh J. Y. Eom S. H. Kang H. C. Yoo Y. J. Kim D. M. yoon J. H. lim Daewoo Institute of Construction Technology Suwon City Korea Next Engineering & Service Seoul Korea The Office of Waterworks Seoul Metropolitan Government Seoul Korea

The pipe system roles as a main bridge between membrane modules and pumps in membrane water treatment plants. Membrane operation modes generally consist of filtration and backwash processes in a normal mode, a pressure decay test as an integrity test and a chemical circulation through pipe system in a cleaning mode. Thus factors effecting on membrane performance should be sufficiently considered before design and operation. This study evaluated flow analysis for vibration diagnostic and evaluation of the fatigue lifetime in the microfiltration system applied for a drinking water treatment plant. Vibration of main membrane pipelines was measured to identify the source of vibration. Also natural frequency and fluid dynamics was calculated by computational fluid dynamics. It showed that maximum magnitude frequencies were at 12 Hz and 22 Hz, respectively at water and air pipeline during filtration and backwash. Backwash process caused mainly vibration on the backwash water pipe. The calculated frequency from analysis of frequency response and CFD was in a good agreement with the measured frequency. Fatigue analysis showed that pipelines were getting little damage caused by vibration. Fatigue lifetime was predicted more than 15 years under the operation condition of daily filtration, and more than 27 years under the operation condition of a daily backwash mode, resulting in minor damage on the pipe lifetime.

关键词： Fatigue Integrity Lifetime Membrane Pipe System Vibration

Effect of SiO2 and CeO2 to Ni bulk catalyst in water gas shift reaction

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Effect of SiO2 and CeO2 to Ni bulk catalyst in water gas shi...

第九届全国氢能学术会议

作者： S.H.Kim J.H.Chung Y.T.Kim S.P.yoon S.W.Nam T.H.lim H.I.Lee Seoul National University Korea Institute of Science and Technology

Ni bulk catalyst had been studied as an alternative to substitute water gas shift catalyst in our previous *** surface properties of the Ni bulk catalyst have been studied by various characterization methods adding SiO and CeO to *** promoted catalysts have been applied to the water gas shift(WGS) reaction which converts CO to *** and CeO

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Growth characteristic,productivity and nutritive value of forages by reseeding methods in forest fire burnt pasture

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Growth characteristic,productivity and nutritive value of fo...

ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： J.K.Lee S.H.yoon Y.C.lim B.S.Jeon K.Y.Kim K.J.Choi H.S.Park S.Seo Grassland & Forages Division National Institute of Animal Science RDACheonanChungnam 330-801Korea

＜正＞Introduction Periodic burning is a management tool used to rejuvenate old stands of *** maintains the vegetation in a more youthful and productive state for *** a plant responds to fire depends on the height above ground of its growing points,a function of plant maturity and plant-growth *** imformation is known about the use of fire on cool-season ***,these may include many of the same objectives associated with burning,such as woody

关键词： Forest fire pasture reseeding dry matter yield nutritive value