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Determination of Effect of Home-Based Oral Chloroquine Treatment on Haematological Indices of <i>P. falciparum</i>Malaria in Children under 5 Years in Jos Metropolis

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Advances in Infectious Diseases 2018年第2期8卷 70-81页

作者： segun afolabi olomu Ubom Gregory Abraham Garba Ibrahim Hassan Department of Biochemistry University of Jos Plateau Nigeria Department of Biochemistry Abubakar Tafawa Balewa University Bauchi Nigeria

Background: The incidence of P. falciparum malaria is characterized by high rates of morbidity and mortality in under 5 children;a trend reportedly prevalent in tropical and subtropical countries including Nigeria, and recently observed in Jos metropolis, has to date defied all constructive, preventive and drug therapy intervention measures and consequently continues to constitute a serious public health problem in this most vulnerable group. Objective: The aim of this study was to determine certain haematological indicators of malaria parasite infection;their role in the clinical manifestation of P. falciparum malaria and effect of first line oral chloroquine treatment in children under 5 years attending Jos University Teaching hospital and OLA Hospital in Jos metropolis. Method: This is a cross-sectional study of 93 malaria and non-malaria children, age 1 - 59 months attending Jos University Teaching Hospital (JUTH), Jos and OLA hospital, Jos, North Central Nigeria. Malaria diagnosis was carried out using microscopical examination of Leishman’s stained thick and thin blood films and complete blood count was done using Beckman Coulter Analyzer. Results: The mean percentage lymphocyte value of chloroquine treated children (39.28% ± 7.45%) was significantly lower than the control (66.38% ± 2.27%). The mean granulocyte value of chloroquine treated children (51.07% ± 6.40%) was significantly higher than the control (26.69% ± 2.43%). Red Blood Cell (RBC) counts (4.01 ± 0.21 × 106/μL), Haemoglobin concentration (9.60 ± 0.51 g/dl) and Haematocrit (30.97% ± 1.43%) of chloroquine treated children were significantly higher than corresponding values in untreated malarious children, but not significantly different from values obtained in non-malaria control children. The RBC counts (2.92 ± 0.39 × 106/μL), Haemoglobin concentration (7.23 ± 1.01 g/dl) and Haematocrit (23.70% ± 3.37%) obtained for untreated malarious children were significantly lower than corresponding values in

关键词： Malaria Chloroquine Children Hospital Treatment

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Investigation of the Efficacy of Home-Based Oral Chloroquine Treatment among Under-Five Children with Plasmodium falciparum Malaria in Some Parts of Jos, Plateau State, Nigeria

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Advances in Infectious Diseases 2022年第1期12卷 118-127页

作者： afolabi segun olomu Ubom Gregory Abraham Gazuwa Yusuf Samuel Johnson Titilayo Okolo Selina Nnuaku Department of Biochemistry University of Jos Plateau Nigeria Paediatrics Department Jos University Teaching Hospital (JUTH) Jos Nigeria

Background: Nigeria is currently a malaria endemic country with an estimated 76% of her population at risk of contracting malaria [1]. According to a study in Nigeria, the first line of action mothers took when their children under 5 years have malaria showed that over 50% of them used non-prescription drugs they have at home or bought from pharmacy stores. And 60% of the most commonly used drugs for malaria treatment were chloroquine [2]. Many recent studies have demonstrated re-emergence of chloroquine-sensitive P. falciparum, suggesting a possible role in future malaria control [3]. Objective: The aim of this study was to investigate the effect of home-based oral chloroquine treatment among children under 5 years with Plasmodium falciparum malaria attending Jos University Teaching Hospital and OLA Hospital in Jos Metropolis. Method: This is a cross-sectional study of 93 malaria and non-malaria children. Malaria diagnosis was carried out using microscopical examination of Leishman’s stained thick and thin blood films, P. falciparum parasitemia was assessed by standard microscopy techniques and complete blood count was done using Beckman Coulter Analyzer. Results: The body temperature on admission was significantly lower (p ˚C ± 0.07˚C) than in the three malaria groups. The mean body temperature of chloroquine treated children with malaria was significantly lower (p Conclusion: The results obtained in this study demonstrate that there was significant positive impact of chloroquine treatment on Plasmodium falciparum parasitemia and degree of anemia in children under 5 years with Plasmodium falciparum in Jos Metropolis.

关键词： Malaria Chloroquine Children Parasitemia Plasmodium falciparum Anemia Nigeria

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Investigation of the effect of malaria and home-based oral chloroquine treatment on biochemical indices of *** malaria infection in children under 5 years in jos metropolis

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Infectious Diseases Research 2022年第1期3卷 29-33页

作者： olomu segun afolabi Samuel Yusufu Gazuwa Garba Ibrahim Hassan Okolo Selina Nnuaku Department of Biochemistry University of JosPlateauNigeria Department of Biochemistry Abubakar Tafawa Balewa UniversityBauchiNigeria Paediatrics Department Jos University Teaching Hospital(JUTH)JosNigeria

Background:In Nigeria,malaria is a leading cause of hospital admission and *** country accounts for highest malaria cases and deaths *** 25% of all malaria cases and deaths in the world occurs in *** 2010,malaria was reported to account for 60% of all outpatient visits and responsible for 30% of all hospital admission of children under the age of five years leaving in ***:The goal of this research work was to investigate the possible role of the state of protein nutrition,kidney and liver functions of the under 5 years children with *** malaria;the assessment of these biochemical parameters as possible indicator of *** infection in the studied subjects and the effect of home-based oral chloroquine treatment in these children leaving in Jos ***:Total of 93 children within the age range of 1 to 59 months and leaving in Jos North,Central Nigeria were recruited for this cross-sectional *** parasite identification was done using microscopic examination of Leishman-stained thick and thin blood films while the complete blood count was carried out using Beckman Coulter ***:The serum albumin concentration of(37.63±0.82 g/L)obtained in the malaria-free children was higher than concentration of(34.07±1.90 g/L)obtained in the chloroquine treated children with malaria,but not different from those obtained in the untreated uncomplicated malaria(37.35±1.19 g/L)and untreated severe malaria(37.43±1.02 g/L)*** Serum globulin concentration of 35.09±1.95 g/L,obtained in the untreated simple malaria group was higher than 30.18±1.30 g/L in the control group,34.57±2.59 g/L in the untreated severe malaria group and chloroquine treated malaria with 30.71±2.38 g/L,***:This study suggests that the biochemical parameters of serum creatinine,serum albumin,total protein,and globulin,serum alkaline phosphatase,serum alanine aminotransferase and serum aspartate aminotransferase a

关键词： chloroquine P.falciparum children Malaria pathogenesis

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