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Free and liposome form of gallic acid improves calvarial bone wound healing in Wistar rats

Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 156-163页

作者： Ahmet Altan Hatice Balci Yuce Ozkan Karatas Mehmet Murat Taskan Fikret Gevrek sefa colak Nihat Akbulut Department of Oral and Maxillofacial Surgery Faculty of DentistryGaziosmanpasa UniversityTokatTurkey Department of Periodontology Faculty of DentistryGaziosmanpasa UniversityTokatTurkey Department of Histology and Embryology Faculty of MedicineGaziosmanpasa UniversityTokatTurkey

Objective:To evaluate the effect of free and liposome form of gallic acid on bone regeneration in critical defects in Wistar ***:Thirty-two female Wistar rats were divided into four study groups:group 1,negative control;group 2,positive control;group 3,gallic acid powder;group 4,gallic acid liposome.A critical-sized defect was created in all *** 2 to 4 had xenograft,autograft and membrane placement while negative control rats did not receive any *** defect area was sutured and rats were kept alive for 30 *** the end of the study,a bone specimen including the defect area was removed from *** specimens were evaluated under the stereomicroscope,then underwent histological *** cell counts,osteoblast,osteoclast counts,receptor activator of nuclear factorκ-B(RANKL),osteoprotegerin(OPG),runt-related transcription factor 2(Runx2),bone morphogenetic protein-2(BMP-2),and alkaline phosphatase were ***:The biggest unhealed defect area was observed in the negative control group and the smallest was observed in the gallic acid liposome *** were no differences between the positive control group *** gallic acid powder group and the gallic acid powder group *** gallic acid liposome *** severity of inflammation was the highest in the negative control group and the lowest in the gallic acid liposome group with significant differences between the *** groups had similar osteoblast counts while osteoclast counts were the highest in the positive control *** acid groups had a lower number of osteoclasts compared with the positive control ***2 and alkaline phosphatase levels were similar in the groups while OPG and BMP-2 levels exhibited a significant increase compared with the negative control group and the positive control *** was similar in the negative control group,the positive control group,and the gallic acid powder groups but decreased in the gallic acid liposome

关键词： Anti-inflammatory Antioxidants Bone regeneration Gallic acid

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