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Strategies for regeneration of components of nervous system: scaffolds, cells and biomolecules

Regenerative Biomaterials 2015年第1期2卷 31-45页

作者： Lingling Tian Molamma P.Prabhakaran seeram ramakrishna Mechanical Engineering Faculty of EngineeringNational University of Singapore2 Engineering Drive 3Singapore 117576 Nanoscience and Nanotechnology Initiative National University of Singapore2 Engineering Drive 3Singapore 117576

Nerve diseases including acute injury such as peripheral nerve injury(PNI),spinal cord injury(SCI)and traumatic brain injury(TBI),and chronic disease like neurodegeneration disease can cause various function disorders of nervous system,such as those relating to memory and voluntary *** nerve diseases produce great burden for individual families and the society,for which a lot of efforts have been *** pathways represent a unidirectional and aligned architecture allowing systematic axonal development within the *** a traumatic injury,the intricate architecture suffers disruption leading to inhibition of growth and loss of *** to limited capacity of the body to regenerate axonal pathways,it is desirable to have biomimetic approach that has the capacity to graft a bridge across the lesion while providing optimal mechanical and biochemical cues for tissue *** for central nervous system injury,one more extra precondition is compulsory:creating a less inhibitory surrounding for axonal *** is a cost-effective and straightforward technique to fabricate extracellular matrix(ECM)-like nanofibrous structures,with various fibrous forms such as random fibers,aligned fibers,3D fibrous scaffold and core-shell fibers from a variety of *** diversity and versatility of electrospinning technique,together with functionalizing cues such as neurotrophins,ECM-based proteins and conductive polymers,have gained considerable success for the nerve tissue *** are convinced that in the future the stem cell therapy with the support of functionalized electrospun nerve scaffolds could be a promising therapy to cure nerve diseases.

关键词： electrospinning nerve tissue engineering nanofibers functionalized scaffolds

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Recent advances in MXenes-based glucose biosensors

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Chinese Chemical Letters 2023年第10期34卷 2-11页

作者： Shunyao Tian Meng Wang Paolo Fornasiero Xiaoyu Yang seeram ramakrishna Shih-Hsin Ho Fanghua Li State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China Department of Chemical and Pharmaceutical Sciences University of TriesteVia L.Giorgieri 1Trieste 34127Italy Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali(INSTM) Unit of Triestevia L.Giorgieri 1Trieste 34127Italy School of Chemical and Environmental Engineering China University of Mining and TechnologyBeijing 100083China Center for Nanotechnology and Sustainability Department of Mechanical EngineeringNational University of SingaporeSingapore 119077Singapore

It is established that monitoring blood glucose on a daily basis is one of the most effective solutions to prevent and treat ***,developing a glucose sensing platform with outstanding sensing performance occupies an indispensable position for the early diagnosis and risk assessment of ***,biosensor has been deemed as a promising apparatus to acquire the signals for glucose monitoring based on 2D ***,it is unsatisfied to deploy some materials widely as a result of some inherent *** nanotubes have comparatively high ***_(2) with unfavourable biocompatibility are still arduously implemented on being ***,MXene,a brand-new and rapidly developing two-dimensional material,exhibits marvellous application potential in the domain of ***,it has exerted tremendous attention from diverse scientific fields owning to its remarkable properties,such as excellent hydrophilicity,metal-like conductivity,abundant surface functional groups,unique layered structure,large specific surface area and remarkable *** review mainly focuses on the main synthetic route of MXenes,as well as the recent advancements of biosensors involving MXenes as an electrode modifier for glucose *** addition,the promising prospects and challenges of glucose sensing technology based on MXenes are also discussed.

关键词： MXenes Biosensor Mechanism Blood glucose Glucose detection

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Mineralized Composite Nanofibrous Mats for Bone Tissue Engineering

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Journal of Donghua University(English Edition) 2013年第5期30卷 359-361页

作者：刘威詹建朝吴桐苏艳莫秀梅廖素三 ramakrishna seeram State Key Laboratory for Modifications of Chemical Fiber and Polymer Materials College of Material Science and EngineeringDonghua University Biomaterials and Tissue Engineering Laboratory College of ChemistryChemical Engineering and BiotechnologyDonghua University College of Materials and Textile Engineering Jiaxing University School of Materials Science and Engineering Nanyang Technological University Department of Mechanical Engineering National University of Singapore

Composite nanofibrous mats consisting of poly( L-lactideco-ε-caprolactone)( PLCL) and collagen type I( COL) were fabricated by electrospinning,and ten times simulated body fluid(10SBF) were employed to mineralize nanofibrous mats. Ballshaped hydroxyapatite( HA) was deposited on the surface of nanofibrous mats in 1. 5 h at room temperature. Human fetal osteoblasts( hFob) were seeded to investigate their proliferation and differentiation on mineralized composite nanofibrous mats. The results showed that hFob grew well on mineralized composite nanofibrous mats and alkaline phosphatase( ALP) activity of hFob on mineralized composite nanofibrous mats at 14 d was much higher than that on untreated nanofibrous mats. Moreover,the expression of osteocalcin of cells on mineralized composite nanofibrous mats was also much higher than those on untreated nanofibrous mats at 7 d and 14 d. This mineralized composite nanofibrous mats may have a great potential for bone tissue engineering.

关键词： electrospnning nanofibrous mat mineralization bone tissue engineering

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Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration

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Regenerative Biomaterials 2017年第1期4卷 21-30页

作者： Xiaoli Wu Liumin He Wen Li Heng Li Wai-Man Wong seeram ramakrishna Wutian Wu Department of Anatomy School of Biomedical ScienceLKS Faculty of MedicineThe University of Hong Kong21 Sassoon RoadHong Kong SARChina State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam21 Sassoon RoadHong Kong SARChina Joint Laboratory of Jinan University and the University of Hong Kong GHM Institute of CNS RegenerationJinan University601 Huangpu Avenue WestGuangzhou510632China Department of Mechanical Engineering Faculty of EngineeringCenter for Nanofibers and NanotechnologyNational University of Singapore117576SingaporeSingapore.

Peripheral nerves are fragile and easily damaged,usually resulting in nervous tissue loss,motor and sensory function *** in neuroscience and engineering have been significantly contributing to bridge the damage nerve and create permissive environment for axonal regrowth across *** have successfully designed two self-assembling peptides by modifying RADA 16-I with two functional motifs IKVAV and *** hydrogel formed when combing the two neutral solutions together,defined as RADA 16-Mix that overcomes the main drawback of RADA16-I associated with low *** the present study,we transplanted the RADA 16-Mix hydrogel into the transected rat sciatic nerve gap and effect on axonal regeneration was examined and compared with the traditional RADA16-I *** regenerated nerves were found to grow along the walls of the large cavities formed in the graft of RADA16-I hydrogel,while the nerves grew into the RADA 16-Mix hydrogel toward distal *** 16-Mix hydrogel induced more axons regeneration and Schwann cells immigration than RADA16-I hydrogel,resulting in better functional recovery as determined by the gait-stance duration percentage and the formation of new neuromuscular junction ***,our results indicated that the functional SAP RADA16-Mix nanofibrous hydrogel provided a better environment for peripheral nerve regeneration than RADA16-I hydrogel and could be potentially used in peripheral nerve injury repair.

关键词： Peripheral nerve regeneration self-assembling peptide IKVAV RGD nanofibrous hydrogel

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功能化纤维素:PET纤维沸石分子筛复合材料对神经毒剂的解毒性研究(英文)

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无机材料学报 2012年第3期27卷 332-336页

作者： Agarwal Satya R Sundarrajan Subramanian ramakrishna seeram Department of Mechanical Engineering Engineering Drive National University of Singapore King Saud University Institute of Materials Research and Engineering National University of Singapore Singapore 117602 Singapore

Presently activated carbon is used as an adsorptive material for chemical and biological warfare agents. It possess excellent surface properties such as large surface area, fire-resistance and plenty availability, but has disadvantages such as its heavy weight, low breathability (after adsorption of moisture) and disposal. In this paper, we propose to utilize novel electrospun polymeric nanostructures having zeolites as catalyst materials. In this respective, the electrospun polymer nanofibers would serve as the best possible substitutes to activated carbon based protective clothing applications. This is the first in the literature that reports the integration of these types of catalysts with nanofiberous membranes. Electrospinning of cellulose/polyethylene terephthalate (PET) blend nanofibers has been carried out. Zeolite catalysts (Linde Type A and Mordenite) for the detoxification of nerve agent stimulant-paraoxon, were prepared due to their relative simplicity of synthesis. The catalysts were then coated onto nanofiber membranes and their morphology was confirmed using SEM. This is the first report on the coating of nanofibers with zeolites and their successful demonstration against nerve agent stimulant. The UV absorption spectra clearly show the detoxification ability of the functionalized fibers and their potential to be used in textiles for protection and decontamination.

关键词：摘要编辑部编辑工作 PET

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Revealing the oxidation growth mechanism and crack evolution law of novel Si-HfO_(2)/Yb_(2)Si_(2)O_(7)/Yb_(2)SiO_(5)environmental barrier coatings during thermal cycling

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Journal of Advanced Ceramics 2024年第10期13卷 1677-1696页

作者： Ruixiang Liu Wenping Liang Qiang Miao Hui Zhao Xiaofeng Zhang Meng Zhang Rongxue Yan Brindha Ramasubramanian seeram ramakrishna College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Mechanical Engineering National University of SingaporeSingapore 117575Singapore National Engineering Laboratory for Modern Materials Surface Engineering Technology Institute of New MaterialsGuangdong Academy of SciencesGuangzhou 510651China

The development of Si-HfO_(2)/Yb_(2)Si_(2)O_(7)/Yb_(2)SiO_(5)environmental barrier coatings(EBCs)aims to improve the operational temperature and longevity of ceramic matrix composites(CMCs)in turbine ***,several critical questions remain unanswered,including the oxidation mechanism of Si-HfO_(2)bond coating,the compatibility of its mixed thermally grown oxide(m-TGO)with adjacent layers during thermal cycling,and the evolution pattern of vertical mud-cracks that impact the overall performance in *** plasma spraying physical vapor deposition(PS-PVD),we fabricated these EBCs on a CMC substrate,and thermal cycling tests at 1400,1450,and 1500℃ revealed that their durability reached 200 h.m-TGO growth followed a parabolic model,with the oxygen diffusion activation energy being 133.69 kJ/mol between 1400 and 1450℃ and 101.47 kJ/mol from 1450 to 1500℃,emphasizing that the transport of molecular oxygen is key to controlling the oxidation of m-TGO in this EBC *** residual stresses and stored elastic strain energy build up between m-TGO and adjacent layers,especially around the cristobalite phase transition temperature,causing interlaminar crack formation in later thermal cycles,the stored elastic strain energy remains lower than that of the silicon oxide-thermally grown oxide(SiO_(2)-TGO)formed in Si bond coating *** addition to[110]dislocations,(001)twinning and interaction zones between twinning and dislocations were discovered for the first time,driving the bifurcation of mud ***,controlling the mud-crack density is vital for protection of Yb_(2)SiO_(5)layer,as bifurcated mud-crack tips may converge with adjacent mud-cracks.

关键词： environmental barrier coatings(EBCs) thermal cycling oxidation crack propagation defects

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Improved functionality of cinnamon oil emulsion-based gelatin films as potential edible packaging film for wax apple

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Food Bioscience 2022年第3期47卷 572-582页

作者： Keisheni Ganeson M.R.Razifah A.Mubarak Amin Kam Sevakumaran Vigneswari seeram ramakrishna Faculty of Science and Marine Environment Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Faculty of Fisheries and Food Science University Malaysia Terengganu21030Kuala NerusTerengganuMalaysia Center for Nanotechnology and Sustainability National University of Singapore119260 Singapore

This study discusses on the tailoring of cinnamon oil emulsion-based gelatin edible films that can encapsulate,protect and release bioactive compounds in food packaging *** effect of this cinnamon oil film for shelf-life extension and storage stabilities of wax apples(Syzygium samarangense L.)was evaluated over 12-day storage at refrigerated temperature(5℃).Emulsion of cinnamon oil and surfactant at different ratios of 70:30(ME1),60:40(ME2)and 50:50(ME3)was incorporated into the films and the interactions between the emulsion and polymeric structure in films were analysed through physical,morphological and functional *** cinnamon oil emulsion-based gelatin films with a ratio of 70:30 exhibited significant increase in mechanical,water barrier,antioxidant activity and thermal *** increase in antioxidant activity of cinnamon oil films revealed that encapsulation of cinnamon oil in gelatin matrix better retains the bioactive compounds for food packaging *** oil emulsion-based films significantly lowered the weight loss of wax apples(12.43%)compared to the control(unwrapped)wax apples(26.40%).Interestingly,this research indicates that encapsulation of bioactive compounds is governed by the ratio of oil to surfactant mixture in *** was proved that the film microemulsion with the 70:30 ratio of oil to surfactant(FME 70)have better overall performances as compared to the control(gelatin films)due to hydrogen and hydrophobic interactions with protein network of *** conclusion,cinnamon oil emulsion-based films could enhance and modify the functionality of protein-based films creating a biodegradable,sustainable and cost-effective food packaging materials.

关键词： Essential oil Emulsion Bioactive compounds Active films Packaging material

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Preparation of PSFO and LPSFO nanofibers by electrospinning and their electronic transport and magnetic properties

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Chinese Physics B 2022年第5期31卷 629-635页

作者： Ying Su Dong-Yang Zhu Ting-Ting Zhang Yu-Rui Zhang Wen-Peng Han Jun Zhang seeram ramakrishna Yun-Ze Long Collaborative Innovation Center for Nanomaterials&Devices College of PhysicsQingdao UniversityQingdao 266071China Center for Nanofibers&Nanotechnology Department of Mechanical EngineeringNational University of SingaporeSingapore 117574Singapore Collaborative Innovation Center for Eco-Textiles of Shandong Province and State Key Laboratory of Bio-Fibers and Eco-TextilesQingdao UniversityQingdao 266071China

Pr_(0.5)Sr_(0.5)FeO_(3)(PSFO)and La_(0.25)Pr_(0.25)Sr_(0.5)FeO_(3)(LPSFO)nanofibers are prepared by electrospinning followed by calcination,and their morphologies,microstructures,electronic transports,and magnetic properties are studied *** temperature-dependent resistance curves of PSFO and LPSFO nanofibers are measured in a temperature range from 300 K to 10 *** the temperature lowering,the resistance increases gradually and then decreases sharply due to the occurrence of ferromagnetic metal *** metal-insulator transition temperatures are about 110 K and 180 K for PSFO and LPSFO nanofibers,*** electronic conduction behavior above the transition temperature can be described by one-dimensional Mott’s variable-range hopping(VRH)*** hysteresis loops and the field-cooled(FC)and zero-field-cooled(ZFC)curves show that both PSFO nanofiber and LPSFO nanofiber exhibit *** the doping of La reduces the overall magnetization intensity of the material,it increases the ferromagnetic ratio of the system,which may improve the performance of LPSFO in solid oxide fuel cell.

关键词： Pr_(0.5)Sr_(0.5)FeO_(3) La_(0.25)Pr_(0.25)Sr_(0.5)FeO_(3) electrospinning electronic transport magnetic properties

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Nanocomposites for electronic applications that can be embedded for textiles and wearables

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Science China(Technological Sciences) 2019年第6期62卷 895-902页

作者： SERRANO-GARCIA William JAYATHILAKA Wanasinghe Arachchige Dumith Madushanka CHINNAPPAN Amutha TRAN Thang Quyet BASKAR Chinnappan THOMAS Sylvia Wilson ramakrishna seeram Department of Electrical Engineering University of South Florida Tampa 33620 USA Department of Mechanical Engineering National University of Singapore Singapore 119077 Singapore THDC Institute of Hydropower Engineering and Technology Tehri Uttarakhand Technical University Dehradun 249001 India

In the present review, we have selected advances in electrospinning nanofibers that we envision to be embedded in textiles and wearables. These nanofibers have been proven to be excellent options for applications such as power generation, sensing, and communication. Their similitude with already known woven meshes makes these fibers perfect for electronically active *** fibers offer well known characteristics such as mechanical flexibility, high surface area-to-volume ratio, light weight and can be tuned by carefully selecting the active materials in the precursor solution. Here we will discuss polymers with electroactive, piezoelectric, triboelectric and their composites that have been used in fiber structures by using the electrospinning technique.

关键词： nanofibers electrospinning electronic textiles electroactive materials

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Strong, lightweight, and highly conductive CNT/Au/Cu wires from sputtering and electroplating methods

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Journal of Materials Science & Technology 2020年第5期40卷 99-106页

作者： Thang Q.Tran Jeremy Kong Yoong Lee Amutha Chinnappan W.A.D.M.Jayathilaka Dongxiao Ji Vishnu Vijay Kumar seeram ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore

In this study, we present a 2-step deposition method via sputtering and electroplating that uses carbon nanotube(CNT) wires synthesized from a wet-spinning technique to produce high-performance CNT/Au/Cu composite wires. After the Au sputtering pre-treatment, the deposition of Cu on the CNT wires was found to be much more homogeneous due to improved wettability and reactivity of the wire surface. At different electrodeposition time, the mechanical strength of the CNT/Au/Cu composite wires could be as high as 0.74 GPa(~2 times stronger than metal wires) while their electrical conductivity could reach 4.65 × 10~5 S/cm(~80% of that for copper). More importantly, the CNT/Au/Cu composite wires with high CNT volume fraction are expected to be lightweight(up to 42% lower than Cu mass density), suggesting that our high-performance composite wires are a promising candidate to substitute conventional heavy metal wires in the future applications.

关键词： Carbon nanotube wires Sputtering Electrical conductivity Electrodeposition

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