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On investigating the soda-lime shot blasting of AZ31 alloy:Effects on surface roughness,material removal rate,corrosion resistance,and bioactivity

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Journal of Magnesium and Alloys 2021年第4期9卷 1278-1290页

作者： Gurmider Singh Sunpreet Singh Chander Prakash seeram ramakrishna SIMAP University of Grenoble AlpesFrance Department of Mechanical Engineering National University of SingaporeSingapore School of Mechanical Engineering Lovely Professional UniversityPhagwaraPunjab 144411India

In the present study,a novel method of surface finish improvement is proposed using shot blasting of soda lime(SBSL)beads on the Mg-AZ31 *** effect of the soda blasting process parameters,such as blast pressure,stand-off distance,and blast duration,have been studied in-response of material removal rate(MRR)and surface roughness(SR)and corresponding statistical models have been *** multi-objective optimization has also been performed to obtain parameters for maximum MRR and minimum *** corrosion behavior of the treated specimens has been performed to study their in-vitro biodegradability in simulated body fluid(SBF)for 1,3,7,10,15,and 21 *** wettability study of the SBSL treated samples has been investigated using sessile drop ***,cell adhesion test has also been performed to study the biocompatibility characteristics of the SBSL treated samples using Huh7 liver cell *** on obtained quantitative data as well as scanning electron microscopy analysis of treated samples,the SBSL treatment of the AZ31 alloy has been found highly useful in producing biocompatibility surfaces along with desirable morphological features.

关键词： AZ31 Soda-lime Surface roughness Material removal rate Corrosion Wettability Biocompatibility

A framework for the sustainability implications of 3D bioprinting through nature-inspired materials and structures

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Bio-Design and Manufacturing 2022年第2期5卷 412-423页

作者： Ruban Whenish seeram ramakrishna Amit Kumar Jaiswal Geetha Manivasagam Center for Biomaterials Cellular and Molecular TheranosticsVellore Institute of TechnologyVelloreTamilnadu 632014India Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1119260Singapore

Introduction The climax of the industrial revolution was marked by the rapid growth of industry,and advancement in technologies have further fueled this industrial expansion,leading to a surge in economic *** technolo... 详细信息

关键词： printing advancement revolution

Prospects for 3D bioprinting of organoids

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Bio-Design and Manufacturing 2021年第3期4卷 627-640页

作者： Preety Rawal Dinesh M.Tripathi seeram ramakrishna Savneet Kaur Department of Molecular and Cellular Medicine Institute of Liver and Biliary Sciences(ILBS)D1Vasant KunjNew Delhi 110070India School of Biotechnology Gautam Buddha UniversityGreater NoidaIndia Department of Mechanical Engineering National University of SingaporeSingaporeSingapore

Three-dimensional(3D)organoids derived from pluripotent or adult tissue stem cells seem to possess excellent potential for studying development and disease mechanisms alongside having a myriad of applications in regenerative ***,lack of precise architectures and large-scale tissue sizes are some of the key limitations of current organoid technologies.3D bioprinting of organoids has recently emerged to address some of these *** this review,we discuss 3D bioprinting with respect to the use of bioinks and bioprinting methods and highlight recent studies that have shown success in bioprinting of stem cells and *** also summarize the use of several vascularization strategies for the bioprinted organoids,that are critical for a complex tissue *** fully realize the translational applications of organoids in disease modeling and regenerative medicine,these areas in 3D bioprinting need to be appropriately harnessed and channelized.

关键词： Three-dimensional bioprinting Bioink Organoid Microfluidics Extracellular matrix(ECM) Biomaterial

Nanobiomaterials for neural regeneration

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Neural Regeneration Research 2016年第9期11卷 1372-1374页

作者： Nuan Chen Lingling Tian Liumin He seeram ramakrishna Center for Nanofibers and Nanotechnology Department of Mechanical Engineering Faculty of Engineering National University of Singapore Singapore Singapore Department of Biomedical Engineering College of Life Science and Technology Jinan University Guangzhou Guangdong Province China Guangdong-Hongkong-Macao Institute of CNS Regeneration (GHMICR) Jinan University Guangzhou Guangdong Province China

Diseases and disorders associated with nervous system such as injuries by trauma and neurodegeneration are shown to be one of the most serious problems in medicine, requiring innovative strategies to trigger and enhance the nerve regeneration. Tissue engineering aims to provide a highly biomimetic environment by using a combination of cells, materials and suitable biological cues, by which the lost body part may be regenerated or even fully rebuilt. Electrospinning, being able to produce extracellular matrix （ECM）-like nanostructures with great flexibility in design and choice of materials, have demonstrated their great po- tential for fabrication of nerve tissue engineered scaffolds. The review here begins with a brief description of the anatomy of native nervous system, which provides basic knowledge and ideas for the design of nerve tissue scaffolds, followed by five main parts in the design of electrospun nerve tissue engineered scaffolds including materials selection, structural design, in vitro bioreactor, functionalization and cellular support. Performances of biomimetic electrospun nanofibrous nerve implant devices are also reviewed. Finally, future directions for advanced electrospun nerve tissue engineered scaffolds are discussed.

关键词： nerve regeneration tissue engineering contact guidance electrospun scaffold nanostructuredmaterials nanofibers

Advancing green energy solution with the impetus of COVID-19 pandemic

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Journal of Energy Chemistry 2021年第8期30卷 688-705,I0014页

作者： Mohamedazeem M.Mohideen seeram ramakrishna Sivaprasath Prabu Yong Liu Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical Technology100029 BeijingChina Center for Nanofibers and Nanotechnology National University of Singapore1157 SingaporeSingapore Institute of Plant Protection Chinese Academy of Agricultural Sciences100193 BeijingChina

The global energy system needs a revolutionary transition from today’s fossil fuel to a low carbon energy system by having deep carbonization in all energy demand *** in the transport sector,fossil fuel-based vehicles contribute to a more massive amount of greenhouse gas emissions(GHG),mainly carbon dioxide(CO_(2))and particulate matter(PM2.5),affecting human health,society,and the climate *** and fuel cell technology is a promising low carbon transition pathway that supports GHG mitigation and achieves sustainable *** hydrogen and fuel cells are assuring,fuel cell vehicle expensiveness and the high cost of hydrogen production with the low carbon footprint are significant hindrances for its widespread *** the situation above,the present corona virus(COVID-19)has devastated our global economy and ramps down the future of fossil *** provides opportunities to rethink and reshape our energy system to a low carbon *** utilizing the situation,governments and policymakers need to eliminate fossil fuel and invest in the hydrogen and fuel cell technologies deployment as future energy *** review article provides a technical overview of a low carbon energy system,production,and end-use service in a hydrogen economy perspective for developing a sustainable energy *** techno-economic analysis of the different hydrogen production routines and fuel cell vehicles and their infrastructures are primarily ***,a long-term policy alignment was outlined to advance the hydrogen energy system for post-COVID-19 in the United Nation’s(UN)sustainable development goals framework.

关键词： Hydrogen economy Low carbon energy system Fuel cell vehicles Renewable energy Sustainable development goals

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

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Bio-Design and Manufacturing 2022年第2期5卷 371-395页

作者： Masoud Sarraf Erfan Rezvani Ghomi Saeid Alipour seeram ramakrishna Nazatul Liana Sukiman Centre of Advanced Materials Department of Mechanical EngineeringFaculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia Department of Materials Science and Engineering Sharif University of TechnologyAzadi Ave.P.O.Box 11365‑9466TehranIran Center for Nanotechnology and Sustainability Department of Mechanical EngineeringNational University of SingaporeSingapore 117581Singapore

Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950 *** to the excellent mechanical tribological properties,corrosion resistance,biocompatibility,and antibacterial properties of titanium,it is getting much attention as a biomaterial for ***,titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant *** properties are crucial for producing high-strength metallic alloys for biomedical *** alloys are manufactured into the three types ofα,β,andα+β.The scientific and clinical understanding of titanium and its potential applications,especially in the biomedical field,are still in the early *** review aims to establish a credible platform for the current and future roles of titanium in *** first explore the developmental history of ***,we review the recent advancement of the utility of titanium in diverse biomedical areas,its functional properties,mechanisms of biocompatibility,host tissue responses,and various relevant antimicrobial *** research will be directed toward advanced manufacturing technologies,such as powder-based additive manufacturing,electron beam melting and laser melting deposition,as well as analyzing the effects of alloying elements on the biocompatibility,corrosion resistance,and mechanical properties of ***,the role of titania nanotubes in regenerative medicine and nanomedicine applications,such as localized drug delivery system,immunomodulatory agents,antibacterial agents,and hemocompatibility,is investigated,and the paper concludes with the future outlook of titanium alloys as biomaterials.

关键词： Titanium and titanium alloys Biomedical application Functional properties Biocompatibility Antibacterial activity Advanced manufacturing

Electrospun Nanofibers-Based Face Masks

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Advanced Fiber Materials 2020年第3期2卷 161-166页

作者： Mike Tebyetekerwa Zhen Xu Shengyuan Yang seeram ramakrishna Research School of Electrical Energy and Materials EngineeringCollege of Engineering and Computer ScienceThe Australian National UniversityCanberraACT 2601Australia Department of Chemical Engineering Imperial College LondonLondon SW72AZUK State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai“Belt&Road”International Joint Laboratory for Advanced Fiber and Low‑Dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China Centre for Nanofibers and Nanotechnology National University of SingaporeSingapore 117581Singapore

Textiles have proved to be very important materials to human beings since the time ***,fibers are the basic building units of these *** this perspective we substantiate the uniqueness and capability of nanofibers as active layers in face masks,to protect people against the novel coronavirus disease(COVID-19).This time-sensitive letter introduces the mechanisms based on which their active filters function,the uniqueness of electrospun nanofibers in face masks and do-it-yourself(DIY)steps to realize a fully functional face mask at home.

关键词： Electrospinning Nanofibers Face masks COVID-19 Textiles

Metal Organic Framework Derived Zirconia-Carbon Nanoporous Mat for Integrated Strain Sensor Powered by Solid‑State Supercapacitor

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Advanced Fiber Materials 2023年第4期5卷 1404-1416页

作者： Brindha Ramasubramanian Vundrala Sumedha Reddy Ye Zhen seeram ramakrishna Vijila Chellappan Department of Mechanical Engineering Center for Nanofibers and NanotechnologyNational University of SingaporeSingapore 117574Singapore Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)#08‑032 Fusionopolis WayInnovisSingapore 138634Singapore

Flexible electronics are essential for the rapid development of human-machine interface technology,encompassing sensors and energy storage ***-state supercapacitors with 1D nanofiber electrodes are critical for enhancing ion *** this study,a flexible supercapacitor integrated with a strain sensor was designed using a polyvinyl alcohol/polymethyl methacrylate(PVA/PMMA)-based electrolyte and a metal-organic framework(MOF)-derived Zr-nanoporous carbon mat(Zr-NPC).The sensor showed remarkable sensitivity over a broad strain range,enabling reliable and precise detection of mechanical *** supercapacitor with Zr-NPC@PVDF electrode also demonstrated a specific capacitance of 286 mF cm^(-2) at 0.5 mA cm^(-2),maintaining high flexibility and mechanical *** fabricated supercapacitor maintained around 81%charge retention after 10,000 ***,the self-powered integrated model was directly connected to the human body to detect physical motion,accentuating its potential for widespread applications in wearable technology.

关键词： Supercapacitor Piezoresistive sensor Porosity Nanocarbon

Recent insights on iron based nanostructured electrocatalyst and current status of proton exchange membrane fuel cell for sustainable transport

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Journal of Energy Chemistry 2022年第6期31卷 466-489,I0013页

作者： Mohamedazeem M.Mohideen Adiyodi Veettil Radhamani seeram ramakrishna Yen Wei Yong Liu Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Department of Physics and Nanotechnology SRM Institute of Science and TechnologyKattankulathur 603203India Center for Nanofibers and Nanotechnology National University of SingaporeSingapore 1157Singapore Department of Chemistry Key Lab of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China

Bridging the performance gap of the electrocatalyst between the rotating disk electrode(RDE) and membrane electrode assembly(MEA) level testing is the key to reducing the total cost of proton exchange membrane fuel cell(PEMFC) vehicles. Presently, platinum metal accounts for ~42% of the total cost of the PEMFC vehicles for usage in the cathode catalyst layer, where the sluggish oxygen reduction reaction(ORR) occurs. An alternative to the platinum catalyst, the Fe-N-C catalyst has attracted considerable interest for PEMFC due to its cost-effectiveness and high catalytic activity towards ORR. However, the excellent ORR activity of Fe-N-C obtained from RDE studies rarely translates the same performance into MEA operating conditions. Such a performance gap is mainly attributed to the lack of atomic-level understanding of Fe-N-C active sites and their ORR mechanism. Besides, unless the cost of expensive electrocatalyst is reduced, the total operation cost of the PEMFC vehicles remains constant. Therefore,developing highly efficient Fe-N-C catalysts from academic and industrial perspectives is critical for commercializing PEMFC vehicles. Here, the scope of the review is three-fold. First, we discussed the atomiclevel insights of Fe-N-C active sites and ORR mechanism, followed by unraveling the different iron-based nanostructured ORR electrocatalysts, including oxide, carbide, nitride, phosphide, sulfide, and singleatom catalysts. And then we bridged their ORR catalytic performance gap between the RDE and MEA tests for real operating conditions of PEMFC vehicles. Second, we focused on bridging the cost barriers of PEMFC vehicles between capital, operation, and end-user. Finally, we provided the path to achieve sustainable development goals by commercializing PEMFC vehicles for a better world.

关键词： Proton exchange membrane fuel cell(PEMFC) Active sites Iron-based nanostructure Sustainable development goals