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Controls on Gosaikunda Lake Chemistry within Langtang National Park in High Himalaya, Nepal

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International Journal of Geosciences 2014年第10期5卷 1100-1115页

作者： Maya P. Bhatt seema Bhatt Birgit Gaye Institute for the Biogeochemistry and Marine Chemistry Klima Campus—University of Hamburg Hamburg Germany School of Environmental Science and Management Pokhara University Kathmandu Nepal

Surface water samples and lake bed sediments were collected and analyzed from Gosaikunda Lake within Langtang National Park (28°05'N, 85°25'E;4380 m a.s.l.) in the central Himalayan region of Nepal during fall 2011. The major cations and anions in equivalents were present in the following order: ?and , respectively. Sulfide oxidation coupled with carbonate dissolution and aluminosilicate dissolution appeared to be the dominant geochemical processes determining lake water dissolved ions. Sulfate concentration was much higher than the alkalinity which is in contrast to glacier meltwater within the same landscape. Alkalinity primarily as bicarbonate contributes 88.6% to the total dissolved inorganic carbon (DIC) followed by carbon dioxide (CO2) and carbonate (CO3) in surface water samples. Organic carbon contributes 0.3% to 5.4% to the sediments and the organic matter is predominantly of aquatic origin. The lake is under saturated with carbon dioxide and the average partial pressure of carbon dioxide (pCO2) appeared quite low (43.4 μatm). Overall, natural biogeochemical processes regulate the chemical species within the lake ecosystem. The lake is oligotrophic, however, nutrients and dissolved organic carbon (DOC) concentrations are enhanced at the near shore sites close to the tracking trail.

关键词： Gosaikunda High Himalaya Langtang Geochemical Processes Nutrients

Yucca:A medicinally significant genus with manifold therapeutic attributes

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Natural Products and Bioprospecting 2012年第6期2卷 231-234页

作者： seema PATEL Better Process Control School Department of Food Science and TechnologyUniversity of California DavisCaliforniaUnited States

The genus Yucca comprising of several species is dominant across the chaparrals,canyons and deserts of American South West and *** genus has long been a source of sustenance and drugs for the Native *** the wake of revived interest in drug discovery from plant sources,this genus has been investigated and startling nutritive and therapeutic capacities have come *** from the functional food potential,antioxidant,antiinflammation,antiarthritic,anticancer,antidiabetic,antimicrobial,and hypocholesterolaemic properties have also been *** saponins,resveratrol and yuccaols have been identified to be the active principles with myriad biological *** stimulate further research on this genus of multiple food and pharmaceutical uses,this updated review has been prepared with references extracted from MEDLINE database.

关键词： Yucca saponin antioxidant cytotoxicity antimicrobial

Diagnosis and management of laryngeal cleft: a single centre experience and a novel endoscopic technique

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World Journal of Otorhinolaryngology 2015年第4期5卷 105-109页

作者： seema Yalamachili Jagdeep Singh Virk Yogesh Bajaj Paediatric ENT Department Barts Children＇s and Royal London HospitalLondon E1 1BBUnited Kingdom

AIM： To examine the presentation, diagnosis and out-comes of patients with laryngeal ***： An 18 mo （from mid-2012 to 2013） pro-spective longitudinal study was performed at the Barts Children’s and Royal London Hospital, a tertiary referral centre. Chart review was performed for all patients including data extraction of demographics, outpatient clinic review documentation, speech therapy findings, medication list, operative findings alongside technique and follow up. A systematic review of contemporary English medical literature was also reviewed to compare series. The study was approved and registered by the hospital clinical governance and audit board. Biosta-tistician review was not ***： Twenty-two children aged 1 to 72 mo （mean age 23.5 mo） with a 7：4 male-female ratio. Twenty had Benjamin-Evans type 1 clefts and 2 had a type 2 cleft. All were symptomatic despite medical management including anti-reflux therapy. Patients presented with dyspnoea （81%）, feeding diffculty （63%）, stridor （54%） and recurrent pneumonia （36%）. Several patients had concomitant aerodigestive abnormalities including 7 with laryngomalacia, 4 subglottic stenosis, 2 subglottic webs and 1 tracheo-oesophageal fstula. To date, 18 patients have undergone endoscopic repair, all of whom have shown radiological and/or clinical signs of improvement. All endoscopic repairs were performed with the novel use of a Negus knot pusher, with Baby Benjamin rigid suspension, to more reliably and easily suture at ***： This is a significant single unit series demonstrating the strong association of laryngeal cleft with combined aerodigestive symptoms and other laryngeal abnormalities. Endoscopic management of type 1 and 2 laryngeal clefts is successful. We recommend the use of a Negus knot pusher to facilitate endoscopic repair.

关键词： Laryngeal cleft Endoscopic Pediatric Dyspnea Aspiration Stridor

DESIGN AND PERFORMANCE OF MICROSTRIP-TO-SLOTLINE TRANSITION

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DESIGN AND PERFORMANCE OF MICROSTRIP-TO-SLOTLINE TRANSITION

不同气候适应类型果蝇体色黑化可塑性的适应性变化(英文)

2002 3rd International Conference on Microwave and Millimeter Wave Technology

作者： A.K.Rastogi seema Hardikar Department of Physics Govt.M.V.M.Bhopal(M.P.) India-462008

This paper describes the work involved in designing a microstrip-to-slotline transition[1]&[2].Two of these transitions would be required in order to meet the specifications of obtaining a maximum insertion loss(S) of -0.5 dB with a minimum return loss of-20 dB throughout the 8-10 GHz range.A CAD package for the design of RF/microwave circuit have been used to analyze and optimize the transition *** transmission line circuit models were used to optimize the *** transition would be fabricated on 1.27 mm thick RT-Duroid 6010.2 substrate and the S-parameters would be measured using standard SMA connectors and a HP-8501A Network Analyzer.A spectral domain Galerkin’s method is used to compute the characteristic impedance of wide slotline on the substrate.

关键词： Microstrip Design optimization Microwave theory and techniques Insertion loss Design automation Packaging Radio frequency Microwave circuits Performance analysis Distributed parameter circuits

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昆虫学报 2011年第10期54卷 1155-1164页

作者： Ravi PARKASH seema RAMNIWAS Chanderkala LAMBHOD Babita KAJLA Department of Genetics Maharshi Dayanand University Rohtak 124001 India

变温昆虫果蝇 Drosophila 深受热选择( 即遗传效应) 或表型诱导效应( 即可塑性) 的影响。表型可塑性是不同生物进行适应的有效方法,但是它在不同的果蝇种中较少受到关注。我们分析了不同发育温度范围和地理分布的果蝇的黑化反应模式。... 详细信息

变温昆虫果蝇 Drosophila 深受热选择( 即遗传效应) 或表型诱导效应( 即可塑性) 的影响。表型可塑性是不同生物进行适应的有效方法,但是它在不同的果蝇种中较少受到关注。我们分析了不同发育温度范围和地理分布的果蝇的黑化反应模式。嗜凤梨果蝇 D. ananassae 和蒲桃果蝇 D. jambulina 对低温敏感,这些物种可在 18 ～32℃下饲育。相反,D. nepalensis 为耐冷且对热敏感的物种,可在 12 ～25℃下饲育。世界广为分布的黑腹果蝇 D. melanogaster 的温度范围宽( 13 ～31℃) ,该物种前 3 个腹节和后 3 个腹节的黑化反应模式未见明显差异。D. nepalensis 的全部 6 个腹节( 第 2 ～7 节) 均具有高度的可塑性。不过,黑腹果蝇 D. melanogaster 只有后 3 个腹节具有可塑性。相反,热带物种嗜凤梨果蝇 D. ananassae 的所有腹节均不具有可塑性。世界广为分布的黑腹果蝇,即使来自冷得多的气候环境,其体色也不加深,与 D. nepalensis 中观察到的体色接近。本研究的目的旨在认识引起体色的形态多样性的过程以及果蝇对不同地理区域的适应性。最后,将体色黑化与物种系统发育谱系的比较表明,在不同的演化谱系中不断发生遗传多态性或表型可塑性两种不同模式的适应。

关键词：果蝇表型气候适应体色黑化发育可塑性遗传多态性物种分布

Identification, occurrence, and validation of DRE and ABRE Cis-regulatory motifs in the promoter regions of genes of Arabidopsis thaliana

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Journal of Integrative Plant Biology 2014年第4期56卷 388-399页

作者： Sonal Mishra Aparna Shukla Swati Upadhyay Sanchita Pooja Sharma seema Singh Ujjal J.Phukan Abha Meena Feroz Khan Vineeta Tripathi Rakesh Kumar Shukla Ashok Shrama Biotechnology Division CSIR-Central Institute of Medicinal and Aromatic Plants A Laboratory Under Council of Scientific and Industrial Research Metabolic and Structural Biology Division CSIR-Central Institute of Medicinal and Aromatic Plants A Laboratory Under Council of Scientific and Industrial Research Botany Department CSIR-Central Drug Research Institute (CSIR-CDRI)

Plants posses a complex co-regulatory network which helps them to elicit a response under diverse adverse conditions. We used an in silico approach to identify the genes with both DRE and ABRE motifs in their promoter regions in Arabidopsis thaliana. Our results showed that Arabidopsis contains a set of 2,052 genes with ABRE and DRE motifs in their promoter regions. Approximately 72~o or more of the total predicted 2,052 genes had a gap distance of less than 40o bp between DRE and ABRE motifs. For positional orientation of the DRE and ABRE motifs, we found that the DR form （one in direct and the other one in reverse orientation） was more prevalent than other forms. These predicted 2,o52 genes include 155 transcription factors. Using microarray data from The Arabidopsis Information Resource （TAIR） database, we present 44 transcription factors out of 155 which are upregulated by more than twofold in response to osmotic stress and ABA treatment. Fifty-one transcripts from the one predicted above were validated using semiquantitative expression analysis to support the microarray data in TAIR. Taken together, we report a set of genes containing both DRE and ABRE motifs in their promoter regions in A. thaliana, which can be useful to understand the role of ABA under osmotic stress condition.

关键词： Abscisic acid abscisic acid-responsive elements dehydration-responsive element osmotic stress response

Mobile phones in the orthopedic operating room: Microbial colonization and antimicrobial resistance

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World Journal of Orthopedics 2020年第5期11卷 252-264页

作者： Nada Qaisar Qureshi Syed Hamza Mufarrih seema Irfan Rizwan Haroon Rashid Akbar Jaleel Zubairi Anum Sadruddin Israr Ahmed Shahryar Noordin Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Basic and Biomedical Sciences Aga Khan University HospitalKarachi 74800Pakistan Department of Pathology and Microbiology Aga Khan University HospitalKarachi 74800Pakistan Department of Orthopedic Surgery Aga Khan University HospitalKarachi 74800Pakistan Department of Orthopedic Surgery Combined Military HospitalRawalpindi 46000Pakistan

BACKGROUND Surgical site infections are a major cause of morbidity and mortality following orthopedic *** efforts to identify sources of contamination in the operating rooms have implicated mobile *** To investigate microbial colonization on the mobile phones of health care professionals in the orthopedic operating *** We conducted a cross-sectional study involving culture and sensitivity analysis of swabs taken from the mobile phones of orthopedic and anesthesia attendings,residents,technicians and nurses working in the orthopedic operating rooms over a period of two *** and cell phone related factors were recorded using a questionnaire and the factors associated with contamination were *** Ninety-three of 100 mobile phones were *** isolated were Coagulase-negative Staphylococcus(62%),Micrococcus(41%)and Bacillus(26%).The risk of contamination was increased with mobile covers and cracked screens and decreased by cell phone *** Mobile phones belonging to health care workers are frequently contaminated with pathogenic bacteria with the potential of transferring drug resistance to nosocomial *** investigating the relationship to surgical site infections need to be *** concept of"mobile hygiene"involving the change of mobile covers,replacement of cracked screens or even wiping the phone with an alcohol swab could yield the cost-effective balance that contaminated cell phones deserve until they are established as a direct cause of surgical site infections.

关键词： Mobile phones Contamination Surgical site infections Orthopedic surgeries Antimicrobial resistance

Chemopreventive Effects of Black Tea Polyphenols in Mouse Skin Model of Carcinogenesis

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Biomedical and Environmental Sciences 1998年第4期11卷 307-313页

作者： seema JAVED N. K. MEHROTRA AND YOGESHWER SHUKLA(Laboratory of Environmental Chrcinogenesis, Industrial Toxicology Research Centre, M. G. Marg, P. O. Box 80,Lucknow - 226001, India) Lab. of Environmental Carcinogenesis Indust. Toxicology Research Centre M. G. Marg P. O. Box 80 Lucknow - 226001 India

In the present investigations, the antitumorigenic effect of black tea polyphenols (BTP) in twcrstage mouse skin model of carcinogenesis was studied. The animals were initiated with a single 'subcarcinogenic' topical dose (52 μg/200 μl acetone ) of 7, 12-dimethylbenzanthracene (DMBA). To evaluate the anti-tumour initiating activity, BTP was topically applied twice a week for three weeks prior to DMBA application, followed by topical treatment with 12-o-tetradecanoyl phorbol-13-acetate (TPA) (5 μg/200 μl acetone, 2x/wk. ) as promoter. For evaluation of antitumor promoting activity, BTP was applied prior to each treatment of TPA. BTP application showed marked inhibitory effect as antitumour initiator as well as antitumour promoter in mouse skin medel of two-stage carcinogenesis. Since initiation involves genetic pathway and tumour promotion involves epigenetic pathway, it seems that BTP exerts its antitumorigenic effect by altering both genetic and epigenetic pathways

关键词： Chemopreventive Effects of Black Tea Polyphenols in Mouse Skin Model of Carcinogenesis

Polymorphism of Renalase Gene in Patients of Chronic Kidney Disease

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Open Journal of Nephrology 2012年第4期2卷 136-143页

作者： Ravinder Singh Ahlawat Swapan Gupta seema Kapoor Premashish Kar Department of Medicine Maulana Azad Medical College New Delhi India Department of Medicine Nephrology Division Maulana Azad Medical College New Delhi India Department of Pediatrics and Molecular Genetics Maulana Azad Medical College New Delhi India

Introduction: Chronic kidney disease (CKD) is an important public health problem. Early detection and treatment is a key factor for prevention of its complications. Hypertensive nephrosclerosis is a subtype of CKD which has a poor correlation between hypertension and development of nephropathy, implying role of genetic factors or epigenetic factors. The knowledge regarding genetic factors is limited. Renalase is a novel hormone with its gene on chromosome 10, which secretes flavin adenine dinucleotide dependent amine oxidase. Renalase metabolizes circulating catecholamines and modulates blood pressure and cardiac function. Recently, two single nucleotide polymorphisms of renalase gene rs2576178 GG and rs2296545 CC have been linked to essential hypertension. The SNPrs2296545 CC is also shown to be associated with cardiac hypertrophy, dysfunction and ischemia. The association of these two single nucleotide polymorphisms with hypertensive nephrosclerosis has not been investigated. Methods: We designed a case-control study to investigate whether the two known renalase gene polymorphisms rs2576178 and rs2296545 are associated with CKD particularly hypertensive nephrosclerosis. We genotyped these two polymorphisms in 287 subjects from North Indian population (106 CKD cases and 181 controls). Results: Comparison shows that subjects with hypertensive nephrosclerosis had higher frequencies of rs2296545 Callele than the healthy controls (0.63 versus 0.47, p 0.02). The odds ratio for rs2296545 CC genotype in hypertensive nephrosclerosis were 2.55 (95% CI, 1.03 to 6.42;p = 0.02) (CC versus GG) and 2.11(95% CI, 1.01 to 4.42;p = 0.03) (CC versus CG + GG) compared to controls. Conclusion: These findings may provide novel insight into the role of additional genomic regions as susceptibility gene in the pathophysiology of hypertensive nephrosclerosis. Further, to account for geoethnic variation, studies on heterogeneous populations involving a larger sample size are required. The co

关键词： Chronic Kidney Disease (CKD) Hypertension Hypertensive Nephrosclerosis Renalase Single Nucleotide Polymorphisms (SNP) End Stage Renal Disease (ESRD)