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Dramatic Changes of Chinese Angola Rabbit Industry from 2011 to 2015:Reasons,Challenges and Recommendations

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Asian Agricultural Research 2017年第2期9卷 16-18页

作者： Longling LI Brian seema Laping WU College of Economics and Management China Agricultural University

In recent years,the demand for rabbit fur in international markets has been declining,especially after the "fur hand-ripping" event at the end of 2013 in *** rabbit fur export of China almost stagnated,and prices dropped *** slowdown of world economic growth caused loss of most fur-skin *** paper studies changes of Chinese Angola rabbit industry from 2011 to 2015 by focusing on price and trade *** results show that there are two turning points of Chinese Angola rabbit industry,one is the end of 2013,and the other is the mid of *** Angola rabbit and rabbit fur face big challenges,finally some related recommendations are provided.

关键词： Angola rabbit Rabbit fur Fur market Rabbit fur export

Current and emerging trends in antimalarial drugs:a comprehensive review

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Drug Combination Therapy 2022年第4期4卷 8-24页

作者： seema Rohilla Ankur Rohilla Davinder Kumar Department of Pharmay Panipat Institute of Engineering and Technology(PIET)Smalkha 132102India Department of Pharmacology University Institute of Pharma SciencesChandigarh UniversityGharuan 140413India Department of Pharmaceutical Sciences Maharishi Dayanand UniversityRohtak 124001India

Malaria is a ubiquitous tropical disease which occurs by the bite of malaria parasite of genus Plasmodium *** procurement and treatment of malaria depend on the cost and emergence of drug resistance,chemical compositions of drug molecules,and different complications and toxic effects associated with *** antimalarials are classified as gametocidal,prophylaxis,blood schizonticides,tissue schizonticides and *** addition,new antimalarial drugs have been discussed in the present review that offers the advantage singly or in combination with other *** ridiculous vector control methods,appearance of drug-resistant parasites,and deficiency of effective vaccines against malaria are the main aspects responsible for the expansion of ***,the development of a new drug is the need of hour to conquer the clinical failures of traditional ***,the discovery and development of a new drug is a costly and lengthy process,hence different nanotechnological techniques may recommend hopeful approaches for the procurement of malaria amid minimum side *** of traditional anti-malarial drugs in nanoform offers an opportunity to improve their therapeutic efficacy,reduced side-effects by targeted delivery and improved patient's *** review article will critically highlight the different traditional,hybrid and new anti-malarial ***,different nanocarriers discovered for the site specific liberation of antimalarials to enhance the therapeutic efficiency of these drugs have been comprehensively discussed in this review.

关键词： malaria Plasmodium antimalarials nanocarriers

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口腔鞋钉血管瘤1例报告

中国口腔医学继续教育杂志 2009年第1期12卷 29-31页

作者： Metgud S. Rashmi Kale D. Alka Charantimath seema 陈淑杰（译）梁成（审）不详北京大学口腔医学院颔面外科北京海淀区中关村南大街22号100081

鞋钉血管瘤是一种罕见的良性血管肿瘤。好发于年轻人，单发、体积小、边界清楚．血管瘤样或表面色素沉着．扁平或外突生长，组织病理呈特征性的双相分化表现。病变常累及躯干和四肢．头颈部也可发生。目前发生于口腔的病例仅有3例个案... 详细信息

鞋钉血管瘤是一种罕见的良性血管肿瘤。好发于年轻人，单发、体积小、边界清楚．血管瘤样或表面色素沉着．扁平或外突生长，组织病理呈特征性的双相分化表现。病变常累及躯干和四肢．头颈部也可发生。目前发生于口腔的病例仅有3例个案报告。本文报道了一例发生在24岁年轻男性患者左下颌牙龈的鞋钉血管瘤。这一罕见病例的诊断应与下列几种疾病进行鉴别．包括网状血管内皮瘤、卡伯氏肉瘤斑块期、良性淋巴管内皮瘤和分化较好的血管肉瘤。

关键词：良性鞋钉血管瘤血管肿瘤

Allogeneic and autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide conditioning therapy for relapsed/refractory non-Hodgkin lymphoma

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Modern Chemotherapy 2013年第4期2卷 57-65页

作者： Neelima Vidula Andrew M. Evens Irene B. Helenowski Borko Jovanovic Jane N. Winter Jayesh Mehta seema Singhal Stephanie F. Williams Olga Frankfurt Jessica K. Altman Joanne Monreal Leo I. Gordon Department of Preventive Medicine Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology Northwestern University Chicago USA Division of Hematology-Oncology The University of Massachusetts Medical School Worcester USA Division of Hematology-Oncology University of California San Francisco USA

The optimal stem cell transplantation (SCT) conditioning therapy for relapsed/refractory non-Hodgkin lymphoma (NHL) is not clearly defined. In a retrospective analysis, we examined 25 patients with “high risk” relapsed/refractory NHL who received busulfan, cyclophosphamide, and etoposide (Bu/Cy/VP16) conditioning with autologous or allogeneic SCT. The majority of patients had aggressive histology and 52% had primary refractory NHL. Furthermore, 48% of patients had chemotherapy-resistant disease at the time of SCT. Fifty-six percent of patients underwent allogeneic SCT, while 44% had autologous SCT. The median engraftment time for neutrophils and platelets was 13.5 and 14 days, respectively. The 100-day treatment-related mortality (TRM) was 16%, while the 2-year non-relapse mortality (NRM) rate was also 16%. At a median follow-up of 15 months, the estimated 2-year disease-free survival (DFS) rate was 64% (95% confidence interval (CI): 36%-82%) and the estimated 2-year overall survival (OS) was 69% (95% CI: 40%-86%). Furthermore, the 2-year disease-specific survival (DSS) rate was 73% (95% CI: 40%-90%). Using Cox proportional hazard modeling, the International Prognostic Index at time of relapse predicted DFS and OS. Altogether, Bu/Cy/VP16 was associated with early TRM;however, late toxicities (including NRM) were uncommon resulting in relatively good survival rates in a high-risk relapsed/refractory NHL population.

关键词： Stem Cell Transplantation Busulfan Cyclophosphamide Etoposide Non-Hodgkin Lymphoma

含笑属植物所含化学成分与其生物活性的综述(英文)

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中西医结合学报 2012年第12期10卷 1336-1340页

作者： Dinesh Kumar Sunil Kumar seema Taprial Deepak Kashyap Ajay Kumar Om Prakash Institute of Pharmaceutical Sciences Kurukshetra University

属木兰科的含笑属植物大约有80多个种类,它们大都分布在南亚国家。这些植物被当地人用于治疗各种疾病,如发烧、绞痛、麻风病、眼疾、炎症以及解蝎子毒。从9种含笑属植物中分离出94种化合物,例如倍半萜烯、类固醇、黄酮类、阿扑啡类、苯... 详细信息

属木兰科的含笑属植物大约有80多个种类,它们大都分布在南亚国家。这些植物被当地人用于治疗各种疾病,如发烧、绞痛、麻风病、眼疾、炎症以及解蝎子毒。从9种含笑属植物中分离出94种化合物,例如倍半萜烯、类固醇、黄酮类、阿扑啡类、苯酚、酯类、生物碱和苯环型化合物等,它们具有抗菌、抗癌以及抗疟原虫活性。本文详细地论述了含笑属植物所含化学成分的生物及化学性能。

关键词：含笑属药理作用综述

Effect of pH on Antioxidant and Phytochemical Activities of Mulhatti Roots (Glycyrrhiza glabra L.)

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Journal of Agricultural Science and Technology(A) 2020年第5期10卷 276-282页

作者： Parvesh Devi Sushila Singh seema Sangwan Promila Dalal Monika Moond Department of Chemistry CCS Haryana Agricultural UniversityHisarHaryana 125004India Department of Microbiology CCS Haryana Agricultural UniversityHisarHaryana 125004India

Glycyrrhiza glabra *** the most widely used herb in the ancient history of Ayurvedic medicine,as a medicinal value as well as an aromatic herb,and it is commonly known as *** roots are useful for medically and are also a good source of phytoproducts and secondary metabolites present in Mulhatti roots are triterpenoid saponin,glycosides,glycyrrhizin,prenylated biaurone,licoaagrone,7-acetoxy-2-methylisoflavone,4-methylcoumarin,liqcoumarin,glycyrrhetinic acid,quercetin,liquiritigenin,isoliquiritigenin,*** study was carried out to study the evaluation of phenolic compounds,2,2-diphenyl-1-picrylhydrazyl(DPPH)free radical activity and general antioxidant capacity of water extracts of Mulhatti roots prepared at different pH values,namely 2,4,7 and *** have shown great differences in terms of *** of the phenolic compounds are at pH 7(19.25),followed by pH 9(17.25),pH 2(14.62)and pH 4(8.89 mg GAE/g),***,the flavonoid data also showed variations,the maximum has been present in pH 2(5.39),then pH 7(3.02),pH 9(1.79)and pH 4(1.40 mg CE/g),*** value for DPPH IC50 free radical scavenging activity was the lowest at pH 7(82.22),followed by pH 2(110.40),pH 4(111.99)and pH 9(146.24μg/mL)and IC50 reference standard(ascorbic acid)was 59.52μg/mL in distilled *** total capacity of the antioxidant was the highest at pH 2(9.93)followed by pH 4(5.54),pH 7(5.34)and pH 9(4.23 mg AAE/g).According to current research,pH 7 is the best for phytochemicals as well as antioxidants that catch harmful radicals.

关键词： Mulhatti(Glycyrrhiza glabra L.)phytochemicals secondary metabolites phenolics flavonoids DPPH free radical scavenging activity total antioxidant capacity

基于腐植酸生物高聚物膜有效去除亚甲基蓝和罗丹明B的研究

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腐植酸 2017年第6期 53-53页

作者： seema S.Shenvi Arun M.Isloor Ahmad F.Ismail 袁晓娜(译) 不详中国腐植酸工业协会

当前，关于一种固定有腐植酸的海藻酸钠／羟乙基纤维素聚丙烯复合膜去除阳离子染料的性能被广泛地研究。本试验研究了该膜对染料的吸附行为受吸附剂的质量、染料初始浓度、pH、时间、温度的影响，通过扫描电子显微镜、能量色散X射线光... 详细信息

当前，关于一种固定有腐植酸的海藻酸钠／羟乙基纤维素聚丙烯复合膜去除阳离子染料的性能被广泛地研究。本试验研究了该膜对染料的吸附行为受吸附剂的质量、染料初始浓度、pH、时间、温度的影响，通过扫描电子显微镜、能量色散X射线光谱仪、傅里叶变换红外光谱和原子力显微镜来研究膜的特征。

关键词：高聚物膜腐植酸罗丹明B 亚甲基蓝傅里叶变换红外光谱阳离子染料扫描电子显微镜生物

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera Krane Kai-Uwe Eckardt Markus P.Schneider Rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor Biology RWTH Aachen UniversityAachenGermany Institute of Medical Biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MBD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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登革热的免疫陷阱

环球科学 2019年第9期 38-47页

作者：希玛·优思敏玛德赫斯莉·慕克吉祝锦杰(翻译) 斯坦福大学《科学美国人》科学与社会板块不详

2015年年12月,菲律宾总统艾奎诺三世(Benigno Aquino Ⅲ)领导的政府与制药公司赛诺菲(Sanofi)达成了一桩协议,购买300万支Dengvaxia。这是全球首支通过审批的登革热疫苗。菲律宾政府计划为100万名9岁的学龄儿童接种疫苗,每人3支,让他们... 详细信息

2015年年12月,菲律宾总统艾奎诺三世(Benigno Aquino Ⅲ)领导的政府与制药公司赛诺菲(Sanofi)达成了一桩协议,购买300万支Dengvaxia。这是全球首支通过审批的登革热疫苗。菲律宾政府计划为100万名9岁的学龄儿童接种疫苗,每人3支,让他们免受登革热导致的恶劣后果:休克、器官衰竭甚至死亡。

关键词：登革热免疫接种疫苗政府计划菲律宾制药公司学龄儿童休克