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Impact of obesity and diabetes on arthritis: An update

Health 2013年第1期5卷 143-156页

作者： Rajesh Pandey Narendra Kumar seema paroha Ram Prasad Mukesh Yadav Shalini Jain Hariom Yadav Amity Institute of Microbial Technology Amity University Noida India College of Advance Studies Datia India Department of Biochemistry Awadhesh Pratap Singh University Rewa India Department of Biochemistry Jawaharlal Nehru Agriculture University Jabalpur India Department of Biotechnology IMS Engineering College Ghaziabad India NIDDK National Institutes of Health Bethesda USA

The incidence of obesity and diabetes has been increased with alarming rate in recent years and became a common problem around the globe including developing as well as in developed countries with incalculable social costs. Obesity and type 2 diabetes are two common co-morbidities occur together. Obesity and diabetes is closely associated with many diseases, osteoarthritis, hypertension, certain form of cancer, sleep-breathing disorders and coronary heart disease. Impacts of obesity and diabetes (insulin resistance) on arthritis have been seen in patients that we associated with combination of various factors like increased availability of high-energy foods, genetic susceptibility and decreased physical activity in modern society. Arthritis is becoming pandemic around the globe and its occurrence with obesity and diabetes has been observed more common than ever. Combination of these two chronic conditions makes these diseases more vulnerable for human health. Till now very limited information is established about the pathological and mechanistic correlation among these health ailments. In this review article we aimed to survey the literature covering the influence of obesity and diabetes on arthritis pathology and tried to establish correlation with these diseases.

关键词： Obesity Diabetes Arthritis Complications

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