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Synthesis and pharmacological activity evaluation of curcumin derivatives

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Chinese Chemical Letters 2016年第7期27卷 1067-1072页

作者： jaggi Lal Sushil K.Gupta D.Thavaselvam Dau D.Agarwal School of Studies in Chemistry Jiwaji University Department of Chemistry Dr. K.N. Modi University Microbiology Division Defence Research Development Establishment

Curcumin 3,4-dihydropyrimidinones/thiones/imines have been synthesized using one-pot cyclocondensation of curcumin with substituted aromatic aldehydes and urea/thiourea/guanidine in the presence of chitosamine hydrochloride as a biodegradable and nontoxic catalyst under solvent-free microwave *** synthesized product was purified by crystallization from ethanol and the process does not involve any hazardous *** the synthesized curcumin derivatives 4a-o were screened for antioxidant and anti-inflammatory *** activity data of the synthesized showed that most of the synthesized compounds exhibited greater antioxidant and anti-inflammatory activity than curcumin.

关键词： Curcumin dihydropyrimidinones/thiones/ imines Microwave irradiations Antioxidant capacity Anti-inflammatory activity

Bioactive nanotherapeutic trends to combat triple negative breast cancer

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Bioactive Materials 2021年第10期6卷 3269-3287页

作者： Pallabita Chowdhury Upasana Ghosh Kamalika Samanta Meena jaggi Subhash C.Chauhan Murali M.Yallapu Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA Department of Biomedical Engineering School of EngineeringRutgers UniversityThe State University of New JerseyPiscatawayNJ08854USA Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTXUSA South Texas Center of Excellence in Cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTXUSA

The management of aggressive breast cancer,particularly,triple negative breast cancer(TNBC)remains a formidable challenge,despite treatment *** newer therapies such as atezolizumab,olaparib,and sacituzumab can tackle the breast cancer prognosis and/or progression,but achieved limited survival benefit(s).The current research efforts are aimed to develop and implement strategies for improved bioavailability,targetability,reduce systemic toxicity,and enhance therapeutic outcome of FDA-approved treatment *** review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s)for breast cancer *** article also documents novel strategies to employ cellular and cell membrane cloaked(biomimetic)nanoparticles for effective clinical *** technologies offer a safe and active targeting nanomedicine for effective management of breast cancer,especially TNBC.

关键词： Breast cancer treatment Triple negative breast cancer Chemotherapy Nanoparticles Membrane cloaked nanoparticles Nanomedicine Biomimetic nanoparticles

When Does Financing an Aircraft Make the Most Sense?

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今日民航 2019年第6期 94-97页

作者： Rohit jaggi 不详

You’ve spent months finding that’perfect’***’s the right model,low on hours and cycles,and has an interior that’s more acceptable than ***,how will you pay for it?Aircraft finance can be a ***’s not so much that any deal could blow up in your face-there are ways to minimize that *** choosing a careful path is the key to emerging on the other side intact.

关键词： Financing Aircraft Sense

Milk exosomes:Nature’s abundant nanoplatform for theranostic applications

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Bioactive Materials 2021年第8期6卷 2479-2490页

作者： Benilde Adriano Nycol M.Cotto Neeraj Chauhan Meena jaggi Subhash C.Chauhan Murali M.Yallapu Department of Immunology and Microbiology School of MedicineThe University of Texas Rio Grande ValleyMcAllenTX78504USA South Texas Center of Excellence in Cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle *** have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological *** various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic *** be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking *** the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging *** review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery *** is emphasized on possible modifications of exosomes towards increasing the stability and delivery of *** article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

关键词： Milk exosomes Extracellular vesicles Drug delivery Imaging agents Theranostic applications

供遥感数据分析的三种分形量测算法的实现和作法

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国外测绘 1994年第5期 30-37页

作者： jaggi,S 张仁霖

分形几何日益成为模拟自然现象的有用工具。作为对欧氏几何概念的一种替换方法，分形可以对自然边界和表面复杂性作更精确的表示。本文的目的是介绍并实施三种按Ｃ语言编程的算法，为的是从遥感数据导出分形量测值。这三种方法是：线分... 详细信息

分形几何日益成为模拟自然现象的有用工具。作为对欧氏几何概念的一种替换方法，分形可以对自然边界和表面复杂性作更精确的表示。本文的目的是介绍并实施三种按Ｃ语言编程的算法，为的是从遥感数据导出分形量测值。这三种方法是：线分值法，方差图法和三角棱柱法，。为了使用三种方法的的第一种计算分维，（ＮＡＳＡ）检验的机载谱扫描仪（ＣＡＭＳ）所获取的遥感慨。这些具有３０ｍ的像元空韶辨率。

关键词：遥感数据分析分形量测算法

Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer

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Acta Pharmaceutica Sinica B 2018年第4期8卷 602-614页

作者： Pallabita Chowdhury Prashanth K.B.Nagesh Sheema Khan Bilal B.Hafeez Subhash C.Chauhan Meena jaggi Murali M.Yallapu Department of Pharmaceutical Sciences and Center for Cancer Research University of Tennessee Health Science Center

The goal of this investigation was to develop and demonstrate a polymer/paclitaxel selfassembly(PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone(PVP)-based PTX-SAs(PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTXSAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy(TEM).FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation(MTS) and clonogenic(colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein(Bcl-x L), upregulation of apoptosis-associated proteins(Bid, Bax, cleaved caspase 7, and cleaved PARP)and β-tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells.

关键词： Drug delivery Nanoparticles Self-assemblies Polymer Cancer therapeutics Breast cancer

Distribution Behaviour of Dimethoate in Tea Leaf

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Journal of Environmental Protection 2011年第4期2卷 482-488页

作者： Shivani jaggi Bikram singh Adarsh Shanker Maya Institute of Technology & Management Selaqui Dehradun Uttarakhand India 2Institute of Himalayan Bioresource Technology (IHBT) Council of Scientific & Industrial Research Palampur (Himachal Pradesh) India

A study was undertaken to assess the distribution behaviour of Dimethoate in tea leaf. Tea bushes were subjected to Dimethoate spray at recommended dose and double the recommended doses. The extraction of pesticide was done using chloroform and the analysis was done using a Hewlett-Packard 5890 series II gas chromatograph with Nitrogen Phosphorus Detector (NPD). The penetration behaviour of Dimethoate was studied in dry and wet seasons. Variations in penetration were observed in dry and wet seasons which was attributed to climatic factors like temperature, humidity, rainfall, sunlight and physicochemical properties of the residue like water solubility, partition coefficient and formulation type. Residues observed in the cell wall and tissues confirm its good penetrating ability inspite of its hydrophilic nature. Higher penetration in wet season as indicated can be attributed to the route through the stomatal pores.

关键词： Tea Cuticle Dimethoate Dissipation

High-speed identification of suspended carbon nanotubes using Raman spectroscopy and deep learning

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Microsystems & Nanoengineering 2022年第1期8卷 259-267页

作者： Jian Zhang Mickael L.Perrin Luis Barba Jan Overbeck Seoho Jung Brock Grassy Aryan Agal Rico Muff Rolf Brönnimann Miroslav Haluska Cosmin Roman Christofer Hierold Martin jaggi Michel Calame Laboratory for Transport at Nanoscale Interfaces EmpaSwiss Federal Laboratories for Materials Science and TechnologyCH-8600 DübendorfSwitzerland Machine Learning and Optimization Laboratory School of Computer and Communication SciencesEPFLCH-1015 LausanneSwitzerland Department of Physics and Swiss Nanoscience Institute University of BaselCH-4056 BaselSwitzerland Micro-and Nanosystems Department of Mechanical and Process EngineeringETH ZurichCH-8092 ZurichSwitzerland

The identification of nanomaterials with the properties required for energy-efficient electronic systems is usually a tedious human task.A workflow to rapidly localize and characterize nanomaterials at the various stages of their integration into large-scale fabrication processes is essential for quality control and,ultimately,their industrial *** this work,we develop a high-throughput approach to rapidly identify suspended carbon nanotubes(CNTs)by using high-speed Raman imaging and deep learning *** for Raman spectra with extremely low signal-to-noise ratios(SNRs)of 0.9,we achieve a classification accuracy that exceeds 90%,while it reaches 98%for an SNR of *** applying a threshold on the output of the softmax layer of an optimized convolutional neural network(CNN),we further increase the accuracy of the ***,we propose an optimized Raman scanning strategy to minimize the acquisition time while simultaneously identifying the position,amount,and metallicity of CNTs on each *** approach can readily be extended to other types of nanomaterials and has the potential to be integrated into a production line to monitor the quality and properties of nanomaterials during fabrication.

关键词： carbon suspended speed

Quantifying Design Parameters of Symbology Page for Automotive Head up Display

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Computer Technology and Application 2011年第8期2卷 658-662页

作者： Gupta Sharad Karar Vinod Saini Surender Singh jaggi Neena Bajpai Phun Phun National Institute of Technology （NIT） Kurukshetra 136119 India Central Scientific Instruments Organisation （CSIR-CSIO） Chandigarh 160030 India

This paper gives an overview of studies on parameters displayed on the Automotive Head Up Display （A-HUD） including calculation and construction of symbology page based on study results. A study has been made on vital parameters required for car drivers and design calculations have been made based on design parameters like field of view, distance from the design eye position, minimum character size viewable from a distance of 1.5m between driver and the projected image, and optical magnification factor. lhe display format suitable for A-HUD applications depends upon the parameters required to be displayed. The aspect ratio chosen is 4：3. This paper also provides method to design the symbology page embedding six vital parameters with their relative positioning and size considering relative position between display device and optical elements which has been considered with a magnification factor of 2.5. The field of view obtained is 6.7° × 4.8°.

关键词： Automotive head up display (A-HUD) magnification symbology character size human factors field of view (FOV). design eye position (DEP).