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The Effect of Luteal-Phase Support with Triptrolin Administration on Implantation and Clinical Pregnancy Rate in Assisted Reproductive Technology

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 571-580页

作者： Marzieh Aghahosseini Ashraf Alleyassin Leili Safdarian Saeedeh Gharahjeh Hojat Saeidi Fatemeh Sarvi sedigheh hosseini Nooshin Mohammadi Golamreza Roshandel Jalal Gharajeh Department of Infertility Tehran University of Medical Sciences Tehran Iran Department of Perinatology Tehran University of Medical Sciences Tehran Iran Golestan Research Center of Gastroenterology and Hepatology Golestan University of Medical Sciences Golestan Iran

Background: Luteal phase support with GnRH agonist administration has been shown to be effective in improving the outcome of assisted reproductive technology. The goal of this study was to evaluate the effect of single dose Triptrolin (a GnRH agonist) on the probability of the clinical pregnancy rate following embryo transfer (ET) in assisted reproductive techniques (ART). Methods: In this double blinded randomized clinical trial, 340 infertile women who were candidates for intra-cytoplasmic sperm injection (ICSI) were randomly assigned to receive GnRH agonist (Triptrolin) in the luteal phase or placebo. In the intervention group, 0.1 mg Triptrolin was injected subcutaneously, while the control group received normal saline. The clinical pregnancy and implantation rate were compared between the two groups using chi-2 and t-test. P-values less than 0.05 were considered significant. The registration number of this clinical trial is IRCT 2014030916912N1. Results: Administration of 0.1 mg Triptrolin on day 6 after oocyte pick up showed no superiority over placebo in implantation (16.9% - 14%, P = 0.40) and clinical pregnancy rates (32% - 29%, P = 0.66), but the rate of clinical pregnancy was higher in women who were below 27 years of age and those with PCO. Conclusion: Administration of Triptrolin was not superior to placebo for luteal phase support.

关键词： Luteal Phase Support GnRH Agonist Implantation Rate Clinical Pregnancy

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Circulation of Brucellaceae,Anaplasma and Ehrlichia *** borderline of Iran,Azerbaijan,and Armenia

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Asian Pacific Journal of Tropical Medicine 2021年第5期14卷 223-230页

作者： Rahimeh Abdoli Hasan Bakhshi sedigheh Kheirandish Faezeh Faghihi Asadollah hosseini-Chegeni Mohammad Ali Oshaghi Zakkyeh Telmadarraiy Mohammad Mehdi Sedaghat Department of Medical Entomology and Vector Control School of Public HealthTehran University of Medical SciencesTehranIran Department of Oral and Maxillofacial Pathology School of DentistryBushehr University of Medical SciencesBushehrIran Cellular and Molecular Research Center Iran University of Medical SciencesTehranIran Department of Plant Protection Faculty of AgricultureLorestan UniversityKhorramabadIran Rahyan Novin Danesh(RND)Private University SariMazandaranIran

Objective:To estimate the infection of ticks to Anaplasma,Ehrlichia,Babesia,Theileria,and Brucellaceae using molecular methods in borderline of Iran,Azerbaijan,and ***:Totally,2022 ticks were collected from different ***,species were diagnosed under stereomicroscope according to valid morphological *** DNA was extracted followed by PCR to detect Anaplasma,Ehrlichia,Theileria,Babesia and Brucellaceae infection in ***:A total of 498 males[24.62%(95%CI 22.76%-26.57%)],741 females[36.64%(95%CI 34.54%-38.79%)],782 nymphs[38.67%(95%CI 36.55%-40.84%)]and 1 larva[0.04%(95%CI 0.00%-0.28%)]were *** identified samples,we found four genera including Hyalomma,Rhipicephalus,Haemaphysalis,and *** assay revealed that the prevalence of ticks to Anaplasma or Ehrlichia,and Brucellaceae was 22.02%(95%CI 16.01%-29.06%)and 15.03%(95%CI 9.43%-22.26%),*** analysis showed that the identified Anaplasma *** the most similarity with Anaplasma centrale,Anaplasma platys,Anaplasma camelii,and Anaplasma phagocytophilum,submitted in ***,the detected Ehrlichia *** Brucellaceae bacterium had the most similarity with Ehrlichia ruminantium and Mycoplana peli,***,no sign of the presence of Theileria and Babesia *** seen in the studied ***:Anaplasmosis,ehrlichiosis and brucellosis should be considered as important health threats in northwestern Iran and consistent monitoring on infection of ticks and livestock should be performed regularly.

关键词： Tick Anaplasma Ehrlichia Brucellaceae PCR

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