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Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates

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Asian Pacific Journal of Tropical Medicine 2016年第9期9卷 866-871页

作者： Tahereh Mikaeili Galeh Abdolhassan Kazemi Mahmoud Mahami-Oskouei Behzad Baradaran Adel Spotin seddigheh sarafraz Majid Karamat Immunology Research Center Tabriz University of Medical Sciences Department of Parasitology and Mycology Faculty of MedicineTabriz University of Medical Sciences East Azerbaijan Province Health Center Tabriz Health Center

Objective:To identify the frequencies(F) of ferredoxin and nitroreductase mutations were identified on Iranian clinical isolates of Giardia lamblia in order to predict whether the nitazoxanide can be prescribed as suitable drug for symptomatic to metronidazoleresistant ***:Forty Giardia lamblia isolates as of 38 symptomatic and two metronidazole-resistant patients were collected from *** were extracted and amplified by targeting ferredoxin and Gl NR *** amplicons were directly sequenced to determine gene ***:The various amino acid substitutions(F:20%,Haplotype diversity:0.891,Tajima's D:-0.44013) were identified by analyzing ferredoxin gene in four symptomatic and two resistant ***,two haplotypes(F:5%,HD:0.345; Tajima's D:0.77815) characterized in metronidazole-resistant isolates of Gl NR,however,no point mutations was found in symptomatic ***:Non-synonymous mutations of ferredoxin oxidoreductase gene reduce translational regulatory protein's binding affinity which concludes reduction of ferredoxin expression and its *** leads to decrease in metronidazole drug delivery into the *** in these isolates may lead to their resistance to *** to low synonymous mutations of Gl NR demonstrates that nitazoxanide can be prescribed as promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in Iranian clinical isolates.

关键词： Giardia lamblia Ferredoxin oxidoreductase Nitroreductase Nitazoxanide Metronidazole

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