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Cognitive attentional syndrome and metacognitive beliefs as potential treatment targets for metacognitive therapy in bipolar disorder

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World Journal of Psychiatry 2021年第9期11卷 589-604页

作者： sedat Batmaz Ali Ercan Altinoz Harun Olcay Sonkurt Department of Psychiatry School of MedicineTokat Gaziosmanpasa UniversityTokat 60100Turkey Department of Psychiatry School of MedicineEskisehir Osmangazi UniversityEskisehir 26000Turkey Psychiatry Clinic Agri Training and Research HospitalAgri 04000Turkey

Most treatment guidelines emphasize the use of psychotropic drugs for both the acute and maintenance treatment of bipolar disorder(BD).However,relying only on psychotropics without adjunctive psychosocial interventions may be insufficient in treating patients with *** its unique view in the explanation of psychopathological states,metacognitive therapy(MCT)might be helpful for *** theory posits that psychopathology is a result of the cognitive attentional syndrome(CAS)and that it is influenced and maintained by dysfunctional metacognitive beliefs,perseverative thinking,attentional biases,and dysfunctional coping *** this review,literature data regarding these areas in BD are *** suggest that perseverative thinking might be among the emotion regulation strategies endorsed in individuals with *** attentional biases,literature data show that state-dependent,moodchanging attentional biases and a ruminative self-focused attention are *** also suggest that cognitive self-consciousness is higher in BD compared to *** is seen that maladaptive coping strategies are frequently reported in BD,and that these strategies are associated with depression severity,negative affect and relapse *** focusing on dysfunctional metacognitive beliefs in BD reported that individuals with BD had higher scores for negative metacognitive beliefs,self-consciousness,need to control thoughts,and a lack of cognitive ***,dysfunctional metacognitive beliefs were associated with depressive *** findings suggest that the components of CAS and dysfunctional metacognitive beliefs are evident in *** a subgroup of patients with BD who fail to respond to evidence-based psychopharmacological and adjunctive psychotherapeutic interventions,MCT might be an alternative way to consider as a treatment *** conclusion,taken the available data together,we propose a sequential treatment protocol for BD,ma

关键词： Attentional biases Bipolar disorder Dysfunctional coping Metacognition Metacognitive therapy Perseverative thinking Threat monitoring

Meckel's diverticulum manifested by a subcutaneous abscess

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World Journal of Gastroenterology 2009年第48期15卷 6123-6125页

作者： Oguzhan Karatepe Gokhan Adas Merih Altiok Deniz Ozcan sedat Kamali Servet Karahan Department of General Surgery Okmeydam Training and Research Hospital Department of Pathology Okmeydam Training and Research Hospital

This case report describes an extremely rare complication of a Meckel's diverticulum:enterocutaneous fistula of the *** presence of Meckel's diverticulum is a well known entity,but subcutaneous perforation of the diverticulum is very *** we report the case of a patient with the complaint of a right lower quadrant abscess,preoperatively diagnosed as enterocutaneous fistula,which was determined intraoperatively to be a fistula resulting from Meckel's diverticulum.

关键词： Meckel's diverticulum Enterocutaneous fistula Abscess

Current and future surgery strategies for spinal cord injuries

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World Journal of Orthopedics 2015年第1期6卷 34-41页

作者： sedat Dalbayrak Onur Yaman Tevfik Y?lmaz Department of Neurosurgery NeurosurgeryNeuro Spinal Academy Clinic of Neurosurgery Tepecik Education and Training Hospital Department of Neurosurgery Faculty of MedicineDicle University

Spinal cord trauma is a prominent cause of mortality and morbidity. In developed countries a spinal cord injury(SCI) occurs every 16 min. SCI occurs due to tissue destruction, primarily by mechanical and secondarily ischemic. Primary damage occurs at the time of the injury. It cannot be improved. Following the primary injury, secondary harm mechanisms gradually result in neuronal death. One of the prominent causesof secondary harm is energy deficit, emerging from ischemia, whose main cause in the early stage, is impaired perfusion. Due to the advanced techniques in spinal surgery, SCI is still challenging for surgeons. Spinal cord doesn't have a self-repair property. The main damage occurs at the time of the injury primarily by mechanical factors that cannot be improved. Secondarily mechanisms take part in the following sections. Spinal compression and neurological deficit are two major factors used to decide on surgery. According to advanced imaging techniques the classifications systems for spinal injury has been changed in time. Aim of the surgery is to decompress the spinal channel and to restore the spinal alinement and mobilize the patient as soon as possible. Use of neuroprotective agents as well as methods to achieve cell regeneration in addition to surgery would contribute to the solution.

关键词： Spinal cord injury Surgery Classification Mechanism Management

Deep learning for non-parameterized MEMS structural design

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Microsystems & Nanoengineering 2022年第4期8卷 251-260页

作者： Ruiqi Guo Fanping Sui Wei Yue Zekai Wang sedat Pala Kunying Li Renxiao Xu Liwei Lin Department of Mechanical Engineering University of CaliforniaBerkeleyCA 94720USA School of Computer Science Wuhan UniversityWuhan 430072China Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China

The geometric designs of MEMS devices can profoundly impact their physical properties and eventual ***,it is challenging for researchers to rationally consider a large number of possible designs,as it would be very time-and resource-consuming to study all these cases using numerical *** this paper,we report the use of deep learning techniques to accelerate the MEMS design cycle by quickly and accurately predicting the physical properties of numerous design candidates with vastly different geometric *** candidates are represented in a nonparameterized,topologically unconstrained form using pixelated black-and-white *** sufficient training,a deep neural network can quickly calculate the physical properties of interest with good accuracy without using conventional numerical tools such as finite element *** an example,we apply our deep learning approach in the prediction of the modal frequency and quality factor of disk-shaped microscale *** reasonable training,our deep learning neural network becomes a high-speed,high-accuracy calculator:it can identify the flexural mode frequency and the quality factor 4.6×10^(3)times and 2.6×10^(4)times faster,respectively,than conventional numerical simulation packages,with good accuracies of 98.8±1.6%and 96.8±3.1%,*** simultaneously predicting the frequency and the quality factor,up to~96.0%of the total computation time can be saved during the design *** proposed technique can rapidly screen over thousands of design candidates and promotes experience-free and data-driven MEMS structural designs.

关键词： structural Deep faster

Association of ezrin expression in intestinal and diffuse gastric carcinoma with clinicopathological parameters and tumor type

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World Journal of Gastroenterology 2007年第27期13卷 3726-3729页

作者： Nebil Bal sedat Yildirim Tarik Z Nursal Filiz Bolat Fazilet Kayaseluk Department of Pathology Ba■kent University Faculty of Medicine Turkey Department of General Surgery Ba■kent University Faculty of Medicine Turkey

AIM： To investigate the correlation between ezrin expression and types of gastric carcinoma and clinicopathological variables.METHODS： We examined ezrin protein expression in 75 gastric carcinoma （53 intestinal types of adenocarcinoma, 22 diffuse types of carcinoma） tissues by immunohistochemistry. The results were compared with clinicopathological parameters such as tumor type, grade of tumor, clinical stage, presence of metastatic lymph node, and depth of invasion. RESULTS： Ezrin immunostaining was positive in 43 cases （81.1%） of intestinal type and in 9 （40.9%） cases of diffuse type adenocarcinomas （P 〈 0.001）. In gastric carcinomas, the expression of ezrin protein correlated with the status of H py/ori and survival. There was no correlation between expression of ezrin with TNM stage and histological grade of gastric carcinomas （P 〉 0.05）. CONCluSION： The low expression of ezrin implicates the loss of adhesion in diffuse carcinomas. Furthermore, overexpression of ezrin in carcinomas with H pylori infection may be a genuine specific pathway in which Hpylori may cause/initiate gastric carcinoma.

关键词： Ezrin Gastric carcinoma Hpylori Metastasis

1，3-二烷基咪唑啉／Pd催化卤代芳烃的Heck和Suzuki反应

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催化学报 2008年第2期29卷 185-190页

作者： sedat YASAR Ismail OEZDEMiR Bekir CETINKAYA 伊诺努大学科学与艺术学院化学系土耳其马拉蒂亚44280 爱琴大学化学系土耳其伊兹密尔35100

合成并表征了一种新型的有空间需求的N-杂环卡宾前驱体1,3-二烷基咪唑啉盐.这些咪唑啉盐与乙酸钯结合形成的高活性催化剂,可在温和条件下催化氯代和溴代芳烃的Heck和Suzuki交叉偶联反应.

关键词： Heck反应 Suzuki反应卤代芳烃咪唑啉盐钯卡宾

Reaching proficiency in laparoscopic splenectomy

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World Journal of Gastroenterology 2009年第32期15卷 4005-4008页

作者： Tarik Zafer Nursal Ali Ezer sedat Belli Alper Parlakgumus Kenan Caliskan Turgut Noyan Department of General Surgery University of BaskentDadaloglu Mah.01200Serin Evler 39.Sk.No.6 Yüregir/AdanaTurkey

AIM:To investigate the proficiency level reached in laparoscopic splenectomy using the learning curve ***:All patients in need of splenectomy for benign causes in whom laparoscopic splenectomy was attempted by a single surgeon during a time period of 6 years were included in the study (n=33). Besides demographics, operation-related variables and the response to surgery were recorded. The patients were allocated to groups of five, ranked according to the date of the operation. Operation duration, complications, postoperative length of stay, conversion to laparotomy and splenic weight were then compared between these ***: There was a significant difference regarding operation times between the groups (P = 0.001). An improvement was observed after the first 5 cases. The learning curve was flat up to the 25th case. Following the 25th case the operation times decreased still further. There was no difference between the groups regarding the other ***: Unlike the widely accepted "L" shape, the learning curve for laparoscopic splenectomy is a horizontal lazy "S" with two distinct slopes. Privileges may be granted after the first 5 cases. However proficiency seems to require 25 cases.

关键词： Laparoscopic splenectomy Education Learning curve Hematology Proficiency

Hepatitis C infection in hemodialysis patients: A review

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World Journal of Hepatology 2015年第6期7卷 885-895页

作者： Digdem Ozer Etik Serkan Ocal Ahmet sedat boyacioglu Department of Gastroenterology Baskent University

Hepatitis C virus （HCV）-related liver disease is asignificant cause of morbidity and mortality in patientswith end-stage renal disease （ESRD） who is treated withdialysis or kidney transplantation （KT）. The survival ratefor HCV-infected renal transplant recipients is betterthan that for HCV-infected hemodialysis patients ontransplant waiting lists. Early diagnosis and treatmentHCV infection prior to KT prevents complications posttransplantationand reduces mortality. In addition toscreening for anti-HCV antibodies and detecting HCVRNA, percutaneous liver biopsy is particularly valuablefor assessing the stage of liver damage in HCV-infectedpatients, because the stage of fibrosis is important

关键词： Hepatitis C virus Hemodialysis End-stagerenal disease Kidney transplantation Hepatitis Ctreatment

Effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure

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World Journal of Gastroenterology 2005年第45期11卷 7183-7187页

作者： Selim Aydemir Binnaz Handan Ozdemir Gurden Gur Ibrahim Dogan Ugur Yilmaz sedat boyacioglu Department of Gastroenterology Department of Pathology

AIM： To evaluate the effects of Helicobacter pylori infection on gastric epithelial cell kinetics in patients with chronic renal failure （CRF）. METHODS： Forty-four patients were enrolled in this study and divided into four groups with respect to their Helicobacter pylori （H pylori） and CRF status. Groups were labeled as follows： la： normal renal function, H pylori negative （n = 12）, lb： normal renal function, H pylori positive （n = 11）, 2a： CRF, H pylori negative （n = 10）, 2b： CRF, H pylori positive （n = 11）. Upper gastrointestinal endoscopy was done in all the patients involved in the study. During endoscopical investigation, antral biopsy specimens were taken from each patient. In order to evaluate the cell apoptosis and proliferation in gastric epithelial cells, Bax and proliferating cell nuclear antigen （PCNA） labeling indexes （LI） were assessed with immunohistochemical staining method. RESULTS： For groups la, lb, 2a, and 2b, mean Bax LI was identified as 34.4±13.7, 44.1±16.5, 46.3±20.5, 60.7±13.8, respectively and mean PCNA LI was identified as 36.2±17.2, 53.6±25.6, 59.5±25.6, 67.2±22, respectively. When the one-way ANOVA test was applied, statistically significant differences were detected between the groups for both Bax LI （P = 0.004 〈0.01） and PCNA LI （P = 0.009 〈0.01）. When groups were compared further in terms of Bax LI and PCNA LI with Tukey＇s HSD test for multiple pairwise comparisons, statistically significant difference was observed only between groups la and 2b （P = 0.006 〈0.01）.CONCluSION： In gastric epithelial cells, expression of both the pre-apoptotic protein Bax and the proliferation marker PCNA increase with H pylori infection. This increase is more evident in patients with uremia. These findings suggest that uremia accelerates apoptosis and proliferation in gastric epithelial cells.

关键词： Helicobacter pylori Chronic renal failure Bax Proliferating cell nuclear antigen