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中华高血压杂志 2014年第2期22卷 198-198页

作者： Catena C Colussi G Martinis F Pezzutto F sechi la 练桂丽

该研究旨在利用组织多普勒成像技术（tissuedopplerimaging，TDI）检查，验证高血压患者空腹和餐后血糖上升与舒张期功能障碍相关这一假设。方法：选取未经治疗、无心血管并发症的非糖尿病高血压患者104例，测量空腹和口服葡萄糖后的血... 详细信息

该研究旨在利用组织多普勒成像技术（tissuedopplerimaging，TDI）检查，验证高血压患者空腹和餐后血糖上升与舒张期功能障碍相关这一假设。方法：选取未经治疗、无心血管并发症的非糖尿病高血压患者104例，测量空腹和口服葡萄糖后的血糖以及胰岛素水平，计算稳态模型评估（homeostaticmodelas—sessment，HOMA）指数以及进行心电图、常规超声心动图和TDI检查。结果：与正常血糖患者相比，空腹血糖或者葡萄糖耐量异常的31例患者的心电图检查更常出现左心室劳损现象和TDI舒张功能异常指标。

关键词：左心室舒张功能高血压患者血糖水平非糖尿病组织多普勒成像技术心电图检查舒张期功能障碍葡萄糖耐量异常

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高血压患者同型半胱氨酸水平升高与代谢综合征和心血管事件相关

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中华高血压杂志 2016年第1期24卷 98-98页

作者： Catena C Colussi G Nait F Capobianco F sechi la 陈云叶鹏

高同型半胱氨酸（homocysteine，Hcy）血症和代谢综合征（metabolic syndrome，MS）是明确的心血管危险因素，常与高血压相关。然而血浆Hcy与MS、胰岛素抵抗相关性存在争议，且在高血压患者中的研究较少。该研究探讨高血压患者Hcy与MS... 详细信息

高同型半胱氨酸（homocysteine，Hcy）血症和代谢综合征（metabolic syndrome，MS）是明确的心血管危险因素，常与高血压相关。然而血浆Hcy与MS、胰岛素抵抗相关性存在争议，且在高血压患者中的研究较少。该研究探讨高血压患者Hcy与MS和心脑血管事件的相关性。

关键词：高同型半胱氨酸高血压患者代谢综合征心血管事件心血管危险因素心脑血管事件胰岛素抵抗 Hcy

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Kidney in primary aldosteronism: A key determinant of treatment outcome

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World Journal of Hypertension 2012年第1期2卷 1-6页

作者： Cristiana Catena Gian Luca Colussi Leonardo A sechi Hypertension Unit Internal Medicine Department of Experimental and Clinical Medicine Clinica Medica University of Udine University Hospital 33100 Udine Italy

Recently, it has been suggested that primary aldosteronism(PA) is associated with a variety of cardiac,vascular, metabolic, and renal sequelae that reflect the capability of elevated aldosterone to induce organ damage beyond that induced by hypertension itself. The evidence supporting of these views has been obtained from experiments conducted in rodents and clinica studies conducted in patients with this endocrine disorder. It has been suggested that untoward effects of high-salt intake are dependent on activation of mineralocorticoid receptors that might result from increased oxidative stress and changes in the intracellular redox potential. Unilateral adrenalectomy or treatment with mineralocorticoid receptor antagonists are the current options for treating an aldosterone-producing adrena adenoma or idiopathic adrenal hyperplasia. Treatments are largely effective in correcting hypertension and hypokalemia, and currently available information on their capability to prevent deterioration of renal function indicates that surgery and medical treatment are equallybeneficial in the long term. This editorial review will focus on the renal aspects of PA and highlights the role of the kidney as a key determinant of both adaptation to aldosterone-induced volume retention and response of blood pressure to treatment.

关键词： Blood pressure Glomerular filtration rate Albuminuria Adrenalectomy Mineralocorticoid receptor antagonists

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Diabetes, diabetic complications, and blood pressure targets

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World Journal of Hypertension 2015年第1期5卷 1-5页

作者： Cristiana Catena Gian Luca Colussi Francesca Nait Gabriele Brosolo Leonardo A sechi Hypertension Unit Interna Medicine Department of Experimental and Clinical Medical Sciences University of Udine

Association of diabetes with hypertension is frequent and it well known that high blood pressure potentiates the probability of diabetic patients to develop macrovascularand microvascular complications. Strong evidence obtained in a number of large scale prospective studies indicates that adequate blood pressure control in diabetic patients is highly beneficial for prevention of cardiovascular events. Nonetheless, only a limited proportion of hypertensive-diabetic individuals included in studies on anti-hypertensive treatment has met the predefined blood pressure goal. The optimal blood pressure goal to be pursued in diabetic patients with hypertension to guarantee effective protection from cardiovascular outcomes is still under intense debate and recommendations of current guidelines on hypertension treatment are still inconsistent. We comment here on the most important studies and conclude that current evidence does not conclusively support the need to reach a blood pressure target in hypertensive patients with diabetes different from nondiabetic hypertensive individuals.

关键词： Diabetes Hypertension Cardiovascular events Guidelines Randomized controlled trials Evidence based medicine

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Early renal failure as a cardiovascular disease:Focus on lipoprotein(a) and prothrombotic state

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World Journal of Nephrology 2015年第3期4卷 374-378页

作者： Cristiana Catena Gian Luca Colussi Francesca Nait Francesca Pezzutto Flavia Martinis Leonardo A sechi Clinica Medica Department of Experimental and Clinical Medical SciencesUniversity of Udine

Patients with renal failure are at increased risk of cardiovascular events even at the earliest stages of *** addition to many classic cardiovascular risk factors,many conditions that are commonly identified as emerging risk factors might contribute to occurrence of cardiovascular *** in circulating levels of many of these emerging risk factors have been demonstrated in patients with early stages of renal failure caused by different types of renal disease and have been associated with detection of cardiovascular ***,for most of these factors evidence of benefits of correction on cardiovascular outcome is *** this article,we comment on the role of lipoprotein(a) and prothrombotic factors as potential contributors to cardiovascular events in patients with early renal failure.

关键词：疾病肾衰竭治疗方法临床分析

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