检索结果-南通市图书馆

作者： (法)塞巴斯蒂安·雅普瑞索(sebastien Japrisot)

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为缓和医疗正名

中国医院院长 2020年第17期16卷 16-17页

作者： Kirsty Boyd sebastien Moine Scott A Murray Deborah Bowman Nicole Brun 赵彧墨不详

改变观念比改变名字更重要。世界卫生组织(WHO)首次提出"缓和医疗(palliative care)"这个概念已经30年了,我们依然没有真正认同这个理念。开展缓和医疗以来,终末期患者的照护情况得到了显著的改善,关于"死亡"的探讨也渐渐不再是禁忌话... 详细信息

改变观念比改变名字更重要。世界卫生组织(WHO)首次提出"缓和医疗(palliative care)"这个概念已经30年了,我们依然没有真正认同这个理念。开展缓和医疗以来,终末期患者的照护情况得到了显著的改善,关于"死亡"的探讨也渐渐不再是禁忌话题。很多国家政府和国际组织开始提倡推广缓和医疗。柳叶刀健康委员会(Lancet Commission)更激进地提出,对于全球数百万终末期患者.

关键词：终末期患者柳叶刀缓和医疗改变观念 Lancet Commission 正名

Assessment of CareStart G6PD rapid diagnostic test and CareStart G6PD biosensor in Mauritania

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Infectious Diseases of Poverty 2021年第4期10卷 33-45页

作者： Oum Kelthoum Mamadou Djigo Yacoub Ould Khalef Mohamed Salem Ould Ahmedou Salem Nicolas Gomez Leonardo Basco sebastien Briolant Ali Ould Mohamed Salem Boukhary Unite de Recherche"Genomes et Milieux"(Jeune Equipe Associee a I'lnstitut de Recherche pour le Developpement) Faculte des Sciences et lechniquesUniversite de Nouakchott Al-AasriyaNouakchottMauritania Service de Pediatrie Centre Hospitalier Mere et EnfantNouakchottMauritania IHU Mediterrande InfectionMarseilleFrance Aix Marseille Univ IRDAP-HMSSAVITROMEMarseilleFrance Unite de Parasitologie Entomologie Departement de Microbiologie et Maladies InfectieusesInstitut de Recherche Biomedicale des Armees(IRBA)MarseilleFrance

Background::The elimination of Plasmodium vivax malaria requires 8-aminoquinolines,which are contraindicated in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency due to the risk of acute haemolytic *** point-of-care devices have been developed to detect G6PD *** objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in ***::Outpatients were screened for G6PD deficiency using CareStart?rapid diagnostic test(RDT)and CareStart?G6PD biosensor in Nouakchott,Mauritania,in ***-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and *** variables were compared using Fisher’s exact ***::Of 323 patients(74 males and 249 females),5 males and 2 homozygous females had the African-type A-genotype:A-(202)in 3 males and 2 females and G6PD A-(968)in 2 *** heterozygous females,13 carried G6PD A-(202),12 G6PD A-(968),and 3 G6PD A-(542)*** had the Mediterranean-type G6PD *** had a positive G6PD RDT result,including all 7 hemizygous males and homozygous females with A-or A-A-(0.12 to 2.34 IU/g haemoglobin,according to G6PD biosensor),but RDT performed poorly(sensitivity,11.1%at the cutoff level of<30%)and yielded many false negative ***-seven(50.0%)males and 141(56.6%)females were *** adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males(n=35)and non-anaemic males and females(n=130)with normal G6PD genotypes using G6PD biosensor,*** on the adjusted median of 5.34 IU/g haemoglobin,the performance of G6PD biosensor against genotyping was as follows:at 30%cut-off,the sensitivity and specificity were 85.7%and 91.7%,respectively,and at 80%cut-off,the sensitivity was 100%while the specificity was 64.9%.Conclusions::Although this pilot study

关键词： Glucose-6-phosphate dehydrogenase Malaria Plasmodium vivax Primaquine Tafenoquine

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南海晚第四纪粘土矿物组合与东亚季风演化

南海晚第四纪粘土矿物组合与东亚季风演化

An algorithm for preferential selection of spectroscopic targets in LEGUE

第三届全国沉积学大会

作者：刘志飞 Christophe Colin Alain Trentesaux sebastien Boulay 汪品先同济大学海洋地质国家重点实验室 Laboratoire UMR Laboratoire 同济大学海洋地质国家重点实验室

＜正＞东亚季风是全球气候系统的一个重要组成部分,控制着亚洲东部季节性变化的风力、降雨量、径流量和陆地植被等气候和环境特征。南海作为西太平洋最大的边缘海,冬季在东北风的驱动下形成逆时针表层洋流,沉积亚洲内陆风蚀作用带来的...

＜正＞东亚季风是全球气候系统的一个重要组成部分,控制着亚洲东部季节性变化的风力、降雨量、径流量和陆地植被等气候和环境特征。南海作为西太平洋最大的边缘海,冬季在东北风的驱动下形成逆时针表层洋流,沉积亚洲内陆风蚀作用带来的粉尘;而夏季在东南风的驱动下形成顺时针表层洋流,接受邻近陆地高降雨量产生的风化剥蚀产物,夏季风的降雨强度可能代表亚洲地区陆地风化和剥蚀的重要指标。因此,南海近年来业已成为东亚季风形成和演化古海洋学研究的理想场所之一（Wang et al.,2005）。

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Research in Astronomy and Astrophysics 2012年第7期12卷 755-771页

作者： Jeffrey L. Carlin sebastien Lepine Heidi Jo Newberg Li-Cai Deng Timothy C. Beers Yu-Qin Chen Norbert Christlie Xiao-Ting Fu Shuang Gao Carl J. Grillmair PuragraGuhathakurta Zhan-Wen Han Jin-Liang Hou Hsu-Tai Lee Jing Li Chao Liu Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Hong-Chi Wang Fan Yang Brian Yanny Yue-Yang Zhan Zheng Zheng Zi Zhu Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 110 8th Street Troy NY 12180 USA carlij@rpi.edu Department of Astrophysics American Museum of Natural History Central Park West at 79thStreet New York NY 10024 USA City University of New York 365 Fifth Avenue New York NY 10016 USA National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China National Optical Astronomy Observatory Tucson AZ 85719 USA Center for Astronomy University of Heidelberg Landesstemwarte Ktinigstuhl 12 D-69117Heidelberg Germany Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA JCO/Lick Observatory Department of Astronomy and Astrophysics University of CaliforniaSanta Cruz CA 95064 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanglai 200030 China Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-141 Taipei 106 China Department of Astronomy & Kavli institute of Astronomy and Astrophysics Peking UniversityBeijing 100875 China Apache Point Observatory PO Box 59 Sunspot NM 88349 USA Department of Physics and Astronomy Rutgers University 136 Frelinghuysen RoadPiscataway NJ 08854-8019 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Fermi National Accelerator Laboratory EO. Box 500 Batavia IL 60510 USA Department of Physics and Astronomy University of Utah Salt Lake City UT 84112 USA Department of Astronomy Nanjing University Nanjing 210011 China

We describe a general target selection algorithm that is applicable to any survey in which the number of available candidates is much larger than the number of objects to be observed. This routine aims to achieve a balance between a smoothly- varying, well-understood selection function and the desire to preferentially select cer- tain types of targets. Some target-selection examples are shown that illustrate differentpossibilities of emphasis functions. Although it is generally applicable, the algorithm was developed specifically for the LAMOST Experiment for Galactic Understanding and Exploration （LEGUE） survey that will be carried out using the Chinese Guo Shou Jing Telescope. In particular, this algorithm was designed for the portion of LEGUE targeting the Galactic halo, in which we attempt to balance a variety of science goals that require stars at fainter magnitudes than can be completely sampled by LAMOST. This algorithm has been implemented for the halo portion of the LAMOST pilot sur- vey, which began in October 2011.

关键词： surveys: LAMOST -- Galaxy: halo -- techniques: spectroscopic

Insight of surface treatments for CMOS compatibility of InAs nanowi

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Nano Research 2019年第3期12卷 581-586页

作者： Daya S. Dhungana Anne Hemeryck Nicolo Sartori Pier-Francesco Fazzini Filadelfo Cristiano sebastien R. Plissard CNRS LAAS-CNRS Universite de Toulouse F-31400 Toulouse France LPCNO INSA Universite de Toulouse Toulouse France

A CMOS compatible process is prese nted in order to grow self-catalyzed InAs nano wires on silic on by molecular beam epitaxy. The crucial step of this process is a new in-situ surface preparation under hydrogen (gas or plasma) during the substrate degassing combined with an in-situ arsenic ann eali ng prior to growth. Morphological and structural characterizati ons of the InAs nano wires are prese nted and growth mecha nisms are discussed in detail. The major in flue nee of surface termi nation is exposed both experime ntally and theoretically using statistics on ensemble of nanowires and density functional theory (DFT) calculations. The differences observed between Molecular Beam Epitaxy (MBE) and Metal Organic Vapor Phase Epitaxy (MOVPE) growth of I nAs nano wires can be explai ned by these differe nt surfaces termi nations. The transition between a vapor solid (VS) and a vapor liquid solid (VLS) growth mechanism is presented. Optimized growth conditions lead to very high aspect ratio nano wires (up to 50 nm in diameter and 3 micron in len gth) without passi ng the 410℃ thermal limit, which makes the whole process CMOS compatible. Overall, our results suggest a new method for surface preparation and a possible tuning of the growth mechanism using different surface termi nations.

关键词： Ⅲ-Ⅴ semiconductors on silicon InAs nanowires self-catalyzed growth hydrogen preparation growth modeling density functional theory (DFT) modeling

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锰对碳素马氏体钢的强度和应变硬化的影响

水钢科技 2014年第1期 57-62页

作者： Artem ARLAZAROV Olivier BOUAZIZ Alain HAZOTTE Mohamed GOUNE sebastien ALLAIN 张东升(译) 刘青(译) 高长益(译) 法国阿塞洛米塔尔钢铁研究与发展中心法国巴黎矿业大学材料研究中心法国洛林大学材料微观结构与性能实验室法国波尔多化学与材料研究所

应用各种碳锰钢的文献资料和试验数据分析研究了碳和锰对马氏体力学性能的复合效应，探讨了碳和锰对马氏体的强度和应变硬化的协同作用，并采用连续组合法建立了碳-锰协同作用模型，该模型经过一个参变量修正后，所预测的应力-应变曲线... 详细信息

应用各种碳锰钢的文献资料和试验数据分析研究了碳和锰对马氏体力学性能的复合效应，探讨了碳和锰对马氏体的强度和应变硬化的协同作用，并采用连续组合法建立了碳-锰协同作用模型，该模型经过一个参变量修正后，所预测的应力-应变曲线与试验得到的应力-应变曲线稳合。

关键词：马氏体碳中锰应变硬化建模

新疆东天山十里坡自然铜矿化区马头滩组玄武岩锆石LA-ICPMS U-Pb年龄及其意义

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岩石学报 2007年第8期23卷 1973-1980页

作者：袁峰周涛发范裕谭绿贵 DavidCOOKE sebastienMEFFRE 王庆民王卫江合肥工业大学资源与环境工程学院合肥230009 澳大利亚塔斯马尼亚大学优秀矿床研究中心(CODES) 新疆维吾尔自治区地质调查院乌鲁木齐830000

新疆北部东天山十里坡地区近年来新发现了与玄武岩有关的自然铜矿化这一新类型。自然铜的赋矿地层-马头滩组中的赋矿玄武岩锆石 LA-ICPMS 年龄为307±4Ma,对应于晚石炭世,显示该套赋矿地层属于上石炭统。从该区自然铜赋矿火山岩所限定... 详细信息

新疆北部东天山十里坡地区近年来新发现了与玄武岩有关的自然铜矿化这一新类型。自然铜的赋矿地层-马头滩组中的赋矿玄武岩锆石 LA-ICPMS 年龄为307±4Ma,对应于晚石炭世,显示该套赋矿地层属于上石炭统。从该区自然铜赋矿火山岩所限定的时间看,成矿背景应属于后碰撞环境。东天山十里坡地区自然铜矿化的构造背景、成矿系统和矿化类型与峨眉山玄武岩自然铜矿化和美国基威诺铜矿床均存在差异,自然铜矿化的成因可能也存在差异。

关键词：自然铜玄武岩 LA-ICPMS 后碰撞十里坡东天山

Molecular investigation of Tuscan sweet cherries sampled over three years: gene expression analysis coupled to metabolomics and proteomics

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Horticulture Research 2021年第1期8卷 1-24页

作者： Roberto Berni Sophie Charton sebastien Planchon Sylvain Legay Marco Romi Claudio Cantini Giampiero Cai Jean-Francois Hausman Jenny Renaut Gea Guerriero Department of Life Sciences University of Sienavia P.A.Mattioli 4I-53100 SienaItaly TERRA Teaching and Research Center Gembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Environmental Research and Innovation Department Luxembourg Institute of Science and Technology41Rue du BrillL-4422 BelvauxLuxembourg Environmental Research and Innovation Department Luxembourg Institute of Science and Technology5rue BommelL-4940 HautcharageLuxembourg Istituto per la BioEconomia(IBE CNR) Dipartimento di Scienze BioAgroAlimentarivia Aurelia 4958022 FollonicaItaly

Sweet cherry(Prunus avium L.)is a stone fruit widely consumed and appreciated for its organoleptic properties,as well as its nutraceutical *** here investigated the characteristics of six non-commercial Tuscan varieties of sweet cherry maintained at the Regional Germplasm Bank of the CNR-IBE in Follonica(Italy)and sampled ca.60 days post-anthesis over three consecutive years(2016-2017-2018).We adopted an approach merging genotyping and targeted gene expression profiling with *** complement the data,a study of the soluble proteomes was also performed on two varieties showing the highest content of *** identified the presence of flavanols and proanthocyanidins in highest abundance in the varieties Morellona and Crognola,while gene expression revealed that some differences were present in genes involved in the phenylpropanoid pathway during the 3 years and among the ***,proteomics on Morellona and Crognola showed variations in proteins involved in stress response,primary metabolism and cell wall *** the best of our knowledge,this is the first multi-pronged study focused on Tuscan sweet cherry varieties providing insights into the differential abundance of genes,proteins and metabolites.

关键词： metabolism maintained sweet

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上海地区结核病患者耐氟喹诺酮药物的研究

中华结核和呼吸杂志 2010年第3期33卷 162-162页

作者：徐鹏李霞赵明桂晓虹 Kathryn De Riemer sebastien Gagneux 梅建高谦复旦大学上海医学院教育部和卫生部医学分子病毒学重点实验室 200032 上海市疾病预防控制中心结核病防治科美国加利福尼亚大学戴维斯分校医学院英国国家医学研究所医学研究理事会分枝杆菌研究部

氟喹诺酮类药物是目前重要的治疗结核病的二线药物，但由于其对结核分枝杆菌具有显著的杀菌活性，被提议作为抗结核病的一线药物使用。由于氟喹诺酮类药物在临床上使用已有近20年时间，被广泛用于其他细菌感染的治疗，人们担心在结核分... 详细信息

氟喹诺酮类药物是目前重要的治疗结核病的二线药物，但由于其对结核分枝杆菌具有显著的杀菌活性，被提议作为抗结核病的一线药物使用。由于氟喹诺酮类药物在临床上使用已有近20年时间，被广泛用于其他细菌感染的治疗，人们担心在结核分枝杆菌中已经存在较高的氟喹诺酮耐药水平而不能作为一线药物使用。本文对上海地区结核病患者中氟喹诺酮耐药水平及其危险因素进行了回顾性研究。

关键词：耐氟喹诺酮药物结核病患者上海地区氟喹诺酮类药物结核分枝杆菌药物使用耐药水平二线药物