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Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals

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Cellular & Molecular Immunology 2022年第5期19卷 588-601页

作者： Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin Department of Microbiology Li Ka Shing Faculty of MedicineThe University of Hong Kong102 Pokfulam RoadPokfulamHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong102 Pokfulam RoadPokfulamHong KongChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong Kong21 Sassoon RoadPokfulamHong KongChina

Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to ***,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point *** virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission *** also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse *** neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 *** immunoglobulin A was detected in the blood and nasal wash of vaccinated *** work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy.

关键词： Live attenuated vaccine NSP16 2'-O-methyltransferase T-cell response Mucosal immunity Sterilizing immunity

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Small bowel entrapment and ureteropelvic junction disruption associated with L3 Chance fracture-dislocation

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World Journal of Clinical Cases 2016年第9期4卷 264-268页

作者： sebastien Pesenti Benjamin Blondel Alice Faure Emilie Peltier Franck Launay Jean-Luc Jouve Pediatric Orthopaedics Hopital d'Enfants de la TimoneAix Marseille University Spine Unit Aix Marseille University Pediatric Surgery H?pital NordAix-Marseille University

Paediatric Chance fracture are rare lesions but often associated with abdominal injuries. We herein present the case of a seven years old patient who sustained an entrapment of small bowel and an ureteropelvic disruption associated with a Chance fracture and spine dislocation following a traffic accident. Initial X-rays and computed tomographic(CT) scan showed a Chance fracture with dislocation of L3 vertebra, with an incarceration of a small bowel loop in the spinal canal and a complete section of the left lumbar ureter. Paraplegia was noticed on the initial neurological examination. A posterior L2-L4 osteosynthesis was performed firstly. In a second time she underwent a sus umbilical laparotomy to release the incarcerated jejunum loop in the spinal canal. An end-toend anastomosis was performed on a JJ probe to suture the left injured ureter. One month after the traumatism, she started to complain of severe headaches related to a leakage of cerebrospinalis fluid. Three months after the traumatism there was a clear regression of the leakage. One year after the trauma, an anterior intervertebral fusion was done. At final follow-up, no neurologic recovery was noticed. In case of Chance fracture, all physicians should think about abdominal injuries even if the patient is asymptomatic. Initial abdominal CT scan and magnetic resonance imaging provide in such case crucial info for management of the spine and the associated lesions.

关键词： Chance fracture Uretero-pelvic disruption Small bowel injuries Seatbelt Dural tear

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The LEGUE input catalog for dark night observing in the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第7期12卷 781-791页

作者： Fan Yang Jeffrey L. Carlin Chao Liu Yue-Yang Zhang Shuang Gao Yan Xu Li-Cai Deng Heidi Jo Newberg sebastien Lepine Jin-Liang Hou Xiao-Wei Liu Norbert Christlieb Hao-Tong Zhang Hsu-Tai Lee Kai-Ke Pan Zhan-Wen Han Hong-Chi Wang Key Lab for Optical Astronomy National Astronomical Observatories Chinese Academy ofSciences Beijing 100012 China fyang@*** Graduate University of Chinese Academy of Sciences Beijing 100049 China Department of Physics Applied Physics-and Astronomy Rensselaer Polytechnic Institute 1108th Street Troy NY 12180 USA American Museum of Natural History Central Park West at 79th Street New York NY 10024USA Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Department of Astronomy & Kavli Institute of Astronomy and Astrophysics Peking UniversityBe~iing 100871 China University of Heidelberg Landessternwarte K6nigstuhl 12 D-69117 Heidelberg Germany Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-14 I Taipei 106 China Apache Point Observatory EO. Box 59 Sunspot NM 88349 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China Purple Mountain Observatory Chinese Academy of Sciences Nanjing 2100-08 China

We outline the design of the dark nights portion of the LAMOST Pilot Survey, which began observations in 2011 October. In particular, we focus on Milky Way stellar candidates that are targeted for the LEGUE （LAMOST Experiment for Galactic Understanding and Exploration） survey. We discuss the regions of sky in which spectroscopic candidates were selected, and the motivations for selecting each of these sky areas. Some limitations due to the unique design of the telescope are discussed, including the requirement that a bright （V 〈 8） star be placed at the center of each plate for wavefront sensing and active optics corrections. The target selection categories and scientific goals motivating them are briefly discussed, followed by a detailed overview of how these selection functions were implemented. We illustrate the difference between the overall input catalog - Sloan Digital Sky Survey （SDSS） photometry - and the final targets selected for LAMOST observations.

关键词： surveys: LAMOST -- Galaxy: halo -- techniques: spectroscopic

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新疆西准噶尔萨吾尔地区后碰撞岩浆作用时限研究

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矿物学报 2007年第Z1期27卷 187-188页

作者：周涛发袁峰范裕谭绿贵 David Cooke sebastien Melfre 杨文平何立新合肥工业大学资源与环境工程学院安徽合肥230009 澳大利亚塔斯马尼亚大学优秀矿床研究中心(CODES) 霍巴特新疆地质勘查局第四地质大队新疆阿勒泰836500

　　后碰撞岩浆活动是包括新疆北部地区在内的中亚造山带古生代陆壳增生的重要原因,并对后碰撞成矿作用具有重要影响(王京彬等,2006;Chen等,2005,Sengor等,1993;Jahn等,2000),因此,后碰撞岩浆活动的时限对新疆北部地区后碰撞构造-成矿... 详细信息

　　后碰撞岩浆活动是包括新疆北部地区在内的中亚造山带古生代陆壳增生的重要原因,并对后碰撞成矿作用具有重要影响(王京彬等,2006;Chen等,2005,Sengor等,1993;Jahn等,2000),因此,后碰撞岩浆活动的时限对新疆北部地区后碰撞构造-成矿作用研究具有重要意义.西准噶尔萨吾尔地区位于哈萨克斯坦一准噶尔板块北缘(何国琦等,1995),区内广泛发育晚古生代岩浆岩.本文将讨论西准噶尔萨吾尔地区后碰撞岩浆作用的时限.……

关键词：新疆西准噶尔萨吾尔地区碰撞岩浆作用后碰撞岩浆活动成矿作用北部地区晚古生代中亚造山带哈萨克斯坦时限碰撞构造碰撞成矿陆壳增生岩浆岩用具区位发育板块

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Popliteal Venous Pseudoaneurysm and Arteriovenous Fistula after Orthopedic Surgery

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World Journal of Cardiovascular Surgery 2013年第1期3卷 1-7页

作者： Bertrand Saint-Lebes Emilie Chastonay Olivier Borens Celine Dubuis sebastien Deglise Francois Saucy Herve Rousseau Jean-Marc Corpataux Department of Thoracic and Vascular Surgery Lausanne University HospitalLausanneSwitzerland Department of Orthopaedic and Trauma Surgery Lausanne University HospitalLausanneSwitzerland Department of Vascular Interventional Radiology University HospitalToulouseFrance

Arthroscopically assisted reconstruction of the anterior cruciate ligament (LCA) is generally a safe and effective procedure with a low rate of vascular complications. We report on a case of a 33-year-old woman with a combined arteriovenous fistula (AVF) and venous popliteal aneurysm that developed 6 months after arthroscopic anterior cruciate ligament reconstruction. At clinical exam the patient presented with left popliteal and calf pain, a tender pulsatile mass posterior to her left knee, popliteal bruit and a thrill at the popliteal fossa. CT scan showed an AVF arising from the left popliteal artery. An aneurysm was seen to fill at the same time as the popliteal vein. Findings at open surgical revision included AVF between the tibioperoneal trunk and the popliteal vein and a venous popliteal aneurysm at the level of the arteriovenous communication. The aneurysm and fistula were repaired. The patient had an uneventful follow up with complete recovery. We also report an endovascular treatment of a iatrogenic arterio-venous fistula.

关键词： Arthroscopy Complication Arteriovenous Fistula Anterior Cruciate Ligament Venous Aneurysm

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Non-Invasive Second Harmonic Generation (SHG) in Macroscopy (MacroSHG) as Bio-Diagnosis to Image Collagen Network Organization in Extracellular Matrix

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Engineering（科研） 2014年第8期6卷 485-490页

作者： Dominique Dumas Elisabeth Werkmeister sebastien Hupont Céline Huselstein Natalia De Isla Marthe Rousseau Patrick Menu Didier Mainard Ingénierie Moléculaire et Thérapeutique (CNRS FR 3209) Plate Forme d’Imagerie Cellulaire et Tissulaire PTIBC-IBISA NANCY Nancy France Plate-Forme Microscopie-Imagerie-Cytométrie du campus Pasteur Lille (MICPaL) IFR 142 Institut Pasteur de Lille Institut de Biologie de Lille Lille France Universite de Lorraine Physiopathologie Pharmacologie et Ingénierie Articulaires (IMOPA CNRS 7365) Nancy France Universite de Lorraine Physiopathologie Pharmacologie et Ingénierie Articulaires (IMOPA CNRS 7365) Nancy France Ingénierie Moléculaire et Thérapeutique (CNRS FR 3209) Plate Forme d’Imagerie Cellulaire et Tissulaire PTIBC-IBISA NANCY Nancy France

In this work, we have considered a new multimodality imaging for macroscopy based on Second Harmonic Generation (SHG) method to monitor invasivelessly the matrix collagen. As the triple helicoidally structure of collagen molecules appearing as not centrosymetric, very organized and spatially oriented, collagen fibrils give rise to a very strong SHG signal and can be imaged without any exogenous dye. To integrate a multidimensional scale with a large field of view (non-sliced samples), we have adapted and validated an instrumental coupling between a two photon excitation laser and a macroscope to collect cartography of SHG signal. We introduced an index (F-SHG) based on decay time response measured by TCSPC for respectively Fluorescence (F) and Second Harmonic Generation (SHG) values. For various sample where protein collagen is the major component of extracellular matrix (vessel, skin, carotide vessel, rat femoral head cartilage, mouse tumor, human wharton’s jelly and rat tendon) or not (nacre), we compared the index distribution obtained with MacroSHG. In this work, we showed for the first time that multiscale large field imaging (Macroscopy) combined to Multimodality approaches (SHG-TCSPC) could be an innovative and non-invasive technique to detect and identify some biological interest molecules (collagen) in biomedical topics.

关键词： Multiphoton Macroscopy Second Harmonic Generation Collagen Extracellular Matrix

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法国学者看中国与中亚军事合作 014

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世界报

作者： sebastien Peyrouse 叶子

编者按在短短几年内，中国便成为了中亚国家不可或缺的经济合作伙伴，甚至有望超越俄罗斯:2008年，中国与中亚地区的贸易额超过25亿美元，而俄罗斯与中亚的贸易额则为27亿美元。在安全方面，中国政府一直在努力维持其与哈萨克斯坦、吉...

编者按在短短几年内，中国便成为了中亚国家不可或缺的经济合作伙伴，甚至有望超越俄罗斯:2008年，中国与中亚地区的贸易额超过25亿美元，而俄罗斯与中亚的贸易额则为27亿美元。在安全方面，中国政府一直在努力维持其与哈萨克斯坦、吉尔吉斯斯坦和塔吉克斯坦之间边境沿线的安全

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The Protection against Lightning of an Overhead Line Uprated from 225 kV to 400 kV

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Journal of Energy and Power Engineering 2012年第2期6卷 267-275页

作者： Alain Xemard sebastien Dennetiere Ivo Uglesic Viktor Milardic Bosko Milesevic Philippe Grand Frangois Sauvegrain Pierre Stevenin Miroslav Mesic Electricity of France Research Division Clamart 92141 France Reseau Transport ElectricitY Transmission System Operator La Defense 92919 France Faculty of Electrical Engineering and Computing University of Zagreb Zagreb 10000 Croatia HEP Transmission System Operator Zagreb 10000 Croatia

The voltage uprating of existing overhead lines is an interesting solution for increasing the transmission of electricity, especially in areas where it is difficult to build new lines. If a line is uprated with minor changes of its design and without improvement of the grounding electrodes of towers, its lightning performance remains unchanged. The consequence is that the uprated line will have a lightning flashover rate very high compared to an overhead line of same nominal voltage but of standard design. One attractive solution to solve this problem is to use line arresters. The goal of this paper is to study the use of line arresters to achieve a satisfactory lightning performance of an overhead line uprated from 225 kV to 400 kV without major design modifications. In order to compare different strategies of line arrester installation the flashover rate is calculated based on a software able to launch automatically EMTP-RV. The software named LIPS has been developed under the cover of a partnership between Hydro-Quebec, RTE and EDF.

关键词： Lightning transmission line voltage uprating insulation coordination.

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东天山自然铜矿化区火山岩的年代学

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矿物学报 2007年第Z1期27卷 118-119页

作者：袁峰周涛发范裕谭绿贵 David Cooke sebastien Meffre 王庆民王卫江合肥工业大学学艺术资源与环境工程学院安徽合肥230009 澳大利亚塔斯马尼亚大学优秀矿床研究中心(CODES) 霍巴特新疆维吾尔自治区地质调查院新疆乌鲁木齐830000

　　近年来在东天山十里坡、黑龙峰、长城山、东尖峰一带相继发现了与玄武岩有关的自然铜矿化这一新矿化类型(董连慧等,2003),并已有一定程度的研究(崔彬等,2006;袁峰等,2006,2007).关于自然铜的成矿作用,一般认为与溢流玄武岩关系密切... 详细信息

　　近年来在东天山十里坡、黑龙峰、长城山、东尖峰一带相继发现了与玄武岩有关的自然铜矿化这一新矿化类型(董连慧等,2003),并已有一定程度的研究(崔彬等,2006;袁峰等,2006,2007).关于自然铜的成矿作用,一般认为与溢流玄武岩关系密切(朱炳泉,2003;White和Mck-enzie,1995),玄武岩的形成时代、形成机制、岩浆演化等对自然铜的成矿作用有重要的制约(Zhu等,2003;Puschner,2001).本文重点对东天山自然铜矿化区进行火山岩年代学研究.……

关键词：东天山自然铜矿化矿化区火山岩溢流玄武岩成矿作用年代学研究岩浆演化形成时代形成机制矿化类型制约尖峰继发程度长城

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硫酸装置一吸塔热量管理

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硫酸工业 2013年第1期 50-52页

作者：瑾奥图泰公司

论述了为提高硫酸装置总工艺效率而提出的一吸塔热量管理设计方案。以常规水冷却器为基准,对空气冷却器、磷酸浓缩器、HEROS热回收系统和HIPROS热回收系统等4种方案进行了比较。指出由于各个装置的生产情况不尽相同,需要根据每位客户的... 详细信息

论述了为提高硫酸装置总工艺效率而提出的一吸塔热量管理设计方案。以常规水冷却器为基准,对空气冷却器、磷酸浓缩器、HEROS热回收系统和HIPROS热回收系统等4种方案进行了比较。指出由于各个装置的生产情况不尽相同,需要根据每位客户的需求对设计概念进行细微的调整,得出环境最合理,因而也是经济最合理的解决方案。

关键词：硫酸装置一吸塔热量管理解决方案

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