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Poor performance of anti-mitochondrial antibodies for the diagnosis of primary biliary cholangitis in female Colombian patients:A singlecenter study

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World Journal of Gastroenterology 2021年第29期27卷 4890-4899页

作者： Valentina Guatibonza-García Paula Valentina Gaete Agustín Pérez-Londoño Danna Kathalina Puerto-Baracaldo sebastián Antonio gutiérrez-Romero Carlos O Mendivil Monica Tapias School of Medicine Universidad de los AndesBogotá110111Colombia Section of Endocrinology Department of Internal MedicineFundación Santa Fe de BogotáBogotá110111Colombia Department of Hepatology Fundación Santa Fe de BogotáBogotá110111Colombia

BACKGROUnD Primary biliary cholangitis(PBC)is a serious disease that causes significant *** is confirmed with liver biopsy but autoantibodies are frequently used as proxies for *** performance of autoantibodies for the diagnosis of PBC seems to vary widely across *** To assess the diagnostic performance of several autoantibodies for the diagnosis of PBC in Latin American *** We studied 85 female adult Colombians,43 cases with biopsy-confirmed PBC and 42 controls in whom a liver biopsy ruled out *** anti-mitochondrial antibodies(AMAs),anti-smooth muscle antibodies(ASMAs)and anti-nuclear antibodies(AnAs),as well as total immunoglobulin(Ig)M and IgG were determined using immunofluorescence or enzyme-linked immunosorbent assay in all study participants within 1 year of the *** all variables,values analyzed were those closest to the date of the *** with viral or alcoholic hepatitis were *** Mean age at diagnosis was 58.7 years for cases and 56.9 years for controls,and the body mass index was lower among *** cases received ursodeoxycholic acid,while most controls received vitamin ***ögren syndrome and Hashimoto’s thyroiditis were the most frequent autoimmune comorbidities of *** prevalence of AMA positivity among PBC cases was unexpectedly *** sensitivity and specificity values were respectively 44.2%and 76.2%for AMA,74.4%and 38.1%for AnA,14.0%and 73.8%for ASMA,26.7%and 80.0%for IgG,and 57.1%and 85.7%for *** combination of positive AMA plus positive IgM had 91%positive predictive value for *** AMA-negative cases,the most prevalent antibodies were AnA(87.5%).In all,62%of AMA-positive and 84.6%of IgM-positive individuals had fibrosis in their *** AMA positivity was very low among female Latin American patients with *** performance of all antibodies was quite *** results highlight the urgent need for better PBC biomarkers.

关键词： Primary biliary cholangitis Antibodies Anti-mitochondrial antibodies Latin America Anti-smooth muscle antibodies

Output feedback adaptive super twisting sliding mode control for quadrotor UAVs

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Control Theory and Technology 2024年第1期22卷 92-105页

作者： Oscar Salas-Peña Jesus DeLeón-Morales Susana V.gutiérrez-Martínez École Centrale de nantes-LS2n UMR 6004 CNRS44300NantesFrance Facultad de Ingeniería Mecánica y Eléctrica Universidad Autónoma de Nuevo León66451San Nicolás de Los GarzaMexico

In this paper, a sliding mode control with adaptive gain combined with a high-order sliding mode observer to solve the tracking problem for a quadrotor UAV is addressed, in presence of bounded external disturbances and parametric uncertainties. The high order sliding mode observer is designed for estimating the linear and angular speed in order to implement the proposed scheme. Furthermore, a Lyapunov function is introduced to design the controller with the adaptation law, whereas an analysis of finite time convergence towards to zero is provided, where sufficient conditions are obtained. Regarding previous works from literature, one important advantage of proposed strategy is that the gains of control are parameterized in terms of only one adaptive parameter, which reduces the control effort by avoiding gain overestimation. numerical simulations for tracking control of the quadrotor are given to show the performance of proposed adaptive control–observer scheme.

关键词： Adaptive super twisting controller High-order sliding modes observer UAV

Single atom Cu-n-C catalysts for the electro-reduction of CO_(2) to CO assessed by rotating ring-disc electrode

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Journal of Energy Chemistry 2024年第1期88卷 169-182,I0004页

作者： S.Pérez-Rodríguez M.gutiérrez-Roa C.Giménez-Rubio D.Ríos-Ruiz P.Arévalo-Cid M.V.Martínez-Huerta A.Zitolo M.J.Lázaro D.sebastián Instituto de Carboquímica(CSIC) Miguel Luesma Castán 450018 ZaragozaSpain Instituto de Catálisis y Petroleoquímica(CSIC) Marie Curie 228049 MadridSpain Synchrotron SOLEIL L’Orme des MerisiersDépartementale 12891190France

The electrochemical CO_(2) reduction reaction(CO_(2)RR) to controllable chemicals is considered as a promising pathway to store intermittent renewable energy. Herein, a set of catalysts based on copper-nitrogendoped carbon xerogel(Cu-n-C) are successfully developed varying the copper amount and the nature of the copper precursor, for the efficient CO_(2)RR. The electrocatalytic performance of Cu-n-C materials is assessed by a rotating ring-disc electrode(RRDE), technique still rarely explored for CO_(2)RR. For comparison, products are also characterized by online gas chromatography in a H-cell. The as-synthesized Cu-nC catalysts are found to be active and highly CO selective at low overpotentials(from -0.6 to -0.8 V ***) in 0.1 M KHCO_(3), while H_(2) from the competitive water reduction appears at larger overpotentials(-0.9 V vs. RHE). The optimum copper acetate-derived catalyst containing Cu-n_(4) moieties exhibits a CO_(2)-to-CO turnover frequency of 997 h^(-1) at -0.9 V vs. RHE with a H_(2)/CO ratio of 1.8. These results demonstrate that RRDE configuration can be used as a feasible approach for identifying electrolysis products from CO_(2)RR.

关键词： Cu-n-C Carbon xerogel Rotating ring disc electrode Carbon dioxide reduction reaction Carbon monoxide

Metal-modulated epitaxy of Mg-doped Al_(0.80)In_(0.20)n-based layer for application as the electron blocking layer in deep ultraviolet light-emitting diodes

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Journal of Semiconductors 2024年第5期45卷 80-89页

作者： Horacio Irán Solís-Cisneros Carlos Alberto Hernández-gutiérrez Enrique Campos-González Máximo López-López Optomechatronics Group Tecnológico Nacional de México Campus Tuxtla Gutiérrezcarretera Panamericana 1080C.P.29050Tuxtla GutiérrezChiapasMéxico Departamento de Física Instituto Nacional de Investigaciones NuclearesCarretera México-Toluca s/nC.P.52750La Marquesa OcoyoacacMéxico Departamento de Física Centro de Investigación y estudios Avanzados del Instituto Politécnico NacionalAv.Instituto Politécnico Nacional 2508San Pedro ZacatencoGustavo A.Madero07360 Ciudad de MéxicoCDMXMéxico

This work reports the growth and characterization of p-AlInn layers doped with Mg by plasma-assisted molecular beam epitaxy(PAMBE).AlInn was grown with an Al molar fraction of 0.80 by metal-modulated epitaxy(MME)with a thickness of 180 nm on Si(111)substrates using Aln as buffer *** substrate temperatures were used to enhance the incorporation of indium atoms into the alloy without clustering,as confirmed by X-ray diffraction(XRD).Cathodoluminescence measurements revealed ultraviolet(UV)range ***,Hall effect measurements indicated a maximum hole mobility of 146 cm^(2)/(V∙s),corresponding to a free hole concentration of 1.23×10^(19)cm^(−3).The samples were analyzed by X-ray photoelectron spectroscopy(XPS)estimating the alloy composition and extracting the Fermi level by valence band ***-doped AlInn layers were studied for use as the electron-blocking layer(EBL)in LED *** varied the Al composition in the EBL from 0.84 to 0.96 molar fraction to assess its theoretical effects on electroluminescence,carrier concentration,and electric field,using SILVACO *** results from this study highlight the importance and capability of producing high-quality Mg-doped p-AlInn layers through *** simulations suggest that an Al content of 0.86 is optimal for achieving desired outcomes in electroluminescence,carrier concentration,and electric field.

关键词： metal-modulated epitaxy AlInn DUV-LED EBL simulation

The Effect of Water and Salt Stress on Paspalum dilatatum,a Constituent of Pampas natural Grasslands

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2009-2018页

作者： Claudia A.Porcelli Gerardo Rubio Flavio H.gutiérrez Boem Raul S.Lavado Departamento de Química Facultad de AgronomíaUniversidad de Buenos AiresBuenos AiresC1417DSEArgentina Instituto de Investigaciones en Biociencias Agricolas y Ambientales(InBA) Facultad de AgronomíaUniversidad de Buenos AiresBuenos AiresC1417DSEArgentina

The effects of the salt stress on plant growth are usually increased by the water *** studied the impact of both stresses in simultaneous pulses of drought and salinity on Paspalum *** forage species is native to South America,spread in grasslands in many tropical,subtropical,and temperate areas of the world,and very common in grasslands of the Flooding Pampas of *** what happens in *** compared a pot experiment,a non-stressed control against water stress for a month(midpoint between field capacity and wilting point),and two saline stresses(moderate,6 d·Sm^(−1)and strong,12 d·Sm^(−1)),also for a *** biomass(green leaf;non-leaf green material,and dry material)and roots were harvested,weighed,and analyzed for nitrogen,phosphorus,and *** biomass of all components significantly decreased when both stresses were *** plus strong saline stress reduced by half the total biomasses,compared to the *** proportion of aerial biomass/root biomass ratio as well as aerial green component/dry materials ratio tend to decrease when subjected to both *** concentration in plants was not significantly affected,but phosphorus concentration increased in aerial biomass components,from 0.10 to 0.18 mg·kg^(−1)between the extreme treatments,but did not change in *** concentration in plants increased(i.e.,in green leave sodium(na)increased from 0.27 to 2.01 mg·kg^(−1)between the extreme treatments),whereas other cations either did not change or decreased,affecting the ratios between *** performance allows us to infer that the na accumulation of *** behaves in an intermediate range,compared to very tolerant to salts or non-salt tolerant species of the Paspalum *** agreement,when salts were applied in the form of a pulse,*** tolerated higher salinity than that found by other authors for the same species,using continuous salinity.

关键词： Dallis grass salinity drought sodium in plants phosphorus in plants potassium/sodium ratio

A review on the parasitic isopod genus notophryxus ***,1883(Crustacea:Isopoda),and first report of notophryxus globularis ***,1885 from Lakshadweep Sea(Amini Island)

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Acta Oceanologica Sinica 2024年第8期43卷 142-153页

作者： Mukkattu nazar Suhaana Jaime Gómez-gutiérrez Paravanparambil Rajakumar Jayachandran Punnakkal Hari Praved Sivasankaran Bijoy nandan Department of Marine Biology Microbiology and BiochemistrySchool of Marine SciencesCochin University of Science and TechnologyKochi-Kerala 682016India Departamento de Plancton y Ecología Marina Centro Interdisciplinario de Ciencias MarinasInstituto Politécnico NacionalLa Paz B.C.S.23096Mexico Applied Research Centre for Environment and Marine Studies King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Isopod crustaceans of the family Dajidae are exclusively marine *** genus notophryxus ***,1883 currently includes nine nominal species,which are very rarely reported as the chances for encountering these specimens are *** comprehension of the taxonomy,biology,ecology,and life cycle of species belonging to the notophryxus genus is notably *** nominal species of notophryxus genus are reviewed here to obtain a comprehensive and integrative taxonomic understanding of this genus,in an attempt to address the *** paper also documents the rediscovery of an ectoparasitic isopod from the genus notophryxus in Indian waters,after 55 *** isopod specimens obtained from the outer reefs of Amini Island in the Lakshadweep archipelago,Southeastern Arabian Sea,display morphological congruence to notophryxus globularis ***,*** only previous report on this species dates back to 1885 from ***'description of *** as an ectoparasite on the euphausiid Thysanoessa gregaria ***,1883 in the north *** discovery represents a range extension of *** from the north Pacific to the Arabian *** cryptoniscid larvae and three adult females of ***(with dwarf males)were found attached to four adult mysid specimens of Siriella aequiremis Hansen,*** present study provides an improved diagnosis of *** with the aid of light microscopy images and line drawings which was not given in the original ***,1885 *** research also provides a concise description of cryptoniscid larvae from the same sampling location and same host which is most likely to be *** larvae.

关键词： Dajiidae Mysid cryptoniscan larvae Southeastern Arabian Sea notophryxus

Roller Screw and Threaded Chain Speed Reducer: An Experimental Evaluation

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Modern Mechanical Engineering 2024年第1期14卷 1-11页

作者： Filiberto gutiérrez Instituto de Ingeniería Universidad Nacional Autónoma de México Mexico City Mexico

We are developing a speed reducer that can be considered a transformation of a worm gear reducer: the worm is replaced by an inverted roller screw, and the gear is replaced by a threaded chain drive. This configuration lessens wear, increases load capacity, and improves efficiency. The threaded chain consists of nut-shaped links. This paper presents the results of tests carried out on a prototype with a reduction ratio of 46.

关键词： Speed Reducer Inverted Roller Screw Chain Drive Threaded Chain Drive

THE SUMERIAn TERM u_(8)/ud_(5)/ab_(2)/eme_(3)/_(6)sila_(4)/maš_(2)/amar du_(3)(-a)

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Journal of Ancient Civilizations 2024年第1期39卷 1-28,123页

作者： Marcos Such-gutiérrez Facultad de Filosofía y Letras Universidad Autónoma de Madrid

The aim of the present article is twofold:firstly,to prove that the expression animal+young du_(3)(-a),which is basically documented in texts from the 3rd millennium BC,refers to a dam that has just given birth,and se... 详细信息

关键词： 3rd millennium BC female animal+young du_(3)(-a) livestock newborn suckling animal UrⅢperiod

Omics-based biomarkers as useful tools in metabolic dysfunctionassociated steatotic liver disease clinical practice:How far are we?

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World Journal of Gastroenterology 2024年第14期30卷 1982-1989页

作者： Julieta Trinks María F Mascardi Adrián Gadano sebastián Marciano Instituto de Medicina Traslacional e Ingeniería Biomédica-Consejo nacional de Investigaciones Científicas y Técnicas-Instituto Universitario del Hospital Italiano-Hospital Italiano de Buenos Aires Ciudad Autónoma de Buenos Aires C1199ACLArgentina Consejo nacional de Investigaciones Científicas y Técnicas Ciudad Autónoma de Buenos Aires C1425FQBArgentina Liver Unit Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina Department of Research Hospital Italiano de Buenos AiresCiudad Autónoma de Buenos Aires C1199DFArgentina

Unmet needs exist in metabolic dysfunction-associated steatotic liver disease(MASLD)risk *** ability to identify patients with MASLD with advanced fibrosis and at higher risk for adverse outcomes is still *** novel biomarkers could represent a meaningful improvement to current risk *** this aim,omics technologies have revolutionized the process of MASLD biomarker discovery over the past *** the research in this field is thriving,much of the publication has been haphazard,often using single-omics data and specimen sets of convenience,with many identified candidate biomarkers but lacking clinical validation and *** we incorporate these biomarkers to direct patients’management,it should be considered that the roadmap for translating a newly discovered omics-based signature to an actual,analytically valid test useful in MASLD clinical practice is rigorous and,therefore,not easily *** article presents an overview of this area’s current state,the conceivable opportunities and challenges of omics-based laboratory diagnostics,and a roadmap for improving MASLD biomarker research.

关键词： Metabolic dysfunction-associated steatotic liver disease non-alcoholic steatohepatitis Biomarker Risk stratification Omics