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山脚下的慢时光萨拉戈萨EA住宅

室内设计与装修 2023年第8期 70-75页

作者： [西班牙]Sergio sebastián Franco 沙漏(编译) 不详

西班牙小镇利塔卡郊区的这栋住宅展现了建筑与周围环境的完美融合。它沿着一片纵向的地块延伸,向西望去,能够眺望壮丽的蒙卡约山。这条山脉不仅定义了该地区的美丽景观,还塑造了这片区域自然公园的特色。住宅在山脉和小镇之间建立了一... 详细信息

西班牙小镇利塔卡郊区的这栋住宅展现了建筑与周围环境的完美融合。它沿着一片纵向的地块延伸,向西望去,能够眺望壮丽的蒙卡约山。这条山脉不仅定义了该地区的美丽景观,还塑造了这片区域自然公园的特色。住宅在山脉和小镇之间建立了一种特殊的视觉关系,仿佛在进行一场富有诗意的对话。

关键词：周围环境萨拉戈萨住宅诗意的对话完美融合西班牙山脉

Computational Thermo-Fluid Dynamic Simulation of a Radiant Off-Gases Cooling System for Copper Smelting in a Pierce Smith Converter

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International Journal of Modern Nonlinear Theory and Application 2014年第5期3卷 236-247页

作者： Yerko Aguilera-Carvajal sebastián Pérez-Cortés Juan Hurtado-Cruz Erick Morales-Quezada Faculty of Engineering University of Santiago Santiago Chile ESSS Chile Santiago Chile

In copper sulfide concentrates smelting, the off-gases from the Pierce Smith converter (PSC) furnace must be treated to prevent environmental impacts as they are highly corrosive and toxic. The purpose of this research project is to present a methodology for the simulation of a capture and cooling system of the smelting off-gases from a Pierce Smith copper converter, using computational fluid dynamics. Through this methodology, it is possible to obtain a simulation model of the smelting off-gases behavior with an average error of 9.88%. Basically, it demonstrates that the simulated tendencies of the metallurgical off-gases on the cooling hood and chamber can be reliable to predict the thermo-fluid dynamic behavior of the off-gases inside the studied off-gases handling system.

关键词： Capture Hood Radiant Cooling System Copper Sulfide Smelting Off-Gases Computational Fluid Dynamics (CFD) Simulation

Intermediate-advanced hepatocellular carcinoma in Argentina:Treatment and survival analysis

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World Journal of Gastroenterology 2019年第27期25卷 3607-3618页

作者： Federico Pinero sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network(LALREAN) Buenos Aires B1629HJArgentina Hospital Italiano de Buenos Cuidad Autónoma de Buenos AiresBuenos Aires C1424BYEArgentina Hospital Británico Cuidad Autonoma de Buenos AiresBuenos Aires C1280AEBArgentina Hospital G Rawson San Juan 5400Argentina Hospital Aleman Cuidad Autonoma de Buenos AiresBuenos Aires C1280AEBArgentina Sanatorio Allende from Córdoba Córdoba 5016Argentina Centro de Educación Médica e Investigaciones Clínicas“Norberto Quirno”(CEMIC) Ciudad de Buenos Aires 1431Argentina Hospital Udaondo Cuidad Autonoma de Buenos Aires C1264AAAArgentina Hospital Ramos Mejía Ciudad de Buenos Aires C1221ADCArgentina Centro Especialidades Medicas Ambulatorias(CEMA) Mar del PlataBuenos Aires 7600Argentina Clínica de Nefrología Santa Fe 3000Argentina Hospital del Centenario RosarioSanta Fe S2002KDTArgentina

BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of *** To describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic *** This longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or *** Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULTS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage *** median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P < 0.0001), respectively. Among BCLC-B patients(n =135), 57% received TACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with TACE HR =0.29(CI: 0.21-0.40) than those without TACE. After tumor reassessment by RECIST 1.1 criteria following the first TACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after TACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior TACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results we

关键词： Hepatocellular carcinoma Therapeutics Survival Real-life

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厄瓜多尔街道办公楼

设计 2016年第18期29卷 36-37页

作者： Jacob sebastián Crespo

这个项目打破了传统的办公楼模式，它通过增加内部的透明度，让建筑从外面看上去具有一定的渗透感，并在两个重要的部位之间创建出了区域之间的过渡部分。由于地理位置的原因，高速公路就建在了建筑物的前面，而大楼内有着各种不同需求... 详细信息

这个项目打破了传统的办公楼模式，它通过增加内部的透明度，让建筑从外面看上去具有一定的渗透感，并在两个重要的部位之间创建出了区域之间的过渡部分。由于地理位置的原因，高速公路就建在了建筑物的前面，而大楼内有着各种不同需求的空间要求，其中就包括了一个拥有有足够灵活性的大型中央开放空间，这里可以满足各种功能之间的互补要求，贯穿整个建筑，在所有楼层上都打造了一条从北角落到东角落的大道，这也将一个大街区通过一个通透性的天桥连接在了一起。建筑所采用的材料也突出了这种理念：所有外立面覆盖了多孔金属网，这在外部交通和内部活动行为之间产生了一个直接的从视觉到感觉上的转变。这种立面允许自然光线以一种合理的方式进入内部，在结合玻璃幕墙就可以作为一个双壳系统用来过滤自然光和自然热量。

关键词：办公楼厄瓜多尔街道自然光线开放空间建筑物地理位置高速公路

Effect of Hydrogen in Adsorption and Direct Dissociation of CO on Fe (100) Surface: A DFT Study

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American Journal of Analytical Chemistry 2015年第1期6卷 38-46页

作者： sebastián Amaya-Roncancio Daniel Humberto Linares Hélio Anderson Duarte Germán Lener Karim Sapag Department of Physics Applied Physics Institute National University of San Luis San Luis Argentina Department of Chemistry—ICEx Universidade Federal de Minas Gerais Belo Horizonte Brazil

Density functional theory was employed to investigate the effect of the hydrogen in the adsorption and direct dissociation of CO on Fe (100) surface. The preadsorption of hydrogen with coverages of 0, 1/3 and 2/3 monolayer (ML) was used in the present investigation. In the case of 1/3 ML of hydrogen, two configurations of adsorption were studied. The presence of hydrogen shows a major transference of electronic density from Fe surface to CO adsorbed, increasing the adsorption energy of CO from 2.00 eV in clean surface, to 2.76 eV in 2/3 ML of hydrogen. Furthermore, the activation barrier for direct dissociation of CO was 1.13 eV and for the recombination energy 2.28 eV on clean Fe (100) surface. In the same way, the activation barrier for CO in the presence of coadsorbed hydrogen was slightly affected presenting values of 1.06 eV and 1.16 eV to 1/3 ML configurations and 0.98 eV for 2/3 ML of hydrogen. Finally, the recombination energy decreases to 1.63 eV and 1.49 eV for 1/3 ML configurations and to 1.23 eV for 2/3 ML of coadsorbed hydrogen. These results indicate that the CO adsorption and dissociation are favored in the presence of hydrogenated surfaces.

关键词： Adsorption Dissociation Carbon Monoxide Density Functional Calculations Iron

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort

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World Journal of Gastroenterology 2019年第4期25卷 433-446页

作者： Patricia Prieto Rafael I Jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez sebastián Cerdán Miguel ángel Peinado Lisardo Boscá Department of Metabolism and Physiopathology of Inflammatory Diseases Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (Ciber-CV) Instituto de Salud Carlos III (ISCIII) Laboratorio de Imagen Médica Hospital Universitario Gregorio Mara?ón Laboratorio de Proteómica Cardiovascular Centro Nacional de Investigaciones Cardiovasculares (CNIC) Instituto de Investigación Sanitaria del Hospital Universitario la Paz(IdiPaz) Programa de Medicina Predictiva y Personalizada del Cáncer (PMPPC) Fundación Instituto de investigación en ciencias de la salud Germans Trias i PujolCtra Can Ruti

BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in *** To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic *** Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap *** Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PN

关键词： Colon Carcinoma Cyclooxygenase Prostaglandin Proteomics High resolution magic angle spinning

Percentage Change on FDG-PET/CT Predicts Complete Response to Neoadjuvant Radiochemotherapy in Esophageal Cancer

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International Journal of Clinical Medicine 2019年第10期10卷 531-542页

作者： Esther Jimenez-Jimenez Irene Ortiz Neus Aymar Raquel Roncero Pedro Mateos Marta Gimenez Jose Pardo sebastià Sabater Radiation Oncology Department Complejo Hospitalario Universitario de Albacete Spain Radiation Oncology Department Hospital Universitari Son Espases Palma de Mallorca Spain Medical Physics Department Hospital Universitari Son Espases Palma de Mallorca Spain Nuclear Medicine Department Hospital Universitari Son Espases Palma de Mallorca Spain.

Objective: We evaluated whether the changes in FDG-PET/CT uptake between pre/and post-treatment might predict a complete response in esophageal cancer (EC). Patients and Methods: Fifty-six patients with 2 PET-CTs studies were evaluated retrospectively. Images were evaluated qualitatively and semiquantitatively (SUVs). Patients were classified as persistence of disease, complete metabolic response and unspecific FDG uptake. The SUVmax values and percentages of change in SUV were measured. Results: A significant difference was found between the persistence group and the non-persistence group regarding the median percentage change in SUVtumor (72.95% vs. 54.12%;p = 0.04) and regarding the percentage change in SUVnode (89.91% vs. 59.91%, p = 0.04). In patients treated with radiochemotherapy (RCTX), a significant difference was found between the persistence group and the no persistence group regarding the percentage change in SUVtumor (58.02% vs. 78.59%). Overall survival rate was related to the percentage of change in the SUVtumor. The group of ≥75% of change SUVtumor showed a median survival of 37.32 months (IC: 95% = 49.93 - 24.70) and the group of <75% of change SUVtumor showed a median survival of 18.39 months (IC: 95% = 25.14 - 11.65) (p = 0.04). In patients with metastatic relapse, a significant difference was found regarding the percentage change in SUVnode (94.63% vs. 74.09%). Conclusion: Our study provides evidence that the percentage change in the SUVmax is a predictor of the response to neoadjuvant treatment in patients with EC. When SUVmax decreases by 72.95% or more, the patient is likely a complete responder.

关键词： PET/CT Esophageal Response SUV Percentage

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厄瓜多尔安巴托法院

设计 2017年第8期30卷 30-31页

作者： jacob sebastián crespo(图)

这是厄瓜多尔国家政府司法系统重组的一部分，建设新法院的宗旨是“保证所有公民都有及时的、高效、质量的途径接近正义。”项目是紧急委托建设，这就意味着设计项目的时间被大幅度减少，并且需要对于常规的设计流程进行重新规划。每个... 详细信息

这是厄瓜多尔国家政府司法系统重组的一部分，建设新法院的宗旨是“保证所有公民都有及时的、高效、质量的途径接近正义。”项目是紧急委托建设，这就意味着设计项目的时间被大幅度减少，并且需要对于常规的设计流程进行重新规划。每个建筑都是由独立的承包商完成，并和设计团队没有任何关联。

关键词：厄瓜多尔法院设计项目系统重组设计流程承包商

Molecular Microbial Diagnostic in Lung Transplant Recipients

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Journal of Cancer Therapy 2012年第5期3卷 511-520页

作者： sebastián Méndez-álvarez Gerardo Pulido-Reyes Javier Donate-Correa Arturo Soriano Benítez de Lugo General Surgery Service Hospital Universitario Ntra. Sra. de Candelaria Santa Cruz de Tenerife Spain. Research Unit Hospital Universitario Ntra. Sra. de Candelaria Santa Cruz de Tenerife Spain

The appearing of microbial lineages carrying multiple dangerous loci are results from the extensive use of antibiotics and has brought a huge increase in the infections-derived morbidity and mortality, which is critical in the hospital setting. Etiologic agents of these non easily tractable infections include bacteria, such as the genus Staphylococcus, but also fungi and virus. Alterations in the immune system allow these organisms to invade and affect the functionality of any tissue, organ or system of the human being. Pulmonary infection occurs as result of deficient lung systemic defence mechanisms which could be altered by medical treatments or by environmental factors. The infective agents commonly gain access to the lung by air, but also by blood or lymphatic system. Staphylococcus aureus strains that share antibiotic resistance and virulence factors represent the aetiological agent responsible of many cases of bacterial pneumonia, thoracic surgery postoperative infections, and diverse tissue infections, resulting in significant disease and morbidity in recipient patients after lung transplantation. The control and treatment of Staphylococcus infections, especially methicillin resistant strains, need for developing reliable and rapid methods of detection and characterization of these microorganisms. Nowadays, new insights into the diagnostic and epidemiology of MRSA and other pathogenic staphylococci have been developed employing molecular methods. This has meant an important advance in the diagnostic and treatment plans of such infective bacteria.

关键词： Molecular Microbial Diagnostic Lung Transplant Recipients