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COVID-19 Patient with Multifocal Pneumonia and Respiratory Difficulty Resolved Quickly: Possible Antiviral and Anti-Inflammatory benefits of Quercinex (Nebulized Quercetin-NAC) as Adjuvant

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Advances in Infectious Diseases 2020年第3期10卷 45-55页

作者： Robert Schettig Trevor sears Matthew Klein Ruth Tan-Lim Ronald Matthias Jr. Christopher Aussems Michael Hummel Rory sears Zachary Poteet Daniel Warren John Oertle Dino Prato Envita Medical Center Scottsdale USA

background: SARS-CoV-2 (COVID-19) is a viral pandemic with no current vaccine or effective treatment. Hydroxychloroquine and azithromycin are not without cardiovascular risk or complications, and these treatments can fail to aid in full recovery from COVID-19. As new treatments become approved for the pandemic, an inexpensive, non-toxic, and safe adjunctive therapy is needed. Case Presentation: A 59-year-old male presented with respiratory symptoms. Chest X-ray revealed classic indications of COVID-19 pneumonia. A PCR nasopharyngeal swab test confirmed a COVID-19 infection and hospital doctors prescribed Rocephin, azithromycin, and hydroxychloroquine. The patient was then prescribed Quercinex, a nebulized formula of quercetin-(cyclodextrin) (20 mg/mL) and N-acetylcysteine (100 mg/mL) three times daily for 14 days by physicians at Envita Medical Center for continued COVID-19 respiratory symptoms. Following 30 minutes after each nebulization treatment, the patient experienced immediate deep breathing relief that lasted for multiple hours. Within the following 48 hours after the first treatment, respiratory symptoms continued to diminish and resolve quickly. Finally, post-treatment follow-up chest X-rays revealed no pulmonary fibrosis (scarring) and clear lung fields. Conclusion: The Quercinex formula appeared to greatly alleviate the unresolved respiratory symptoms rapidly. Several mechanisms of the formula, namely antiviral and anti-inflammatory action, with direct administration via nebulizer to the deep lung tissue, could potentially explain the fast and complete recovery. We recommend that the Quercinex formula be considered for further clinical study as an adjuvant or on its own for COVID-19 and possibly other viral pulmonary conditions.

关键词： Quercetin N-Acetylcysteine (NAC) SARS-CoV-2 (COVID-19) Quercinex Envita Zinc Pneumonia Case Study Severe Acute Respiratory Syndrome Flavonoid Lung Antiviral Human

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物理学第1-3册第1版

物理学第1-3册

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1952年

作者： F.W.sears 吴逸瀚赵富鑫合译

物理学第1-3册

ISBN: (纸本)13055·14

物理学第1-3册

关键词：数理科学和化学物理学

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Comparison of intravitreal ranibizumab and bevacizumab for the treatment of macular edema secondary to retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 86-91页

作者： Alex Yuan baseer U.Ahmad David Xu Rishi P.Singh Peter K.Kaiser Daniel F.Martin Jonathan E.sears Andrew P.Schachat Justis P.Ehlers Vitreoretinal Service Cole Eye InstituteCleveland Clinic The Retina Institute

AIMTo compare the efficacy of ranibizumab and bevacizumab for macular edema due to retinal vein occlusion (RVO).

关键词： macular edema retinal vein occlusion bevacizumab ranibizumab optical coherence tomography

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新生儿回家了

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丛书名：小宝贝0～3岁系列

2003年

作者：（美）威廉·西尔斯（William sears）（美）玛莎·西尔斯（Martha sears）林增祥译

本书作者以其行医二十多年的经验，亲身照顾8个孩子的体验，从专业的角度，叙述在宝宝的成长过程中，新手父母必须注意的点点滴滴。

ISBN: (纸本)7534118484

本书作者以其行医二十多年的经验，亲身照顾8个孩子的体验，从专业的角度，叙述在宝宝的成长过程中，新手父母必须注意的点点滴滴。

关键词：婴幼儿哺育

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教养难带宝宝百科养育0-5岁高需求孩子的必备知识

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丛书名：新手父母

2003年

作者：（美）威廉·西尔斯（William sears）（美）玛莎·西尔斯（Martha sears）刘清彦译

本书语言生动，通俗易懂，讲述了有效安抚哭闹孩童的创意方法，宝宝的催眠方法，宝宝的有效喂食方法，找出婴儿哭闹原因，难教养孩子的有效管教方法等。

ISBN: (纸本)781036538X

关键词：婴幼儿学科:保健学科:基本知识学科:家庭教育保健家庭教育

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Omega-3 EPA/DHA对孕妇,儿童和婴幼儿的重要性

Omega-3 EPA/DHA对孕妇,儿童和婴幼儿的重要性

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2010膳食脂肪酸与健康学术研讨会

作者： William sears

＜正＞～～

关键词：

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西尔斯亲密育儿经

西尔斯亲密育儿经

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作者： (美)威廉·西尔斯(William sears)，(美)玛莎·西尔斯(Martha sears)

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A systematic review on embodiment and breast reconstruction:a patient-centered framework for evolving breast outcome measures

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Plastic and Aesthetic Research 2023年第1期10卷 783-796页

作者： Madeline G.Chin Sahand C.Eftekari Steven P.Moura D’Andrea T.Donnelly Ellen C.Shaffrey Lucas sears Aaron M.Dingle Division of Plastic Surgery The Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53705USA

Embodiment describes the sense of one’s own body,encompassing dimensions of being,having,and using a *** breast reconstruction,embodiment can be understood as how effectively the reconstructed breast replaces the patient’s missing *** there has been increasing attention in recent decades on understanding and measuring embodiment in the prosthetic limb,there is limited literature applying embodiment to the context of breast *** posit that the literature on prosthetic embodiment can be applied to evolving discussions on breast reconstruction outcomes and patient *** breast reconstruction techniques continue to evolve,such as advances in nerve coaptation and reinnervation of the breasts,the concept of embodiment may help broaden the scope of how patient outcomes can be more holistically *** systematic review examines existing literature on embodiment after breast reconstruction,summarizes embodiment and its subcomponents,and discusses how embodiment can be a helpful framework for the future of breast reconstruction outcome measures.

关键词： Embodiment breast reconstruction prosthetic embodiment

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Item-Level Analysis of the Revised Occupational Therapy Fieldwork Performance Evaluation Applied in Practice

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Open Journal of Therapy and Rehabilitation 2024年第2期12卷 145-159页

作者： Cynthia L. sears brad E. Egan Patricia F. Tomsic Craig A. Velozo Graduate College of Health Professions Occupational Therapy Program Hawai&#8217i Pacific University Honolulu HI USA College of Science and Health Occupational Therapy Program DePaul University Chicago IL USA Department of Occupational Therapy Wingate University Wingate NC USA College of Health Professions Department of Rehabilitation Sciences Division of Occupational Therapy Medical University of South Carolina Charleston SC USA

Competency-based assessments for healthcare professionals are critical for safe and effective client outcomes. Rehabilitation clinical skill competency assessments must be validated and revised to produce safe and skilled practitioners. The revised American Occupational Therapy Association (AOTA) Fieldwork Performance Evaluation (FWPE) instrument measures occupational therapy student performance to determine readiness for practice. The assessment includes thirty-seven competencies that address both profession specific clinical skills and general professional behavior skills. The objective of this study was to use Rasch methods to explore the use of the revised FWPE in actual fieldwork practice and to determine the instrument’s psychometric properties when separating the item components into two distinct subdomains: General Health Professions Competences and Occupational Therapy-Specific Competencies. Internal construct validity and test reliability were analyzed using data from 149 occupational therapy students after completing their initial Level II A fieldwork clinical internship. This study examined the item difficulty hierarchy, item fit, person-fit to model, person separation index, person separation reliability coefficient, strata, ceiling and floor effect, and unidimensionality of the FWPE instrument as a whole and as two separate domains. With the exception of not meeting the criteria for unidimensionality, the full FWPE instrument and the Occupational Therapy-Specific Competencies subdomain showed acceptable item-level psychometrics for reliability and precision. While the General Health Professions Competencies subdomain showed good item-level psychometrics, it was below the criterion for reliability and only separated the sample into two strata. Results support the validity, reliability, and clinical use of the revised FWPE full instrument and the Occupational Therapy-Specific Competencies subdomain to measure entry-level clinical skill competencies in pr

关键词： Rehabilitation Competency-based Assessments Occupational Therapy Measurement Rasch Analysis

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Essential neural anatomy for creating a clinically translatable osseointegrated neural interface for prosthetic control in sheep

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Plastic and Aesthetic Research 2023年第1期10卷 600-614页

作者： Kirsten A.Gunderson Scott K.Odorico Zeeda H.Nkana Lucas sears Grant Seils Rashea L.Minor Weifeng Zeng Samuel O.Poore Aaron M.Dingle Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53792USA University of Wisconsin-Madison School of Veterinary Medicine MadisonWI 53706USA

Aim:Ovine models for osseointegrated prosthetics research are well established,but do not consider neural control of advanced *** validity of interfacing technologies,such as the Osseointegrated Neural Interface(ONI),in their ability to provide communication between native nerves and advanced prosthetics is required,necessitating a stable,longitudinal large animal model for *** objective of this study is to provide a detailed anatomic description of the major nerves distal to the carpal and tarsal joints,informing the creation of a chronic ONI for prosthetic control in ***:Six pelvic and six thoracic cadaveric limbs from mature female,non-lactating sheep were *** were obtained to determine average bone length,medullary canal diameter,and cortical bone *** dissection was performed to discern topographical neuroanatomy and average circumferences of the major nerves of the pelvic and thoracic *** analysis was performed.A surgical approach for the creation of ONI was ***:Average metacarpal and metatarsal length was 15.0 cm(±0.0)and 19.7 cm(±1.0),*** intramedullary canal diameter was 12.91 mm(±3.69)for forelimbs and 12.60 mm(±3.69)for *** thoracic limb nerves consisted of one dorsal and three ventral nerves,with an average circumference of 5.14 mm(±2.00)and 5.05 mm(±1.06),*** limb nerves consisted of two dorsal and one ventral nerve with an average circumference of 6.27 mm(±1.79)and 5.40 mm(±0.53),***:These anatomic data inform the surgical approach and manufacture of a sensory ONI for chronic testing in awake,freely ambulating animals for future clinical translation.

关键词： Amputation prosthesis prostheses neural interface clinical translation large animal osseointegration neuroprosthesis

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