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中国妇幼保健 2017年第11期32卷 2432-2435页

作者：王鹤 Ramesh Reddy Ngoc Minh Phuong Nguyen seang l tan Rima Slim 广西医科大学附属肿瘤医院妇瘤科广西南宁530021 麦吉尔大学人类健康中心人类基因部加拿大蒙特利尔魁北克省H4A 3J1 麦吉尔大学人类健康中心妇产科加拿大蒙特利尔魁北克省H4A 3J1

目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显... 详细信息

目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMP15基因的多态性,并采用蛋白功能预测软件预测各SNPs对BMP15蛋白功能的影响。结果在BMP15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.l148P,p.A180T,p.H200Y)和1个插入突变,(***263dup)。通过预测,p.l148P突变可能会严重影响BMP15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNPs对BMP15蛋白功能基本无影响。结论 BMP15基因突变除了可能与RHMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。

关键词：骨形态发生蛋白15 基因多态性 RHMs 习惯性流产

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The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests

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National Science Review 2022年第3期9卷 85-95页

作者： Xiaoming Zhang Qi liu Hui Zhang Shilei Zhao Jiahui Huang Tuot Sovannary long Bunnath Hong seang Aun Ham Samnom Bing Su Hua Chen State Key laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences CAS Key laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences China National Center for Bioinformation School of Future Technology and Sino-Danish College University of Chinese Academy of Sciences Kunming College of life Science University of Chinese Academy of Sciences Department of Geography and land Management Royal University of Phnom Penh Capacity Development Facilitator for Handicap International Federation and Freelance Research

Southeast Asian aborigines, the hunter-gatherer populations living in tropical rainforests, exhibit distinct morphological phenotypes, including short stature, dark skin, curly hair and a wide and snub nose. The underlying genetic architecture and evolutionary mechanism of these phenotypes remain a long-term mystery. We conducted whole genome deep sequencing of 81 Cambodian aborigines from eight ethnic groups. Through a genome-wide scan of selective sweeps, we discovered key genes harboring Cambodian-enriched mutations that may contribute to their phenotypes, including two hair morphogenesis genes(TCHH and TCHHl1), one nasal morphology gene(PAX3) and a set of genes(such as ENTPD1-AS1) associated with short stature. The identified new genes and novel mutations suggest an independent origin of the distinct phenotypes in Cambodian aborigines through parallel evolution, refuting the long-standing argument on the common ancestry of these phenotypes among the worldwide rainforest hunter-gatherers. Notably, our discovery reveals that various types of molecular mechanisms, including antisense transcription and epigenetic regulation, contribute to human morphogenesis, providing novel insights into the genetics of human environmental adaptation.

关键词： Cambodian aborigines environmental adaptation genomic polymorphism morphogenesis parallel evolution positive selection

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Effect of Different Mulching Types on Insect and Disease Infestation and Yield of Onions (Allium cepa l.) in loamy Sand

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Journal of Environmental Science and Engineering(B) 2021年第4期10卷 151-156页

作者： Chanthin Ouk Kim Eang Tho Sophoanrith Ro Samraksa seang Theary leng Penghaing ly Division of Research and Extension Royal University of AgriculturePhnom Penh 120501Cambodia Faculty of Agronomy Royal University of AgriculturePhnom Penh 120501Cambodia

This research was carried out to assess the effect of different varieties and mulching types on insect and disease infestation,and the yield of *** experiment was conducted in Sangkat TuekVil,KrongSiem Reap,in Cambodia.A 2×4 factorial in RCBD(Randomized Complete Blocks Design)was used to layout the trial,in which two varieties(Texas Early Grano 502 PRR and Earth F1)and four mulch types(non-mulch,rice Straw,silver plastic mulching and black plastic mulching)were used as the *** of these treatments was to enhance soil temperature,leaf number plant-1,stand count,bulb diameter,single bulb weight,insect incidence,disease incidence and bulb yield are different to all *** the result,the bulb yields of onions among these treatments were found superior in Texas Early Grano 502 PRR combined with Black Plastic mulch followed by Texas Early Grano 502 PRR combined with silver plastic mulch and Texas Early Grano 502 PRR combined rice straw mulch,whereas the lowest was found in Earth F1combined with non-mulch.

关键词： Onion(Allium cepa l.) mulching infestation disease insect and yield

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Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr luying Yan Keisha Roden David Troilo Chanyi lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan lu Jie Chen Jinhua Bao liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal l. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo liu Fen li Xiaoqing li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. lee Erica G. landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin li Qinglin Xu Hong Zhong Chenglin Pan Weizhong lan Xiaoning li ling Chen Zhikuan Yang Scott A. Read seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun li Guo-Zhong Xu Furong Huang Xiong-li Yang Yong-Mei Zhong Earl l Smith, III Baskar Arumugam li-Fang Hung lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit li Quan liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key laboratory Cultivation Base and Key laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

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