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Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients

Stroke & Vascular Neurology 2022年第2期7卷 124-131页

作者： Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal sean p dukelow Nils Daniel Forkert Biomedical Engineering Graduate program Hotchkiss Brain InstituteUniversity of CalgaryCalgaryAlbertaCanada Department of Radiology Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Hotchkiss Brain Institute University of CalgaryCalgaryAlbertaCanada Department of Clinical Neurosciences University of CalgaryCalgaryAlbertaCanada Department of Electrical and Computer Engineering University of CalgaryCalgaryAlbertaCanada Department of Community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Department of Medicine Cumming School of MedicineUniversity of CalgaryCalgaryAlbertaCanada Alberta Children's Hospital Research Institute University of CalgaryCalgaryABCanada

Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical *** clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to *** far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS ***,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not *** Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCApE *** NIHSS domains were grouped into six categories using two *** was conducted for each category of the two groupings and the total NIHSS *** Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised *** These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging.

关键词： patients score category

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Seasonal changes in Hermit Thrush (Catharus guttatus) song syntax

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Avian Research 2024年第2期15卷 172-179页

作者： sean p.Roach Luke C.McLean Jeff W.MacLeod Leslie S.phillmore psychology Department University of New Brunswick Saint John100 Tucker Park RoadSaint JohnNBCanada Department of psychology and Neuroscience Dalhousie University1355 Oxford StHalifaxNSB3H 4J1Canada

In many songbird species,birdsong features phonological syntax,meaning that the units within their vocal se-quences are ordered in a non-random way that adheres to a *** such syntactical patterns have been richly described in many species,comparatively little is known about how those patterns contribute to song achieving its important *** each of song’s main functions,territorial defense and mate attraction,evidence of a role for syntax is *** species for which syntax has been thoroughly described is the Hermit Thrush(Catharus guttatus),which presents song types from their repertoires in a semi-predictable order and,in doing so,rapidly cycle up and down the frequency *** objective of the present study was to explore the importance of song syntax in the Hermit Thrush through a within-subject examination of how measures of syntax,such as the predictability of song type order within song sequences,shift over the breeding *** hypothesized that,if such syntactical characteristics are important to breeding behaviour,they would be most prominent at the start of the breeding season when activity associated with territory establishment and mate attraction is most *** revealed that,as predicted,the rigidness of song type ordering within se-quences was highest at the start of the season and declined *** song type sequences were most predictable at the vitally important early part of the breeding season fit our hypothesis that this aspect of song syntax is important to song’s functions related to territory establishment and/or mate *** work will clarify whether that role relates to one of song’s two main functions or serves song transmission in some broader way.

关键词： Birdsong Hermit Thrush Seasonal change Stereotypy Syntax

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Subsequent total joint arthroplasty: Are we learning from the first stage?

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World Journal of Orthopedics 2024年第3期15卷 230-237页

作者： Christine Jiang Wu Colin penrose sean patrick Ryan Michael paul Bolognesi Thorsten Markus Seyler Samuel Secord Wellman Department of Orthopaedic Surgery Duke University HospitalDurhamNC 27710United States Department of Orthopaedic Surgery Midwest Center for Joint ReplacementIndianapolisIN 46241United States

BACKGROUND With the increasing incidence of total joint arthroplasty(TJA),there is a desire to reduce peri-operative complications and resource *** degenerative conditions progress in multiple joints,many patients undergo multiple *** To determine if both physicians and patients learn from the patient’s initial arth-roplasty,resulting in improved outcomes following the second *** The institutional database was retrospectively queried for primary total hip arth-roplasty(THA)and total knee arthroplasty(TKA).patients with only unilateral THA or TKA,and patients undergoing same-day bilateral TJA,were *** demographics,comorbidities,and implant sizes were collected at the time of each procedure and patients were stratified by first vs second *** metrics evaluated included operative time,length of stay(LOS),disposition,90-d readmissions and emergency department(ED)*** A total of 642 patients,including 364 undergoing staged bilateral TKA and 278 undergoing bilateral THA,were *** was no significant difference in demographics or comorbidities between the first and second procedure,which were separated by a mean of 285 *** THA and TKA,LOS was significantly less for the second surgery,with 66%of patients having a shorter hospitalization(ppatients had significantly decreased operative time only when the same sized implant was utilized(p=0.025).The vast majority(93.3%)of patients were discharged to the same type of location following their second ***,when a change in disposition was present from the first surgery,patients were significantly more likely to be discharged to home after the second procedure(p=0.033).There was no difference between procedures for post-operative readmissions(p=0.438)or ED visits(p=0.915).CONCLUSION After gaining valuable experience recovering from the initial surgery,a patient’s perioperative outcomes are improved for their second *** may

关键词： Staged total joint arthroplasty Asynchronous total joint arthroplasty Subsequent total joint arthroplasty Contralateral total joint arthroplasty perioperative outcomes

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Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.persson Magnus Ekstrom sean p.Healey Zhiqiang Yang Johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele papucci patrik Ulvdal Hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

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Network analyses:Inhibition of androgen receptor signaling reduces inflammation in the lung through AR-MAF-IL6 signaling axes

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Genes & Diseases 2024年第3期11卷 140-143页

作者： Albert R.Wang Andrew M.Baschnagel Zijian Ni sean R.Brennan Hypatia K.Newton Darya Buehler Christina Kendziorski Randall J.Kimple Gopal lyer Department of Human Oncology University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering University of Wisconsin-MadisonMadisonWI 53705USA University of Wisconsin Carbone Cancer Center MadisonWI 53705USA Department of Biostatistics and Medical Informatics University of Wisconsin-MadisonMadisonWI 53706USA Department of Biology Tufts UniversityMedfordMA 02155USA Department of pathology and Laboratory Medicine University of Wisconsin School of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA

Androgen receptor(AR)is a major transcription factor that plays a role in inflammatory response including interleukin-6(IL6)signaling.1 While AR regulation through paracrine loop signaling in prostate tissue is well-studied,its impact through an IL6 autocrine loop in the lung has not been wellstudied despite the organ's response to respiratory viral *** inhibition and RNA knockdown of AR identified a bZIp transcription factor MAF to be a common target of inflammation using these perturbations in lung cells.

关键词： inflammation lung respiratory

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Smoking cessation prior to elective total joint arthroplasty results in sustained abstinence postoperatively

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World Journal of Orthopedics 2024年第7期15卷 627-634页

作者： Billy Insup Kim Jeffrey O'Donnell Colleen M Wixted Thorsten Markus Seyler William A Jiranek Michael paul Bolognesi sean patrick Ryan Department of Orthopedic Surgery Hospital for Special SurgeryNew YorkNY 10021United States Department of Orthopedic Surgery New York UniversityNew YorkNY 10003United States Department of Orthopedic Surgery Duke University HospitalDurhamNC 27560United States

BACKGROUND Tobacco use is a well-documented modifiable risk factor for perioperative *** To determine the tobacco abstinence rates of patients who made cessation efforts prior to a total joint arthroplasty(TJA)*** A retrospective evaluation was performed on 88 self-reported tobacco users who underwent TJA between 2014-2022 and had tobacco cessation dates within 3 mo of *** patients were contacted via phone survey to understand their tobacco use pattern,and patient reported outcomes.A total of 37 TJA patients *** Our cohort was on average 61-years-old,60%(n=22)women,with an average body mass index of 30 kg/m^(2).The average follow-up time was 2.9±1.9 years.A total of 73.0%(n=27)of patients endorsed complete abstinence from tobacco use prior to *** cessation methods were used perioperatively including prescription therapy(13.5%),over the counter nicotine replacement(18.9%),cessation programs(5.4%).At final follow up,43.2%(n=16)of prior tobacco smokers reported complete *** who were able to maintain cessation postoperatively had improved patient-Reported Outcomes Measurement Information System(pROMIS)-10 mental health scores(49 vs 58;p=0.01),and hip dysfunction and osteoarthritis outcome score for joint replacement(***)scores(63 vs 82;p=0.02).No patients in this cohort had a prosthetic joint infection or required revision *** We report a tobacco cessation rate of 43.2%in patients undergoing elective TJA nearly 3 years *** undergoing TJA who were able to remain abstinent had improved pROMIS-10 mental health scores and *** *** perioperative period provides clinicians a unique opportunity to assist active tobacco smokers with cessation efforts and improve postoperative outcomes.

关键词： Smoking cessation Total joint arthroplasty Outcomes Tobacco use postoperative abstinence

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Effect of operating pressure on the performance of THAI-CApRI in situ combustion and in situ catalytic process for simultaneous thermal and catalytic upgrading of heavy oils and bitumen

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petroleum Research 2022年第2期7卷 155-164页

作者： Muhammad Rabiu Ado Malcolm Greaves sean p.Rigby Department of Chemical Engineering College of EngineeringKing Faisal UniversityP.O.Box:380Al-Ahsa31982Saudi Arabia Department of Chemical and Environmental Engineering University of NottinghamUniversity ParkNottinghamNG72RDUK Department of Chemical Engineering University of BathClaverton DownBathBA27AYUK

According to the analysis of the 2020 estimates of the International Energy Agency(2020),the world will require up to 770 billion barrels of oil from now to ***,based on the British petroleum(Bp)statistical review of world energy 2020,the world-wide total reserve of the conventional light oil is only 520.2 billion barrels as at the end of *** implies that the remaining 249.8 billion barrels of oil urgently needed to ensure a smooth transition to a decarbonised global energy and economic systems is provided must come from unconventional oils(*** oils and bitumen)*** heavy oils and bitumen are very difficult to produce and the current commercial production technologies have poor efficiency and release large quantities of greenhouse ***,these resources should ideally be upgraded and produced using technologies that have greener *** is where the energy-efficient,environmentally friendly,and self-sustaining THAI-CApRI coupled in situ combustion and in situ catalytic upgrading process comes ***,the novel THAI-CApRI process is trialled only once at field and it has not gained wide recognition due to poor understanding of the optimal design parameters and ***,this work reports the first ever results of investigations of the effect of operating pressure on the performance of the THAI-CApRI *** experimental scale numerical models of the process based on Athabasca tar sand properties were run at pressures of 8000 kpa and 500 kpa respectively using CMG *** study has shown that the higher the operating pressure,the larger the ApI gravity and the higher the cumulative volume of high-quality oil is produced(i.e.a 2300 cm3 of z24 oApI oil produced at 8000 kpa versus the 2050 cm3 of z17.5 oApI oil produced at 500 kpa).The study has further shown that despite presence of annular catalyst layer,the THAI-CApRI process operates ***,it is found that a more stable and safer operation of th

关键词： Toe-to-heel air injection(THAI) Enhanced oil recovery(EOR) Reservoir simulation In situ combustion(ISC) Heavy oil/Bitumen/Tar sand In situ catalytic upgrading

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Numerical simulation investigations of the applicability of THAI in situ combustion process in heavy oil reservoirs underlain by bottom water

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petroleum Research 2023年第1期8卷 36-43页

The presence of a bottom water(BW)layer in heavy oil reservoirs can present substantial problems for efficient oil recovery for all recovery ***,it is necessary to know how particular production processes are affected by different BW layer thicknesses,and how standard production procedures can be adapted to handle such ***-to-heel air injection(THAI)is a thermally efficient process,generating in situ energy in the reservoir by burning a fraction of the oil-in-place as coke and has the potential to economically and environmentally friendly work in reservoirs with BW ***,to ascertain that,studies are needed *** are conducted via numerical simulations using commercial reservoir thermal simulator,CMG *** work has shown that the shape of the combustion zone in THAI remains forward-leaning even in the presence of a BW layer,indicating that the process is stable,and that there is no oxygen bypassing of the combustion ***,the oil recovery rate is highly negatively affected by how large the thickness of the BWzone is,and the severity of such effect is determined to be proportional to the thickness of the BW *** study also shows that there is a period of low oil production rate which corresponds to mobilised oil displacement into the BW zone which in turn causes a surge in water production *** practical implication of this is that prolonged period of low oil production rates will expose companies and/or investors to higher risk due to the oil market *** this study,it is also revealed that the height of the mobilised oil that is displaced into the BW zone equates to that of the displaced and replaced water thereby implying that when the BW layer thickness is 50%that of the oil layer(OL),less than 50%of the mobilised oil will be recovered when the entire reservoir is swept by the combustion ***,conclusively,applying the THAI process in its conventional form in reservoirs containing bott

关键词： In situ combustion(ISC) Enhanced oil recovery(EOR) Tar sand/heavy oil/bitumen Reservoir simulation Toe-to-heel air injection(THAI)

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Simulation of catalytic upgrading in CApRI,an add-on process to novel in-situ combustion,THAI

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petroleum Research 2022年第3期7卷 297-307页

作者： Muhammad Rabiu Ado Malcolm Greaves sean pRigby Department of Chemical Engineering College of EngineeringKing Faisal UniversityP.o.Box:380Al-Ahsa31982Saudi Arabia Department of Chemical and Environmental Engineering University of NottinghamUniversity ParkNottinghamNG72RDUK Department of Chemical Engineering University of BathClaverton DownBathBA27AYUK

Based on the analysis of recent projections by the International Energy Agency(IEA),to meet the growing and subsequently declining demands of oil from now to 2040,we need up to around 770 billion barrels of *** the worldwide total proved reserves of easy-and-cheaper-to-produce conventional oils is roughly only 520.2 billion barrels,the remaining 249.8 billion barrels must be obtained from unconventional petroleum resources(*** oils and bitumen).These resources are however very difficult and costly to upgrade and produce due to their inherently high asphaltene contents which are reflected in their very high viscosities and large ***,still they should prove attractive development prospects if,as much as practicably possible,their upgrading can be performed in conjunction with in situ or downhole catalytic upgrading *** projects will contribute significantly towards smoother and greener transition to full *** technologies,such as the toe-to-heel air injection coupled to its add-on in situ catalytic process(***-CApRI processes),have the potential to develop these reserves,but require further developmental understanding to realise their full *** this work,a new detailed procedure for numerically simulating the THAI-CApRI processes is *** numerical model is made-up of Athabasca-type bitumen and it has a horizontal producer(Hp)well that is surrounded by an annular layer of alumina-supported cobalt-oxide-molybdenum-oxide(CoMo/γ-Al2O3)*** simulation is performed using the computer modelling group(CMG)reservoir simulator,*** new work has shown that the choice of the frequency factor of the catalytic reactions allowed model validation based on the degree of catalytic upgrading in form of ApI ***,the work herein identifies the important parameters,such as ApI gravity,peak temperature,oil production rate,cumulative oil production,produced oxygen concentration,temperatur

关键词： Toe-to-heel air injection(THAI) Enhanced oil recovery(EOR) In situ combustion(ISC) Reservoir simulation Heavy oil/tar sand/bitumen In situ catalytic upgrading process(CApRI)

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Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease?

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Neural Regeneration Research 2023年第6期18卷 1213-1219页

作者： Zhengtao Hu Tomas Ondrejcak pengpeng Yu Yangyang Zhang Yin Yang Igor Klyubin sean p.Kennelly Michael J.Rowan Neng-Wei Hu Department of physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Wannan Medical CollegeWuhuAnhui ProvinceChina Department of pharmacology&Therapeutics and Institute of Neuroscience Trinity CollegeDublinIreland Department of Age-Related Healthcare Tallaght University HospitalDublinIreland Department of Medical Gerontology Trinity CollegeDublinIreland

Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology,in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the *** evidence indicates that tau hyperphosphorylation caused by either amyloid-βor long-term depression,a form of synaptic weakening involved in learning and memory,share similar *** from our group and others demonstrate that long-term depression-inducing low-frequency stimulation triggers tau phosphorylation at different residues in the hippocampus under different experimental conditions including ***,certain forms of long-term depression at hippocampal glutamatergic synapses require endogenous tau,in particular,phosphorylation at residue *** the exact mechanisms of interaction between tau and long-term depression may help our understanding of the physiological and pathological functions of tau/tau(hyper)*** first summarize experimental evidence regarding tau-long-term depression interactions,followed by a discussion of possible mechanisms by which this interplay may influence the pathogenesis of Alzheimer’s ***,we conclude with some thoughts and perspectives on future research about these interactions.

关键词： aging Alzheimer’s disease amyloid-β Aβoligomers hippocampus long-term depression long-term potentiation LTD LTp metabotropic glutamate receptor N-methyl-D-aspartate receptor tau hyperphosphorylation tau phosphorylation tau

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