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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

丛书名： Includes CD-ROM

2006年

作者： Boutros sean g. Luce Craig.A. Millman Arthur L. Zide Barry M

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Neural Reg.neration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam sean O’Dowd Antoinette O’Connor Department of Neurolog. Tallaght University HospitalDublinIreland Academic Unit of Neurolog. Trinity College DublinIreland

Introduction:Fluid and positron emission tomog.aphy(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diag.osis of *** evolution of AD diag.ostic criteria to include biolog.cal characterization(Alzheimer’s Association Working.g.oup,2023)provides an appropriate framework to reduce levels of clinico-patholog.c mismatch and improve in-vivo diag.ostic *** the therapeutic landscape for neurodeg.nerative disease evolves,it is increasing.y incumbent on clinicians to provide timely,and patholog.cally precise diag.oses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diag.osis

Direct Air Carbon Capture Takes Baby Steps-g.ant Strides Are Needed sean O’Neill

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Eng.neering 2022年第1期8卷 3-5页

作者： sean O’Neill 机构不详

In September 2021,the world’s larg.st industrial plant to pull carbon dioxide(CO_(2))directly out of the atmosphere officially became operational in *** and built by the Zurich,Switzerland-based company Climeworks,it... 详细信息

关键词： remove store permanent

VOC removal from contaminated g.oundwater throug. membrane pervaporation. (Ⅱ): 1,1,1-trichloroethane-SDS surfactant solution system

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Journal of Environmental Sciences 2003年第6期15卷 821-826页

作者： sean LIU Department of Food Science Rutgers University

The conventional “pump-and-treat' technolog. for subsurface remediation of g.oundwater contaminated with volatile org.nic compounds(VOCs) such as 1,1,1-trichloroethane(TCA), a common chlorinated org.nic solvent, has limitation of prohibitively long.treatment time due to extremely low water solubility of the VOCs. Surfactant-based soil remediation has emerg.d as the effective technolog. that substantially reduces the treatment time. In order to make the whole process economical, the surfactant used in soil washing.has to be recovered and reused. This study examined the recovery of anionic surfactant, sodium dodecyl sulfate(SDS), from soil remediation fluids containing.TCA, using.a bench-scale membrane pervaporation unit. The effects of hig. TCA concentration, surfactant dosag., and flow rate on permeation flux and selectivity(α value) of the process were evaluated. In g.neral, hig.er surfactant concentration yielded lower TCA flux and constant water flux, resulting.in declining.α values; hig.er flow rate of TCA feed stream results in hig.er VOC flux and selectivity, an indication of the effect of concentration polarization; hig.er TCA feed concentration produces hig.er TCA permeation across the membrane, however, the selectivity was virtually unchang.d unless the total TCA concentration exceeded 2000 ppm.

关键词： pervaporation VOCs SDS surfactant g.oundwater remediation 1,1,1-trichloroethane

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XML by example building.E-Commerce applications sean Mcg.ath.

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Call for action:Increased healthcare utilization with g.owing.use of percutaneous cholecystectomy tube over initial cholecystectomy in cirrhotics

1998年

作者： sean Mcg.ath.

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 56-62页

作者： Srikanth Vedachalam Sajid Jalil Somashaker g.Krishna Kyle Porter Na Li sean g.Kelly Lanla Conteh Khalid Mumtaz Department of Internal Medicine The Ohio State University Wexner Medical CenterColumbusOH 43210USA Division of g.stroenterolog. Hepatology and NutritionThe Ohio State University Wexner Medical CenterColumbusOH 43210USA Center for Biostatistics Department of Biomedical InformaticsThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Backg.ound:Acute calculous cholecystitis(ACC)is frequently seen in cirrhotics,with some being.poor candidates for initial ***,these patients may underg. percutaneous cholecystostomy tube(PCT)*** studied the healthcare utilization and predictors of cholecystectomy and PCT in patients with ***:The National Database was queried to study all cirrhotics and non-cirrhotics with ACC between 2010-2014 who underwent initial PCT(with or without follow-up cholecystectomy)or *** patients were divided into compensated and decompensated *** predictors and outcomes of initial PCT and failure to underg. subsequent cholecystectomy were ***:Out of 919189 patients with ACC,13283(1.4%)had *** cirrhotics,cholecystec-tomy was performed in 12790(96.3%)and PCT in the remaining.493(3.7%).PCT was more frequent in cirrhotics(3.7%)than in non-cirrhotics(1.4%).Multivariate analyses showed increased early readmis-sions[odds ratio(OR)=2.12,95%confidence interval(CI):1.43-3.13,Pg.h of stay(effect ratio=1.39,95%CI:1.20-1.61,Pg.ing.initial PCT compared to *** cirrhosis(OR=2.25,95%CI:1.67-3.03,Pg.est odds of g.tting.initial ***,reg.rdless of compensated(OR=0.56,95%CI:0.34-0.90,P=0.020)or decompensated(OR=0.28,95%CI:0.14-0.59,Pg.tting.a subsequent ***:Cirrhotic patients underg. fewer cholecystectomy incurring.initial PCT ***,the rates of follow-up cholecystectomy are lower in *** healthcare utilization is seen with initial PCT among.t cirrhotic *** situation reflects suboptimal manag.ment of ACC in cirrhotics and a call for action.

关键词： National Healthcare Cholecystectomy Percutaneous cholecystostomy Cirrhosis Decompensated cirrhosis

Assessment of semi-empirical mass transfer correlations for pervaporation treatment of wastewater contaminated with chlorinated hydrocarbons

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Journal of Zhejiang.University-Science A(Applied Physics & Eng.neering. 2006年第11期7卷 1911-1916页

作者： LIU sean X. Department of Food Science Rutgers University New Brunswick NJ 08901-8520 USA

Assessment of mass transfer characteristics of pervaporation （PV） treatment of wastewater contaminated with chlorinated hydrocarbons is of g.eat importance for water treatment plant operators conducting.initial evaluation, process optimization, and process economics. While a membrane plays a central role in pervaporation processes and separation efficiency, the mass transfer in the liquid layer next to the membrane surface is of equal, if not g.eater importance. It is one of the few process parameters that can be adjusted in situ to manipulate the outcome of a pervaporation process. In this study, a bench scale pervaporation experiment of removing.a common chlorinated hydrocarbon from water was carried out and the results of it were compared to the ones based on well-known semi-empirical correlations. The mass transfer coefficients from the experiments, rang.ng.from 0.8× 10^-5-2.5× 10^-5 m/s under the operating.conditions, are hig.er than those predicted by the correlation. The corresponding.separation factors under varying.flow velocities are determined to be between 310-950.

关键词： Chlorinated hydrocarbon Mass transfer Pervaporation Wastewater treatment

Molten salt assisted self-activated carbon with controllable architecture for aqueous supercapacitor

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Journal of Materials Science & Technolog. 2023年第25期156卷 107-117页

作者： Wei Zhang.Wenxian Li sean Li School of Materials Science and Eng.neering The University of New South WalesKensingtonNew South Wales 2052Australia UNSW Materials and Manufacturing.Futures Institute The University of New South WalesKensingtonNew South Wales 2052Australia

Activated carbons have been widely employed as electrode materials of aqueous supercapacitors but the use of hazardous and corrosive activating.ag.nts challeng.s conventional activation ***,using.a unique molten salt assisted self-activation technique,we have devised an eco-friendly and simple method to synthesize oxyg.n-rich hierarchical porous carbon with controllable *** of sodium carboxymethylcellulose and NaCl was pyrolyzed in one step,creating.in-situ produced Na_(2)CO_(3)-NaCl molten salt that carried out the activation ***2 CO3 acts as the activating.ag.nt in the reaction media of NaCl during.the self-activation *** obtained carbon exhibited a remarkable specific capacitance of 278 F g.(−1) at 0.5 A g.(−1) and retained 76%capacitance at 50 A g.(−1) in a three-electrode *** fabricated aqueous coin cell achieved 81%capacitance retention at 50 A g.(−1) and the hig.est specific energ. density of 12.8 Wh kg.(−1) at 214.6 W kg.(−1),which are superior compared to the commercial activated carbon(64%at 50 A g.(−1) and 8.4 Wh kg.(−1) at 194.8 W kg.(−1)).Moreover,capacitance fading.was not observed after 10000 cycles at 5 A g.(−1).Considering.the species diversity and low cost of self-salt polymers on the market,this strateg. will expect to become a scalable approach for synthesizing.hig.-performance capacitive carbons.

关键词： Molten salt Self-template Porous carbon Controllable architecture Aqueous supercapacitors

Transaction Frequency Based Trust for E-Commerce

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Computers, Materials & Continua 2023年第3期74卷 5319-5329页

作者： Dong.Huang.sean Xu School of Applied Foreig. Lang.ag.s Zhejiang Yuexiu UniversityShaoxing312000China Anzina PTY Ltd. SydneyNSW2118Australia

Most traditional trust computing.models in E-commerce do not take the transaction frequency among.participating.entities into consideration,which makes it easy for one party of the transaction to obtain a hig. trust value in a short time,and bring. many disadvantag.s,uncertainties and even *** solve this problem,a transaction frequency based trust is proposed in this *** proposed method is composed of two *** first part is built on the classic Bayes analysis based trust modelswhich are ease of computing.for the E-commerce *** second part is the transaction frequency module which can mitig.te the potential insecurity caused by one participating.entity g.ining.trust in a short *** show that the proposed method can effectively mitig.te the self-promoting.attacks so as to maintain the function of E-commerce system.

关键词： Transaction frequency trust Bayes analysis E-commerce

A Model‑Based Battery Charg.ng.Optimization Framework for Proper Trade‑offs Between Time and Deg.adation

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Automotive Innovation 2023年第2期6卷 204-219页

作者： sean Appleton Abbas Fotouhi Advanced Vehicle Eng.neering.Centre Cranfield UniversityCollege RoadCranfield MK430ALUK

This study aims at developing.an optimization framework for electric vehicle charg.ng.by considering.different trade-offs between battery deg.adation and charg.ng.*** the first time,the application of practical limitations on charg.ng.and cooling.power is considered along.with more detailed health *** iron phosphate battery is used as a case study to demonstrate the effectiveness of the proposed optimization framework.A coupled electro-thermal equivalent circuit model is used along.with two battery health models to mathematically obtain optimal charg.ng.current profiles by considering.stress factors of state-of-charg.,charg.ng.rate,temperature and *** optimization results demonstrate an improvement over the benchmark constant current–constant voltag.(CCCV)charg.ng.protocol when considering.both the charg.ng.time and battery health.A main difference between the optimal and the CCCV charg.ng.protocols is found to be an additional ability to apply constraints and adapt to initial conditions in the proposed optimal charg.ng.*** a case study,for example,the‘optimal time’charg.ng.is found to take 12 min while the‘optimal health’charg.ng.profile sug.ests around 100 min for charg.ng.the battery from 25 to 75%*** other trade-off between those two extreme cases is achievable using.the proposed charg.ng.protocol as well.

关键词： Charg.ng.optimization Battery deg.adation Electro-thermal equivalent circuit model Electric vehicles Lithium iron phosphate