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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu sean Carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik J.Persson Magnus ekstrom sean P.Healey Zhiqiang Yang Johan Holmgren eva Lindberg Kenneth Nystrom emanuele Papucci Patrik Ulvdal Hans OleØrka erik Næsset Zhengyang Hou Håkan Olsson Ronald e.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

BloomDT-An improved privacy-preserving decision tree inference scheme

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Journal of Information and Intelligence 2024年第2期2卷 130-147页

作者： sean Lalla Rongxing Lu Yunguo Guan Songnian Zhang Canadian Institute for Cybersecurity(CIC) Faculty of Computer ScienceUniversity of New Brunswick(UNB)Fredericton E3B 5A3Canada

Outsourcing decision tree models to cloud servers can allow model providers to distribute their models at scale without purchasing dedicated hardware for model ***,model providers may be forced to disclose private model details when hosting their models in the *** to the time and monetary investments associated with model training,model providers may be reluctant to host their models in the cloud due to these privacy ***,clients may be reluctant to use these outsourced models because their private queries or their results may be disclosed to the cloud *** this paper,we propose BloomDT,a privacy-preserving scheme for decision tree inference,which uses Bloom filters to hide the original decision tree's structure,the threshold values of each node,and the order in which features are tested while maintaining reliable classification results that are secure even if the cloud servers *** scheme's security and performance are verified through rigorous testing and analysis.

关键词： Decision tree Privacy-preserving machine learning Bloom filter Model outsourcing

普惠GTF发动机问题导致的飞机停飞数量持续增加

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航空维修与工程 2024年第6期 17-18页

作者： sean Broderick 赵平(编译) 不详

普惠GTF发动机问题导致全球范围内多个机型的飞机停飞,受影响的机型包括空客A320neo、A220以及巴航工业e190-e2飞机。根据业内最新统计和预测,目前飞机停飞数量还在持续增加,并将在2024年上半年达到停飞数量的最高峰。

关键词：全球范围普惠停飞

Compressibility of a natural kyanite to 17.5 GPa

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Progress in Natural Science:Materials International 2009年第10期19卷 1281-1286页

作者： sean R. Shieh Michael e. Fleet Department of earth Sciences University of Western Ontario

The compressional behaviour of a natural kyanite,(Al1.99Fe0.01)SiO5,has been investigated to about 17.5 GPa at 300 K using a diamond-anvil cell and synchrotron X-ray *** pressure-volume data fitted to the third-order Birch-Murnaghan equation of state(eoS) yield an isothermal bulk modulus(K0T) of 192 ± 6 GPa and pressure derivative(K00T) of 6 ± *** K00T is fixed as 4,the derived K0T is 201 ± 2 *** values are in excellent agreement with most experimental determinations in the ***,it can be concluded that the compressibility of kyanite under high pressures has been accurately constrained.

关键词： Compressibility High-pressure Isothermal bulk modulus Kyanite Synchrotron X-ray diffraction

Characterization of Deciliation-Regeneration Process of Tetrahymena Pyriformis for Cellular Robot Fabrication

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Journal of Bionic engineering 2011年第3期8卷 273-279页

作者： Dal Hyung Kim sean e. Brigandi Paul Kim Doyoung Byun Min Jun Kim Department of Mechanical engineering & Mechanics Drexel University Philadelphia PA 19104 USA Department of Aerospace Information engineering Konkuk University Seoul 143-701 South Korea

magnetotactic Tetrahymena pyriformis GL （T. pyriformis） cells were created by the internalization of iron oxide nano particles and became controllable with a time-varying external magnetic field. Thus, T. pyriformis can be utilized as a cellular robot to conduct micro-scale tasks such as transportation and manipulation. To complete these tasks, loading inorganic or organic materials onto the cell body is essential, but functionalization of the cell membrane is obstructed by their motile organelles, cilia. Dibucaine HC1, a local anesthetic, removes the cilia from the cell body, and the functional group would be absorbed more efficiently during cilia regeneration. In this paper, we characterize the recovery of artificial magnetotactic T. pyriformis after the deciliation process to optimize a cellular robot fabrication process. After sufficient time to recover, the motility rate and the average velocity of the deciliated cells were six and ten percent lower than that of non-deciliated cells, respectively. We showed that the motile cells after recovery can still be controlled using magnetotaxis, making T. pyrfformis a good candidate to be used as a celIular robot.

关键词： Tetrahymena pyriformis deciliation cellular robot Helmholtz coil magnetic field magnetotaxis

Author correction to“Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironmenthematopexis-microbiota circuits”[Acta Pharm Sin B 14(2024)2732e2747]

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4193-4193页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu Haiting Xu sean Carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenhua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA 3Bs Research Group I3Bs d Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The authors regret that there are errors in the author information and author *** name of the corresponding author,Zhenghua Zhu,should be corrected to Zhenhua *** modification does not affect the results of the *** au... 详细信息

关键词： journal correction contributions

Hematologic and biochemical reference intervals for specific pathogen free 6-week-old Hampshire-Yorkshire crossbred pigs

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Journal of Animal Science and Biotechnology 2014年第3期5卷 286-290页

作者： Caitlin A Cooper Luis e Moraes James D Murray sean D Owens Department of Animal Science University of California Department of Population Health and Reproduction University of California Department of Pathology Microbiology and ImmunologySchool of Veterinary MedicineUniversity of California One Shields AvenueDavisCA 95616USA

Background： Hematologic and biochemical reference intervals depend on many factors, including age. A review of the literature highlights the lack of reference intervals for 6-wk-old specific pathogen free （SPF） Hampshire-Yorkshire crossbred pigs. For translational research, 6-wk-old pigs represent an important animal model for both human juvenile colitis and diabetes mellitus type 2 given the similarities between the porcine and human gastrointestinal maturation process. The aim of this study was to determine reference intervals for hematological and biochemical parameters in healthy 6-wk-old crossbred pigs. Blood samples were collected from 66 clinically healthy Hampshire-Yorkshire pigs. The pigs were 6 wks old, represented both sexes, and were housed in a SPF facility. Automated hematological and biochemical analysis were performed using an ADVIA 120 Hematology System and a Cobas 6000 C501 Clinical Chemistry Analyzer. Results： Reference intervals were calculated using both parametric and nonparametric methods. The mean, median, minimum, and maximum values were calculated. Conclusion： As pigs are used more frequently as medical models of human disease, having reference intervals for commonly measured hematological and biochemical parameters in 6-wk-old pigs will be useful. The reference intervals calculated in this study will aid in the diagnosis and monitoring of both naturally occurring and experimentally induced disease. In comparison to published reference intervals for older non SPF pigs, notable differences in leukocyte populations, and in levels of sodium, potassium, glucose, protein, and alkaline phosphatase were observed.

关键词： Biochemical analytes Hematology Pigs Reference interval SPF

Use of sodium bicarbonate and blood gas monitoring in diabetic ketoacidosis: A review

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World Journal of Diabetes 2018年第11期9卷 199-205页

作者： Mit P Patel Ali Ahmed Tharini Gunapalan sean e Hesselbacher Department of Internal Medicine Eastern Virginia Medical School Medicine Service Hampton Veterans Affairs Medical Center

Diabetic ketoacidosis(DKA) is a severe and toocommon complication of uncontrolled diabetes mellitus. Acidosis is one of the fundamental disruptions stemming from the disease process, the complications of which are potentially lethal. Hydration and insulin administration have been the cornerstones of DKA therapy; however, adjunctive treatments such as the use of sodium bicarbonate and protocols that include serial monitoring with blood gas analysis have been much more controversial. There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate. However, there is scant data to support or refute the role of bicarbonate therapy in very severe acidosis. Arterial blood gas(ABG) assessment is an element of some treatment protocols, including society guidelines, for DKA. We review the evidence supporting these recommendations. In addition, we review the data supporting some less cumbersome tests, including venous blood gas assessment and routine chemistries. It remains unclear that measurement of blood gas pH, via arterial or venous sampling, impacts management of the patient substantially enough to warrant the testing, especially if sodium bicarbonate administration is not being considered. There are special circumstances when serial ABG monitoring and/or sodium bicarbonate infusion are necessary, which we also review. Additional studies are needed to determine the utility of these interventions in patients with severe DKA and pH less than 7.0.

关键词： Diabetic ketoacidosis Sodium bicarbonate Blood gas analysis Acidosis Ketosis Ketone bodies Hyperglycemia