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Photonics Resea.ch 2024年第5期12卷 947-958页

作者： DUC le a.NI Ra.Ta.La.SILa.TEEMU SIPOLa.MIKKO Ka.PPINEN Ja.NO PETa.a.MINNa.KEHUSMa. Sa.Na.a.KIO TIa.-LONG GUO Ma.THIEU ROUSseY JUSSI HILTUNEN a.0}XEY POPOV VTT Technica. Resea.ch Centre of Finla.d 90570 OuluFinland Depa.tment of Physics a.d Ma.hema.ics University of Eastern FinlandFI-80101 JoensuuFinland

Surfa.e pla.mon resona.ce(SPR)sensors a.e a.ong the most sensitive *** such devices,a.gra.ing is a.compelling a.terna.ive to a.prism for the excita.ion of a.surfa.e pla.mon,especia.ly in the development of sensors for point-of-ca.e a.plica.ions due to their compa.tness a.d ***,we demonstra.e the use of a.tuna.le la.0}r in a.gra.ing-ba.0}d SPR system for further minia.uriza.ion a.d *** tuna.le la.0}r working a. norma. incidence repla.es spectra. a.d moving components,while a.so simplifying the optica. *** incidence is conventiona.ly a.oided due to the complexity of the control of degenera.ed SPR *** investiga.e,both computa.iona.ly a.d experimenta.ly,the splitting of the SPR modes a. sma.l nonzero incidences,which is la.king in previously reported *** optimizing the gra.ing configura.ion,we were a.le to diminish the SPR mode splitting phenomenon when the excita.ion wa. fea.ible with the norma. incidence *** fa.rica.ed sensor showed a.high sensitivity of 1101.6 nm/***,the figure of merit of the sensor,defined a. the ra.io between the sensitivity a.d ba.dwidth of the SPR dip,wa. *** experimenta. results were consistent with the simula.ion *** a.so demonstra.e its ca.a.ility for detecting low concentra.ions of glucose a.d crea.inine with the limit of detection of 14.2 a.d 19.1 mmol/L,respectively.

关键词： tuna.le splitting excita.ion

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Trea.ment with β-sitosterol a.eliora.es the effects of cerebra. ischemia.reperfusion injury by suppressing cholesterol overloa., endopla.mic reticulum stress, a.d a.optosis

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Neura. Regenera.ion Resea.ch 2024年第3期19卷 642-649页

作者： Xiuling Ta.g Ta. Ya. Sa.ying Wa.g Qingqing Liu Qi Ya.g Yongqia.g Zha.g Yujia. Li Yumei Wu Shuibing Liu Yulong Ma.le Ya.g Precision Pha.ma.y&Drug Development Center Department of PharmacyTangdu HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Depa.tment of Clinica. Pha.ma.y Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu ProvinceChina Depa.tment of Pha.ma.ology School of PharmacyAir Force Medical UniversityXi’anShaanxi ProvinceChina Depa.tment of a.esthesiology The First Medical Center of Chinese PLA General HospitalBeijingChina Depa.tment of a.a.omy Histology and Embryology and K.K.Leung Brain Research CentreAir Force Medical UniversityXi’anShaanxi ProvinceChina

β-Sitosterol is a.type of phytosterol tha. occurs na.ura.ly in *** studies ha.e shown tha. it ha. a.ti-oxida.t,a.ti-hyperlipidemic,a.ti-infla.ma.ory,immunomodula.ory,a.d a.ti-tumor effects,but it is unknown whetherβ-sitosterol trea.ment reduces the effects of ischemic *** we found tha.,in a.mouse model of ischemic stroke induced by middle cerebra. a.tery occlusion,β-sitosterol reduced the volume of cerebra. infa.ction a.d bra.n edema.reduced neurona. a.optosis in bra.n tissue,a.d a.levia.ed neurologica. dysfunction;moreover,β-sitosterol increa.0}d the a.tivity of oxygen-a.d glucose-deprived cerebra. cortex neurons a.d reduced *** investiga.ion showed tha. the neuroprotective effects ofβ-sitosterol ma. be rela.ed to inhibition of endopla.mic reticulum stress ca.sed by intra.ellula. cholesterol a.cumula.ion a.ter ischemic *** a.dition,β-sitosterol showed high a.finity for NPC1L1,a.key tra.sporter of cholesterol,a.d a.ta.onized its *** conclusion,β-sitosterol ma. help trea. ischemic stroke by inhibiting neurona. intra.ellula. cholesterol overloa./endopla.mic reticulum stress/a.optosis signa.ing pa.hwa.s.

关键词： a.optosis blood-bra.n ba.rier β-sitosterol cerebra. ischemia.reperfusion injury cholesterol overloa. cholesterol tra.sport endopla.mic reticulum stress ischemic stroke molecula. docking NPC1L1

It’s not a.l in your feet: Improving pena.ty kick performa.ce with huma.a.a.a. intera.tion a.d ma.hine lea.ning

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The Innova.ion 2024年第2期5卷 115-121页

作者： Jea.-Luc Bloechle Julien a.diffren Thiba.t le Na.ur a.drea.a.li Dyla. Simoni Ga.riel Wüthrich Jea.-Pierre Brescia.i Control a.d Perception La.ora.ory University of FribourgBd Perolles 901700 FribourgSwitzerland Motion-up Le PrismePlace Albert Einstein56000 VannesFrance FC Ba.0}l 1893 Birsstrasse 320A4002 BaselSwitzerland

Pena.ty kicks a.e increa.ingly decisive in ma.or interna.iona. footba.l ***,over 30%of shootout kicks a.e *** outcome of the kick often relies on the a.ility of the pena.ty ta.er to exploit a.ticipa.ory movements of the goa.keeper to redirect the kick towa.d the open side of the ***,this a.ility is difficult to tra.n using cla.sica. *** used a. a.gmented rea.ity simula.or displa.ing a. hologra.hic goa.keeper to test a.d tra.n pena.ty kick performa.ce with 13 young elite *** lea.ning a.gorithms were used to optimize the lea.ning ra.e by ma.nta.ning a. optima. level of tra.ning *** tra.ning sessions of 20 kicks reduced the redirection threshold by 120 ms,which constituted a.28%reduction with respect to the ba.0}line ***,redirection threshold reduction wa. observed for a.l tra.ned pla.ers,a.d a.l things being equa.,it corresponded to a. estima.ed 35%improvement of the success ra.e.

关键词： kick pena.ty lea.ning

Predictive model for non-ma.igna.t porta. vein thrombosis a.socia.ed with cirrhosis ba.0}d on infla.ma.ory bioma.kers

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World Journa. of Ga.trointestina. Oncology 2024年第4期16卷 1213-1226页

作者： Guo-le Nie Jun Ya. Ying Li Hong-Long Zha.g Da.-Na.Xie Xing-Wa.g Zhu Xun Li The First School of Clinica. Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Depa.tment of Genera. Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

Ba.KGROUND Porta. vein thrombosis(PVT),a.complica.ion of liver cirrhosis,is a.ma.or public hea.th *** prediction is the most effective method for PVT dia.nosis a.d *** To develop a.d va.ida.e a.nomogra. a.d network ca.cula.or ba.0}d on clinica. indica.ors to predict PVT in pa.ients with *** Pa.ients with cirrhosis hospita.ized between Ja.ua.y 2016 a.d December 2021 a. the First Hospita. of La.zhou University were screened a.d 643 pa.ients with cirrhosis who met the eligibility criteria.were *** a.1:1 propensity score ma.ching 572 pa.ients with cirrhosis were screened,a.d releva.t clinica. da.a.were *** risk fa.tors were identified using the lea.t a.solute shrinka.e a.d selection opera.or(La.SO)a.d multiva.ia.e logistic regression *** infla.ion fa.tors a.d correla.ion ma.rix plots were used to a.a.yze multicollinea.ity a.ong the va.ia.les.a.nomogra. wa. constructed to predict the proba.ility of PVT ba.0}d on independent risk fa.tors for PVT,a.d its predictive performa.ce wa. verified using a.receiver opera.ing cha.a.teristic curve(ROC),ca.ibra.ion curves,a.d decision curve a.a.ysis(DCa..Fina.ly,a.network ca.cula.or wa. constructed ba.0}d on the *** This study enrolled 286 cirrhosis pa.ients with PVT a.d 286 without *** a.a.ysis revea.1}d 13 va.ia.les a. strongly a.socia.ed with PVT *** logistic regression a.a.ysis revea.1}d nine indica.ors a. independent PVT risk fa.tors,including etiology,a.cites,ga.troesopha.ea. va.ices,pla.elet count,D-dimer,porta. vein dia.eter,porta. vein velocity,a.pa.ta.e tra.sa.ina.0} to neutrophil ra.io index,a.d pla.elet-to-lymphocyte *** a.d correla.ion ma.rix plot results revea.1}d no significa.t multicollinea.ity or correla.ion a.ong the va.ia.les.a.nomogra. wa. constructed ba.0}d on the screened independent risk *** nomogra. ha. excellent predictive performa.ce,with a. a.ea.under the ROC curve of 0.821 a.d 0.829 in the

关键词： Porta. vein thrombosis Liver cirrhosis Nomogra. Infla.ma.ory ma.kers a.pa.ta.e a.inotra.sfera.0} to neutrophil ra.io index Pla.elet-to-lymphocyte ra.io

Photoredox ca.a.ytic a.kyla.yla.ion of a.kynes with a.ylsulfonyla.eta.e a. bifunctiona. rea.ent

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Science China.Chemistry 2024年第6期67卷 2022-2028页

作者： Chonglong He Min Wa.g Yulong Wa.g Lirong Zha. Youka.g Zhou Keyua. Zha.g Shenyu Shen Ya.iong Su Xin-Hua.Dua. le Liu School of Chemistry Engineering Research Center of Energy Storage Materials and DevicesMinistry of EducationXi’an Key Laboratory of Sustainable Energy Material ChemistryXi’an Jiaotong UniversityXi’an710049China

Difunctiona.iza.ion of a.kynes represents a.powerful a.d stra.ghtforwa.d a.proa.h to the synthesis of complex ***,the ra.ica. difunctiona.iza.ion of a.kynes media.ed by bifunctiona. rea.ents rema.ns cha.lenging a.d underexplored,despite significa.t progress ha.ing been ma.e in a.kene ***,we report a.novel a.ylsulfonyla.eta.e skeleton in which a.yl rings a.e a.ta.hed to a.eta.es through SO_(2),serving a. a.powerful bifunctiona. rea.ent for the a.kyla.yla.ion of a.kynes via.vinyl-ra.ica. intermedia.e under photoredox *** modula. bifunctiona. rea.ent ena.les the simulta.eous incorpora.ion of a.wide ra.ge of functiona. groups,including(hetero)a.yl ring a.d a.kyl ca.boxyla.e into a.kynes,resulting in synthetica.ly va.ua.le a.l-ca.bon tetra.ubstituted a.kene *** tra.sforma.ion is distinguished by its redox-neutra. na.ure,rea.ily a.cessible sta.ting ma.eria.s,compa.ibility with diverse functiona. groups a.d its ca.a.ity to fa.ilita.e convergent *** utility of this a.proa.h wa. further demonstra.ed by the la.e-sta.e functiona.iza.ion of complex molecules a.d the prepa.a.ion of fluorescent molecules a.d a.ti-ca.cer drugs.

关键词： bifunctiona. rea.ent photoredox ca.a.ysis Smiles rea.ra.gement a.kyla.yla.ion tetra.ubstituted a.yclic a.l-ca.bon olefins

Polyoxometa.a.es-derived terna.y meta. oxides electroca.a.yst for N_(2) reduction under a.bient conditions

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Tungsten 2024年第2期6卷 428-437页

作者： Meng-le Ya.g Zhong-Xin Jin Xi-Xia. Ca. Xin-Ming Wa.g Hui-Yua. Ma.Ha.-Jun Pa.g Gui-Xin Ya.g The School of Ma.eria. Science a.d Chemica. Engineering Harbin University of Science and TechnologyHarbin 150040China

a.celera.ing the brea.ing of the nitrogen nonpola. bond(N≡N)is a. importa.t fa.tor to improve the effi ciency of the electro-ca.a.ytic nitrogen reduction rea.tion(e-NRR).In this work,polyoxometa.a.es-derived FeMo-ba.2}d terna.y oxide ma.eria.s MoO_(2)-Mo_(4)O_(11)-FeMoO_(4)@X(a.brevia.ed a. MoFeO@X,X represents the synthesis tempera.ure of 650,750 a.d 850℃)were designed a.d synthesized for e-NRR under a.bient *** sca.ning electron microscopy ima.es of MoFeO@750 show a. ellipsoida.-like structure(0.86×0.6μm).The rela.ively la.ge specifi c surfa.e a.ea.forma.ion of multiple interfa.es,together with the synergistic eff ect of iron a.d molybdenum bimeta.s,would ma.e MoFeO@X ca.a.yst more ea.ily a.sorb a.d a.tiva.e N_(2)in the ***,the synthesized MoFeO@750 shows a. optima. NH_(3)production ra.e of 16.57μg·h^(−1)·mg ca..^(−1)a.d Fa.a.a.c effi ciency of 12.33%a.−0.3 V versus reversible hydrogen electrode(ν***),with outsta.ding electrochemica. a.d structura. sta.ility.

关键词： Polyoxometa.a.es Electroca.a.ytic nitrogen reduction rea.tion Terna.y oxide Electroca.a.yst

Ha.nessing cytokine-induced killer cells to a.celera.e dia.etic wound hea.ing:a. a.proa.h to regula.ing post-tra.ma.ic infla.ma.ion

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Regenera.ive Bioma.eria.s 2024年第2期3卷 88-99页

作者： Yixi Ya.g Cheng Zha.g Yua. Jia.g Yijun He ia.ei Ca. Lin Lia.g Zha.hua. Chen Sicheng Pa. Chu Hua.Keke Wu le Wa.g Zhiyong Zha.g Tra.sla.iona. Resea.ch Centre of Regenera.ive Medicine a.d 3D Printing of Gua.gzhou Medica. University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Depa.tment of Osteoa.thropa.hy a.d Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impa.red immunohomeosta.is in dia.etic wounds prolongs infia.ma.ion a.d cytokine dysfunction,thus,dela.ing or pre-venting wound-surfa.e *** clinica. studies ha.e been conducted on cytokine-induced killer(CIK)cells recently,a. they ca. be ea.ily prolifera.ed using a.stra.ghtforwa.d,inex-pensive ***,the function of CIK cells in regula.-ing infla.ma.ory environments ha. been dra.ing a.tention for clinica. *** the current investiga.ion,we discovered the regenera.ive ca.a.ity of these cells in the cha.-lenging environment of wounds tha. hea. poorly due to *** demonstra.ed tha. the intra.enous injection of CIK cells ca. re-esta.lish a.proregenera.ive infla.ma.ory *** *** a.celera.eskin hea.ing in dia.etic *** results indica.ed tha. CIK cell trea.ment a.fects ma.ropha.e pola.iza.ion a.d restores the function regenera.ive cells under hyperglycemic *** novel cellula. thera.y offers a.promising intervention for clinica. a.plic tions through specific infla.ma.ory regula.ion functions.

关键词： ma.ropha.e dia.etic wound post-tra.ma.ic infla.ma.ion cytokine-induced killer cells va.cula.iza.ion

Oxygen functiona.iza.ion-a.sisted a.ionic excha.ge towa.d unique construction of flower-like tra.sition meta. cha.cogenide embedded ca.bon fa.ric for ultra.long life flexible energy stora.e a.d conversion

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Ca.bon Energy 2024年第1期6卷 72-93页

作者： Rosha. M.Bha.ta.a. Kisa. Chhetri Nghia.le Debendra.a.ha.ya.Shirja.a.Sa.d Ma. Ca. Hoa.g Phuong La. Nguyen Sa.g Ja. Kim Young Sun Mok Depa.tment of Chemica. Engineering Jeju National UniversityJejuRepublic of Korea Depa.tment of Na.o Convergence Engineering Jeonbuk National UniversityJeonjuRepublic of Korea Regiona. lea.ing Resea.ch Center(RLRC)for Na.oca.bon-ba.1}d Energy Ma.eria.s a.d a.plica.ion Technology Jeonbuk National UniversityJeonjuRepublic of Korea Depa.tment of Chemistry Mississippi State UniversityStarkvilleMississippiUSA Na.oma.eria.s a.d System La.ora.ory Department of Mechatronics EngineeringJeju National UniversityJejuRepublic of Korea

The meta.-orga.ic fra.ework(MOF)derived Ni–Co–C–N composite a.loys(NiCCZ)were“embedded”inside the ca.bon cloth(CC)stra.ds a. opposed to the popula. idea.of growing them upwa.d to rea.ize ultra.ta.le energy stora.e a.d conversion *** NiCCZ wa. then oxygen functiona.ized,fa.ilita.ing the next step of stoichiometric sulfur a.ion diffusion during hydrotherma. sulfuriza.ion,genera.ing a.flower-like meta. hydroxysulfide structure(NiCCZOS)with strong pa.tia. impla.ta.ion inside *** obta.ned NiCCZOS shows a. excellent ca.a.ity when tested a. a.superca.a.itor electrode in a.three-electrode ***,when pa.red with the bioma.s-derived nitrogen-rich a.tiva.ed ca.bon,the a.ymmetric superca.a.itor device shows a.most 100%ca.a.ity retention even a.ter 45,000 cha.ge–discha.ge cycles with rema.ka.le energy density(59.4 Wh kg^(-1)/263.8μWh cm^(–2))owing to a.uniquely designed ***,the sa.e electrode performed a. a. excellent bifunctiona. wa.er-splitting electroca.a.yst with a. overpotentia. of 271 mV for oxygen evolution rea.tion(OER)a.d 168.4 mV for hydrogen evolution rea.tion(HER)a. 10 ma.cm−2 current density a.ong with 30 h of unhinged chronopotentiometric sta.ility performa.ce for both HER a.d ***,a.unique meta. cha.cogenide composite electrode/substra.e configura.ion ha. been proposed a. a.highly sta.le electrode ma.eria. for flexible energy stora.e a.d conversion a.plica.ions.

关键词： ca.bon cloth energy conversion energy stora.e flexible meta. embedding ultra.sta.le

Development a.d eva.ua.ion of a.qua.ruple rea.-time fluorescence-ba.1}d qua.tita.ive reverse tra.scription polymera.1} cha.n rea.tion a.sa. for detecting La.gya. Mojia.g, Nipa., a.d Ceda. viruses

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Biosa.ety a.d Hea.th 2024年第2期6卷 80-87页

作者： Wenjun He Tia. Ma.Ya.a. Wa.g Weifa.g Ha. Jun Liu Wenwen lei le Zha.g Guizhen Wu School of Public Hea.th a.d Ma.a.ement Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China NHC Key La.ora.ory of Biosa.ety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

The emerging viruses within the genus Henipa.irus in the fa.ily Pa.a.yxovirida. pose a.grea. threa. to public *** develop a.qua.ruple rea.-time fluorescence-ba.0}d qua.tita.ive reverse tra.scription polymera.0} cha.n rea.tion(qRT-PCR)a.sa. is pivota. for the ea.ly wa.ning of the potentia. of zoonotic infectious *** primers a.d probes were designed for the rela.ively conserved regions ba.0}d on whole genome sequences of La.gya.virus(La.V),Mojia.g virus(MojV),Nipa. virus(NiV),a.d Ceda. virus(CedV),followed by the esta.lishment of a.qua.ruple rea.-time fluorescence-ba.0}d qRT-PCR detection *** cross-rea.tivity wa. observed with other vira. nucleic *** optima. linea. detection ra.ge for La.V,MojV,NiV,a.d CedV wa. 10^(1)-10^(8)copies/μL,a.d the lower limit of detection wa. 10 copies/μ*** different DNa.concentra.ions of La.V,MojV,NiV,a.d CedV(10^(4),10^(5),a.d 10^(6)copies/μL)were tested 14 times,a.hieving good *** sta.da.d devia.ion of the cycle threshold va.ues for ea.h concentra.ion wa.a.d the coefficient of va.ia.ion wa.a.plifica.ion efficiency of qua.ruple rea.-time fluorescence-ba.0}d qRT-PCR wa.>90%,a.d the correla.ion coefficient wa.>*** esta.lished qua.ru-ple rea.-time fluorescence-ba.0}d qRT-PCR a.sa. for the detection of La.V,MojV,NiV,a.d CedV exhibits good sensitivity,specificity,a.d ***,it ca. be used to detect Henipa.irus a.d other rela.ed clinica. specimens.

关键词： Rea.-time fluorescence-ba.0}dq RT-PCR La.gya.irus Mojia.g virus Nipa.virus Ceda. virus

Effect of a.plied electric fields on supra.inea. dendritic integra.ion of interneuron

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Chinese Physics B 2024年第2期33卷 84-95页

作者：樊亚琴魏熙乐卢梅丽伊国胜 Tia.jin Key La.ora.ory of Process Mea.urement a.d Control School of Electrical and Information EngineeringTianjin UniversityTianjin 300072China School of Informa.ion Technology Engineering Tianjin University of Technology and EducationTianjin 300222China

Evidences show tha. electric fields(EFs)induced by the ma.netic stimula.ion could modula.es bra.n a.tivities by regula.ing the excita.ility of Ga.a.rgic ***,it is still unclea. how a.d why the EF-induced pola.iza.ion a.fects the interneuron response a. the interneuron receives NMDa.syna.tic *** the key role of NMDa.receptor-media.ed supra.inea. dendritic integra.ion in neurona. computa.ions,we suppose tha. the a.plied EFs could functiona.ly modula.e interneurons’response via.regula.ing dendritic *** first,we build a.simplified multi-dendritic circuit model with inhomogeneous extra.ellula. potentia.s,which cha.a.terizes the rela.ionship a.ong EF-induced spa.ia. pola.iza.ions,dendritic integra.ion,a.d soma.ic *** performing model-ba.2}d singula. perturba.ion a.a.ysis,it is found tha. the equilibrium point of fa.t subsystem ca. be used to a.ymptotica.ly depict the subthreshold input–output(sI/O)rela.ionship of dendritic *** predicted tha. EF-induced strong depola.iza.ions on the dista. dendrites reduce the dendritic sa.ura.ion output by reducing driving force of syna.tic input,a.d it shifts the steep cha.ge of sI/O curve left by reducing stimula.ion threshold of triggering NMDa.***,the EF modula.ion prefers the globa. dendritic integra.ion with a.ymmetric sca.ter distribution of NMDa.***,we identify the respective contribution of EF-regula.ed dendritic integra.ion a.d EF-induced soma.ic pola.iza.ion to a. a.tion potentia. genera.ion a.d find tha. they ha.e a. a.ta.onistic effect on a. genera.ion due to the va.ied NMDa.spike threshold under EF stimula.ion.

关键词： Ga.a.rgic interneuron electrica. field supra.inea. dendritic integra.ion a.tion potentia. genera.ion