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Analysis of the corrosion performance of binder jet additive manufactured magnesium alloys for biomedical applications

纳米材料科学 2024年第2期 115页

作者： Qiang Zhu Pin jin ong Si Hui Angela Goh Reuben j.Yeo Suxi Wang Zhiyuan liu Xian jun loh

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journal of Magnesium and Alloys 2022年第5期10卷 1296-1310页

作者： Kai Xiang Kuah Daniel j.Blackwood Wee Kit ong Mojtaba Salehi hang li seet Mui ling Sharon Nai Sudesh Wijesinghe Department of Materials Science&Engineering National University of Singapore9 Engineering Drive 1117575 Singapore Reliability and Characterisation Unit Singapore Institute of Manufacturing Technology(SIMTech)Agency forScienceTechnology and Research(A^(∗)STAR)73 Nanyang Drive637662 Singapore Additive Manufacturing Group Singapore Institute of Manufacturing Technology(SIMTech)Agency forScienceTechnology and Research(A^(∗)STAR)73 Nanyang Drive637662 Singapore

Binder jet printing(BjP)is a state-of-the-art additive manufacturing technique for producing porous magnesium *** MgZn-Zr based BjP samples were assessed for corrosion performance in simulated body fluids by electrochemical and hydrogen evolution *** corrosion rates of the BjP specimens were significantly higher than solid controls,even after accounting for their larger surface areas,suggesting that the BjP microstructure is detrimental to corrosion performance.X-ray computed tomography revealed nonuniform corrosion within the porous structure,with corrosion products forming on the pore *** the pores with hydroxyapatite or polymers greatly improved the corrosion resistance of the BjP samples.

关键词： Magnesium Additive manufacturing Binder jetting Porous Corrosion Biodegradability

The role of soluble sugars during drought in tropical tree seedlings with contrasting tolerances

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journal of Plant Ecology 2020年第4期13卷 389-397页

作者： Michael j.O’Brien Annabelle Valtat Samuel Abiven Mirjam S.Studer Robert ong Bernhard Schmid Área de Biodiversidad y Conservación Universidad Rey Juan Carlosc/Tulipán s/n.E-28933 MóstolesMadridSpain Southeast Asia Rainforest Research Partnership The Peak VistaLorang Punjak 1Tanjung LipatKota KinabaluSabah 88400Malaysia Department of Evolutionary Biology and Environmental Studies University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland Department of Geography University of ZurichWinterthurerstrasse 1908057 ZurichSwitzerland laboratoire de Géologie UMR 8538Ecole Normale SupérieurePSL Research UniversityCNRSParisFrance Centre de recherche enécologie expérimentale et prédictive(CEREEP-Ecotron IleDeFrance) Département de biologieEcole normale supérieureCNRSPSL University77140St-Pierre-les-NemoursFrance Forest Research Centre Sepilok90715 SandakanSabahMalaysia

Aims Non-structural carbohydrates(NSCs)are plant storage compounds used for metabolism,transport,osmoregulation and regrowth following the loss of plant *** in conditions suitable for optimal growth,plants continue to store *** storage may be due to passive accumulation from sink-inhibited growth or active reserves that come at the expense of *** former pathway implies that NSCs may be a by-product of sink limitation,while the latter suggests a functional role of NSCs for use during poor *** Using 13C pulse.labelling,we traced the source of soluble sugars in stem and root organs during drought and everwet conditions for seedlings of two tropical tree species that differ in drought tolerance to estimate the relative allocation of NSCs stored prior to drought versus NSCs assimilated during *** monitored growth,stomatal conductance,stem water potential and NSC storage to assess a broad carbon response to *** Findings We found that the drought-sensitive species had reduced growth,conserved NSC concentrations in leaf,stem and root organs and had a larger proportion of soluble sugars in stem and root organs that originated from pre-drought storage relative to seedlings in control *** contrast,the drought-tolerant species maintained growth and stem and root NSC concentrations but had reduced leaf NSCs concentrations with a larger proportion of stem and root soluble sugars originated from freshly assimilated photosynthates relative to control *** results suggest the drought-sensitive species passively accumulated NSCs during water deficit due to growth inhibition,while the drought-tolerant species actively responded to water deficit by allocating NSCs to stem and root *** strategies seem correlated with baseline maximum growth rates,which supports previous research suggesting a trade-off between growth and drought tolerance while providing new evidence for the importance of plasticity in

关键词： ^(13)C labelling carbohydrate storage drought tolerance hydraulic function Shorea parvifolia Shorea beccariana source–sink allocation

Biodiversity Assessment of Avifauna in the Forest Reservation of Aurora State College of Technology (ASCOT), Philippines

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Differential regulation of cPlA2 and iPlA2 expression in the brain

Open journal of Ecology（生态学期刊） 2024年第4期 292页

作者： Afed S.Daiwey Heherson B.ong Emerson V.Barcellano Edmundo C.Gumpal Michelle Ann M.Calubaquib Rafael j.Padre

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Frontiers in Biology 2012年第6期7卷 514-521页

作者： Kazuhiro TANAKA Nikhat j. SIDDIQI Abdullah S. AlHOMIDA Akhlaq A. FAROOQUI Wei-Yi ong Neurobiology and Ageing Research Programme National University of Singapore Singapore 117456 Singapore Department of Biochemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Molecular and Cellular Biochemistry The Ohio State University Columbus OH 43210 USA Department of Anatomy National University of Singapore Singapore 119260 Singapore

The phospholipase A2 （PlA2） family members arc critical regulators of membrane structure and lipid composition and have been implicated in neuroinflammation, oxidative stress and neurodegeneration. Here, we review the published data describing regulation of cPlA2 and iPlA2 gene expression. Based on promoter sequence, cPlA2 expression can be regulated by glucocorticoid and pro-inflammatory cytokines, whereas transcription of iPlA2 can be controlled in response to sterol level. RNA degradation in 3＇ UTR and epigenetic mechanisms may be involved in the regulation of cPlA2 and iPlA2 expression, respectively. MicroRNA target sequences lie within cPlA2 and iPlA2 mRNAs. Together, these findings indicate differential regulation of cPlA2 and iPlA2 expression. It is hoped that determination of diverse regulatory mechanisms of the PlA2 family may open new doors for development of novel therapeutic compounds that modulate PlA2 expression and function in the treatment of brain diseases.

关键词： phospholipase A2 transcriptional regulation single nucleotide polymorphism miRNA

Correlates of HIV self-testing among female sex workers in China: implications for expanding HIV screening

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Infectious Diseases of Poverty 2020年第5期9卷 128-128页

作者： Cheng Wang Ya‑jie Wang joseph D.Tucker Ming‑Zhou Xiong Hong‑Yun Fu M.Kumi Smith Wei‑Ming Tang jason j.ong He‑Ping Zheng Bin Yang Dermatology Hospital of Southern Medical University GuangzhouGuangdongChina 不详

Background:Human immunodefciency virus(HIV)self-testing may help improve test uptake among female sex *** has implemented many HIV self-testing programs among men who have sex with men,creating an opportunity for promotion among female sex ***,there is a limited literature on examining HIV selftesting among female sex *** study aimed to examine HIV self-testing experiences and its determinants among female sex workers in ***:A venue-based,cross-sectional study was conducted among Chinese female sex workers in *** completed a survey including social-demographic characteristics,sexual behaviors,and HIV self-testing history,the distribution of which were analyzed using descriptive *** logistic regression was conducted to identify associations with HIV ***:Among 1287 Chinese female sex workers,1072(83.3%,95%confdence interval[CI]81.2-85.3%)had ever tested for HIV,and 103(8.0%,95%CI 6.6-9.6%)had ever used HIV *** than half reported that the selftest was their frst HIV test(59.2%,61/103),around one-ffth reported HIV self-testing results infuenced the price of sex(21.4%,22/103).A minority of individuals reported ever experiencing pressure to undertake HIV self-testing(6.8%,7/103).After adjusting for covariates,HIV self-testing was positively associated with receiving anal sex in the past month(adjusted odds ratio[aOR]=2.2,95%CI 1.4-3.5),using drugs before or during sex(aOR=2.8,95%CI 1.8-4.5),injecting drugs in the past 6 months(aOR=2.6,95%CI 1.2-6.0),being diagnosed with other sexually transmitted infections(aOR=1.6,95%CI 1.0-2.5),tested for other sexually transmitted infections in the past six months(aOR=3.4,95%CI 2.1-5.5),ever tested in the hospital(aOR=3.4,95%CI 2.0-5.6),and ever tested in the community(aOR=1.5,95%CI 1.2-1.9).Conclusions:Our fndings suggest that HIV self-testing could expand overall HIV testing uptake,increase HIV testing frequency,reach sub-groups o

关键词： HIV self-testing Female sex workers China

Multi-scale investigation of short-range order and dislocation glide in MoNbTi and TaNbTi multi-principal element alloys

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npj Computational Materials 2023年第1期9卷 1430-1442页

作者： Hui Zheng lauren T.W.Fey Xiang-Guo li Yong-jie Hu liang Qi Chi Chen Shuozhi Xu Irene j.Beyerlein Shyue Ping ong Department of NanoEngineering University of California San DiegoLa JollaCA 92093-0448USA Materials Department University of CaliforniaSanta BarbaraCA 93106-5050USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA 19104USA Department of Mechanical Engineering University of CaliforniaSanta BarbaraCA 93106-5070USA

Refractory multi-principal element alloys(RMPEAs)are promising materials for high-temperature structural ***,we investigate the role of short-range ordering(SRO)on dislocation glide in the MoNbTi and TaNbTi RMPEAs using a multi-scale modeling *** carlo/molecular dynamics simulations with a moment tensor potential show that MoNbTi exhibits a much greater degree of SRO than TaNbTi and the local composition has a direct effect on the unstable stacking fault energies(USFEs).From mesoscale phase-field dislocation dynamics simulations,we find that increasing SRO leads to higher mean USFEs and stress required for dislocation *** gliding dislocations experience significant hardening due to pinning and depinning caused by random compositional fluctuations,with higher SRO decreasing the degree of USFE dispersion and hence,amount of ***,we show how the morphology of an expanding dislocation loop is affected by the applied stress.

关键词： alloys dislocation element

Automated generation and ensemble-learned matching of X-ray absorption spectra

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npj Computational Materials 2018年第1期4卷 566-574页

作者： Chen Zheng Kiran Mathew Chi Chen Yiming Chen hanmei Tang Alan Dozier joshua j.Kas Fernando D.Vila john j.Rehr louis F.j.Piper Kristin A.Persson Shyue Ping ong Department of NanoEngineering University of California San Diego9500 Gilman DriveMail Code 0448La JollaCA 92093-0448USA Department of Materials Science University of California BerkeleyBerkeleyCA 94720USA Division of Applied Research and Technology National Institute for Occupational Safety and HealthCenters for Disease ControlCincinnatiOH 45226USA Department of Physics University of WashingtonSeattleWA 98195USA Department of Physics Applied Physics and AstronomyBinghamton UniversityBinghamtonNY 13902USA Materials Science&Engineering Binghamton UniversityBinghamtonNY 13902USA

X-ray absorption spectroscopy(XAS)is a widely used materials characterization technique to determine oxidation states,coordination environment,and other local atomic structure *** of XAS relies on comparison of measured spectra to reliable reference ***,existing databases of XAS spectra are highly limited both in terms of the number of reference spectra available as well as the breadth of chemistry *** this work,we report the development of XASdb,a large database of computed reference XAS,and an Ensemble-learned Spectra IdEntification(ElSIE)algorithm for the matching of *** currently hosts more than 800,000 K-edge X-ray absorption near-edge spectra(XANES)for over 40,000 materials from the open-science Materials Project *** discuss a high-throughput automation framework for FEFF calculations,built on robust,rigorously benchmarked *** is a computer program uses a real-space Green’s function approach to calculate X-ray absorption *** will demonstrate that the ElSIE algorithm,which combines 33 weak“learners”comprising a set of preprocessing steps and a similarity metric,can achieve up to 84.2% accuracy in identifying the correct oxidation state and coordination environment of a test set of 19 K-edge XANES spectra encompassing a diverse range of chemistries and crystal *** XASdb with the ElSIE algorithm has been integrated into a web application in the Materials Project,providing an important new public resource for the analysis of XAS to all materials ***,the ElSIE algorithm itself has been made available as part of veidt,an open source machine-learning library for materials science.

关键词： matching XANES ensemble

3D printed tacrolimus suppositories for the treatment of ulcerative colitis

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Asian journal of Pharmaceutical Sciences 2021年第1期16卷 110-119页

作者： Iria seoane-Viano jun jie ong Asteria luzardo-Alvarez Miguel Gonzalez-Barcia Abdul W.Basit Francisco j.Otero-Espinar Alvaro Goyanes Department of Pharmacology Pharmacy and Pharmaceutical TechnologyFaculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Department of Pharmaceutics UCL School of PharmacyUniversity College LondonLondon WC1N 1AXUK Pharmacy Department University Clinical Hospital Santiago de Compostela(SERGAS)(CHUS)Santiago de Compostela 15706Spain FabRx ltd. AshfordKent TN240RWUK Departamento de Farmacologia Farmacia y Tecnologia FarmaceuticaI+D Farma Group(GI-1645)Universidade de Santiago de CompostelaSantiago de Compostela 15782Spain

Ulcerative colitis is a global health problem,affecting millions of individuals *** an inflammatory condition localised in the large intestine,rectal delivery of immunosuppressive therapies such as tacrolimus is a promising strategy to maximise drug concentration at the site of action whilst minimising systemic side ***,for the first time,self-supporting 3D-printed tacrolimus suppositories were prepared without the aid of moulds using a pharmaceutical semi-solid extrusion(Sse)3D *** suppositories were printed vertically in three different sizes using combinations of two lipid pharmaceutical excipients(Gelucire 44/14 or Gelucire 48/16)and coconut *** both suppository formulations had the appropriate viscosity characteristics for printing,the Gel 44 formulation required less energy and force for extrusion compared to the Gel 48 *** Gel 44 disintegrated more rapidly but released tacrolimus more slowly than the Gel 48 *** the tacrolimus release profiles were significantly different,both suppository systems released more than 80% drug within 120 *** and XRD analysis was inconclusive in determining the solid-state properties of the drug in the *** summary,this article reports on the fabrication of 3D printed selfsupporting suppositories to deliver personalised doses of a narrow therapeutic index drug,with potential benefits for patients with ulcerative colitis.

关键词： 3D printed drug products semi-solid extrusion 3D printing Inflammatory bowel disease Suppository drug delivery Pressure assisted syringe M3dimaker

彼得·拉莫和循道宗的命名:拉莫式布道术以降的中世纪科学

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跨文化研究 2021年第2期 79-92,287页

作者：瓦尔特·昂格叶仁杰(译) 不详中国人民大学哲学院

"方法"与约翰·卫斯理所创建的新教教派"循道宗"(Meth-odism)之间的联系一直都是个谜题,甚至卫斯理本人也不清楚。卫斯理错误地认为这个词来自于早期的医学团体,指的是那些在日常生活中严格遵循规律的人。事实上,这个词最初指的是彼得... 详细信息

"方法"与约翰·卫斯理所创建的新教教派"循道宗"(Meth-odism)之间的联系一直都是个谜题,甚至卫斯理本人也不清楚。卫斯理错误地认为这个词来自于早期的医学团体,指的是那些在日常生活中严格遵循规律的人。事实上,这个词最初指的是彼得·拉莫的方法,属于纯粹的逻辑学,并能够应用于所有学科。拉莫推动了18世纪的"方法崇拜",但很多布道者仅仅是"口头尊崇"拉莫主义方法,以至于18世纪晚期的人不能理解"循道宗"的确切含义。笔者认为卫斯理虽然不知道这个词的来源,但远比其自以为的更接近"循道宗"的最初含义,因为其著作反映了拉莫的深远影响。

关键词：循道宗方法拉莫主义者逻辑学