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Exact Time-Dependent Wave Functions of a Confined Time-Dependent Harmonic Oscillator with Two Moving Boundaries

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Communications in Theoretical Physics 2009年第11期52卷 820-824页

作者： C.F.lo Institute of Theoretical Physics and Department of Physics The Chinese University of Hong Kong

By applying the standard analytical techniques of solving partial differential equations, we have obtained the exact solution in terms of the Fourier sine series to the time-dependent Schrodinger equation describing a quantum one-dimensional harmonic oscillator of time-dependent frequency confined in an infinite square well with the two walls moving along some parametric trajectories. Based upon the orthonormal basis of quasi-stationary wave functions, the exact propagator of the system has also been analytically derived. Special eases like （i） a confined free particle, （ii） a confined time-independent harmonic oscillator, and （iii） an aging oscillator are examined, and the corresponding time- dependent wave functions are explicitly determined. Besides, the approach has been extended to solve the case of a confined generalized time-dependent harmonic oscillator for some parametric moving boundaries as well.

关键词： infinite square well harmonic oscillator moving boundaries Fourier series

Defective lysosomal acidification:a new prognostic marker and therapeutic target for neurodegenerative diseases

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Translational Neurodegeneration 2023年第1期12卷 500-510页

作者： Chih Hung lo Jialiu Zeng Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s *** genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle *** lysosomal abnormalities are also present in sporadic forms of neurodegeneration,although the underlying pathogenic mechanisms are unclear and remain to be ***,recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage ***,there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic ***,we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical *** further discuss current preclinical pharmacological agents that modulate lysosomal acidification,including small molecules and nanomedicine,and their potential clinical translation into lysosome-targeting *** timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.

关键词： Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection Prognostic marker Small molecules Nanomedicine Nanoparticles

Soil genetic erosion: New conceptual developments in soil security

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International Soil and Water Conservation Research 2019年第4期7卷 317-324页

作者： Carmelo Dazzi Giuseppe lo Papa University of Palermo Italy Department of Agricultural Food and Forest Sciences Viale delle Scienze 90128 PalermoItaly

In the last decades,in some Mediterranean areas,pedodiversity decreased mainly due to pedotechnique application in large-scale farming that transformed original soils into *** the consideration that soils can be considered as living systems,the original concept of'soil genetic erosion'is ***,extrapolated and modeled from a Soil Information System in a study case representative of a Mediterranean landscape,predicted that most of the soil types would disappear in few years leading to a decrease of the soil diversity and originating soil genetic *** circumstance is intentionally here told in form of a story where the fairy tale characters are some roils facing extinction in the *** genetic erosion could result in a negative impact on the environment because it reduces the soil's security through a drastic reduction of the soil ecosystem services with a decrease of the immaterial benefit for the *** conviction that soils,as well as animals and plants,are living bodies,and pedodiversity is equally important as biodiversity in maintaining sustainability and ecosystem services,might truly attract the attention of the public ***,focussing more on the soil economic dimension and strengthening the assignation of'economic value'to the soil ecosystem services,also politicians and administrators could increase their interest in soil security.

关键词： Soil genetic erosion Pedodiversity Anthropogenic soils Soil ecosystem services Soil security

Synchronously Pumped Mode-locked 1.89 μm Tm-Doped Fiber Laser with High Detuning Toleration

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Chinese Physics Letters 2018年第11期35卷 35-37页

作者： Gen Li Yong Zhou Shu-aie Li PeiJun Yao Wei-qing Gao Chun Gu Li-Xin Xu Department of Optics and Optical Engineering University of Science and Technology of China

We propose and demonstrate a synchronously pumped mode-locked Tm-doped fiber（TDF） laser without any extra mode-locking elements. Pumped by a 1.56 μm pulse fiber laser, the TDF laser generates 1.17 ps pulses with a spectral width of 9.7 nm and a repetition rate of 9.33 MHz. The emission wavelength is tunable along with the cavity length detuning in a wide range of 3 mm. The high detuning toleration is beneficial to achieve high temperature and vibration stability in all-fiber configuration lasers.

关键词： TDF RBW kHz m Tm-Doped Fiber Laser with High Detuning Toleration Synchronously Pumped Mode-locked 1.89 Tm

Can we grow sperm？ A translational perspective on the current animal and human spermatogenesis models

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Asian Journal of Andrology 2011年第5期13卷 677-682页

作者： Kirk C lo Trustin Domes Department of Surgery University of Toronto Toronto Ont. Canada Division of Urology Department of Surgery Mount Sinai Hospital Toronto Ont. Canada

There have been tremendous advances in both the diagnosis and treatment of male factor infertility; however, the mechanisms responsible to recreate spermatogenesis outside of the testicular environment continue to elude andrologists. Having the ability to ＇grow＇ human sperm would be a tremendous advance in reproductive biology with multiple possible clinical applications, such as a treatment option for men with testicular failure and azoospermia of multiple etiologies. To understand the complexities of human spermatogenesis in a research environment, model systems have been designed with the intent to replicate the testicular microenvironment. Currently, there are both in vivoand in vitro model systems. In vivo model systems involve the transplantation of either spermatogonial stem cells or testicular xenographs. In vitro model systems involve the use of pluripotent stem cells and complex coculturing and/or three-dimensional culturing techniques. This review discusses the basic methodologies, possible clinical applications, benefits and limitations of each model system. Although these model systems have greatly improved our understanding of human spermatogenesis, we unfortunately have not been successful in demonstrating complete human spermatogenesis outside of the testicle.

关键词： fertility preservation spermatogenesis models spermatogonial stem cells

Re-visiting supersymmetric Janus solutions: a perturbative construction

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Chinese Physics C 2020年第7期44卷 43-54页

作者： Nakwoo Kim se-Jin Kim Department of Physics and Research Institute of Basic Science Kyung Hee UniversitySeoul 02447Republic of Korea

We construct holographic Janus solutions,which describe a conformal interface in the theory of M2-branes,in four-dimensional gauged supergravities using a perturbative *** particular,we study three Einsteinscalar systems and their BPS equations,which are derived by Bobev,Pilch,and Warner(2014).The actions of our interest are all consistent truncations of D=11 supergravity,chosen to be invariant under SO(4)×SO(4),SU(3)×U(1)×U(1),and G2 symmetry subgroups of SO(8).The utility of our semi-analytic result is illustrated by the calculation of minimal area surface and the associated holographic entanglement entropy.

关键词： holography Janus solutions supergravity entanglement entropy

Automatic Mesh Generation on a Regular Background Grid

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Journal of Computer Science & Technology 2002年第6期17卷 882-887页

作者： lo S.H 刘剑飞 Department of Civil Engineering The University of Hong Kong Hong Kong P.R. China Department of Mechanics Peking University Beijing 100871 P.R. China

This paper presents an automatic mesh generation procedure on a 2D domain based on a regular background grid. The idea is to devise a robust mesh generation scheme with equal emphasis on quality and efficiency. Instead of using a traditional regular rectangular grid, a mesh of equilateral triangles is employed to ensure triangular element of the best quality will be preserved in the interior of the domain. As for the boundary, it is to be generated by a node/segment insertion process. Nodes are inserted into the background mesh one by one following the sequence of the domain boundary. The local structure of the mesh is modified based on the Delaunay criterion with the introduction of each node. Those boundary segments, which are not produced in the phase of node insertion, will be recovered through a systematic element swap process. Two theorems will be presented and proved to set up the theoretical basic of the boundary recovery part. Examples will be presented to demonstrate the robustness and the quality of the mesh generated by the proposed technique.

关键词： mesh generation background grid triangular mesh boundary recovery

Population Shrinkage in Resource-dependent Cities in China: Processes, Patterns and Drivers

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Chinese Geographical Science 2020年第1期30卷 1-15页

作者： LI He Kevin lo ZHANG Pingyu Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China Department of Geography Hong Kong Baptist UniversityKowloon Tong999077Hong KongChina College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Resource-dependent cities(RCs)are a vulnerable group of urban settlements that often face population shrinkage;however,population changes in RCs in China are not well *** study offers new insight into this matter through a robust analysis that features a longer time scale,a larger sample of RCs,and a finer unit of *** finds new evidence that problems of population shrinkage in RCs are more serious than previous literature has *** 30%of the studied units have experienced either long-term or short-term population shrinkage,and many more are experiencing a slowing down of population *** are especially common among three types of RCs:the resource-depleted RCs,the forestry-based RCs,and RCs in Northeast *** results underscore transition policy inadequacies in addressing population loss,and call for a more comprehensive and diversified population policy that tackles the multifaceted factors that contribute to population shrinkage,including lack of industrial support,maladjustment to market oriented reformation,poor urban environment and natural population decline.

关键词： resource-dependent cities urban shrinkage population change urbanization,China

Insights into the genetic architecture of congenital heart disease from animal modeling

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Zoological Research 2023年第3期44卷 577-590页

作者： Wenjuan Zhu Cecilia W.lo The Chinese University of Hong Kong Hong Kong SARChina Department of Developmental Biology University of Pittsburgh School of MedicinePittsburghPA15201 USA Kunming Institute of Zoology-The Chinese University of Hong Kong(KIZ-CUHK)Joint Laboratory of Bioresources and Molecular Research of Common Diseases Hong Kong SARChina

Congenital heart disease(CHD)is observed in up to 1%of live births and is one of the leading causes of mortality from birth *** hundreds of genes have been implicated in the genetic etiology of CHD,their role in CHD pathogenesis is still poorly *** is largely a reflection of the sporadic nature of CHD,as well as its variable expressivity and incomplete *** reviewed the monogenic causes and evidence for oligogenic etiology of CHD,as well as the role of de novo mutations,common variants,and genetic *** further mechanistic insight,we leveraged single-cell data across species to investigate the cellular expression characteristics of genes implicated in CHD in developing human and mouse embryonic *** the genetic etiology of CHD may enable the application of precision medicine and prenatal diagnosis,thereby facilitating early intervention to improve outcomes for patients with CHD.

关键词： Congenital heart disease Genetic modifier Single cell sequencing De novo mutation Protective variant Common copy number variant