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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María Pérez-Zabalza Antoni Oliver-Gelabert JoséMaría Vallejo-Gil Javier Fañanás-Mastral Manuel Vázquez-Sancho Javier AndréBellido-Morales Alexánder se.astián Vaca-núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

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Mathematical epidemiology in a data-rich world

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Infectious Disease Modelling 2020年第1期5卷 161-188页

作者： Julien arino Department of Mathematics&Data Science nEXUS University of ManitobaWinnipegManitobaCanada

I discuss the acquisition and use of“background”data in mathematical epidemiology models,advocating a proactive approach to the incorporation of said data.I illustrate various mechanisms for acquiring data,mainly fr... 详细信息

关键词： Mathematical epidemiology Data acquisition Open data

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Intermediate filament dynamics： Disassembly regulation

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International Journal of Biomathematics 2017年第1期10卷 273-294页

作者： Chengjun Sun Julien arino Stephanie Portet School of Management and EconomicsKunming University of Science and Technology Kunming P. R. China Department of Mechanical Engineering University of Hong Kong Pokfulam Road Hong Kong Department of Mathematics University of Manitoba Winnipeg Manitoba R3T 2N2 Canada

A mechanism of intermediate filament disassembly regulation is proposed in which disas- sembly is regulated by the amount of proteins assembled in networks. It is Mso hypothe- sized that a delay might exist between regulation and actuM disassembly. Under realistic biological conditions of assembly and disassembly, it is shown that such a delay is harm- less and does not destabilize the organization of intermediate filaments in networks. However, for high rates of disassembly, the model predicts that delay can destabilize the organization, with the intermediate filament material oscillating between organizations mainly in networks and in nonfilamentous particles.

关键词： Cytoskeleton organization intermediate filaments time delay global asymp-totic stability bifurcation periodic solution.

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Spatio-temporal spread of infectious pathogens of humans

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Infectious Disease Modelling 2017年第2期2卷 218-228页

作者： Julien arino Department of Mathematics&Centre for Disease Modelling(West) University of ManitobaWinnipegManitobaR3T 2N2Canada

Spatio-temporal aspects in the propagation of infectious pathogens of humans are *** modelling of these issues using metapopulation models is presented.

关键词： Mathematical patio pathogens

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A simple model for COVID-19

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Infectious Disease Modelling 2020年第1期5卷 309-315页

作者： Julien arino Stéphanie Portet Department of Mathematics&Data Science nEXUS University of ManitobaCanada Centre for Disease Modelling Canada Canadian COVID-19 Mathematical Modelling Task Force Canada

An SL1L2I1I2A1A2R epidemic model is formulated that describes the spread of an epidemic in a *** model incorporates an Erlang distribution of times of sojourn in incubating,symptomatically and asymptomatically infectious *** properties of the model are explored,with focus on properties important in the context of current COVID-19 pandemic.

关键词： COVID-19 Mathematical model Erlang distribution Asymptomatic infections

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Deciphering the role of monosaccharides during phage infection of Staphylococcus aureus

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nano Research 2022年第10期15卷 9234-9242页

作者： Baptiste Arbez Marion Gardette Christophe Gantzer neus vilà Isabelle Bertrand Sofiane El-Kirat-Chatel Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement(LCPME) CNRSUniversité de Lorraine405 rue de Vandoeuvre54602 Villers-lès-NancyFrance

As phages are extensively investigated as novel therapy tools but also as transfer agents for antibiotic resistance genes,thorough understanding of phage–host interactions becomes *** for phage infection is its adhesion to the host ***,we used atomic force microscopy-based single-particle force spectroscopy with phage-decorated tips to decipher the adhesion of phage 187 on living Staphylococcus aureus *** found that addition of free n-acetyl-Dglucosamine was able to decrease phage adhesion,suggesting that this monosaccharide plays major role in phage 187 infection of ***,phage 187 adhesion on monosaccharide-coated model surfaces combined with plaque forming unit counts suggested that a direct link can be established between the propensity to bind to a saccharide and the capability of the latter to inhibit phage *** a nanoscale level,single-particle force spectroscopy was successfully used to identify a major receptor required for phage 187 infection of *** but also evidenced that this receptor was responsible for phage adhesion on *** work demonstrates that single-particle force spectroscopy is a powerful platform to screen and predict the molecular target of phages on their host surfaces.

关键词： atomic force microscopy single-particle force spectroscopy phage 187 Staphylococcus aureus phage-bacteria interactions

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Visible-light-induced synthesis of phosphorylated n-heterocycles through proton-coupled electron transfer

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Science China Chemistry 2021年第5期64卷 681-683页

作者： Vera A.vil’ Igor B.Krylov Alexander O.Terent’ev n.D.Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences Moscow 119991Russia

Phosphorus-containing organic compounds are important feedstock for the synthesis of value-added bioactive ***,the development of highly efficient synthetic methods for the construction of phosphorus-element bonds has drawn huge attention in the past decades[1].Particularly,the formation of P–C bonds from phosphoruscentered radicals has been demonstrated to be one of the most efficient and convenient strategies,which has been widely applied for the synthesis of organic phosphorus compounds in recent years.

关键词： synthesis bonds phosphorus

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Risk of COVID-19 variant importation-How useful are travel control measures?

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Infectious Disease Modelling 2021年第1期6卷 875-897页

作者： Julien arino Pierre-Yves Boëlle Evan Milliken Stephanie Portet Department of Mathematics&Data Science nexus University of ManitobaWinnipegManitobaCanada Sorbonne Universite Institut Pierre Louis d’Epidemiologie et de Sante Publique(IPLESP)France Department of Mathematics University of LouisvilleLouisvilleKYUSA

We consider models for the importation of a new variant COVID-19 strain in a location already seeing propagation of a resident *** distinguishing contaminations generated by imported cases from those originating in the community,we are able to evaluate the contribution of importations to the dynamics of the disease in a *** find that after an initial seeding,the role of importations becomes marginal compared to that of community-based *** also evaluate the role of two travel control measures,quarantine and travel *** conclude that quarantine is an efficacious way of lowering importation rates,while travel interruptions have the potential to delay the consequences of importations but need to be applied within a very tight time window following the initial emergence of the variant.

关键词： COVID-19 Variants Importation risk

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时滞微分方程的缓振荡解

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northeastern Mathematical Journal 1999年第2期15卷 217-222页

作者： n.Yousfi O.arino

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Late secondary Rupture of Flexor Tendons in the Palm of the Hand

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Case Reports in Clinical Medicine 2015年第10期4卷 334-336页

作者： Toshitaka Okabayashi Hiroshi arino Koichi nemoto Department of Orthopaedic Surgery National Defense Medical College Tokorozawa Japan

normal tendon substance is strong and is unlikely to break before the muscle origin, muscle, musculotendinous junction or the insertion yield. In almost all the cases, closed ruptures of the flexor tendon within the tendinous portion have been described in association with distinct underlying pathologies. We report a case of flexor tendon rupture of the index finger which seems to be associated with previous trauma occurred more than 40 years ago and abnormal healing.

关键词： Flexor Tendon Rupture Previous Trauma Abnormal Healing Tendon Transfer Quadriga Syndrome

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