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Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration

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Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： se-hwan lee Kang-Gon lee Jaeyeon lee Yong Sang Cho Min-Soo Ghim Soojin Kim Su-Jin Heo Yongdoo Park Young-Sam Cho Bu-Kyu lee McKay Orthopaedic Research Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mechanical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mechanical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MECHABIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(HA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing HA-based hydrogel and bulk-type HA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing HA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(H&E),Masson’s trichrome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic hydrogel Bone morphogenetic protein-2(BMP-2)

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Characteristics of damaged layer in micro-machining of copper material

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中国有色金属学会会刊：英文版 2009年第B09期19卷 295-300页

作者： Dong-Hee KWON Jeong-Suk KIM Myung-Chang KANG se-Hun KWON Jong-hwan lee School of Mechanical Engineering Pusan National University National Core Research Center for Hybrid Materials Solution Pusan National University Department of Mechatronics Busan College of Korea Polytechnic Ⅶ

The study on damaged layer is necessary for improving the machinability in micro-machining because the damaged layer affects the micro mold life and micro machine parts. This study examined the ultra-precision micro-machining characteristics, such as cutting speed, feed rate and cutting depth, of a micro-damaged layer produced by an ultra-high speed air turbine spindle. The micro cutting force, surface roughness and plastic deformation layer were investigated according to the machining conditions. The damaged layer was measured using optical microscope on samples prepared through metallographic techniques. The scale of the damaged layer depends on the cutting process parameters, particularly, the feed per tooth and axial depth of the cut. According to the experimental results, the depth of the damaged layer is increased by increasing the feed per tooth and cutting depth, also the damaged layer occurs less in down-milling compared with up-milling during the micro-machining operation.

关键词：机械加工性微观特征损伤层铜材样品制备技术微型机器切削速度切削深度

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Rigid reflections and Kac-Moody algebras

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Science China Mathematics 2019年第7期62卷 1317-1330页

作者： Kyu-hwan lee Kyungyong lee Department of Mathematics University of Connecticut Storrs CT 06269 USA Department of Mathematics University of Nebraska-Lincoln Lincoln NE 68588 USA Korea Institute for Advanced Study Seoul 02455 Republic of Korea

Given any Coxeter group, we define rigid reflections and rigid roots using non-self-intersecting curves on a Riemann surface with labeled curves. When the Coxeter group arises from an acyclic quiver, they are related to the rigid representations of the quiver. For a family of rank 3 Coxeter groups, we show that there is a surjective map from the set of reduced positive roots of a rank 2 Kac-Moody algebra onto the set of rigid reflections. We conjecture that this map is bijective.

关键词： Coxeter groups rigid reflections rigid roots non-self-crossing curves Kac-Moody algebras

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Measuring nasolacrimal duct volume using computed tomography images in nasolacrimal duct obstruction patients in Korean

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 100-105页

作者： Jin-hwan Park Jung-Ah Huh Jun-Feng Piao Hwa lee se-Hyun Baek Department of Ophthalmology Korea University College of Medicine

AIM: To investigate nasolacrimal duct(NLD) volume in Korean patients and to examine the correlation between NLD volume and obstruction. METHODS: Of patients who underwent orbital computed tomography from March 2013 to January 2016, patients diagnosed with NLD obstruction were classified into the patient group and patients without obstruction were classified into the control group. The NLD volume was measured using the Image J program, which showed the NLD in axial,coronal, and sagittal images on computed tomography. RESULTS: The average value of men's NLD volume,265.33±90.57 mm3, was significantly larger than women's,211.87±68.61 mm3(P=0.009). In the patient group, the NLD volume of the obstructed eyes, 242.49±82.93 mm3,and the non-obstructed eyes, 225.20±73.20 mm3, were significantly higher than the control group, 217.61±82.04 mm3(Psed a chronic change in the bone around the NLD and affect the measurement of NLD volume.

关键词： computed tomography nasolacrimal duct obstruction nasolacrimal duct volume

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PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

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Single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Influence of Processing Parameters on the Mechanical Properties of a Plasma Radical Nitrided SCM440 Steel

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Journal of Materials Science & Technology 2008年第3期24卷 356-358页

作者： seok-hwan Ahn Insup lee School of Mechanical Engineering Pukyong National University Department of Materials and Metallurgical Engineering Dongeui University

Plasma radical nitriding was performed to harden the surface of SCM440 steel for 1-10 h at temperature range of 450-550℃. This process involved the use of NH3 gas instead of N2 gas employed for the well-established plasma nitriding method. No compound layer was formed during this process except the experiment carried out at 500℃ for 10 h. The main phase produced in the diffusion zone was identified to be γ＇-Fe4（N, C）. A diffusion depth increased with increasing treatment temperature and time （up to about 250 μm）. The surface hardness of radical nitrided layer was about two times higher than that of the untreated surface. The tensile test was carried out to estimate the mechanical properties of surface-hardened SCM440 steel prepared at various plasma radical nitriding treatment time and temperature. The influence of radical nitriding treatment on the tensile strength of the specimen was found to be insignificant. The highest value of the ultimate tensile strength was obtained in the experiment carried out at 500℃ for 1 h. However, the elongation was greatly affected by the radical nitriding processing parameters. The maximum value of elongation, which is equal to about 18.1%, was also obtained under the condition of 500℃ for 1 h.

关键词： Plasma radical nitriding Tensile strength Elongation Surface hardness Diffusion depth Compound layer

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Myostatin gene role in regulating traits of poultry species for potential industrial applications

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Journal of Animal Science and Biotechnology 2024年第5期15卷 1793-1801页

作者： Joonbum lee Dong‑hwan Kim Kichoon lee Department of Animal Sciences The Ohio State UniversityColumbusOH 43210USA

The myostatin(MSTN)gene is considered a potential genetic marker to improve economically important traits in live-stock,since the discovery of its function using the MSTN knockout *** anti-myogenic function of the MSTN gene was further demonstrated in farm animal species with natural or induced *** poultry species,myo-genesis in cell culture was regulated by modulation of the MSTN ***,different expression levels of the MSTN gene in poultry models with different muscle mass have been reported,indicating the conserved myogenic function of the MSTN gene between mammalian and avian *** advances of CRISPR/Cas9-mediated genome edit-ing techniques have led to development of genome-edited poultry species targeting the MSTN gene to clearly dem-onstrate its anti-myogenic function and further investigate other potential functions in poultry *** review summarizes research conducted to understand the function of the MSTN gene in various poultry models from cells to whole ***,the genome-edited poultry models targeting the MSTN gene are reviewed to inte-grate diverse effects of the MSTN gene on different traits of poultry species.

关键词： Chicken Economic traits Myostatin Quail

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Dynamic observation of dendrite growth on lithium metal anode during battery charging/discharging cycles

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npj Computational Materials 2022年第1期8卷 960-972页

作者： Hae Gon lee se Young Kim Joon Sang lee Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)12Jeongiui-gilSeongsan-guChangwon-siGyeongsangnam-do51543Republic of Korea Department of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Republic of Korea

Lithium metal is considered one of the most promising anode materials for application in next-generation ***,despite decades of research,practical application of lithium metal batteries has not yet been achieved because the fundamental interfacial mechanism of lithium dendrite growth is not yet fully *** this study,a series of reactive molecular dynamics (MD) simulations was performed to investigate the electrochemical dynamic reactions at the electrode/electrolyte *** allows quantitative characterization of morphological phenomena and real-time interfacial visualization of the dynamic growth of dead lithium and dendrites during repeated *** computational protocol was utilized to investigate the dendrite mitigation mechanism when an electrolyte additive (hydrogen fluoride) is dissolved in an organic ethylene carbonate (EC) electrolyte *** was confirmed that beneficial decomposition reactions between electrolyte components form a protective film on the anode surface,suppressing large interphase volume changes and unnecessary degradation reactions.

关键词： battery lithium electrolyte

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Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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