检索结果-南通市图书馆

Identification and comparison of the local physicochemical structures of transition metal-based layered double hydroxides for high performance electrochemical oxygen evolution reactions

引用

Journal of Energy Chemistry 2023年第12期87卷 89-97,I0004页

作者： Min Sung Kim Bipin Lamichhane ju-Hyeon lee Jin-Gyu Bae Jeong Yeon Heo Hyeon Jeong lee Shyam Kattel Ji Hoon lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea KNU Advanced Material Research Institute Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Department of Physics Florida A&M UniversityTallahasseeFlorida 32307United States

Layered double hydroxides(LDHs) have attracted considerable attention as a cost effective alternative to the precious iridium-and ruthenium-based electrocatalysts for an oxygen evolution reaction(OER),a bottleneck of water electrolysis for sustainable hydrogen *** their excellent OER performance,the structural and electronic properties of LDHs,particularly during the OER process,remain to be poorly *** this study,a series of LDH catalysts is investigated through in situ X-ray absorption fine structure analyses and density functional theory(DFT) *** experimental results reveal that the LDH catalyst with equal amounts of Ni and Fe(NF-LDH) exhibits the highest OER activity and catalytic life span when compared with its counterparts having equal amounts of Ni and Co(NC-LDH)and Ni only(Ni-LDH).The NF-LDH shows a markedly enhanced OER kinetics compared to the NC-LDH and the Ni-LDH,as proven by the lower overpotentials of 180,240,and 310 mV,respectively,and the Tafel slopes of 35.1,43.4,and 62.7 mV dec^(-1),*** DFT calculations demonstrate that the lowest overpotential of the NF-LDH is associated with the active sites located at the edge planes of NF-LDH in contrast to those located at the basal planes of Ni-LDH and *** current study pinpoints the active sites on various LDHs and presents strategies for optimizing the OER performance of the LDH catalysts.

关键词： Layered double hydroxides Oxygen evolution reaction In situ X-ray analyses Density functional theory Catalytic active sites

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of methanol extract of Schisandrae Fructus on high fat diet induced hyperlipidemic mice

引用

Journal of Traditional Chinese Medicine 2019年第6期39卷 818-825页

作者： se-Eun lee Hyungwoo Kim Chang-Hyun Kim Chiyeon Lim Suin Cho Department of Korean Medicine School of Korean MedicineYangsan Campus of Pusan National UniversityYangsan 50612Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea

OBJECTIVE:To investigate the effects and molecular targets of Schisandrae Fructus(SF)methanol extract(SFme)in mice with hyperlipidemia induced by high fat ***:We observed changes in body weight,blood serum content of total cholesterol,high-density lipoprotein(HDL)-cholesterol,and *** extent of accumulation of lipid peroxide due to lipid metabolism disorder also evaluated by measuring malondialdehyde(MDA)*** addition,after getting gene expression in hepatic tissues,target protein of SFme was identified using a protein interaction ***:SFme significantly decreased total cholesterol and triglyceride levels without alteration of body weight in mice,and the livercontent of MDA was statistically decreased by *** expression changes of cyclindependent kinase 1(Cdk1)and leucine-rich repeat kinase 2(Lrrk2)were restored by ***:The effect of SFme on the highfat-diet induced hyperlipidemia via decreasing total cholesterol and triglyceride levels may involve the expression of Cdk1 and Lrrk2 proteins.

关键词： Schisandra hyperlipidemias Obesity Cardiovascular diseases CDC2 protein kinase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

引用

Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho jung-Hwan Yoon Jeong-ju Yoo Minjong lee Dong Hyeon lee Eun ju Cho Jeong-Hoon lee Su Jong Yu Yoon jun Kim Chung Yong Kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Three-dimensional kagome structures in a PCL/HA-based hydrogel scaffold to lead slow BMP-2 release for effective bone regeneration

引用

Bio-Design and Manufacturing 2023年第1期6卷 12-25页

作者： se-Hwan lee Kang-Gon lee Jaeyeon lee Yong Sang Cho Min-Soo Ghim Soojin Kim Su-Jin Heo Yongdoo Park Young-Sam Cho Bu-Kyu lee McKay Orthopaedic Research Laboratory Department of Orthopaedic SurgeryPerelman School of MedicineUniversity of Pennsylvania36th Street and Hamilton WalkPhiladelphiaPA 19104USA Department of Biomedical Sciences College of MedicineKorea University73Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Medical Device Development Center Daegu-Gyeongbuk Medical Innovation Foundation(K-MEDI hub)80Cheombok-roDong-guDaegu 41061Republic of Korea Department of Mechanical Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea Biomedical Engineering Research Center Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea Department of Mechanical Design Engineering College of EngineeringWonkwang University460Iksan-daeroIksan 54538Republic of Korea MECHABIO Group Wonkwang University460Iksan-daeroIksan 54538Republic of Korea Department of Oral and Maxillofacial Surgery Asan Institute for Life SciencesAsan Medical Center88Olympic-roSongpa-guSeoul 05505Republic of Korea

Osteoconductive function is remarkably low in bone disease in the absence of bone tissue surrounding the grafting site,or if the bone tissue is in poor ***,an effective bone graft in terms of both osteoconductivity and osteoinductivity is required for clinical ***,the three-dimensional(3D)kagome structure has been shown to be advantageous for bone tissue regeneration due to its mechanical *** this study,a polycaprolactone(PCL)kagome-structure scaffold containing a hyaluronic acid(HA)-based hydrogel was fabricated using a 3D printing *** retention capacity of the hydrogel in the scaffold was assessed in vivo with a rat calvaria subcutaneous model for 3 weeks,and the results were compared with those obtained with conventional 3D-printed PCL grid-structure scaffolds containing HA-based hydrogel and bulk-type HA-based *** retained hydrogel in the kagome-structure scaffold was further evaluated by in vivo imaging system *** further reinforce the osteoinductivity of the kagome-structure scaffold,a PCL kagome-structure scaffold with bone morphogenetic protein-2(BMP-2)containing HA hydrogel was fabricated and implanted in a calvarial defect model of rabbits for 16 *** bone regeneration characteristics were evaluated with hematoxylin and eosin(H&E),Masson’s trichrome staining,and micro-CT image analysis.

关键词： Kagome-structure scaffold Retention capacity Biomimetic hydrogel Bone morphogenetic protein-2(BMP-2)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The extract of Celtis choseniana Nakai alleviates testosterone-in-duced benign prostatic hyperplasia through inhibiting 5αreductase type 2 and the Akt/NF-κB/AR pathway

引用

Chinese Journal of Natural Medicines 2022年第7期20卷 518-526页

作者： HONG Geum-Lan KIM Tae-Won lee Hui-ju KIM Yae-Ji KIM Kyung-Hyun juNG ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Republic of Korea

Benign prostatic hyperplasia(BPH)is a chronic male disease characterized by the enlarged *** choseniana Nakai(***)is medicinally used to alleviate pain,gastric disease,and lung *** this study,the effect of *** extract on BPH was investigated using testosterone-induced *** Dawley rats were divided into five groups:control,BPH(testosterone 5 mg·kg^(−1)),Fina(finasteride 2 mg·kg^(−1)),and ***(50 and 100 mg·kg^(−1)).After four weeks of TP treatment with finasteride or ***,prostate weights and DHT levels were *** addition,the prostates were histopathologically examined and measured for protein kinase B(Akt)/nuclear factor-κB(NF-κB)/AR signaling,proliferation,apoptosis,and ***-state weight and epithelial thickness were reduced in the *** groups compared with that in the BPH *** extract of *** acted as a 5αreductase inhibitor,reducing DHT levels in the ***,the extract of *** blocked the activation of p-Akt,nuclear NF-κB activation and reduced the expression of AR and PSA compared with ***,the ex-pression of Bax,PARP-1,and p53 increased,while the expression of bcl-2 *** present study demonstrated that ***-ana extract alleviated testosterone-induced BPH by suppressing 5αreductase and Akt/NF-κB activation,reducing AR signaling and in-ducing apoptosis and autophagy in the *** results suggested that *** probably contain potential herbal agents to alleviate BPH.

关键词： Apoptosis Androgen receptor Benign prostate hyperplasia Celtis choseniana Nakai 5α-Reductase type 2 NF-κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Korean red ginseng alleviates benign prostatic hyperplasia by dysregulating androgen receptor signaling and inhibiting DRP1-mediated mitochondrial fission

引用

Chinese Journal of Natural Medicines 2024年第7期22卷 599-607页

作者： HONG Geum-Lan KIM Kyung-Hyun CHO Sung-Pil lee Hui-ju KIM Yae-Ji juNG ju-Young Department of Veterinary Medicine&Institute of Veterinary Science Chungnam National UniversityDaejeon 34134Korea Department of Anatomy College of MedicineKonyang UniversityDaejeon 35365Korea

Panax ginseng(***.)has been traditionally employed in Korea and China to alleviate fatigue and digestive *** particular,Korean red ginseng(KRG),derived from streamed and dried ***,is known for its anti-aging and anti-inflammatory ***,its effects on benign prostatic hyperplasia(BPH),a representative aging-related disease,and the underlying mechanisms remain *** study aims to elucidate the therapeutic effects of KRG on BPH,with a particular focus on mitochondrial dynamics,including fission and fusion *** effects of KRG on cell proliferation,apoptosis,and mitochondrial dynamics and morphology were evaluated in a rat model of testosterone propionate(TP)-induced BPH and TP-treated LNCaP cells,with mdivi-1 as a *** results revealed that KRG treatment reduced the levels of androgen receptors(AR)and prostate-specific antigens in the BPH *** inhibited cell proliferation by downregulating cyclin D and proliferating cell nuclear antigen(PCNA)levels,and it promoted apoptosis by increasing the ratio of B-cell lymphoma protein 2(Bcl-2)-associated X protein(Bax)to Bcl-2 ***,KRG treatment enhanced the phosphorylation of dynamin-related protein 1(DRP-1,serine 637)compared with that in the BPH group,which inhibited mitochondrial fission and led to mitochondrial *** modulation of mitochondrial dynamics was associated with decreased cell proliferation and increased *** dysregulating AR signaling and inhibiting mitochondrial fission through enhanced DRP-1(ser637)phosphorylation,KRG effectively reduced cell proliferation and induced *** findings suggest that KRG’s regulation of mitochondrial dynamics offers a promising clinical approach for the treatment of BPH.

关键词： Androgen Benign prostatic hyperplasia Fission Korean red ginseng Mitochondria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tenebrio molitor Gram-negative-binding protein 3 (TmGNBP3)is essential for inducing downstream antifungal Tenecin 1 gene expression against infection with Beauveria bassiana JEF-007

引用

Insect Science 2018年第6期25卷 969-977页

作者： Yi-Ting Yang Mi Rong lee se Jin lee Sihyeon Kim Yu-Shin Nai Jae Su Kim Department of Agricultural Biology Chonbuk National UniversityKorea Department of Biotechnology and Animal Science National llan UniversityllanTaiwanChina plant Medical Research Center College of Agricultural and Life SciencesChonbuk National UniversityJenojuKorea

The Toll signaling pathway is responsible for defense against both Grampositive bacteria and ***-negative binding protein 3(GNBP3)has a strong affinity for the fungal cell wall component,β-1,3-glucan,which can activate the prophenoloxidase (proPO)cascade and induce the Toll signaling *** differentiation factor 88 (MyD88)is an intracellular adaptor protein involved in the Toll signaling *** this study,we monitored the response of 5 key genes (TmGNBP3,TmMyD88,and Tenecin 1,2, and 3)in the Toll pathway of the mealworm Tenebrio molitor immune system against the fungus Beauveria bassiana JEF-007 using ***3,Tenecin 1,and Tenecin 2 were significantly upregulated after fungal *** better understand the roles of the Toll signaling pathway in the mealworm immune system,TmGNBP3and TmMyD88 were knocked down by RNAi *** gene expression levels decreased at 2 d postknockdown and were dramatically reduced at 6 d post-dsRNA ***, mealworms were compromised by *** JEF-007at 6d post-dsRNA injection. Silencing of TmMyD88 and TmGNBP3 resulted in reduced resistance of tilde host to fun- gal ***,reducing TmGNBP3 levels obviously downregulated Tenecin 1 and Tenecin 2expression levels,whereas silencing TmMyD88 expression resulted in de- creased Tenecin 2 *** results indicate that TmGNBP3 is essential to induce downstream antifungal peptide Tenecin i expression against *** JEF-007.

关键词： Beauveria bassiana RNAi Tenebrio molitor TmGNBP3 TmMyD88

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative standardized ileal amino acid digestibility and metabolizable energy contents of main feed ingredients for growing pigs when adding dietary β-mannanase

引用

Animal Nutrition 2019年第4期5卷 359-365页

作者： se Min Jeon Abdolreza Hosseindoust Yo Han Choi Min ju Kim Kwang Yeol Kim jun Hyung lee Dong Yong Kil Beob Gyun Kim Byung Jo Chae Department of Animal Resources Science College of Animal Life SciencesKangwon National UniversityChuncheon 24341South Korea Swine Division National Institute of Animal ScienceRural Development AdministrationCheonan 31000South Korea Department of Animal Science and Technology Chung-Ang UniversityAnseong-siGyeonggi-do 17546South Korea Department of Animal Science and Technology Konkuk UniversitySeoul 143-701South Korea

The present study was conducted to test whether the dietary supplementation of β-mannanase affects amino acids(AA) digestibility,metabolizable energy(ME) contents of corn,wheat,soybean meal,distillers dried grains with solubles,and palm kernel meal(PKM),nutrient digestibility,and growth performance of *** Exp.1,22 cannulated pigs were used for 10 dietary treatments including 5 feed ingredients and 2 β-mannanase concentrations(0 and 0.5 g/kg of the diet) in 6 periods in an incomplete Latin square design to determine the AA and energy *** Exp.2,200 growing pigs were randomly allotted to 4 treatments with 2 nutrient levels(high and low) and 2 concentrations of β-mannanase(2×2 factorial arrangement) in 2 phases(phase 1,d 0 to 21;and phase 2,d 22 to 42).In Exp.1,β-mannanase increased the mean standardized ileal digestibility(SID) of AA in all feed *** amount of digestible energy was increased(P se-treated *** fed β-mannanase showed a greater(P se in the diets had greater(P se 2,the concentration of fecal ammonia was decreased(P se increases the SID of AA,which has to be considered in balancing the rations.

关键词： Growing pigs β-mannanase Standardized ileal amino acids Ammonia Metabolizable energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

引用

Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-ju Park Hyo Won Chang Ji Hyun Back Su Jin lee Yae Eun Park Eun Hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon Ji Eun lee Yoon se lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impairment of gastrointestinal quality of life in severely obese patients

引用

World Journal of Gastroenterology 2014年第22期20卷 7027-7033页

作者： Po-jui Yu ju-juin Tsou Wei-Jei lee Kuo-Ting lee Yi-Chih lee Department of Nursing National Taiwan University Department of Surgery Min-Sheng General Hospital Department of Surgery National Cheng-Kung University Hospiyal Department of International Business Chien Hsin University of Science and Technology

AIM: To investigate the common gastro-intestinal symptoms and quality of life in severely obese subjects.

关键词： severe obesity Quality of life Gastro-intestinal symptoms Glycosylated hemoglobin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：