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β-Arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity

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Genes & Diseases 2023年第2期10卷 348-351页

作者： Minsuh Kim Ji Min Kim Eun Jeong Cho Chang Ohk Sung Joon Kim se jin jang Asan Institute for Life Sciences Asan Medical CenterSeoul 05505Republic of Korea University of Ulsan College of Medicine Seoul 05505Republic of Korea Department of Pathology Asan Medical CenterSeoul 05505Republic of Korea Graduate School of Medical Science and Engineering KAISTDaejeon 34141Republic of Korea OncoClew Life Science Co. LtdSeoul 05505Republic of Korea

Dysregulation of the Hippo pathway has been frequently identified in various human cancers. The Hippo pathway is a highly complex pathway involving multiple types of proteins, and the activation of YAP by LATS kinase is the final effector step in the transcription process. In this study, we linked the roles of the multifunctional adapter proteins β-arrestins (β-arrestin 1 and 2) in cooperation with other signaling pathways such as GPCR and Wnt to essential cellular functions involved in carcinogenesis, including the regulation of cell proliferation, migration, and differentiation as well as stem cell properties.1 Although β-arrestin 1 and 2 have high structural similarities, they have different roles in carcinogenesis as β-arrestin 1 aids cancer cell survival and metastasis2 and β-arrestin 2 inhibits tumor growth.1 In the Hippo signaling pathway, β-arrestins function as scaffold proteins that mediate the phosphorylation of key molecules, and their association with human cancers is a major research topic. In this study, we demonstrated that β-arrestin 2 inhibits YAP activation through the formation of the β-arrestin 2-LATS-YAP trimeric complex, which results in the promotion of the kinase activity of LATS in cancer cell lines and patient-derived colon cancer organoids.

关键词： cancer carcinogenesis activation

Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： jin-Bok Hwang Hyo-Jeong jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

Optimal design of FRMSM to decrease detent force

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Journal of Central South University 2011年第2期18卷 458-464页

作者： jang Ki-Bong PYO se-Ho AN Ho-jin KIM Gyu-Tak School of Mechatronics Changwon National University

An optimal configuration of the flux-reversal linear synchronous motor (FRLSM) with the optimal number of attachment permanent magnets (PMs) was presented. The optimal model of 2 000 N was designed to reduce the detent force by redesigning the air-gap structure and skewing. The design parameters,mover PMs and stator core,were selected for optimal design by DOE. The thrust and the detent force of the designed optimal models were compared by finite element analysis (FEA). As a result,the thrust of the optimal model is slightly decreased by 1.97% compared with the basic model,and the detent force of the optimal model is greatly decreased by 88.47% compared with the basic model.

关键词： flux-reversal linear synchronous motor detent force thrust design of experiment skew and overhang

Plasmid DNA-loaded asymmetrically porous membrane for guided bone regeneration

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Journal of Materials Science & Technology 2021年第4期63卷 161-171页

作者： se Heang Oh June-Ho Byun So Young Chun Young-Joo jang jin Ho Lee Department of Nanobiomedical Science Dankook UniversityCheonan 31116Republic of Korea Department of Oral and Maxillofacial Surgery Gyeongsang National University School of MedicineGyeongsang National University HospitalInstitute of Health SciencesGyeongsang National UniversityJinju 52727Republic of Korea BioMedical Research Institute Kyungpook National University HospitalDaegu 41404Republic of Korea Department of Advanced Materials Hannam UniversityDaejeon 34054Republic of Korea

Although bone defects can be restored spontaneously,bone reconstruction with sufficient strength and volume continues to be a challenge in clinical *** recent years,the use of a variety of biomaterials with bioactivity has been attempted to compensate for this ***,we fabricated a pDNA(encoding for BMP-2)-loaded asymmetrically porous polycaprolactone(PCL)/Pluronic F127 membrane as a bioactive guided bone regeneration(GBR)membrane,using a modified immersion-precipitation *** was observed that the GBR membrane allows continuous release of pDNA for more than20 *** pDNA was sufficiently transfected into human bone marrow stem cells(h BMSCs)without significant cytotoxicity and the gene-transfected cells showed prolonged synthesis of *** in vitro osteogenic differentiation and in vivo animal studies,the effective induction of osteogenic differentiation of h BMSCs and enhanced bone regeneration by the pDNA-loaded asymmetrically porous PCL/Pluronic F127 membrane was observed,suggesting that the pDNA-loaded membrane as a bioactive GBR membrane can be an alternative therapeutic technique for effective bone regeneration.

关键词： loaded porous attempted

Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas

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World Journal of Gastroenterology 2011年第14期17卷 1866-1873页

作者： Young jin Jun se Min jang Hu lin Han Ki-seok jang seung Sam Paik Kang Hong Lee Department of Pathology College of Medicine Hanyang University Seoul 133-792 South Korea Department of Surgery College of Medicine Hanyang University Seoul 133-792 South Korea

AIM:To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas. METHODS:We used tissue microarrays consisting of 26 normal mucosa,50 adenomas,515 adenocarcinomas,and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed. RESULTS:GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However,GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009),non-mucinous tumor type (P = 0.045),poorer differentiation (P = 0.001),lymph node metastasis (P se correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis,patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021,respectively,log-rank test). CONCLUSION:GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas.

关键词： Adenocarcinoma Colorectum Glucose transporter 1 Apoptosis-activating factor-1 Prognosis Survival

Re-visiting supersymmetric Janus solutions: a perturbative construction

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Chinese Physics C 2020年第7期44卷 43-54页

作者： Nakwoo Kim se-jin Kim Department of Physics and Research Institute of Basic Science Kyung Hee UniversitySeoul 02447Republic of Korea

We construct holographic Janus solutions,which describe a conformal interface in the theory of M2-branes,in four-dimensional gauged supergravities using a perturbative *** particular,we study three Einsteinscalar systems and their BPS equations,which are derived by Bobev,Pilch,and Warner(2014).The actions of our interest are all consistent truncations of D=11 supergravity,chosen to be invariant under SO(4)×SO(4),SU(3)×U(1)×U(1),and G2 symmetry subgroups of SO(8).The utility of our semi-analytic result is illustrated by the calculation of minimal area surface and the associated holographic entanglement entropy.

关键词： holography Janus solutions supergravity entanglement entropy

A self-Learning Data-Driven Development of Failure Criteria of Unknown Anisotropic Ductile Materials with Deep Learning Neural Network

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Computers, Materials & Continua 2021年第2期66卷 1091-1120页

作者： Kyungsuk jang Gun jin Yun Department of Aerospace Engineering Seoul National UniversitySeoul088262South Korea Institute of Advanced Aerospace Technology Seoul National UniversitySeoul08826South Korea

This paper first proposes a new self-learning data-driven methodology that can develop the failure criteria of unknown anisotropic ductile materials from the minimal number of experimental *** failure criteria of anisotropic ductile materials requires time-consuming tests and manual data *** proposed method can overcome such practical *** methodology is formalized by combining four ideas:1)The deep learning neural network(DLNN)-based material constitutive model,2)self-learning inverse finite element(seLIFE)simulation,3)Algorithmic identification of failure points from the selflearned stress-strain curves and 4)Derivation of the failure criteria through symbolic regression of the genetic *** update and the algorithmic tangent operator were formulated in terms of DLNN parameters for nonlinear finite element ***,the seLIFE simulation algorithm gradually makes the DLNN model learn highly complex multi-axial stress and strain relationships,being guided by the experimental boundary *** the failure point identification,a self-learning data-driven failure criteria are eventually developed with the help of a reliable symbolic regression *** methodology and the self-learning data-driven failure criteria were verified by comparing with a reference failure criteria and simulating with different materials orientations,respectively.

关键词： Data-driven modeling deep learning neural networks genetic programming anisotropic failure criterion

Development of a two-stage virtual impactor for the generation of micrometer-scale monodisperse aerosols

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Particuology 2024年第12期95卷 189-197页

作者： Jun-Hyung Lim Igor Kim se-jin Yook School of Mechanical Engineering Hanyang UniversitySeoul04763Republic of Korea

Monodisperse particles are useful across a wide range of industrial applications,such as LCD displays,solar cells and rechargeable batteries,due to their uniformly small ***,generating high volumes of monodisperse particles remains *** this study,it was aimed to generate mono-disperse aerosols by classifying micrometer-scale solid aerosol particles within a narrow size ***,a new particle-size classification device with two virtual impactors connected in series and clean air cores was *** first-stage virtual impactor had a slightly larger cutoff size than the second-stage,and the major flow discharged from the first-stage was directed to the *** target particle size range was altered by changing the nozzle sizes in the first and second stages or by adjusting the flow ***,the classification performance of the two-stage virtual impactor was simulated and validated through an experiment using Arizona test *** implemented combi-nations of cutoff sizes for the first and second stages were 3.0 and 2.0μm,3.9 and 2.7μm,or 6.7 and 4.8μ*** a result,monodisperse aerosol particles were classified at a geometric standard deviation of 1.04-1.14 and a particle size range of 2-6.7μ*** two-stage virtual impactor developed herein may be useful for various research and performance evaluations,as it can classify micrometer-scale solid particle aerosols that exhibit high monodispersity.

关键词： Virtual impactor Clean air core Dust collection efficiency Monodispersity

Time-domain channel estimator based on cyclic correlationfor OFDM systems with guard interval

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The Journal of China Universities of Posts and Telecommunications 2008年第2期15卷 26-31页

作者： IM se-bin CHOI Hyung-jin Communication Research Center Harbin Institute of Technology

Channel impulse response （CIR） can be estimated on the basis of cyclic correlation in time-domain for orthogonal frequency division multiplexing （OFDM） systems, This article proposes a generalized channel estimation method to reduce the estimation error by taking the average of different CIRs. Channel impulse responses are derived according to the different starting points of cyclic correlation. In addition, an effective CIR length estimation algorithm is also presented. The whole proposed methods are more effective to OFDM systems, especialiy to those with longer cyclic prefix. The analysis and the simulation results verify that the mean square error performance is 4-5 dB better than the conventional schemes under the same conditions.

关键词： CIR OFDM channel estimation mean squareerror (Mse)