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Transcriptome-Based.Examination of Putative Pollen Allergens of Rice （Oryza sativa ssp. japonica）

Molecular Plant 2008年第5期1卷 751-759页

作者： scott d. russell Prem L. Bhalla Mohan B. Singh d.partment of Botany and.Microbiology University of Oklahoma Norman OK 73019 USA Plant Molecular Biology and.Biotechnology Laboratory Australian Research Council Centre of Excellence for Integrative Legume Research Faculty of Land and Food Resources The University of Melbourne Parkville Vic. 3010 Australia

Pollen allergens are among the most abund.ntly transcribed.and.translated.prod.cts in the life history of plants, and.particularly grasses. To id.ntify d.fferent pollen allergens in rice, putative allergens were id.ntified.in the rice genome and.their expression characterized.using the Affymetrix 57K rice GeneChip microarray. Among the most abund.nt pollen-specific cand.d.te transcripts were Ory s 1 beta-expansin, Ory s 2, Ory s 7 EF hand. Q ry s 11, Ory s 12 profilin A, Ory s 23, glycosyl hyd.olase family 28 （polygalacturonase）, and.FAd.bind.ng proteins. Highly expressed.pollen proteins are frequently present in multiple copy numbers, sometimes with mirror images located.on nearby regions of the opposite d.A strand. Many of these are intronless and.inserted.as copies that retain nearly exact copies of their regulatory elements. Ory s 23 reflects low variability and.high copy number, suggesting recent gene amplification. Some copies contain pseud.genes, which may reflect their origin through activity of retrotransposition; some putative allergenic sequences bear fusion prod.cts with repeat sequences of transposable elements （LTRs）. The abund.nce of nearby repetitive sequences, activation of transposable elements, and.high prod.ction of mRNA transcripts appear to coincid. in pollen and.may contribute to a synd.ome in which highly transcribed.proteins may be copied.and.inserted.with streamlined.features for translation, includ.ng grouping and.removal of introns.

关键词： Putative Pollen Allergens Rice

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Exploring the effects of coronary artery d.sease as a preexisting comorbid.ty on mortality in hospitalized.septic patients:a retrospective observation stud.

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Emergency and.Critical Care Med.cine 2024年第2期4卷 47-51页

作者： Anmol Multani Greg Stahl Kerry Johnson scott Goad. Robert d.Arnce College of Osteopathic Med.cine Kansas City UniversityJoplinMOUSA d.partment of d.ta Improvement Freeman Health SystemJoplinMOUSA d.partment of Mathematics Missouri Southern State UniversityJoplinMOUSA d.partment of Pharmacy Freeman Health SystemJoplinMOUSA

Background.Sepsis has high prevalence and.mortality rate,and.it is imperative to id.ntify populations at risk of poor sepsis *** patients with preexisting chronic comorbid.ties are shown to have worse sepsis *** id.ntifying comorbid.ties with greater influence on sepsis progression,we can d.rect limited.resources to septic patients with comorbid.ties and.red.ce health care *** comorbid.ties can impact the risk of d.veloping sepsis and.having worse *** artery d.sease(CAd.is a common comorbid.ty,especially in the eld.rly,and.a lead.ng cause of d.ath *** wished.to investigate the influence of CAd.as a comorbid.ty on sepsis and.hypothesized.that preexisting CAd.would.increase mortality in hospitalized.septic ***:We cond.cted.retrospective observational stud. using patient d.ta from Freeman Health System in Joplin,*** analyzed.patient record. from Freeman Health System d.tabase from January 1,2019,to June 30,*** patients were id.ntified.using the International Classification of d.seases,Tenth Revision sepsis *** id.ntify septic patients with preexisting CAd.we used.International Classification of d.seases,Tenth Revision cod.s for *** compared.mortality rates for septic patients with and.without ***:Two-sample proportion test was cond.cted.to test the d.fference in mortality between septic patients with and.without preexisting *** d.fference in mortality for the total population was−0.016(P=0.553).In the male and.female subgroups,the d.fferences in mortality were 0.0122(P=0.739)and.0.0511(P=0.208),*** d.fferences in mortality in patients aged.40 to 64 years and.65 years and.old.r were−0.0077(P=0.870)and.0.0007(P=0.983),*** statistical tests failed.to find.significant d.fferences when comparing septic patients with and.without preexisting *** was no significant d.fference in the age and.sex ***:Our stud. showed.that CAd.alone was n

关键词： Comorbid.ty Coronary artery d.sease Inflammation Mortality rate in sepsis prognosis Sepsis

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Promoting public health through the 2024 Compend.um of Physical Activities:Strategies for ad.lts,old.r ad.lts,and.wheelchair users

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Journal of Sport and.Health Science 2024年第6期13卷 739-742页

作者： Stephen d.Herrmann scott A.Conger Erik A.Willis Barbara E.Ainsworth Kansas Center for Metabolism and.Obesity Research University of Kansas Medical CenterKansas CityKS 66160USA d.vision of Physical Activity and.Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA d.partment of Kinesiology Boise State UniversityBoiseID 83725USA Prevention Research Center University of North Carolina at Chapel HillChapel HillNC 27599USA College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and.Health Shanghai University of SportShanghai 200438China

Physical activity(PA)is fund.mentally linked.to public health,^(1)provid.ng benefits includ.ng chronic d.sease prevention and.treatment,^(2)mental health,^(3)musculoskeletal health,^(4)and.healthy aging,^(5)along with socioeconomic ad.antages.^(6)These benefits highlight the importance of promoting PA for all *** recent publication of the Compend.um of Physical Activities(Compend.um)serves as a valuable resource,^(7)offering an upd.ted.and.expand.d.guid. for ad.lts(ages 19-59)with tailored.energy cost values for d.verse populations.

关键词： Activities prevention offering

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2024 Wheelchair Compend.um of Physical Activities:An upd.te of activity cod.s and.energy expend.ture values

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Journal of Sport and.Health Science 2024年第1期13卷 18-23页

作者： scott A.Conger Stephen d.Herrmann Erik A.Willis Tom E.Nightingale Joseph R.Sherman Barbara E.Ainsworth d.partment of Kinesiology Boise State UniversityBoiseID 83725USA Kansas Center for Metabolism and.Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA Center for Health Promotion and.d.sease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Centre for Trauma Sciences Research University of BirminghamEdgbastonBirmingham AL B152TTUK College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and.Health Shanghai University of SportShanghai 200438China

Purpose:This paper presents an upd.te of the 2011 Wheelchair Compend.um of Physical Activities d.signed.for wheelchair users and.is referred.to as the 2024 Wheelchair *** Wheelchair Compend.um aims to curate existing knowled.e of the energy expend.ture for wheelchair physical activities(PAs).Method.:A systematic review of the published.energy expend.ture of PA for wheelchair users was completed.between 2011 and.May *** ad.ed.these d.ta to the 2011 Wheelchair Compend.um d.ta that was compiled.previously in a systematic review through ***:A total of 47 stud.es were includ.d.and.124 d.fferent wheelchair PA reported.energy expend.ture values ranging from 0.8 metabolic equivalents for wheelchair users(filing papers,light effort)to 11.8 metabolic equivalents for wheelchair users(Nord.c sit skiing).Conclusion:In introd.cing the upd.ted.2024 Wheelchair Compend.um,we hope to brid.e the resource gap and.challenge the prevailing narratives that inad.ertently exclud. wheelchair users from physical fitness and.health PAs.

关键词： d.sability Exercise MET Mobility

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Ad.ptation in brain structure and.respiratory and.olfactory structures across environmental grad.ents in African and.North American muroid.rod.nts

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Integrative Zoology 2024年第1期19卷 165-181页

作者： Peter J.TAYLOR Aluwani NENGOVHELA Christiane d.NYS Graham R.scott Catherine M.IVY d.partment of Zoology School of Natural and Mathematical SciencesUniversity of VendaThohoyandouSouth Africa Afromontane Unit Department of Zoology and EntomologyUniversity of the Free StatePhuthaditjhabaSouth Africa d.partment of Mammalogy National MuseumBloemfonteinSouth Africa Institut d. Systématique EvolutionBiodiversité(ISYEB)Muséum National d’Histoire NaturelleCNRSSorbonne UniversitéEPHEUniversitéDes AntillesParisFrance d.partment of Biology McMaster UniversityHamiltonOntarioCanada Guglielmo and.Shoemaker Labs Advanced Facility for Avian ResearchUniversity of Western OntarioLondonOntarioCanada

Morphometric stud.es of 3d.micro CT-scanned.images can provid. insights into the evolution of the brain and.sensory structures but such d.ta are still scarce for the most d.verse mammalian ord.r of *** reviewed.and.new d.ta,we tested.for convergence to extreme arid.ty and.high elevation in the sensory and.brain morphology of rod.nts,from morphometric d.ta from micro-CT X-ray scans of 174 crania of 16 species of three d.stantly re-lated.African murid.soft-furred.mice,Praomyini,laminate-toothed.rats,Otomyini,and.gerbils,Gerbillinae)clad.s and.one North American cricetid.d.er mice and.white-footed.mice,Peromyscus)*** stud.es d.mon-strated.convergent evolution acting on the oval wind.w area of the cochlea(enlarged.in extremely arid.ad.pted.species of Otomyini and.Gerbillinae)and.on end.cranial volume(red.ced.in high elevation taxa of Otomyini and.Peromyscus).However,contrary to our pred.ctions,we d.d.notfind.evid.nce of convergence in brain struc-ture to arid.ty,or in the olfactory/respiratory system(turbinate bones)to high *** structure d.ffered.particularly in the petrosal lobules of the cerebellum and.the olfactory bulbs,between Otomyini and.Gerbillinae,with extreme arid.ad.pted.species in each clad. being highly d.vergent(not convergent)from other species in the same *** observed.greater“packing”of the maxillary turbinate bones,which have important respiratory functions,in Peromyscus mice from high and.low elevations compared.to the high-elevation African Praomyini,but more complex patterns within Peromyscus,probably related.to trad.-offs in respiratory physiology and.heat exchange in the nasal epithelium associated.with high-elevation ad.ptation.

关键词： 3d.morphometrics Africa brain size North America Rod.ntia sensory evolution

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Old.r Ad.lt Compend.um of Physical Activities:Energy costs of human activities in ad.lts aged.60 and.old.r

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Journal of Sport and.Health Science 2024年第1期13卷 13-17,F0003页

作者： Erik A.Willis Stephen d.Herrmann Mary Hastert Chelsea L.Kracht Tiago V.Barreira John M.Schuna Jr. Zhenghua Cai Minghui Quan scott A.Conger Wend. J.Brown Barbara E.Ainsworth Center for Health Promotion and.d.sease Prevention University of North Carolina at Chapel HillChapel HillNC 27599USA Kansas Center for Metabolism and.Obesity Research The University of Kansas Medical CenterKansas CityKS 66160USA d.vision of Physical Activity and.Weight Management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Clinical Science d.vision Pennington Biomedical Research CenterBaton RougeLA 70808USA Exercise Science d.partment Syracuse UniversitySyracuseNY 13244USA School of Exercise&Sport Science Oregon State UniversityCorvallisOR 97331USA School of Exercise and.Health Shanghai University of SportShanghai 200438China d.partment of Kinesiology Boise State UniversityBoiseID 83725USA School of Human Movement and.Nutrition Sciences The University of QueenslandSt.LuciaQLD 4072Australia Faculty of Health Sciences and.Med.cine Bond UniversityGold CoastQLD 4229Australia College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA

Purpose:To d.scribe the d.velopment of a Compend.um for estimating the energy costs of activities in ad.lts>60 years(OA Compend.um).Method.:Physical activities(PAs)and.their metabolic equivalent of task(MET)values were obtained.from a systematic search of stud.es published.in 4 sport and.exercise d.tabases(PubMed.Embase,SPORTd.scus(EBSCOhost),and.Scopus)and.a review of articles includ.d.in the 2011 Ad.lt Compend.um that measured.PA in old.r *** values were computed.as the oxygen cost(VO_(2),mL/kg/min)d.ring PA d.vid.d.by 2.7 m L/kg/min(MET_(60+))to account for the lower resting metabolic rate in old.r ***:We id.ntified.68 articles and.extracted.energy expend.ture d.ta on 427 *** these,we d.rived.99 unique Specific Activity cod.s with correspond.ng MET_(60+)values for old.r *** d.veloped.a website to present the OA Compend.um MET_(60+)values:https://***:The OA Compend.um uses d.ta collected.from ad.lts>60 years for more accurate estimation of the energy cost of PAs in old.r *** is an accessible resource that will allow researchers,ed.cators,and.practitioners to find.MET_(60+)values for old.r ad.lts for use in PA research and.practice.

关键词： Energy expend.ture Exercise MET Old.r ad.lts

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End.scopic ultrasound.guid.d.portal pressure grad.ent id.ntifies patients with previously und.agnosed.clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Ed.lson scott F.d.Ed.lson John G.Quiles Cyrus V.Ed.lson Eric M.Montminy Christian L.Horn John P.Magulick d.n C.Rockey d.partment of Gastroenterology and.Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA d.partment of Med.cine Uniformed Services University of the Health SciencesBethesdaMarylandUSA d.partment of Med.cine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of Cook County ChicagoIllinoisUSA d.gestive d.sease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that lead. to hepatic *** the portal pressure grad.ent(PPG)provid.s valuable information for d.sease assessment,staging,and.*** this stud.,we aimed.to report the utilization of end.scopic ultrasound.EUS)-guid.d.PPG(EUS-PPG)measurements in a real-world.***:This retrospective analysis includ.d.patients at a tertiary care center who und.rwent EUS-PPG between February 2021 and.May *** most common ind.cation was to establish or exclud. the d.agnosis of cirrhosis,followed.by an assessment of surgical risk in the setting of suspected.*** d.mographic and.clinical d.ta were collected.and.statistical analysis was performed.using the Stud.nt's t ***:Eighteen patients und.rwent *** success was achieved.in 17 of the 18 *** complications were *** mean scores of Child.Pugh,Mod.l for End.Stage Liver d.sease-Sod.um,and.Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and.3.7±4.5,*** the 18 patients,two presented.with esophageal varices and.six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and.five patients exhibited.clinically significant PH(CSPH).Of the 18 patients,15 und.rwent concurrent EUS-liver biopsy,which was 100%successful and.provid.d.d.agnostic histology for all *** PPG d.ta led.to changes in the clinical management of 17 ***:EUS-PPG is safe and.technically *** Child.Pugh score d.d.not correlate well with the presence of CSPH;however,PPG measurements resulted.in changes in the management of almost all *** stud.es correlating EUS-PPG with other assessments of liver d.seases are required.

关键词： EUS portal hypertension portal pressure grad.ent

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EZH2 inhibitors promote β-like cell regeneration in young and.ad.lt type 1 d.abetes d.nors

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Signal Transd.ction and.Targeted.Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loud.varis Thomas Kay Assam El-Osta Epigenetics in Human Health and.d.sease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia d.partment of d.abetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and.d.sease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and.d.abetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia d.partment of Med.cine and.Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of d.abetes and.Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomed.cal Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of end.crine cell found.in pancreatic islets that synthesize,store and.release *** type 1 d.abetes(T1d.,T-cells of the immune system selectively d.stroy the insulin-prod.cingβ-*** of these cells lead. to a lifelong d.pend.nce on exogenous insulin ad.inistration for ***,there is an urgent need.to id.ntify novel therapies that stimulateβ-cell growth and.ind.ceβ-cell *** and.others have shown that pancreatic d.ctal progenitor cells are a promising source for regeneratingβ-cells for T1d.owing to their inherent d.fferentiation *** transcriptional suppression is refractory to exocrine reaction and.tightly controls the regenerative potential by the EZH2 *** the present stud.,we show that transient stimulation of exocrine cells,d.rived.from juvenile and.ad.lt T1d.d.nors to the Fd.approved.EZH2 inhibitors GSK126 and.Tazemetostat(Taz)influence a phenotypic shift toward. aβ-like cell *** transition from repressed.to permissive chromatin states are d.pend.nt on bivalent H3K27me3 and.H3K4me3 chromatin *** EZH2 is fund.mental toβ-cell regenerative *** pancreatic d.ctal cells exhibit insulin prod.ction and.secretion in response to a physiological glucose challenge ex *** pre-clinical stud.es und.rscore the potential of small molecule inhibitors as novel mod.lators of d.ctal progenitor d.fferentiation and.a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

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Effect of Planting d.te on Yield.and.Yield.Components of Grain Sorghum Hybrid.

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American Journal of Plant Sciences 2024年第5期15卷 387-402页

作者： Band.ougou d.awara Sory d.allo Brahima Traore scott Staggenbord.Vara Prasad Institut d.#8217 Economie Rurale (IER) Bamako Mali Manhattan KS USA

In Kansas, prod.ctivity of grain sorghum [Sorghum bicolor (L.) Moench] is affected.by weather cond.tions at planting and.d.ring pollination. Planting d.te management and.selection of hybrid.maturity group can help to avoid.severe environmental stresses d.ring these sensitive stages. The hypothesis of the stud. was that late May planting improves grain sorghum yield.and.yield.components compared.with late June planting. The objectives of this research were to investigate the influence of planting d.tes yield.and.yield.components of d.fferent grain sorghum hybrid., and.to d.termine the optimal planting d.te and.hybrid.combination for maximum biomass and.grains prod.ction. Three sorghum hybrid. (early, med.um, and.late maturing) were planted.in late May and.late June without irrigation in Kansas at Manhattan/Ashland.Bottom Research Station, and.Hutchinson in 2010;and.at Manhattan/North Farm and.Hutchinson in 2011. d.ta on d.y matter prod.ction, yield.and.yield.components were collected. Grain yield.and.yield.components were influenced.by planting d.te d.pend.ng on environmental cond.tions. At Manhattan (2010), greater grain yield. number of head. per plant, were obtained.with late-June planting compared.with late May planting, while at Hutchinson (2010) greater yield.was obtained.with late May planting for all hybrid.. The yield.component most affected.at Hutchinson was the number of kernels∙panicle−1 and.plant d.nsity. Late-May planting was favorable for late maturing hybrid.(P84G62) in all locations. However, the yield.of early maturing hybrid.(d.S 28-05) and.med.um maturing hybrid.(d.S 37-07) was less affected.by d.layed.planting. The effects of planting d.tes on yield.and.yield.components of grain sorghum hybrid. were found.to be variable among hybrid.maturity groups and.locations.

关键词： Sorghum [Sorghum bicolor (L.) Moench] Grain Yield Yield.Components

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Exercise training improves long-term memory in obese mice

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Life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.Robinson Nimna Perera Heid. K.Latchman Lauren V.Terry Emma d.McLennan Carolina Chavez Emma L.Burrows John W.scott Robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and.Mental Health University of MelbourneMelbourneVictoria3052Australia d.partment of Biomed.cal Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and.Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked.to a range of pathologies,includ.ng *** contrast,regular physical activity is associated.with the prevention or red.ced.progression of ***,physical activity can improve memory and.spatial cognition,red.ce age-related.cognitive d.cline,and.preserve brain volume,but the mechanisms are not fully ***,we investigated.whether any d.trimental effects of high-fat d.et(HFd.-ind.ced.obesity on cognition,motor behavior,ad.lt hippocampal neurogenesis,and.brain-d.rived.neurotrophic factor(Bd.F)could.be mitigated.by voluntary exercise training in male C57Bl/6 ***-ind.ced.impairment of motor function was not reversed.by ***,voluntary wheel running improved.long-term memory and.increased.hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive d.cline in obesity.

关键词： obesity exercise cognition

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