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Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & Cirrhosis 2024年第2期3卷 67-74页

作者： Jerome C.Edelson scott F.D.Edelson John G.Quiles Cyrus V.Edelson Eric M.Montminy Christian L.Horn John P.Magulick Don C.Rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of Cook County ChicagoIllinoisUSA Digestive Disease Research Center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of Child-Pugh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(CSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** Child-Pugh score did not correlate well with the presence of CSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

Future of Ecocriticism:Strategic-openness and Sustainability—An Interview with scott Slovic

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Comparative Literature:East & West 2010年第2期 105-116页

作者： SLOVIC scott The University of Nevada Reno

斯科特·斯洛维克现为美国内华达大学(里诺)英语系文学与环境教授,美国生态批评运动的主要倡导者之一。他创立了生态批评领域规模最大、最具影响力的学术组织——文学与环境研究会(As Sociation for theStudy of Li terature and Enviro... 详细信息

斯科特·斯洛维克现为美国内华达大学(里诺)英语系文学与环境教授,美国生态批评运动的主要倡导者之一。他创立了生态批评领域规模最大、最具影响力的学术组织——文学与环境研究会(As Sociation for theStudy of Li terature and Environment/ASLE)并长期担任会长。该研究会拥有一千多名会员。他积极帮助英国、德国、加拿大、印度、日本、韩国、澳大利亚及新西兰等十多个国家的学者建立了环境研究会分会,主编生态批评的权威期刊《文学与环境的跨文化研究》(Interdisciplinary Studies inLiterature and Environment,简称ISLE),编辑环境文学教材、文集近20种,代表作包括《探寻美国自然写作中的觉醒意识》、《走出去思考》等多部专著,发表论文1 50余篇。2010年5月到山东大学讲学,期间应邀到包括四川师范大学在内的几所大学访学并做系列讲座。本篇访谈是斯洛维克成都讲座基础上的一个拓展,主要集中讨论了生态批评的一些热点问题和生态批评的未来发展。斯洛维克认为,生态批评的策略开放和可持续发展是生态批评的活力和未来发展趋势。

关键词：生态批评环境研究文学教材山东大学编辑环境跨文化研究美国内华达学术组织澳大利亚自然写作

Plants and Global Environmental Change:A Special Issue Highlighting Younger Scientists

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Journal of Integrative Plant Biology 2008年第11期50卷 1337-1338页

作者： scott A.Heckathorn The University of Toledo

Humans are changing the global environment to such an extent that they are changing global climate （IPCC 2007; http：//***/）. The pace, if not the eventual extent, of this climate change may be rare in Earth＇s history, and these rapid changes in climate will have profound negative impacts on biodiversity of the planet and on the quality of human life （Millennium Ecosystem Assessment; http：*** en/***）. It is already widely believed that the Earth has entered a new geological period termed the Anthropocene, in recognition of the impact that humans are having on the Earth, and it is predicted that human-caused changes to Earth＇s environment and climate will likely be the foremost problems facing humans in the coming decades.

关键词： Plants and Global Environmental Change

Unsupervised learning of load signatures to estimate energy-related building features using surrogate modelling techniques

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Building Simulation 2023年第7期16卷 1273-1286页

作者： Shane Ferreira Burak Gunay Araz Ashouri scott Shillinglaw Carleton University OttawaK1S 5B6Canada National Research Council Canada OttawaK1A 0R6Canada

Characterization of an existing building’s energy-related features is critical to inform maintenance and retrofit ***,existing field-scale characterization methods tend to be labour intensive,invasive,and require high fidelity longitudinal data gathered through tightly regulated *** highlights the need for a low cost,scalable,and efficient screening *** paper puts forward a surrogate model-based approach to rapidly estimate energy-related building *** this end,EnergyPlus models for 12 midrise office archetypes,all with a rectangular footprint,are *** thousand variants of each archetype are generated by altering envelope,causal heat gain,and heating,ventilation,and air conditioning operation features.A unique load signature is derived for each variant’s heating and cooling energy *** parameters of the load signatures are clustered,then each cluster is associated with a set of plausible energy-related *** accuracy of the results was evaluated using five test buildings not seen by the *** method could effectively identify building features with reasonable accuracy and no significant degradation in performance across all 12 archetypes.

关键词： remote characterization energy-related building features surrogate modelling cluster analysis

A decade of Bt cotton in Chinese fields: Assessing the direct effects and indirect externalities of Bt cotton adoption in China

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Science China(Life Sciences) 2010年第8期53卷 981-991页

作者： scott ROZELLE Carl PRAY Food Security and the Environment Program Freeman Spogli Institute for International Studies Stanford University School of Environmental and Biological Sciences Rutgers the State University of New Jersey

The objective of this study is to examine whether or not the gains from reduced spraying for bollworms are being sustained more than one decade after the initial adoption in 2007. Based on farm-level data collected by the authors in 1999–2007 in 16 villages from 4 provinces, this study shows that insecticides applied for controlling bollworms have declined. This analysis supports Chinese policy makers’ decision to not require refuges of non-Bt cotton fields. It also suggests that past studies may have underestimated the benefits from adopting Bt technology.

关键词： biotechnology Bt cotton insecticide sustainability externalities China

Purinergic signaling systems across comparative models of spinal cord injury

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Neural Regeneration Research 2022年第3期17卷 2391-2398页

作者： Eva E.Stefanova Angela L.scott Department of Pathology and Molecular Medicine McMaster UniversityHamiltonONCanada

Within the last several decades,the scientific community has made substantial progress in elucidating the complex pathophysiology underlying spinal cord ***,despite the many advances using conventional mammalian models,both cellular and axonal regeneration following spinal cord injury have remained out of *** this sense,turning to non-mammalian,regenerative species presents a unique opportunity to identify pro-regenerative cues and chara cterize a spinal cord microenvironment permissive to *** the signaling pathways hypothesized to be dysregulated during spinal cord injury is the purinergic signaling *** addition to its well-known role as energy currency in cells,ATP and its metabolites are small molecule neurotransmitte rs that mediate many diverse cellular processes within the central nervous *** our unde rstanding of the roles of the purinergic system following spinal cord injury is limited,this signaling pathway has been implicated in all injury-induced secondary processes,including cellular death,inflammation,reactive gliosis,and neural *** that the purinergic system is also evolutionarily conserved between mammalian and non-mammalian species,comparisons of these roles may provide important insights into conditions responsible for recovery ***,we compare the secondary processes between key model species and the influence of purinergic signaling in each *** our understanding of this signaling system and pro-regenerative conditions continues to evolve,so does the potential for the development of novel therapeutic interventions for spinal cord injury.

关键词： cell death differenriation glia inflammation neurogenesis proliferation purinergic signaling reactive gliosis regeneration spinal cord injury teleost

Calibration of the Albian/Cenomanian Boundary by Ammonite Biostratigraphy:*** Interior

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Acta Geologica Sinica(English Edition) 2007年第6期81卷 940-948页

作者： Robert W.scott University of Tulsa and Precision Stratigraphy Associates

Calibration of numerical ages to the geological time scale is a long scientific pursuit that requires the integration of multiple data sets. A case study of the Albian/Cenomanian stage boundary, also the Lower/Upper Cretaceous series boundary, illustrates the calibration process. The numerical age of this boundary has shifted from 96 Ma to 99 Ma over a time span of nearly fifty years. Recalibration resulted first from improvements in radiometric dating, and later from inferences about ammonite phylogeny, and most recently from radiometric dates of newly discovered volcanic beds interbedded with diagnostic guide fossils. However, the calibration process continues with study of cosmopolitan dinoflagellates.

关键词： Albian/Cenomanian ammonite biostratigraphy age calibration

Understanding metabolic flexibility: a potential key to unlocking metabolic therapies in amyotrophic lateral sclerosis?

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Neural Regeneration Research 2020年第9期15卷 1654-1655页

作者： scott P.Allen Sheffield Institute for Translational Neuroscience University of Sheffield

The role of metabolism in amyotrophic lateral sclerosis(ALS):ALS,is a predominantly sporadic,neurological disorder resulting in degeneration of both upper and lower motor neurons,resulting in the progressive failure of the neuromuscular *** lifetime risk factor for developing ALS sits between 1 in 300 and 1 in ***,due to the speed of the disease course(2–3 years post-diagnosis)and the lack of effective therapies,ALS is still classified as a rare disease.

关键词： metabolism amyotrophic degeneration

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火焰喷射器

环球科学 2024年第8期 44-45页

作者：斯科特·达特菲尔德不详

数千年来,人类发明了各式各样的火焰喷射器。不过,世界上第一支手持火焰喷射器是在第一次世界大战期间亮相的,由德国的理查德.菲勒德(Richard Fiedler)发明。这款手持火焰喷射器配有背负式燃料罐和枪管式喷嘴,扣动扳机后能够向敌人持续... 详细信息

数千年来,人类发明了各式各样的火焰喷射器。不过,世界上第一支手持火焰喷射器是在第一次世界大战期间亮相的,由德国的理查德.菲勒德(Richard Fiedler)发明。这款手持火焰喷射器配有背负式燃料罐和枪管式喷嘴,扣动扳机后能够向敌人持续喷射火焰。

关键词：喷射火焰背负式第一次世界大战火焰喷射器手持