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STCF conceptual design report (Volume 1): Physics & detector

Frontiers of physics 2024年第1期19卷 1-154页

作者： m.Achasov X.C.Ai L.P.An r.Aliberti Q.An X.Z.bai Y.bai O.bakina A.barnyakov V.blinov V.bobrovnikov d.bodrov A.bogomyagkov A.bondar I.boyko Z.H.bu F.m.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao d.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen S.L.Chen S.m.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.r.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.dai L.Y.dai X.C.dai d.dedovich A.denig I.denisenko J.m.d.as d.Z.ding L.Y.dong W.H.dong V.druzhinin d.S.du Y.J.du Z.G.du L.m.d.an d.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge C.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong b.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han m.Han X.Q.Hao J.b.He S.Q.He X.G.He Y.L.He Z.b.He Z.X.Heng b.L.Hou T.J.Hou Y.r.Hou C.Y.Hu H.m.Hu K.Hu r.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.S.Huang J.S.Huang m.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.b.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.b.Jiang J.Jiang S.Z.Jiang J.b.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang b.C.Ke m.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li d.Y.Li F.Li G.Li G.Li H.b.Li H.Li H.N.Li H.J.Li H.L.Li J.m.Li J.Li L.Li L.Li L.Y.Li N.Li P.r.Li r.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.r.Liao L.Z.Liao Y.Liao C.X.Lin d.X.Lin X.S.Lin b.J.Liu C.W.Liu d.Liu F.Liu G.m.Liu H.b.Liu J.Liu J.J.Liu J.b.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.b.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.r.Lyu J.P.ma P.ma Y.ma Y.m.ma F.maas S.malde d.matvienko Z.X.meng r.mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata b.b.Qi Y.Q.Qi W.b.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.S.Qin T.L.Qiu J.rademacker C.F.redmer H.Y.Sang Anhui University Hefei 230039China beihang University Beijing 100191China budker Institute of Nuclear Physics Novosibirsk 630090Russia CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central South University Changsha 410083China China University of Geosciences Wuhan 430074China China University of mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of m.d.rn Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the bEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STCF project in China is under development with an extensive r&d *** document presents the physics opportunities at the STCF,describes conceptual designs of the STCF detector system,and discusses future plans for detector r&d and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STCF detector conceptual design

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Extracellular vesicles-coupled mirNAs from oviduct and uterus m.d.late signaling pathways related to lipid metabolism and bovine early embryo development

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Journal of Animal Science and biotechnology 2024年第4期15卷 1528-1549页

作者： rosane mazzarella Karina Canon‑beltran Yulia N.Cajas meriem Hamdi Encina m.Gonzalez Juliano C.da Silveira Claudia L.V.Leal d.rizos department of Animal reproduction INIA-CSICMadridSpain department of biochemistry and molecular biology Veterinary FacultyComplutense University of Madrid(UCM)MadridSpain department Agrarian Production Technical University of MadridUPMMadridSpain departamento de Ciencias biologicas Universidad Tecnica Particular de LojaUTPLLojaEcuador department of Anatomy and Embryology FV-UCMMadridSpain department of Veterinary m.d.cine FZEA-USPPirassunungaBrazil

background Extracellular vesicles(EVs) present in oviductal(OF) and uterine fluid(UF) have been shown to enhance bovine embryo quality during in vitro culture by reducing lipid contents and m.d.lating lipid metabolism-related genes(LmGs), while also influencing cell proliferation, suggesting their involvement on the regulation of different biological pathways. The regulation of signaling pathways related to cell differentiation, proliferation, and metabo-lism is crucial for early embryo development and can determine the success or failure of the pregnancy. bioactive molecules within EVs in maternal reproductive fluids, such as micro rNAs(mirNAs), may contribute to this regulatory process as they m.d.late gene expression through post-transcriptional *** This study evaluated mirNA cargo in OF-EVs from the early luteal phase and UF-EVs from the m.d.luteal phase, coinciding with embryo transit within oviduct and uterus in vivo, and its possible influence on LmGs and sign-aling pathways crucial for early embryo development. A total of 333 mirNAs were detected, with 11 exclusive to OF, 59 to UF, and 263 were common between both groups. From the 20 differentially expressed mirNAs, 19 up-regulated in UF-EVs(bta-mir-134, bta-mir-151-3p, bta-mir-155, bta-mir-188, bta-mir-181b, bta-mir-181d, bta-mir-224, bta-mir-23b-3p, bta-mir-24-3p, bta-mir-27a-3p, bta-mir-29a, bta-mir-324, bta-mir-326, bta-mir-345-3p, bta-mir-410, bta-mir-652, bta-mir-677, bta-mir-873 and bta-mir-708) and one(bta-mir-148b) in OF-EVs. These mirNAs were predicted to m.d.late several pathways such as Wnt, Hippo, mAPK, and lipid metabolism and degradation. differ-ences in mirNAs found in OF-EVs from the early luteal phase and UF-EVs from m.d.luteal phase may reflect differ-ent environments to meet the changing needs of the embryo. Additionally, mirNAs may be involved, particularly in the uterus, in the regulation of embryo lipid metabolism, immune system, and *** Our study su

关键词： Embryo-maternal interaction Epigenetic Exosomes mammalian Preimplantation reproductive fluids

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Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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bone research 2024年第1期12卷 180-198页

作者： morten S.Hansen Kaja m.d.en maria Price Kent Søe Yasunori Omata mario m.Zaiss Caroline m.Gorvin morten Frost Alexander rauch molecular Endocrinology Laboratory(KmEb) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark department of Clinical research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of metabolism and Systems research(ImSr)and Centre for diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for membrane Proteins and receptors(COmPArE) Universities of Birmingham and NottinghamBirmingham B152TTUK department of molecular m.d.cine University of Southern DenmarkDK-5000 Odense CDenmark department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan department of Internal m.d.cine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany deutsches Zentrum Immuntherapie(dZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aim.d.to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from Cd14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on rNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin b(FLNb)and oxidized low-density lipoprotein receptor 1(OLr1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological m.d.lation of complement 5 A receptor 1(C5Ar1),somatostatin receptor 2(SSTr2),and free fatty acid receptor 4(FFAr4/GPr120).Activating C5Ar1 enhanced osteoclast formation,while activating SSTr2 decreased the resorptive activity of mature osteoclasts,and activating FFAr4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

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Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： roland Joseph d.Tan Gary John V.mercado Patricia E.Cabrera Paulita Pamela P.Astudillo rolando Enrique d.domingo Josept mari S.Poblete Charmaine Grace m.Cabebe Adriel Vincent r.Te melissa Anne S.Gonzales Jocelyn G.Sy beltran Alexis A.Aclan Jayson T.So Fatima G.regala Kimberley Amanda K.Comia Josemaria m.Castro mara Augustine S.Galang Aldous dominic C.Cabanlas benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo michael maniwan Andrei P.martin Calvin Y.martinez John Alfred H.Lim rena Ivy bascuna rachel m.Ng Kevin b.Agsaoay Kris Zanna A.Acluba-Arao Ellaine rose V.Apostol beatriz m.Prieto department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines department of Ophthalmology Manila Doctors HospitalManila 1000Philippines department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIm:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Pd those from the Visayas(Pbased on the International retinoblastoma Staging System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

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三轴形变核^(131)ba中的奇异集体激发模式

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物理学报 2024年第11期73卷 89-100页

作者：韦锐周厚兵王思成丁兵强赟华贾晨旭陈红星郭松 C.m.Petrache d.mengoni A.Astier E.dupont 吕冰锋 d.bazzacco A.boso A.Goasduff F.recchia d.Testov F.Galtarossa G.Jaworski d.r.Napoli S.riccetto m.Siciliano J.J.Valiente-dobon C.Andreoiu F.H.Garcia K.Ortner K.Whitmore A.Ataç-Nyberg T.bäck b.Cederwall E.A.Lawrie I.Kuti d.Sohler T.marchlewski J.Srebrny A.Tucholski 广西师范大学物理科学与技术学院桂林541004 广西核物理与核技术重点实验室桂林541004 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 巴黎萨克雷大学 CNRS/IN2P3IJCLab奥赛91405 帕多瓦大学物理和天文学系帕多瓦I-35131 意大利国家核物理研究所帕多瓦分部帕多瓦I-35131 意大利国家核物理研究所莱尼亚罗国家实验室莱尼亚罗(帕多瓦)I-35020 费拉拉大学理学与自然科学院费拉拉西蒙菲莎大学化学系本拿比BC V5A 1S6 皇家理工学院物理系斯德哥摩尔S-10691 国家研究基金会iThemba加速器科学实验室西萨默塞特7123 西开普大学物理与天文系贝尔维尔ZA-7535 HUN-rEN原子核研究所德布勒森4001 华沙巴斯德拉大学重离子实验室华沙02-093

利用意大利Legnaro实验室串列静电加速器提供的65 meV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.... 详细信息

利用意大利Legnaro实验室串列静电加速器提供的65 meV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.正负宇称手征带通过一系列增强的E1跃迁连接,表明它们之间存在八极关联.在低自旋区域搭建了一条新的转动带,通过一系列γ跃迁向νh1_(1/2)晕带退激.这种能级结构与摇摆带相似,但基于现有的实验证据还难以将它确认为摇摆带,不能排除其他集体激发机制,如γ振动的影响.

关键词：高自旋态手征带赝自旋八极关联摇摆运动

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Colonic schistosomiasis mimicking cancer,polyp,and inflammatory bowel disease:Five case reports and review of literature

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 472-482页

作者： Sebhatleab T mulate Abdulsem.d.m Nur Abel T Tasamma rodas T Annose Esmael m.d.wud Kinfe W Ekubazgi Hailemichael d mekonnen Hidaya Y mohamm.d.meron b Hailemeskel Shimelis A Yimer department of Internal m.d.cine Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia department of Internal m.d.cine Division of Gastroenterology and HepatologyAddis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia department of Internal m.d.cine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 9086Ethiopia department of Internal m.d.cine Hawassa UniversityHawassa PO Box 05Ethiopia department of Internal m.d.cine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia department of Pathology Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia department of Pathology St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia department of Pathology Ethio Tebib General HospitalAddis Ababa 1111Ethiopia

bACKGrOUNd Schistosomiasis,officially nam.d.as a neglected tropical disease by The World Health Organization,is a serious parasitic disease caused by trematode flukes of the genus *** is a common infectious disease,endemic in more than 78 *** disease can involve various organs and poses far-reaching public health *** SUmmArY Here,we present a series of five patients with variable presentations:an asymptomatic patient who was diagnosed with colonic schistosomiasis upon screening colonoscopy;2 patients with clinical suspicion of colonic cancer;and 2 patients with a clinical diagnosis of inflammatory bowel *** patients were subsequently confirm.d.to have colonic schistosomiasis after colonoscopy and histopathologic *** clinical manifestations,colonoscopy features and histologic findings of the patients are *** of the patients showed significant clinical improvement following administration of oral *** Intestinal schistosomiasis can present with features mimicking other gastrointestinal *** disease should be a diagnostic consideration in patients who live in or have traveled to endemic areas.

关键词： Schistosomiasis Schistosoma Colon Polyp Ethiopia Case report

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Generalized time-dependent generator coordinate method for induced fission dynamics

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Frontiers of physics 2024年第4期19卷 1-12页

作者： b.Li d.Vretenar T.Nikšić J.Zhao P.W.Zhao J.meng State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Physics department Faculty of ScienceUniversity of Zagreb10000 ZagrebCroatia Center for Circuits and Systems Peng Cheng LaboratoryShenzhen 518055China

The generalized time-dependent generator coordinate method(Td-GCm)is extended to include pairing *** correlated GCm nuclear wave function is expressed in terms of time-dependent generator states and weight *** particle–hole channel of the effective interaction is determined by a Hamiltonian derived from an energy density functional,while pairing is treated dynamically in the standard bCS approximation with time-dependent pairing tensor and single-particle occupation *** the inclusion of pairing correlations,various time-dependent phenomena in open-shell nuclei can be described more *** m.d.l is applied to the description of saddle-to-scission dynamics of induced *** generalized Td-GCm charge yields and total kinetic energy distribution for the fission of 240Pu,are compared to those obtained using the standard time-dependent density functional theory(Td-dFT)approach,and with available data.

关键词： nuclear density functional theory generator coordinate method fission dynamics

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reactions induced by 30 meV 3He beam on 9be:cluster transfer reactions

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Chinese Physics C 2024年第1期48卷 61-70页

作者： b.A.Urazbekov T.Issatayev S.m.Lukyanov A.Azhibekov A.S.denikin K.mendibayev d.m.Janseitov Yu E.Penionzhkevich K.A.Kuterbekov T.K.Zholdybayev Gumiliyev Eurasian National University 2 Satpayev StrAstanaKazakhstan Institute of Nuclear Physics 1 Ibragimov StrAlmatyKazakhstan bogolubov Laboratory of Theoretical Physics JINR20 Joliot Curie StrDubnaRussia Flerov Laboratory of Nuclear reactions JINR20 Joliot Curie StrDubnaRussia Korkyt-ata State University 29A Aiteke-Byi StrKyzylordaKazakhstan dubna State University 19 Universitetskaya StrDubnaRussia Al-Farabi Kazakh National University AlmatyKazakhstan

An experiment was conducted for studying the cluster structure of be induced by He ions at an energy of 30 *** results of the nuclear reaction^(3)He+^(9)be,the differential cross sections for the exit channels–elastic,inelastic,α+^(8)be,^(6)He+^(6)be,^(6)Li+^(6)Li,and^(7)be+^(5)He–were *** and inelastic scattering data were treated within both the optical m.d.l and coupled channel method.A new set of optical potentials was considered for the elastic *** deformation parameter was established for the transition 3/2→5/*** transfer reactions were analyzed via the coupled reaction channel *** nuclear reactions with the exit channels^(6)He+^(6)be,^(6)Li+^(6)Li,and^(7)be+^(5)He were complemented by two-step transfer *** contribution of each reaction mechanism were shown and compared with the findings of other authors.

关键词： cluster transfer reaction mechanisms coupled equations

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Exercise training improves long-term memory in obese mice

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Life metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey L.Egan Tina L.robinson Nimna Perera Heidy K.Latchman Lauren V.Terry Emma d.mcLennan Carolina Chavez Emma L.burrows John W.scott robyn m.murphy Henriette van Praag martin Whitham mark A.Febbraio monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia La Trobe Institute for molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and mental Health University of MelbourneMelbourneVictoria3052Australia department of biom.d.cal Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of Life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFd)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(bdNF)could be mitigated by voluntary exercise training in male C57bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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Promoting public health through the 2024 Compendium of Physical Activities:Strategies for adults,older adults,and wheelchair users

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Journal of Sport and Health Science 2024年第6期13卷 739-742页

作者： Stephen d.Herrmann scott A.Conger Erik A.Willis barbara E.Ainsworth Kansas Center for metabolism and Obesity research University of Kansas Medical CenterKansas CityKS 66160USA division of Physical Activity and Weight management Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA department of Kinesiology Boise State UniversityBoiseID 83725USA Prevention research Center University of North Carolina at Chapel HillChapel HillNC 27599USA College of Health Solutions Arizona State UniversityPhoenixAZ 85003USA School of Exercise and Health Shanghai University of SportShanghai 200438China

Physical activity(PA)is fundamentally linked to public health,^(1)providing benefits including chronic disease prevention and treatment,^(2)mental health,^(3)musculoskeletal health,^(4)and healthy aging,^(5)along with socioeconomic advantages.^(6)These benefits highlight the importance of promoting PA for all *** recent publication of the Compendium of Physical Activities(Compendium)serves as a valuable resource,^(7)offering an updated and expanded guide for adults(ages 19-59)with tailored energy cost values for diverse populations.

关键词： Activities prevention offering

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