检索结果-南通市图书馆

Role of ion channels in gastrointestinal cancer

World Journal of Gastroenterology 2019年第38期25卷 5732-5772页

作者： Kyle J Anderson Robert T Cormier Patricia m scott Department of Biomedical Sciences University of Minnesota Medical School

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer *** functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of *** this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and *** members of the TRP superfamily,including TRPm8,TRPm7,TRPm6 and TRPm2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon ***-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle *** VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC *** have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer ***2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).more than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal *** distinct types of K+channels are found dysregulated in the GI *** are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CR

关键词： Ion channels Gastrointestinal cancer Colorectal cancer Gastric cancer Pancreatic cancer Esophageal cancer Hepatocellular carcinoma Prognostic biomarker Novel therapies Clinical targets

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pasture-finishing of bison improves animal metabolic health and potential health-promoting compounds in meat

引用

Journal of Animal Science and Biotechnology 2023年第4期14卷 1759-1776页

作者： Stephan van Vliet Amanda D.Blair Lydia m.Hite Jennifer Cloward Robert E.Ward Carter Kruse Herman A.van Wietmarchsen Nick van Eekeren scott L.Kronberg Frederick D.Provenza Center for Human Nutrition Studies Department of NutritionDieteticsand Food SciencesCollege of Agriculture and Applied SciencesUtah State UniversityLoganUT 84322USA Department of Wildland Resources Utah State UniversityLoganUT 84332USA Department of Animal Science South Dakota State UniversityBrookingsSD 57707USA Turner Institute of Ecoagriculture BozemanMT 59718USA Louis Bolk Institute Bunnik 3981AJthe Netherlands Northern Great Plains Research Laboratory USDA-Agricultural Research ServiceMandanND 58554USA

Background With rising concerns regarding the effects of red meat on human and environmental health,a growing number of livestock producers are exploring ways to improve production systems.A promising avenue includes agro-ecological practices such as rotational grazing of locally adapted ***,growing consumer interest in pasture-finished meat(i.e.,grass-fed)has raised questions about its nutritional ***,the goal of this study was to determine the impact of two common finishing systems in North American bison—pasture-finished or pen-finished on concentrates for 146 d—on metabolomic,lipidomic,and fatty acid profiles of striploins(*** lumborum).Results Six hundred and seventy-one(671)out of 1570 profiled compounds(43%)differed between pasture-and penfinished conditions(n=20 animals per group)(all,Pmals,the muscle of pen-finished animals displayed elevated glucose metabolites(~1.6-fold),triglycerides(~2-fold),markers of oxidative stress(~1.5-fold),and proteolysis(~1.2-fold).In contrast,pasture-finished animals displayed improved mitochondrial(~1.3-fold higher levels of various Krebs cycle metabolites)and carnitine metabolism(~3-fold higher levels of long-chain acyl carnitines)(all Pmeat,while having lower levels of a common advanced lipoxidation(4-hydroxy-nonenal-glutathione;~2-fold)and glycation end-product(N6-carboxymethyllysine;~1.7-fold)(all Pmins B5,B6,and C,gamma/beta-tocopherol,and three phenolics commonly found in alfalfa were~2.5-fold higher in pen-finished animals(all Pme concentrate feeding,or grazing plants rich in those compounds,may be *** Pasture-finishing(i.e.,grass-fed)broadly improves bison metabolic health and accumulates additional po

关键词： Bison Grass-fed meat Nutrition Omega-3 fats Pasture-raised Phytochemicals

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Newfound Coding Potential of Transcripts Unveils missing members of Human Protein Communities

引用

Genomics, Proteomics & Bioinformatics 2023年第3期21卷 515-534页

作者： Se´bastien Leblanc marie *** Jean-Franc¸ois Jacques Amina m.Lekehal Andre´a Duclos Alexia Tremblay Alexis Bruggeman-Gascon Sondos Samandi myle`ne Brunelle Alan A.Cohen michelle S.scott Xavier Roucou Department of Biochemistry and Functional Genomics Universite´de SherbrookeSherbrookeQC J1E 4K8Canada PROTEO Quebec Network for Research on Protein FunctionStructureand EngineeringQuebec CityQC G1V 0A6Canada Department of Family medicine Universite´de SherbrookeSherbrookeQC J1H 5N4Canada

Recent proteogenomic approaches have led to the discovery that regions of the transcriptome previously annotated as non-coding regions[i.e.,untranslated regions(UTRs),open reading frames overlapping annotated coding sequences in a different reading frame,and non-coding RNAs]frequently encode proteins,termed alternative proteins(altProts).This suggests that previously identified protein–protein interaction(PPI)networks are partially incomplete because altProts are not present in conventional protein ***,we used the proteogenomic resource OpenProt and a combined spectrum-and peptide-centric analysis for the re-analysis of a highthroughput human network proteomics dataset,thereby revealing the presence of 261 altProts in the *** found 19 genes encoding both an annotated(reference)and an alternative protein interacting with each *** the 117 altProts encoded by pseudogenes,38 are direct interactors of reference proteins encoded by their respective parental ***,we experimentally validate several interactions involving *** data improve the blueprints of the human PPI network and suggest functional roles for hundreds of altProts.

关键词： Alternative protein Protein network Protein–protein interaction Pseudogene Affinity purification mass spectrometry

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An immunoglobulin Y that specifically binds to an in silico-predicted unique epitope of Zika virus non-structural 1 antigen

引用

Asian Pacific Journal of Tropical medicine 2022年第1期15卷 35-43页

作者： Leonardo A.Guevarra Jr scott Dean P.De Sagon Treena Rica D.Teh maria Katrina Diana mCruz Nikki Cyrill C.Capistrano Austine James Z.Stamaria Laarni Grace m.Corales Leslie michelle m.Dalmacio Department of Biochemistry and molecular Biology College of MedicineUniversity of the Philippines ManilaPhilippines Department of Biochemistry Faculty of PharmacyUniversity of Santo TomasPhilippines Research Center for Natural and Applied Sciences University of Santo TomasPhilippines

Objective:To identify unique immunogenic epitopes of Zika virus non-structural 1(NS1)antigen and produce immunoglobulin Y(IgY)for potential use in he diagnosis of of Zika virus ***:Immunogenic epitopes were identified using in silico B-cell epitope prediction.A synthetic peptide analog of the predicted epitope was used to induce antipeptide IgY production in hens which was purified using affinity *** of purified IgY and its binding specificity were performed by gel electrophoresis and ELISA,***:Out of the nine continuous epitopes identified,the sequence at position 193-208(LKVREDYSLECDPAVI)was selected and used to produce anti-peptide *** produced IgY was found to bind to the synthetic analog of the Zika virus NS1 immunogenic epitope but not to other flaviviruses and random peptides from other ***:In this study,we identified an immunogenic epitope unique to Zika virus that can be used to develop a serodiagnostic tool that specifically detect Zika virus infection.

关键词： Immunoglobulin Y IgY B-cell epitope prediction Flavivirus Non-structural 1 antigen Zika virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Substance use and inhalation injury in adult burn patients:retrospective study of the impact on outcomes

引用

Burns & Trauma 2019年第1期7卷 132-138页

作者： Kevin m.Klifto Luis Quiroga C.scott Hultman Department of Plastic and Reconstructive Surgery Johns Hopkins Burn CenterThe Johns Hopkins Hospital4940 Eastern AvenueBaltimore 21224USA

Background:Substance use,alcohol use,and smoking use have all been associated with burn *** studies have investigated associations with substances,alcohol,smoking,inhalational only burns,and patient *** purpose of the study was to identify risk factors for pulmonary failure in patients suffering inhalation injury,focusing on the impact of substance,alcohol,and cigarette ***:This is a single-center retrospective analysis of 115 patients admitted to the Johns Hopkins Bayview Burn Center with inhalational injury from January 1,2010,through September 30,*** were excluded if they were under the age of 18 years or had burn involvement of the skin>5%.Primary outcome variables measured were if patients were intubated,length of total time intubated,substance use,alcohol use,and smoking *** outcome variables measured were types of substances used(amphetamines,barbiturates,benzodiazepines,cannabinoids,cocaine,methadone,codeine/morphine),total number of substances used,intensive care unit(ICU)length of stay(LOS),hospital LOS,secondary complications,and patient *** was performed with Fisher’s exact test and the mann-Whitney U test.A sub-group analysis for each substance,alcohol,smoking,and control subgroup was compared to its respective sub-group without substance,alcohol,smoking,and control within the no intubation and intubation group.A sub-group analysis of substance use,alcohol use,smoking use,and control was further analyzed with binomial logistic regression within the intubation ***:Following inhalation injury,50/115(43%)patients required ***-two of the 50(84%)patients intubated had substance use(pmoking(p=0.038).Among the specific substances used,26/50(52%)patients intubated were using benzodiazepines(p<0.001)and 7/50(14%)patients were using cocaine(p=0.022).The lengths of intubation,ICU LOS,and hospital LOS with no substanc

关键词： Intubation Smoking Burn Risk factors Cocaine Benzodiazepines morphine Inhalation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Accuracy of genomic selection in biparental populations of flax(Linum usitatissimum L.)

引用

The Crop Journal 2016年第4期4卷 290-303页

作者： Frank m.You Helen m.Booker scott D.Duguid Gaofeng Jia Sylvie Cloutier morden Research and Development Centre Agriculture and Agri-Food Canada Crop Development Centre Department of Plant Sciences University of Saskatchewan Ottawa Research and Development Centre Agriculture and Agri-Food Canada

Flax is an important economic crop for seed oil and stem fiber. Phenotyping of traits such as seed yield, seed quality, stem fiber yield, and quality characteristics is expensive and time consuming. Genomic selection(GS) refers to a breeding approach aimed at selecting preferred individuals based on genomic estimated breeding values predicted by a statistical model based on the relationship between phenotypes and genome-wide genetic markers. We evaluated the prediction accuracy of GS(rmP) and the efficiency of GS relative to phenotypic selection(RE) for three GS models: ridge regression best linear unbiased prediction(RR-BLUP),Bayesian LASSO(BL), and Bayesian ridge regression(BRR), for seed yield, oil content, iodine value, linoleic, and linolenic acid content with a full and a common set of genome-wide simple sequence repeat markers in each of three biparental populations. The three GS models generated similar rmPand RE, while BRR displayed a higher coefficient of determination(R^2)of the fitted models than did RR-BLUP or BL. The mean rmPand RE varied for traits with different heritabilities and was affected by the genetic variation of the traits in the *** for seed yield generated a mean RE of 1.52 across populations and marker sets, a value significantly superior to that for direct phenotypic selection. Our empirical results provide the first validation of GS in flax and demonstrate that GS could increase genetic gain per unit time for linseed breeding. Further studies for selection of training populations and markers are warranted.

关键词： Genomic selection SSR Flax Linseed Seed yield Fatty acid composition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

What are the evolutionary origins of stomatal responses to abscisic acid in land plants?

引用

Journal of Integrative Plant Biology 2017年第4期59卷 240-260页

作者： Frances C. Sussmilch Timothy J. Brodribb scott A. m. mcAdam School of Biological Sciences University of Tasmania Hobart Tasmania Australia

The evolution of active stomatal closure in response to leaf water deficit, mediated by the hormone abscisic acid （ABA）, has been the subject of recent debate. Two different models for the timing of the evolution of this response recur in the literature. A single-step model for stomatal control suggests that stomata evolved active, ABA- mediated control of stomatal aperture, when these structures first appeared, prior bryophyte and vascular plant gradualistic model for stomatal to the divergence of neages. In contrast, a control proposes that the most basal vascular plant stomata responded passively to changes in leaf water status. This model suggests that active ABA-driven mechanisms for stomatal responses to water status instead evolved after the divergence of seed plants, culminating in the complex, ABA-mediated responses observed in modern angiosperms. Here we review the findings that form the basis for these two models, including recent work that provides critical molecular insights into resolving this intriguing debate, and find strong evidence to support a gradualistic model for stomatal evolution.

关键词： ABA What are the evolutionary origins of stomatal responses to abscisic acid in land plants acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental and modeling Study of Forest Fire Effect on Soil Thermal Conductivity

引用

Pedosphere 2016年第4期26卷 462-473页

作者： Kathleen m.SmITS Elizabeth KIRBY William J.mASSmAN Larry scott BAGGETT Center for the Experimental Study of Subsurface Environmental Processes Department of Civil and Environmental EngineeringColorado School of Mines USDA Forest Service Rocky Mountain Research Station

An understanding of soil thermal conductivity after a wildfire or controlled burn is important to land management and post-fire recovery efforts. Although soil thermal conductivity has been well studied for non-fire heated soils, comprehensive data that evaluate the long-term effect of extreme heating from a fire on the soil thermal conductivity are limited. The purpose of this study was to evaluate the long-term impact of fire on the effective thermal conductivity of soils by directly comparing fire-heated and no-fire control soils through a series of laboratory studies. The thermal conductivity was measured for ten soil samples from two sites within the manitou Experimental Forest, Colorado, USA, for a range of water contents from saturation to the residual degree of saturation. The thermal conductivity measured was compared with independent estimates made using three empirical models from literature, including the Campbell et al.(1994), Cté and Konrad(2005), and massman et al.(2008) models. Results demonstrate that for the test soils studied, the thermal conductivity of the fire-heated soils was slightly lower than that of the control soils for all observed water *** results show that the Campbell et al.(1994) model gave the best agreement over the full range of water contents when proper fitting parameters were employed. Further studies are needed to evaluate the significance of including the influence of fire burn on the thermal properties of soils in modeling studies.

关键词：土壤有效森林火灾热导率实验室模拟经验模型水含量恢复工作

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High temperature polymer electrolyte membrane fuel cell

引用

电池 2006年第5期36卷 347-353页

作者： K.scott m.mamlouk School of Chemical Engineering & Advanced materials Universityof NewcastleNE1 7RUUK

One of the majorissuesli mitingtheintroduction of polymer electrolyte membranefuel cells(PEmFCs) is thelowtemperature ofoperation which makes platinum-based anode catalysts susceptible to poisoning by the trace amount of CO,inevitably present in *** order to alleviate the problemof COpoisoning andi mprove the power density of the cell,operating at temperature above 100 ℃***-type perfluorosulfonated polymers have been typically used for ***,the conductivity of Nafion-typepolymers is not high enoughto be usedfor fuel cell operations at higher temperature(>90 ℃) and atmospheric pressure because they dehy-drate under these *** additional problem which faces the introduction of PEmFCtechnology is that of supplying or storing hydrogen for cell operation,especially for vehicular *** the use of alternative fuels such as methanol and ethanol is of interest,especially if thiscan be used directlyinthe fuel cell,without reformationto *** mitation of the direct use of alcohol is thelower activity of oxida-tionin comparison to hydrogen,which means that power densities are considerably *** to i mprove activity and power outputhigher temperatures of operation are *** achieve this goal,requires a newpolymer electrolyte membrane which exhibits stabilityand high conductivityin the absence of liquid *** mental data on a polybenzi midazole based PEmFC were *** mple steady-stateisothermal model of the fuel cell is alsoused to aidin fuel cell performance opti *** governing equations involve the coupling of kinetic,ohmic and mass *** also considers the advances madeinthe performance of direct methanol and solid polymer electrolyte fuel cells and considers theirli mi-tations in relation to the source and type of fuels to be used.

关键词： polybenzi midazole(PBI) high-temperature polymer electrolyte fuel cell methanol ethanol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced stabilization of inorganic cesium lead triiodide （CsPbl3） perovskite quantum dots with tri-octylphosphine

引用

Nano Research 2018年第2期11卷 762-768页

作者： Lu, Chang Li, Hui Kolodziejski, Kathy Dun, Chaochao Huang, Wenxiao Carroll, David Geyer, scott m. Department of Chemistry Wake Forest University Winston-Salem USA Center for Nanotechnology and molecular materials Department of Physics Wake Forest University Winston-Salem USA

In recent years, significant attention has been paid to perovskite materials. In particular, lead triiodide-based perovskites have exhibited superb optoelectronic properties. Enhancing the stability of these materials is an essential step towards large-scale applications. In this stud） by simply adding trioctylphosphine （TOP） as part of the post-synthesis treatment, we significantly enhance the stability of CsPbI3 quantum dots （QDs） in the solution phase, which otherwise decay rapidly in hours. For CsPbI3 QDs treated with TOP, the absorption and photoluminescence emission properties are unchanged over the course of weeks, and the quantum yield remains almost constant at 30% even after 1 month. The morphologies of both treated and untreated QDs are initially cubic; however, the treated QDs largely maintain their initial size and shape, while the untreated ones lose size uniformity, which is a sign of degradation. Infrared spectroscopy and X-ray photoelectron spectroscopy confirm the presence of P in the TOP-treated QDs. We hope that the technique of utilizing a ligand post-treatment will lead to new insights that help to resolve the intrinsic instability issue of triiodide perovskite materials and devices.

关键词： perovskite quantum dots ligand chemistry phase stabilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：