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Storylines of family medicine Ⅸ:people and places—diverse populations and locations of care

Family medicine and Community Health 2024年第S3期12卷 79-88页

作者： William B Ventres Leslie A Stone Emad R Abou-Arab Julio meza David S Buck Jerome W Crowder Jennifer Y C Edgoose Alexander Brown Ellen J Plumb Amber K Norris Jay J Allen Lauren E Giammar John E Wood scott m dickson G Austin Brown Family and Preventive medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family medicine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community medicine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and Behavioral Sciences University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family medicine Residency ConcordNew HampshireUSA San Francisco VA medical Center San FranciscoCaliforniaUSA Duluth Family medicine Residency Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAmS Northeast Regional Campus Family medicine Residency Program JonesboroArkansasUSA Cascades East Family medicine Residency Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storylines of Family medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅸ:people and places—diverse populations and locations of care’,authors address the following themes:‘LGBTQIA+health in family medicine’,‘A family medicine approach to substance use disorders’,‘Shameless medicine for people experiencing homelessness’,“Difficult”encounters—finding the person behind the patient’,‘Attending to patients with medically unexplained symptoms’,‘making house calls and home visits’,‘Family physicians in the procedure room’,‘Robust rural family medicine’and‘Full-spectrum family medicine’.may readers appreciate the breadth of family medicine in these essays.

关键词： illustration family dimensions

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manipulation of photosensory and circadian signaling restricts phenotypic plasticity in response to changing environmental conditions in Arabidopsis

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molecular Plant 2024年第9期17卷 1458-1471页

作者： martin William Battle scott Fraser Ewing Cathryn dickson Joseph Obaje Kristen N.Edgeworth Rebecca Bindbeutel Rea LAntoniou-Kourounioti Dmitri A.Nusinow matthew Alan Jones Plant Science Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Science Center St.LouisMO 63132USA Department of Biological and Biomedical Sciences Washington University in St.LouisSt.LouisMO 63130USA Present address:School of Biological and Environmental Sciences Liverpool John Moores UniversityLiverpool L22QPUK

Plants exploit phenotypic plasticity to adapt their growth and development to prevailing environmental *** of light and temperature signals is aided by the circadian system,which provides a temporal *** plasticity provides a selective and competitive advantage in nature but is obstructive during large-scale,intensive agricultural practices since economically important traits(including vegetative growth and flowering time)can vary widely depending on local environmental *** prevents accurate prediction of harvesting times and produces a variable *** this study,we sought to restrict phenotypic plasticity and circadian regulation by manipulating signaling systems that govern plants'responses to environmental *** modeling of plant growth and develop-ment predicted reduced plant responses to changing environments when circadian and light signaling pathways were *** tested this prediction by utilizing a constitutively active allele of the plant photoreceptor phytochrome B,along with disruption of the circadian systemvia mutation of *** found that these manipulations produced plants that are less responsive to light and temper-ature cues and thus fail to anticipate *** engineered plants have uniform vegetative growth and flowering time,demonstrating how phenotypic plasticity can be limited while maintaining plant *** has significant implications for future agriculture in both open fields and controlled environments.

关键词： circadian developmental plasticity phenotypic plasticity external coincidence light temperature

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Single doses of p38 mAP kinase inhibitors or prednisolone affect CRP and IL-6 in patients with active Rheumatoid Arthritis (RA)

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Open Journal of Immunology 2012年第3期2卷 85-97页

作者： Pauline T. Lukey Hayley C. Perry Shuying Yang Simon Parry marion C. dickson Virginia H. Norris Paul G. Russell marie Watissée Inmaculada Rioja Keith P. Ray scott Crowe michael Binks GlaxoSmithKline R&D Medicines Research Centre Stevenage UK

Purpose: To investigate the effects of single doses of losmapimod, dilmapimod (inhibitors of p38 mAPK) and prednisolone on biomarkers of systemic inflammation (serum C-reactive protein (CRP) and interleukin (IL)-6) in subjects with active rheumatoid arthritis (RA). methods: Two randomized, double blind, placebo controlled, parallel group, single dose studies investigated the CRP and IL-6 dose-response relationships for losmapimod (study A) and dilmapimod and prednisolone (study B) in patients with active RA on stable weekly doses of methotrexate. CRP, IL-6 and other exploratory biomarkers were measured in blood at baseline and up to 72 hours post-dosing. Results: In study A, 51 subjects were randomized to receive losmapimod (7.5, 20 and 60 mg) or placebo and in study B, 77 subjects were randomized to receive dilmapimod (7.5, 15 and 25 mg) or prednisolone (10, 20 and 50 mg) or placebo. Single doses of prednisolone caused a decrease in circulating IL-6 detectable at 3 and 24 hours post-dose as well as a CRP single-dose relationship at 48 hours post-dose in patients with active RA. All doses of losmapimod produced a statistically significant reduction in serum IL-6, 3 hours post-dose but had no effect on CRP. Dilmapimod had no effect on IL-6 or CRP at any dose or time. Conclusion: This single-dose response clinical study design could be useful in the early clinical development of anti-inflammatory agents for the treatment of rheumatoid arthritis. Inhibition of both circulating IL-6 and CRP would increase confidence that a new chemical entity may have the potential to deliver clinical benefit in RA. Trial registration: [***: NCT00256919 and NCT00134693].

关键词： p38 mAPK Prednisolone RA Biomarkers Proof of mechanism Randomised Controlled Trial

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