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ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases

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Neural Regeneration Research 2024年第4期19卷 721-722页

作者： Hiu Chuen Lok Glenda M.Halliday Woojin scott kim Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNSWAustralia

ATP-binding cassette(ABC)transporters are ubiquitous membrane-bound proteins that are responsible for the translocation of a broad spectrum of substrates across cellular membranes,including lipids,amino acids,nucleosides,sugars,and ***,ABC transporters are highly expressed in the *** their functions in the brain still need to be elucidated,several members are implicated in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease(AD),Parkinson’s disease(PD),and frontotemporal *** this perspective,we will review current knowledge of ABC transporters in the central nervous system in terms of physiological functions and pathology in ***,we will explore the possibilities of ABC transporters as potential targets in the development of therapeutics for neurodegenerative diseases.

关键词： sugar degenerative diseases

Magnetically controlled growing instrumentation for early onset scoliosis: Caution needed when interpreting the literature

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World Journal of Orthopedics 2019年第11期10卷 394-403页

作者： Kenneth Aaron Shaw Justin M Hire scott kim Dennis P Devito Michael L Schmitz Joshua S Murphy Department of Orthopaedic Surgery Dwight D.Eisenhower Army Medical CenterFort GordonGA 30905United States Department of Orthopaedic Surgery General Leonard Wood Army Community HospitalFort Leonard WoodMO 65473United States University of Tennessee Health Science Center MemphisTN 38163United States Department of Pediatric Orthopaedic Surgery Children’s Healthcare of AtlantaScottish Rite CampusAtlantaGA 30342United States

BACKGROUND Magnetically controlled growing rods(MCGR) are a novel treatment option for early onset scoliosis(EOS). Although the complication profile with MCGR use has been reviewed, these reviews do not take into account important implants modifications, termed iterations, that were made due to early on postoperative complications is not well reported or *** To assess the effect of MCGR implant iterations on post-operative complications in *** A systematic review was performed to identify studies investigating MCGR specifically for the treatment of EOS, refined to those reporting the implant iteration, specifically the incorporation of the keeper plate to the implant *** with mixed implant iteration usage were excluded. Complications following surgery were recorded as well as potential risk factors and compared between implant *** Although 20 articles were identified for inclusion, 5 included mixed implant iteration leaving a total of 271 patients identified through 15 clinical studies thatmet inclusion criteria. The average follow-up was 25.4-mo. Pre-keeper plate implants were utilized in 3 studies with a total of 49 patients. Overall, 115(42.4%)post-operative complications were identified, with 87% defined as major. The addition of the keeper plate significantly decreased the rate of post-operative complications per study(35.7% vs 80.6%, P = 0.036), and the rate of distraction failure(8.1% vs 40.8%, P = 0.02). Unplanned reoperation occurred in 69(26.7%)patients but was not different between implant iteration cohorts(25.5% without keeper plate vs 27.1% with keeper plate, P = 0.92).CONCLUSION MCGR for EOS has a cumulative complication rate of 42.4% but this is significantly reduced to 35.7% when reviewing only keeper-plate enabled implants. However, 25% of published articles included mixed implant *** studies should discern between implants iterations when reporting on the usage of MCGR for EOS.

关键词： Complications Early onset scoliosis Magnetically controlled growing instrumentations Keeper plate Reoperation Systematic review

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心中的明天 1

Effect of annealing on two different niobium-clad stainless steel PEMFC bipolar plate materials

丛书名：澳大利亚文学作品选

2003年

作者：（澳）吉姆·斯科特（kim scott）郇忠李尧译

这是一部小说化的家族史。澳大利亚土著人混血儿哈利，通过白人祖父厄尼的笔记和家族血缘图谱发现白人种族主义者鼓吹的所谓“社会工程实验”，实际上是白种男人借机发泄兽欲的幌子。无数土著妇女成为这一工程的牺牲品。一代又一代混血... 详细信息

ISBN: (纸本)7536664257

这是一部小说化的家族史。澳大利亚土著人混血儿哈利，通过白人祖父厄尼的笔记和家族血缘图谱发现白人种族主义者鼓吹的所谓“社会工程实验”，实际上是白种男人借机发泄兽欲的幌子。无数土著妇女成为这一工程的牺牲品。一代又一代混血儿因其肤色深浅的不同，在社会上的地位虽各不相同，但无一能完全摆脱被奴役，甚至被侮辱的命运。哈利通过对自己身世的追溯，揭露了以厄尼为代表的白人种族主义者企图对土著人施行灭绝政策的阴谋，从中揭示了土著人因此而经受的至今鲜为人知，令人无法想象的苦难。小说以多场景多情节展开，通过对众多任务经历的叙述，为我们展示了一幅西澳土著人灾难沉重的历史画卷。

关键词：文学大洋州文学

来源：汇雅图书（南通市图书馆... 评论

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中国有色金属学会会刊：英文版 2009年第B9期19卷 56-60页

作者： Sung-Tae HONG Dae-Wook kim Yong-Joo YOU K.scott WEIL School of Mechanical and Automotive Engineering University of Ulsan Department of Material Science and Engineering University of Ulsan Pacific Northwest National Laboratory

Niobium (Nb)-clad stainless steels(SS) produced via roll bonding are being considered for use in the bipolar plates of polymer electrolyte membrane fuel cell(PEMFC) stacks. Because the roll bonding process induces substantial work hardening in the constituent materials, thermal annealing is used to restore ductility to the clad sheet so that it can be subsequently blanked, stamped and dimpled in forming the final plate component. Two roll bonded materials, niobium clad 340L stainless steel (Nb/340L SS) and niobium clad 434 stainless steel (Nb/434 SS) were annealed under optimized conditions prescribed by the cladding manufacturer. Comparative mechanical testing conducted on each material before and after annealing shows significant improvement in ductility in both cases. However, corresponding microstructural analyses indicate an obvious difference between the two heat treated materials. During annealing, an interlayer with thick less than 1 μm forms between the constituent layers in the Nb/340L SS, whereas no interlayer is found in the annealed Nb/434 SS material. Prior work suggests that internal defects potentially can be generated in such an interlayer during metal forming operations. Thus, Nb/434 SS may be the preferred candidate material for this application.

关键词：质子交换膜燃料不锈钢材料双极板材料退火条件复合板铌聚合物电解质微观结构分析

Genic C-Methylation in Soybean Is Associated with Gene Paralogs Relocated to Transposable Element-Rich Pericentromeres

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Molecular Plant 2018年第3期11卷 485-495页

作者： Moaine El Baidouri Kyung Do kim Brian Abernathy Ying-Hui Li Li-Juan Qiu scott A. Jackson Center for Applied Genetic Technologies University of Georgia 111 Riverbend Road Athens GA 30602 USA Corporate R&D LG Chem LG Science Park 30 Magokjungang 10-ro Gangseo-gu Seoul 07796 Republic of Korea The National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI) Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing China These authors contributed equally to this article.

Most plants are polyploid due to whole-genome duplications （WGD） and can thus have duplicated genes. Following a WGD, paralogs are often fractionated （lost） and few duplicate pairs remain. Little attention has been paid to the role of DNA methylation in the functional divergence of paralogous genes. Using high- resolution methylation maps of accessions of domesticated and wild soybean, we show that in soybean, a recent paleopolyploid with many paralogs, DNA methylation likely contributed to the elimination of ge- netic redundancy of polyploidy-derived gene paralogs. Transcriptionally silenced paralogs exhibit partic- ular genomic features as they are often associated with proximal transposable elements （TEs） and are pref- erentially located in pericentromeres, likely due to gene movement during evolution. Additionally, we provide evidence that gene methylation associated with proximal TEs is implicated in the divergence of expression profiles between orthologous genes of wild and domesticated soybean, and within populations.

关键词： soybean paralog gene methylation proximal transposable element methylation spreading

Analysis of simple sequence repeats in rice bean(Vigna umbellata) using an SSR-enriched library

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The Crop Journal 2016年第1期4卷 40-47页

作者： Lixia Wang Kyung Do kim Dongying Gao Honglin Chen Suhua Wang Suk Ha Lee scott A. Jackson Xuzhen Cheng Institute of Crop Science Chinese Academy of Agricultural Sciences Center for Applied Genetic Technologies University of Georgia Plant Genomics and Breeding Institute Seoul National University

Rice bean(Vigna umbellata Thunb.), a warm-season annual legume, is grown in Asia mainly for dried grain or fodder and plays an important role in human and animal nutrition because the grains are rich in protein and some essential fatty acids and minerals. With the aim of expediting the genetic improvement of rice bean, we initiated a project to develop genomic resources and tools for molecular breeding in this little-known but important *** we report the construction of an SSR-enriched genomic library from DNA extracted from pooled young leaf tissues of 22 rice bean genotypes and developing SSR *** 433,562 reads generated by a Roche 454 GS-FLX sequencer, we identified 261,458 SSRs, of which 48.8% were of compound form. Dinucleotide repeats were predominant with an absolute proportion of 81.6%, followed by trinucleotides(17.8%). Other types together accounted for 0.6%. The motif AC/GT accounted for 77.7% of the total, followed by AAG/CTT(14.3%), and all others accounted for 12.0%. Among the flanking sequences, 2928 matched putative genes or gene models in the protein database of Arabidopsis thaliana, corresponding with 608 non-redundant Gene Ontology terms. Of these sequences, 11.2% were involved in cellular components, 24.2% were involved molecular functions, and 64.6% were associated with biological processes. Based on homolog analysis, 1595 flanking sequences were similar to mung bean and 500 to common bean genomic sequences. Comparative mapping was conducted using 350 sequences homologous to both mung bean and common bean sequences. Finally, a set of primer pairs were designed, and a validation test showed that58 of 220 new primers can be used in rice bean and 53 can be transferred to mung ***, only 11 were polymorphic when tested on 32 rice bean varieties. We propose that this study lays the groundwork for developing novel SSR markers and will enhance the mapping of qualitative and quantitative traits and marker-assisted selection in rice b

关键词： Vigna umbellata SSR Distribution and frequency Mapping Primer design

High-Resolution 3-D Radar Imaging through Nonuniform Fast Fourier Transform(NUFFT)

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Communications in Computational Physics 2006年第1期1卷 176-191页

作者： Jiayu Song Qing H.Liu Kangwook kim Waymond R.scott,Jr. Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

This paper applies a 3-D nonuniform fast Fourier transform(NUFFT)migration method to image both free-space and buried targets from data collected by a ultra-wideband ground penetrating radar(GPR)*** method incorporates the NUFFT algorithm into 3-D phase shift migration to evaluate the inverse Fourier transform more accurately and more efficiently than the conventional migration ***,the nonuniform nature of the wavenumber space required linear interpolation before the regular fast Fourier transform(FFT)could be ***,linear interpolation usually degrades the quality of reconstructed *** NUFFT method mitigates such errors by using high-order spatial-varying *** NUFFT migration method is utilized to reconstruct GPR images collected in laboratory.A plywood sheet in free space and a buried plexiglas chamber are successfully *** results in 3-D visualization demonstrate the outstanding performance of the method to retrieve the geometry of the *** buried landmines are also scanned and reconstructed using this *** the images resolve the features of the objects well,they can be utilized to assist the landmine discrimination.

关键词： Ground-penetrating radar(GPR) migration interpolation phase shift nonuniform fast Fourier transform(NUFFT)

Temporal clinical, proteomic, histological and cellular immune responses of dextran sulfate sodium-induced acute colitis

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World Journal of Gastroenterology 2018年第38期24卷 4341-4355页

作者： Natalia Schneider Nunes Saejeong kim Maggie Sundby Parwathy Chandran scott Robert Burks Ana Helena Paz Joseph Alan Frank Frank Laboratory Radiology and Imaging Sciences Clinical Center National Institutes of Health Gastroenterology and Hepatology Sciences Graduate Program Universidade Federal do Rio Grande do Sul National Institute of Biomedical Imaging and Bioengineering National Institutes of Health

AIM To investigate the temporal clinical, proteomic, histological and cellular immune profiles of dextran sulfate sodium(DSS)-induced acute *** Acute colitis was induced in C57 BL/6 female mice by administration of 1%, 2% or 3% DSS in drinking water for 7 d. Animals were monitored daily for weight loss, stool consistency and blood in the stool, while spleens and colons were harvested on day 8. A time course analysis was performed in mice ingesting 3% DSS, which included colon proteomics through multiplex assay, colon histological scoring by a blinded investigator, and immune response through flow cytometry or immunohistochemistry of the spleen, mesenteric lymph node and *** Progressive worsening of clinical colitis was observed with increasing DSS from 1% to 3%. In mice ingesting 3% DSS, colon shortening and increase in proinflammatory factors starting at day 3 was observed, with increased spleen weights at day 6 and day 8. This coincided with cellular infiltration in the colon from day 2 to day 8, with progressive accumulation of macrophages F4/80^+, T helper CD4^+(Th), T cytotoxic CD8^+(Tcyt) and T regulatory CD25^+(Treg) cells, and progressive changes in colonic pathology including destruction of crypts, loss of goblet cells and depletion of the epithelial barrier. Starting on day 4, mesenteric lymph node and/or spleen presented with lower levels of Treg, Th and Tcyt cells, suggesting an immune cell tropism to the gut. CONCLUSION These results demonstrate that the severity of experimental colitis is dependent on DSS concentration, correlated with clinical, proteomic, histological and cellular immune response on 3% DSS.

关键词： Ulcerative colitis Dextran sulfate sodium Proteomics Inflammatory bowel diseases Inflammation

Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADNRI)

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Neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew N.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia Jukka Jolkkonen Woojin scott kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of Neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CNS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular Neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for Neurological Disorders and Department of Neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of Neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease Neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective